Synovial Fibroblast Extracellular Vesicles Induce Inflammation via Delivering miR-21-5p in Osteoarthritis by Vasileios Konteles, Ioanna Papathanasiou, Maria Tzetis, Anastasios Kriebardis, Aspasia Tsezou

“…Synovial fibroblasts-derived small EVs (FS_OA_sEVs) were characterized according to ISEV guidelines and used for miRNA profiling and bioinformatics analysis. miR-21-5p was identified as one of the most abundant, and its target genes, such as KLF6, were enriched in OA-related processes including inflammation. …”
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Potential for circular economy in the construction sector. An explorative study about single-use masks and sustainable building material based on a customer and construction compan... by Daniela Ludin, Erika Mueller, Asli Ercengiz, Jannick Lumpp, Wanja Wellbrock

“…The systems imposed cause a great amount of negative environmental impact and must be re-examined. As most mask material is non-recyclable, one must find ways to use them sustainably. …”
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Microplastic contamination in river and its impact on fish health by U. Yanuhar, E.N. Wiratno, H. Suryanto, D.R. Machfuda, N.R. Caesar

“…Average neutrophil is 11.82 percent, higher than that obtained in the normal fish. Most stations indicated the lymphocyte in below normal levels. …”
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Vertical Dense Jets in Crossflows: A Preliminary Study with Lattice Boltzmann Methods by Maria Grazia Giordano, Jérôme Jacob, Piergiorgio Fusco, Sabina Tangaro, Daniela Malcangio

“…The simulations successfully capture general flow characteristics corresponding to jets with varying crossflow parameter <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>u</mi><mi>r</mi></msub><mi>F</mi></mrow></semantics></math></inline-formula> and most of the typical vortical structures associated with JICF. …”
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Vertical and Horizontal Variability of Chlorophyll-a and Its Relationship with Environmental Parameters in the Waters of Sangihe and Talaud Islands, North Sulawesi, Indonesia by Mochamad Ramdhan Firdaus, Arief Rachman, Nurul Fitriya, Lady Ayu Sri Wijayanti, Rozirwan Rozirwan, Adi Purwandana, Hanif Budi Prayitno, Yustian Rovi Alfiansyah, Oksto Ridho Sianturi, Hagi Yulia Sugeha

“…The concentration of chlorophyll-a varied between 0.0017 and 1.2155 mg.m-3, with most of the water column in Sangihe-Talaud considered oligotrophic, although some stations or depths were mesotrophic or slightly eutrophic. …”
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Patient Preferences and Functional Outcomes of Forearm Crutches vs Hands-Free Single Crutches After Foot and Ankle Surgery: A Randomized Crossover Trial by Vincent Georg Werner MD, Christian Plaass MD, Sarah Ettinger MD, Leif Claassen MD, Anna Altemeier-Sasse MD, Lars-Rene Tuecking MD, Kiriakos Daniilidis MD, Daiwei Yao MD

“…Results: Although FCs performed better in most mobility tests, patients favored HFSCs because of enhanced comfort and lower perceived exertion. …”
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2, 2′, 4, 4′-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells by Guangshan Xie, Jinping Lu, Jiayi Song, Jianqing Zhang

“…2, 2’, 4, 4’-tetrabromodiphenyl ether (BDE-47), one of the most abundant and toxic congeners of polybrominated diphenyl ethers (PBDEs), has been implicated in thyroid disorders, but its thyroid toxicity in human thyroid cells and underlying mechanisms remain unclear. …”
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Integration of Industry 4.0 and Lean Six Sigma: Critical Success Factors for Overcoming Socioeconomic Challenges in the Telecommunication Sector by Ahmed Said El Shenawy, Nevien F. Khourshed, Mohamed A. Ragheb, Mahmoud H. Beshr

“…The study identified strong management commitment (51.0%) as the most significant factor. Critical factor for Industry 4.0 and Lean Six Sigma integration, followed by training programs (24.5%) and new information technologies (12.8%). …”
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Barriers and facilitators to seeking psychological support among healthcare professionals: a qualitative study using the Theoretical Domains Framework by Sha Liu, Yinhuan Hu, Holger Pfaff, Xiaoyun Lei, Zhen Qi, Xiandong Feng

“…We identified seven relevant domains in influencing the behaviour of seeking psychological support: knowledge, beliefs about capabilities, environmental context and resources, social/professional role and identity, emotion, social influences, and behavioural regulation. The most common facilitators of psychological help-seeking include accessible resources, positive interpersonal relationships, increased awareness, effective behavioural strategies, and emotional acknowledgement, while barriers include privacy concerns, stigma, time constraints, doubts about the effectiveness of psychological services, limited knowledge, and perceived professional role conflicts. …”
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Integrated plasma metabolomics and lipidomics profiling highlight distinctive signatures with hashimoto’s thyroiditis by Guoqiang Wang, Xuan Ye, Ting Lu, Yunxi Yang, Bingwei Sun, Hui Xiao

“…Stats package, with Fisher’s exact test employed to identify biological pathways most relevant to the experimental conditions. Metabolomics identified 6384 metabolites (2943 in positive ion mode and 3441 in negative), with 195 differential metabolites, comprising 114 upregulated and 81 downregulated in the HT group. …”
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Physicochemical properties and soluble whey protein composition of local and imported commercial ultra-high-temperature milk in China by Shichu Zhou, Meng Wang, Chunyu Xu, Jinhui Fan, Qijing Du, Dengpan Bu, Rongbo Fan, Hongning Jiang, Rongwei Han, Yongxin Yang

“…The results showed that local brands exhibited a higher pH and a lower degree of protein structural denaturation compared with most imported brands. These characteristics indirectly contribute to the lower sedimentation levels observed in local brands. …”
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Origin and risk assessment of natural radioactivity in groundwater from the Eastern Gonghe Basin, Tibetan Plateau by Zhao-xuan Niu, Zhi-hui Deng, Xue Niu, Dong-fang Chen, Gui-lin Zhu, Wen-hao Xu, Lin-you Zhang, Qing-da Feng

“…Furthermore, single-radionuclide α radioactivity from 230Th, 226Ra, 210Po, and 232Th exceeded regulatory thresholds in some samples, suggesting potential long-term health risks. While most samples complied with effective dose limits, four showed 210Po α radioactivity exceedances within controllable risk ranges. …”
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Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis by Rui Sun, Ying Zhao, Yao Liu, Mengyao Zhang, Ziyi Qiu, Xiaohong Ma, Lina Wei, Wei Lu, Zhiming Liu, Jie Jiang

“…Abstract Endometrial cancer (EC) is among the most prevalent gynecological malignancies, with advanced or recurrent cases posing significant treatment challenges due to limited responses to conventional therapies. …”
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Small mammals as hosts of vector-borne pathogens in the High Tatra Mountains region in Slovakia, Central Europe by Bronislava Víchová, Michal Stanko, Martina Miterpáková, Zuzana Hurníková, Yaroslav Syrota, Patrícia Schmer-Jakšová, Petronela Komorová, Lucia Vargová, Veronika Blažeková, Dana Zubriková, Klaudia Mária Švirlochová, Gabriela Chovancová

“…The prevalence of vector-borne pathogens in the studied animals reached 74.35%, with Bartonella spp. being the most common, identified in 57.7% of the animals, particularly in Apodemus flavicollis and Clethrionomys glareolus. …”
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How good is your synthetic data? SynthRO, a dashboard to evaluate and benchmark synthetic tabular data by Gabriele Santangelo, Giovanna Nicora, Riccardo Bellazzi, Arianna Dagliati

“…SynthRO offers accessible quality evaluation metrics and automated benchmarking, helping users determine the most suitable synthetic data models for specific use cases by prioritizing metrics and providing consistent quantitative scores. …”
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Solar Surface Magnetic Field Simulation from 2010 to 2024 and Anomalous Southern Poleward Flux Transport in Cycle 24 by Ruihui Wang, Jie Jiang, Yukun Luo

“…After 2016, poleward migrations of leading-polarity flux become dominant, despite most ARs following Joy’s and Hale’s laws. This reversal is likely due to prolonged intervals between AR emergences, which allow the leading-polarity flux to distribute across a broad latitude range before cancellation by subsequent ARs. …”
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Managing Aminotransferase Elevations in Patients with Friedreich Ataxia Treated with Omaveloxolone: A Review and Expert Opinion on Use Considerations by Susan Perlman, Mathieu Anheim, Sylvia Boesch, James H. Lewis, David R. Lynch

“…In the MOXIe study, alanine and aspartate aminotransferase (ALT and AST) elevations were among the most common treatment-emergent adverse events (TEAEs) in the omaveloxolone arm and were mild to moderate, generally asymptomatic, transient, and reversible; no patients who received omaveloxolone had laboratory abnormalities that met the Hy’s law criteria. …”
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Aneurysmal degeneration after drug-eluting stent implantation in lower limb arteries: A systematic review and case reports by Angela Luongo, Nicola Cantile, Davide Turchino, Abdul Karim Markabaoui, Raffaele Serra, Umberto Marcello Bracale

“…The incidence of aneurysmal degeneration ranged from 0 % to 15.7 %, with the superficial femoral artery (SFA) being the most affected site. Conservative management was common, although some cases required open surgical treatment. …”
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A multi-objective optimization-based ensemble neural network wind speed prediction model by Haoyuan Ma, Chang Liu, Ziyuan Qiao, Yuan Liang, Hongqing Wang

“…Wind speed prediction plays a crucial role in the efficient utilization of wind energy. However, most existing short-term wind speed forecasting methods rely solely on historical wind speed sequences, neglecting other influential factors. …”
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Furosemide Reduces Radionuclide Activity in the Bladder in ¹⁸F-PSMA-1007-PET/CT: A Single-Center Retrospective Intra-Individual Comparative Study by Martin A. Cahenzli, Andreas S. Kreusch, Philipp Huber, Marco Dressler, Janusch P. Blautzik, Gregor Sommer

“…Physiological tracer uptake in most organs was not significantly influenced by furosemide (all <i>p</i> > 0.05). …”
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