The effect of manganese(II) excess on growth and antioxidant status of barley seedlings by O. A. Simonova, M. V. Simonov, E. V. Tovstik

“…According to the level of AOA SOD, the most sensitive variety was Farmer 198-12, its change of AOA SOD in the roots (% of control) was 158.8; 167.2 and 169.4% in accordance with the dose of manganese 30.0; 60.0 and 90.0 mg / l (AOA SOD in the control was 52.4±0.4%; in the experiment 83.2±2.2; 87.6±2.0 and 88.7±0.6, respectively), and in the shoots ˗ 121.0; 128.3 and 125.6 %, respectively (66.7±7.9 % in the control and 80.7±0.5; 85.6±1.4; 83.8±0.6 % in the experiment in accordance with the dose of Mn 2+).…”
Get full text

A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma by Yue Fu, Yue Fu, Weiyue Fang, Fuqiang Qiu, Juncai Lai, Yangjin Xu, Bin Chen, Yang Li, Xiaohui Zhu, Xiaohui Zhu

“…IntroductionHepatocellular carcinoma (HCC) ranks among the three most prevalent cancer-related diseases in terms of incidence. …”
Get full text

Reflexed cryptococcal antigenaemia detection rates in the Western Cape, South Africa by Naseem Cassim, Manuel P. da Silva, Lindi-Marie Coetzee

“…Conclusion: The study findings of a CrAg detection rate of 4.0% in the Western Cape province justifies their decision to extend reflexed screening to a threshold of 200 cells/µL. However, most CrAg-positive specimens were identified for a count 100 cells/µL. …”
Get full text

A tri-layer tissue engineering heart valve scaffold based on atelocollagen, hyaluronic acid, and elastin by Zhaoying Ma, Robin J. Scales, David D. Brand, Jan T. Czernuszka

“…Aim: This study aims to fabricate and characterise a novel tri-layer scaffold based on type I atelocollagen, hyaluronic acid (HA), and a novel fibrillar elastin gel, mimicking the native heart valve leaflets in structure, composition, and mechanical properties, among which, the bending anisotropic behaviour in both the with curvature (WC) and the against curvature (AC) directions, is the most desired. The use of atelocollagen is of significant importance in highlighting the non-antigenic potential of the design. …”
Get full text

Real-world insights into safety, tolerability, and predictive factors of adverse drug reactions in treating idiopathic pulmonary fibrosis with pirfenidone and nintedanib by Alessio Provenzani, Daniele Leonardi Vinci, Miriam Alaimo, Salvatore Di Maria, Fabio Tuzzolino, Gaetano Floridia, Roberta Di Stefano, Anna Carollo, Adriana Callari, Piera Polidori, Patrizio Vitulo

“…Results: The nintedanib group had more frequent ADRs related to gastrointestinal and hepatobiliary disorders, with nausea, diarrhea, anorexia, and weight loss as the most common. The pirfenidone group had more ADRs related to skin, nervous system, and vascular disorders, such as rash, nausea, dizziness, and blood pressure imbalances. …”
Get full text

Distinct roles of plant and microbial communities in ecosystem multifunctionality during grassland degradation and restoration by Linna Ma, Chaoxue Zhang, Jinchao Feng, Chunyue Yao, Xiaofeng Xu

“…Structural equation modeling identified plant and microbial communities as the most important predictors of EMF, even after accounting for climate and soil properties. …”
Get full text

Impact of academic cheating and perceived online learning effectiveness on academic performance during the COVID-19 pandemic among Pakistani students by Aamir Abbas Malik, Mehdi Hassan, Muhammad Rizwan, Iqra Mushtaque, Tauqeer Ahmed Lak, Mussarat Hussain

“…School students had an average age of (M = 15, SD = 4.65), college students had an average age of (M = 20, SD = 5.64), and university students had an average age of (M = 24, SD = 5.01).ResultThe results indicated that 60% of students admitted to cheating during online exams most of the time; 30% of students admitted to cheating at least once during an online exam. …”
Get full text

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex by Markella Konstantinidou, Marios Zingiridis, Marloes A. M. Pennings, Michael Fragkiadakis, Johanna M. Virta, Jezrael L. Revalde, Emira J. Visser, Christian Ottmann, Luc Brunsveld, Constantinos G. Neochoritis, Michelle R. Arkin

“…Cellular stabilization of 14-3-3/ERα for the most potent analogs is confirmed using a NanoBRET assay with full-length proteins in live cells. …”
Get full text

Neisseria gonorrhoeae antimicrobial susceptibility testing: application of traditional agar dilution to a high-throughput 96-well microtiter assay by Joyce E. Kuipers, Laura Seidel, Nicole E. Garnier, Cezar M. Khursigara

“…Essential agreement (EA) and categorical agreement (CA) ranged from 33% to 100%, with gentamicin contributing the most variability across methods. This study establishes the 96-well microtiter assay with Kellogg’s supplement as a reliable and scalable tool for N. gonorrhoeae antimicrobial susceptibility testing, reducing the time and resources required for resistance profiling.IMPORTANCEThe rapid emergence of antimicrobial resistance in Neisseria gonorrhoeae presents a critical challenge for global public health. …”
Get full text

New Genotypes and Phenotypes in Patients with 3 Subtypes of Waardenburg Syndrome Identified by Diagnostic Next-Generation Sequencing by Wu Li, Lingyun Mei, Hongsheng Chen, Xinzhang Cai, Yalan Liu, Meichao Men, Xue Zhong Liu, Denise Yan, Jie Ling, Yong Feng

“…Waardenburg syndrome (WS) is one of the most common forms of syndromic deafness with heterogeneity of loci and alleles and variable expressivity of clinical features. …”
Get full text

Analysis of Cross Flow Downstream Two Rod Bundles with Different Mixing Vane Grids Based on PIV Measurement by JIANG Li, SHAN Jianqiang, ZHOU Shan, ZOU Yixiang, GUO Junliang, GUI Miao

“…One of the most important components in PWR fuel assembly is spacer grid and mixing vane attached to grid strap has a significant influence on mixing effect in rod bundles. …”

Optimization of Phellinus hartigii extracts: Biological activities, and phenolic content analysis by Orhan Ünal, Ayşenur Gürgen, Tetiana Krupodorova, Mustafa Sevindik, Şanlı Kabaktepe, Ilgaz Akata

“…LC–MS/MS analysis identified nine phenolic compounds, with gallic acid and catechin hydrate as the most abundant. Conclusions The extract of P. hartigii obtained under optimal conditions demonstrated substantial antioxidant, anticholinesterase, and antiproliferative activities, highlighting its therapeutic potential.…”
Get full text

High frequency of SARS-CoV-2 infection in children admitted to academic hospitals in central South Africa by O P Khaliq, S C Brown, B Pitso, N E Tabane

“…Our study showed that a high number of hospitalised children tested positive for SARS‐CoV‐2 while admitted for conditions unrelated to COVID‐19. Most, if not all, children did not exhibit COVID‐19‐specific symptoms, and this may be due to the Omicron variant, which was highly infectious but less virulent, and was associated with mild disease. …”
Get full text

Systematic Review and Meta-Analysis of Inflammatory Biomarkers in Individuals Exposed to Radon by Anel Lesbek, Yasutaka Omori, Meirat Bakhtin, Polat Kazymbet, Shinji Tokonami, Nursulu Altaeva, Danara Ibrayeva, Yerlan Kashkinbayev

“…Among individuals exposed to high residential radon levels, serum CRP and TNF-α were the most frequently assessed biomarkers, with pooled mean levels of 2.11 mg/L (95% CI, 1.32–2.89) and 2.20 pg/mL (95% CI, 0.25–4.64), respectively. …”
Get full text

Lipoblastoma of the foot in a pediatric patient: A case report by Soukaina Beyyato, MD, Yousra Mouhcine, MD, Hajar Ouazzani, PhD, Ismail Chaouche, PhD, Amal Akammar, PhD, Nizar El Bouardi, PhD, Meriem Haloua, PhD, Badreeddine Alami, PhD, Moulay Youssef Alaoui Lamrani, PhD, Mustapha Maaroufi, PhD, Meryem Boubbou, PhD

“…Lipoblastoma is a rare benign tumor originating from embryonic adipose tissue, most commonly found in the limbs of young children, but it rarely involves the foot. …”
Get full text

Improving Dehydration Efficiency and Quality in Highbush Blueberries via Combined Pulsed Microwave Pretreatment and Osmotic Dehydration by Shokoofeh Norouzi, Valérie Orsat, Marie-Josée Dumont

“…The highest rate of reduction in the total soluble solid content in the osmotic solution was observed during the initial hours (0–4 h) of the process. The most effective combination for reducing the total soluble content of the osmotic agent involved the microwave-pretreatment of the blueberries at 70 °C, using a sample to solution ratio of 1:4, resulting in a decrease of 11.98%, compared to 7.83% for non-pretreated samples. …”
Get full text

Land Surface Condition-Driven Emissivity Variation and Its Impact on Diurnal Land Surface Temperature Retrieval Uncertainty by Lijuan Wang, Ping Yue, Yang Yang, Sha Sha, Die Hu, Xueyuan Ren, Xiaoping Wang, Hui Han, Xiaoyu Jiang

“…Land surface emissivity (LSE) is the most critical factor affecting land surface temperature (LST) retrieval. …”
Get full text

Children’s health risk assessment based on the content of toxic metals Pb, Cd, Cu and Zn in urban soil samples of Podgorica, Montenegro by Mugoša Boban, Đurović Dijana, Pirnat Aleksandra, Bulat Zorica, Barjaktarović-Labović Snežana

“…Urbanization and traffic are the main sources of pollution of the urban soils of Podgorica. Most of the samples (93.5%) had a high Pb content, 12.9% of the samples had a higher content of Cd, while Cu and Zn were within the limits prescribed by national legislation. …”
Get full text

Macromicroscopic Method for Vitreous Body Anatomy Studying by N. M. Kislitsyna, A. V. Shatskikh, S. M. Dibirova, D. M. Sultanova, M. P. Veselkova, S. V. Novikov

“…In the literature there are attempts to describe the anatomy of the vitreous body, since the II century. The most relevant works are the studies of J. Worst et al. in 1973, in which the authors proposed new methods of CT preparation with the introduction of dyes. …”
Get full text

Mite Domatia and Associated Mite Density in a North American Eastern Deciduous Forest in Michigan by Carolyn D. K. Graham, Lillian R. Bailey, Ashley E. Cole, Anna M. Cress, Emma Dawson‐Glass, Bailee D. Duke, Liam J. Estill, Lauren D. Jones, Gabrielle R. Leon, Samantha Molino, Nia G. Paton, Abrianna J. Soule, Christopher A. Talbot, Addison L. Yerks, Marjorie G. Weber

“…ABSTRACT Mite–plant defense mutualisms are among the most common defense mutualisms in the world—yet studies providing basic information on their prevalence in plant communities remain rare. …”
Get full text