Safety Profile and Suicidality Associated with the Use of Esketamine in the Treatment of Major Depressive Disorder in European Countries: An EudraVigilance Database Analysis by Ilaria Ammendolia, Carmen Mannucci, Emanuela Esposito, Gioacchino Calapai, Mariaconcetta Currò, Paola Midiri, Cristina Mondello, Luigi Cardia, Fabrizio Calapai

“…<b>Results:</b> Increases in blood pressure (15.4%) and dissociation (15.0%) were the most frequently reported SARs. The sex distribution indicates the prevalence of women, except for increased blood pressure and completed suicide, which were signaled in men, while adults (18–64 years) and elders (65–85 years) were the ages with the largest number of reported adverse reactions to esketamine. …”
Get full text

Association between statin administration and Clostridium difficile-induced enteritis: a retrospective analysis of the MIMIC-IV database by Renli Wang, Rongjun Liu, Hua Wang, Zhaojun Xu

“…The results indicate that statins can decrease the prevalence of CDE in patients in ICU (odds ratio (OR): 0.758, 95% confidence interval (CI): 0.666–0.873, P &lt; 0.05), which was further confirmed through PSM (OR: 0.760, 95% CI: 0.661–0.873, P &lt; 0.05) and IPTW (OR: 0.818, 95% CI: 0.754–0.888, P &lt; 0.05) analyses. For most subgroups, statins’ favorable effect in reducing CDE remained constant. …”
Get full text

Optimization of freeze-drying process for anti-Chlamydia hyperimmune serum by V. V. Evstifeev, S. I. Yakovlev, F. M. Khusainov, I. R. Akbashev, S. V. Sadykova

“…Based on the test results, the freeze-drying procedure employing a lower pressure and the highest heating temperature was found to be the most effective for the specific sera. The serum tests for compliance with characteristics laid down in the technical specifications for the test kit showed that the serum quality met all relevant requirements. …”
Get full text

Outcomes of abdominal wall reconstruction in complex ventral hernia patients: a single institution based prospective study by Bhawani Khanal, Abhijeet Kumar, Ashok Panta, Susmita Khadka Chhetri, Parbatraj Regmi, Vijay Pratap Sah, Bikash Kumar Sah, Davide Lomanto, Rakesh Kumar Gupta

“…Data on demographics, hernia characteristics, surgical technique, operative time, complications, hospital stay, recurrence, and chronic pain were collected and analysed.ResultsOf 88 ventral hernia cases, 44 were complex; 38 underwent repair. Most were incisional hernias located at M2–M5, with a mean defect size of 7.1 ± 2.9 cm. …”
Get full text

Cytokines and neopterin in antiphospholipid syndrome by E N Alexandrova, A A Novikov, T M Reshetnyak, T V Popkova, N G Klyukvina, M A Diatroptova, M V Cherkasova, L N Denisov, E L Nasonov

“…TNFα elevation in PAPS was associated with damage of cardiac valves (p&lt;0,05) and CNS (p&lt;0,01), IL18 elevation – with chronic leg ulcers (p&lt;0,001). Most prominent sTNFα-R elevation in SAPS was revealed in pts with thrombocytopenia (p&lt;0,05). …”
Get full text

Staged CBI for Reducing Anxiety and Depression in Lung Cancer Patients Undergoing Chemotherapy: A Retrospective Cohort Analysis by Chen L, Sun Y, Yu H, Sun M

“…The follow-up data were collected 6– 8 weeks after the Staged CBI sessions.Results: The SF-36 showed that effect size was large for most of the domains (Cohen’s d &gt; 1.2) and post CBI intervention was not significant except physical function. …”
Get full text

Using machine learning models based on cardiac magnetic resonance parameters to predict the prognostic in children with myocarditis by Dongliang Hu, Manman Cui, Xueke Zhang, Yuanyuan Wu, Yan Liu, Duchang Zhai, Wanliang Guo, Shenghong Ju, Guohua Fan, Wu Cai

“…Results Among the four models, the three most important features were late gadolinium enhancement (LGE), left ventricular ejection fraction (LVEF), and SAXPeak Global Circumferential Strain (SAXGCS). …”
Get full text

Efficient microaneurysm segmentation in retinal images via a lightweight Attention U-Net for early DR diagnosis by Muhammad Zeeshan Tahir, Xingzheng Lyu, Muhammad Nasir, Wengan He, Abeer Aljohani, Sanyuan Zhang

“…Among the earliest and most detectable signs of DR are microaneurysms (MAs). …”
Get full text

Assessing training needs of primary care pharmacists: a cross-sectional survey in China by Qingran Sun, Yanan You, Kejia Cao, Yuankai Huang, Xiaoyu Xi

“…Descriptive statistics was used to report characteristics of the sample and paired chi-square test was used to test whether the training contents and training approaches meeting the needs of primary care pharmacists. Results Most of primary care pharmacists enter the field of pharmacy by receiving pharmaceutical education in colleges and universities, and have obtained professional title qualification and licensed pharmacist qualification certificate. …”
Get full text

Russian nonverbal communication in teaching representatives of different cultures by Radif R. Zamaletdinov, Galina S. Kalinina, Gulshat Kh. Zinnatullina

“…The students must choose the correct or the most relevant answer. The complex approach helped to collect declarative information on difficulties and practical results on the ability to correctly identify Russian gestures in intercultural communication. …”
Get full text

The Impact of Physical Workload and Personal Factors on Nutritional Status Among Manufacturing Workers: A Cross-Sectional Study by Indah Lutfiya, Mursyidul Ibad, Nur Anisah Rahmawati, Ratih Damayanti, Tofan Agung Eka Prasetya, Ibrahim Al Khowwas

“…More than half of the respondents are female, do not have a high school education, and have never exercised. Most do not have a smoking habit. The results showed that physical workload (p=0.001), exercise habits (p=0.001), gender (p=0,004), and educational level (p=0.037) were related to nutritional status. …”
Get full text

EDITORIAL by Ivan Čuk

“…They present a review article about our most common element – handstand. When kids are doing handstand they instinctively correct their position, but for us it is important to recognize and understand the laws of how to maintain the inverted position. …”
Get full text

Role of neuropeptide Y in development of valproate-induced eating behaviour disorder by N. A. Shnayder, V. V. Grechkina, M. Ya. Kissin, D. V. Dmitrenko, R. F. Nasyrova

“…NPY has received special attention in recent years because it is one of the most potent brain orexigenic peptides and its expression level directly affects the quantity and quality of food intake. …”
Get full text

Risk of hernia-related complications after transjugular intrahepatic portosystemic shunt creation in patients with pre-existing ventral abdominal hernias: 15-year experience at a q... by Ruth Bell, Sasan Partovi, Michael Rosen, Baljendra Kapoor, Charles McDaniel, Natalie Farha, Catherine Vozzo, Jennifer Bullen, Carlos Romero-Marrero

“…Using a Wilcoxon rank-sum test, the characteristics of patients who developed hernia-related complications versus the characteristics of those without complications were compared.Results A total of 167 patients with pre-existing asymptomatic abdominal hernias were included in the analysis. The most common reason for TIPS placement was refractory ascites (80.6%). …”
Get full text

Stemness Characteristics of Periodontal Ligament Stem Cells from Donors and Multiple Sclerosis Patients: A Comparative Study by Francesca Diomede, Thangavelu Soundara Rajan, Marco D’Aurora, Placido Bramanti, Ilaria Merciaro, Marco Marchisio, Valentina Gatta, Emanuela Mazzon, Oriana Trubiani

“…Multiple sclerosis (MS) is the most prevalent and progressive autoimmune disease that affects the central nervous system, and currently, no drug is available for the treatment. …”
Get full text

Evaluating Inflorescence Morphology in Two Species and Subspecies of the Genus <i>Hierochloë</i> R. Brown by Károly Penksza, Tünde Szabó-Szöllösi, András Neményi, László Sipos, Szilárd Szentes, Zsombor Wagenhoffer, Balázs Palla, Dániel Ákos Balogh, Eszter Saláta-Falusi

“…The statistical analyses were non-parametric methods, the Kruskal–Wallis test, and principal component analysis. (3) Morphological traits showed consistent patterns within each subspecies, indicating their suitability for taxonomic differentiation. The most reliable diagnostic traits were the length of the outer glume of the first flower and the lengths of the awns. (4) The study concludes that while some subspecies can be clearly distinguished based on inflorescence morphology, no single trait is sufficient to completely separate all taxa. …”
Get full text

MFEM-CIN: A Lightweight Architecture Combining CNN and Transformer for the Classification of Pre-Cancerous Lesions of the Cervix by Peng Chen, Fobao Liu, Jun Zhang, Bing Wang

“…<italic>Goal:</italic> Cervical cancer is one of the most common cancers in women worldwide, ranking among the top four. …”
Get full text

Effects of blue light during and after exposure on auditory working memory by Kyungshil Kim, Koichi Yokosawa, Ken Okada, Hayate Onishi, Yumiko Tan, Sang-il Lee

“…., blue light) has been shown to enhance cognitive function in humans. While most prior studies have focused on visuospatial working memory, the effects of blue light on auditory working memory, particularly tasks involving the phonological loop, remain underexplored. …”
Get full text

How the families of the victims of suicide through self-incineration function before and after the event — a qualitative assessmen by L.H. Mabuza, G.A. Ogunbanjo, R.N. Malete

“…Suicide is as old as human history itself. It is most frequently seen as a fatal sequel of psychiatric illnesses and it is thought that suicide only occurs in a state of insanity, and that it is by itself a special form of insanity. …”
Get full text

Sentiment Analysis Using a Large Language Model–Based Approach to Detect Opioids Mixed With Other Substances Via Social Media: Method Development and Validation by Muhammad Ahmad, Ildar Batyrshin, Grigori Sidorov

“…Various strategies have been developed by federal and local governments and health organizations to address this crisis. One of the most significant objectives is to understand the epidemic through better health surveillance, and machine learning techniques can support this by identifying opioid users at risk of overdose through the analysis of social media data, as many individuals may avoid direct testing but still share their experiences online. …”
Get full text