Hepatoprotective effects of Curcuma xanthorrhiza Roxb. extract via free radical scavenger, inhibiting apoptosis and inflammation mechanisms in acetaminophen-induced liver injury by I Nyoman Lister, Linda Chiuman, Maya Mutia, Hartono Hartono, Ermi Girsang, Annisa Sutendi, Hanna Kusuma, Dhanar Hadiprasetyo, Wahyu Widowati

“…The study presented a concentration-dependent response, with 125 μg/ml CXE exhibiting the most pronounced effects. CXE effectively modulated immune responses, decreased oxidative stress, and inhibited apoptotic and inflammatory pathways in APAP-mediated hepatotoxic cells.Conclusion: These studies highlight the CXE potential as a therapeutic candidate for liver disorders, particularly in drug-mediated liver injury.…”
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Prevalence of Frailty and Associated Factors in a US‐Wide Cohort of Rheumatic Diseases by Katherine D. Wysham, Catherine L. A. Chang, Namrata Singh, James S. Andrews, Kristin Wipfler, Sarah B. Lieber, Sebastian E. Sattui, Rachael Stovall, Joshua F. Baker, Patricia P. Katz, Kaleb Michaud

“…Difficulty with ambulation was the most common frailty feature. With OA as referent, those with CTD had a higher odds of frailty (odds ratio [OR] 1.44, 95% confidence interval [CI] 1.01–2.04), and those with SpA had a lower odds (OR 0.45, 95% CI 0.31–0.67). …”
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The Effect of the Incorporation Level of <i>Rosa rugosa</i> Fruit Pomace and Its Drying Method on the Physicochemical, Microstructural, and Sensory Properties of Wheat Pasta by Grażyna Cacak-Pietrzak, Agata Marzec, Aleksandra Rakocka, Andrzej Cendrowski, Sylwia Stępniewska, Renata Nowak, Anna Krajewska, Dariusz Dziki

“…Taking into account both the level of pomace enrichment and the drying technique, the most optimal outcomes were achieved when microwave–vacuum drying was applied and the pomace addition did not exceed 4%.…”
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Prospective association of daily toothbrushing frequency and the prevalence of childhood functional constipation: the Japan Environment and Children’s Study by Masahiro Tsuchiya, Shinobu Tsuchiya, Haruki Momma, Ryoichi Nagatomi, Nobuo Yaegashi, Takahiro Arima, Chiharu Ota, Kaoru Igarashi, Yuichiro Miura, the Japan Environment and Children’s Study Group

“…Abstract Functional constipation is the most common gastrointestinal disorder during childhood. …”
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Prediction of UHPC mechanical properties using optimized hybrid machine learning model with robust sensitivity and uncertainty analysis by ZhiGuang Zhou, Jagaran Chakma, Md Ahatasamul Hoque, Vaskar Chakma, Asif Ahmed

“…Overall, the ET-LGB model proved to be the most reliable and accurate, followed closely by XGB-LGB, demonstrating strong potential for practical UHPC property prediction.…”
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Proteomic and protein interaction network analysis of human T lymphocytes during cell‐cycle entry by Stephen J Orr, Daniel R Boutz, Rong Wang, Constantinos Chronis, Nicholas C Lea, Thivyan Thayaparan, Emma Hamilton, Hanna Milewicz, Eric Blanc, Ghulam J Mufti, Edward M Marcotte, N Shaun B Thomas

“…Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2/SF3B4), showed, respectively, that human T cells can enter the cell cycle without growing in size, or increase in size without entering the cell cycle.…”
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Enhancing drought monitoring in Southern Alberta: A comparative evaluation of drought indices for regional applicability by Sharad Aryal, Hatef Dastour, Babak Farjad, Gopal Achari, Anil Gupta, Quazi K. Hassan

“…Overall, SPEI-9 is recommended as the most robust index for drought monitoring in Southern Alberta, with SPI, EDI, and PDSI offering additional support for comprehensive drought assessment.…”
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Integrative path modeling and QTL mapping identify maturity, stem strength, and cell wall composition driving lettuce resistance to Sclerotinia minor by Ivan Simko, Bullo Erena Mamo, Shane L. Cantu, Hui Peng, Rebecca Grube Sideman, Ryan J. Hayes, Krishna V. Subbarao

“…Breeding for resistance is the most effective control strategy; however, full resistance has not been achieved, and current partial resistance sources are often linked with undesirable traits, such as early bolting. …”
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Targeting HSV-1 glycoprotein D through riboflavin-mediated photodynamic therapy: Insights from bioinformatics analysis and in vitro evaluation by Maryam Pourhajibagher, Sayed Mahdi Marashi, Abbas Bahador

“…Introduction: The herpes simplex virus type 1 (HSV-1) causes painful viral lesions in the mucosal and cutaneous areas of the oral cavity as well as the head and neck. photodynamic therapy (PDT) effectively inactivates HSV-1 by targeting multiple structures and molecules without the risk of developing resistant strains. The most significant factor influencing the antiviral efficacy of PDT is the type of photosensitizer used. …”
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Identifying pyroptosis-related genes as novel therapeutic targets in diabetic foot ulceration by Kang Liu, Lei Lei, Xin-lei Yang, Xin-he Zhang

“…Abstract Diabetic foot ulcer (DFU) is considered one of the most challenging chronic complications for individuals with diabetes, and its global incidence continues to rise, imposing a substantial burden on society. …”
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Drought Detection in Satellite Imagery: A Layered Ensemble Machine Learning Approach by Muhammad Owais Raza, Naeem Ahmed Mahoto, Mana Saleh Al Reshan, Ali Alqazzaz, Adel Rajab, Asadullah Shaikh

“…Tharparkar is one of the most drought-stricken regions in Pakistan. The proposed approach combines conventional machine learning algorithms (Support Vector Machine (SVM), Logistic Regression (LR), Decision Tree (DT), Random Forest (RF), Naive Bayes (NB), and k-Nearest Neighbor (k-NN)) with ensemble methods (Bagging and Voting) in a layered fashion for detecting drought from satellite imagery. …”
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The benefits for health care staff of involvement in applied health research: a scoping review by Andria Hanbury, Emily Parker, Rebecca Lawton, Jayne Marran, Jane Schofield, Laurie Cave, Lynn McVey, Emma Eyers, Peter Van der Graaf, Roman Kislov

“…Findings In total, 49 records were reviewed, 42 records were from the database search and 7 from the grey literature search. Records were most commonly journal articles (n = 44), covering multiple care settings (n = 15) and mixed professional groups (n = 24), used qualitative methods (n = 22) and focussed on clinical academic roles (n = 21). …”
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Lupus eritematoso sistémico de inicio en la infancia en el Hospital María, Especialidades Pediátricas, 2019-2023 by Christopher Wilhelm Rivera Lazzo, Adolfo Martín Díaz, Dina Raquel Álvarez, Dilcia Sauceda Acosta, Karla Zobeyda Fernández

“…Renal involvement was the most frequent manifestation, affecting 62.5% (30/48) of patients. …”
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A research on low-earth-orbit signal-of-opportunity interference suppression algorithm based on adaptive signal iterative subspace projection technique by Lihao Yao, Lihao Yao, Bin Fan, Honglei Qin, Deyong Xian, Boyun Gu, Hai Sha, Gangqiang Guan, Zhijun Liu, Donghan He, Liwei Zhang

“…However, few studies have deeply investigated their anti-jamming performance, particularly regarding the most common interference type faced by ground receivers - Periodic Frequency Modulation (PFM) interference. …”
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Fatty acid profile of newly extruded embryos of brown crab (Cancer pagurus) and potential value of their lipids for human consumption by Simão Maia, Felisa Rey, M. Rosário Domingues, Joana Figueira, Sam Dupont, Sérgio M. Leandro, Ricardo Calado

“…Cancer pagurus is the most consumed crab species in Europe, with the tight packing of embryos within the brooding chamber of females eventually affecting their nutritional value. …”
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Instytucja dyktatury w Republice Rzymskiej by Jan Rudnicki

“…During the two centuries of classical Roman Republic the Senate developed many ways to make use of this institution. First and most important was to grant a supreme power to one trusted man in face of a military crisis (rei gerundae causa) or dangerous disturbance in internal affairs (seditionis sedandae causa). …”
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Assessment of Trans-Environmental Transitions of Heavy Metals and Arsenic in Herbal Drugs and Herbal Medicinal Products of Valerian Rhizomes with Roots and Motherwort Herb by M. S. Galenko, I. V. Gravel

“…In the tinctures, Zn, Cu, Mg, and Ti were the most abundant elements, and Sb and Cd were present in minimum amounts.Conclusions. …”
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Quality of Life in Pediatric Cutaneous Leishmaniasis: The Role of Lesion Type, Location, and Treatment by Farhad Ali Khattak PhD, Naseem Khan Wazir MPH, Hafsa Zia BDS, Sajjad Khan PhD, Ikram Khan MPH, Pharm-D, Muhammad Sohaib PhD Scholar, Khalid Rehman PhD

“…Out of total of 384 children with cutaneous leishmaniasis, the mean age of participants was 9.96 ± 3.20 years, with a mean CDLQI score of 8.21 ± 4.71. Most lesions were dry (98.7%) and non-ulcerative (91.4%), commonly located on the head, neck, and face (64.6%). …”
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Comparative analysis of frequency characteristics for constructing digital models options of components of electrical complexes aperiodic units by Alexander S. Glazyrin, Evgeniy I. Popov, Semen S. Popov, Vladimir A. Kopyrin, Sergey N. Kladiev, Andrey P. Leonov, Nataliya A. Voronina, Vladimir Z. Kovalev

“…With appropriate assumptions about the stationarity of the dynamic system, the Tustin method can be recommended as the main one for constructing digital models for most engineering problems. However, when signs of non-stationarity of a dynamic system appear or increased requirements for the synthesis of regulators, according to the authors, it is worth paying attention to analytical models of dynamic systems.…”
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Clinically available predictors of obstructive sleep apnoea requiring treatment in type 2 diabetes patients in primary care by Jonas Agholme, Kim Ahtola, Ebba Toll, Carl-Johan Carlhäll, Pontus Henriksson, Stergios Kechagias, Peter Lundberg, Patrik Nasr, Oleg Sysoev, Magnus Wijkman, Mattias Ekstedt, Martin Ulander, Fredrik Iredahl

“…., moderate to severe OSA) proved challenging, as typical clinical symptoms and most other readily available clinical parameters proved to be unreliable indicators. …”
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