Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context by Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala

“…Post-withdrawal aHUS relapses were mostly mild and did not lead to permanent kidney function impairment, ultimately leading to long-term treatment withdrawal in 92.5% of discontinued cases. …”
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Targeting hyperlipidemia: A polarity-driven ternary extraction of Apium graveolens bioactives—A coupled in-vivo, in-vitro and in-silico investigation by Nargis Sultana Chowdhury, Tasnuva Sharmin Zaman, Rifah Noor Chowdhury, Md Abdur Rahman, Sheikh Rakibul Alam, Romana Akter, Md. Nazmus Samdani, Syeda Sadia Afrin, Md. Rafat Tahsin, Fahima Aktar, Ishrat Jahan, Nasiba Binte Bahar, Salehuddin Ayubee, Umme Habiba Ria, Md Zakir Sultan, Mohammad Borhan Uddin, Jakir Ahmed Chowdhury, Md. Selim Reza, Abu Asad Chowdhury, Shaila Kabir, Md. Shah Amran

“…Objective: Considering previous research (96 % Ethanol), we modified the solvent system (70 % methanol and 30 % aqueous acetone). In 96 % ethanol, mostly the hydrophobic compound can be dissolved. …”
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Clinical Features and Natural Progression of Unilateral High Myopia in Adults: A Comparison Study by Dong Geun Kim, MD, Seok Hyun Bae, MD, Dong Ju Kim, MD, Jong Suk Lee, MD, Kwangsic Joo, MD, PhD, Sang Jun Park, MD, PhD, Se Joon Woo, MD, PhD, Kyu Hyung Park, MD, PhD

“…Conclusions: Adult UHM patients mostly lacked associated environmental factors. The poorer visual acuity in the longer eyes of UHM patients, which cannot be explained by structural abnormalities, suggests that the interocular difference may have originated in early childhood. …”
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A highly conserved sRNA downregulates multiple genes, including a σ54 transcriptional activator, in the virulence mode of Bordetella pertussis by Minji Sim, Jeffers Nguyen, Karolína Škopová, Kyungyoon Yoo, Chin-Hsien Tai, Leslie Knipling, Qing Chen, David Kim, Summer Nolan, Rawan Elaksher, Nadim Majdalani, Hernan Lorenzi, Scott Stibitz, Kyung Moon, Deborah M. Hinton

“…In the human pathogen Bordetella pertussis, the causative agent of whooping cough, hundreds of sRNAs have been identified, but their roles in B. pertussis biology are mostly unknown. Here we characterize the Hfq-dependent sRNABpsA, whose level is dramatically higher in the virulence (Bvg+) mode. …”
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Seroprevalence of Zika virus and dengue virus infections in migrants in Italy by Federica Frasca, Federica Frasca, Francesco Eugenio Romani, Elio Gentilini Cacciola, Francesca Colavita, Enrico Palermo, Luca Maddaloni, Luca Maddaloni, Luigi Rosa, Alessandra D’Auria, Valentina Baccolini, Giuseppe Migliara, Giulia Matusali, Giancarlo Ceccarelli, Guido Antonelli, Guido Antonelli, Fabrizio Maggi, Gabriella d’Ettorre, Carolina Scagnolari, Carolina Scagnolari

“…The seroprevalence of anti-DENV IgG by ELISA was 59.37% (n=38/64), mostly confirmed by IFA (97.36%, n=37/38). Furthermore, anti-DENV IgM were detected in 9 serum samples (n=9/64, 14.06%) by ELISA, previously tested negative for anti-DENV IgG. …”
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Breeding report of a new Canarium album cultivar Qingyin Ganlan by XIAO Weiqiang, LI Zhucheng, CHEN Gaixun, NI Xiaorong, LAI Duo, ZHUANG Qingli, SHAO Xuehua, QIN Jian, ZHANG LI, LIN Jieyao, LIU Chuanbin

“…The inflorescences are extracted from the axils of fruit branches, mostly on the top of the final and subfinal branches. …”
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Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence by M. Barbagallo, M. Barbagallo, M. Zahn, M. Zahn, J. Zimmermann, J. Zimmermann, R. Klövekorn, R. Klövekorn, J. Held, J. Held, B. Nemeth, B. Nemeth, B. Reolon, B. Reolon, J. Bellomo, J. Bellomo, A. Schwarz, J. M. Veerbeek, C. H. B. Van Niftrik, C. H. B. Van Niftrik, M. Sebök, M. Sebök, M. Piccirelli, M. Piccirelli, L. Michels, L. Michels, A. R. Luft, A. R. Luft, A. R. Luft, Z. Kulcsar, Z. Kulcsar, L. Regli, L. Regli, G. Esposito, G. Esposito, J. Fierstra, J. Fierstra, P. Thurner, P. Thurner, T. Schubert, T. Schubert, S. Wegener, S. Wegener

“…Our current understanding of the underlying pathomechanisms is limited and mostly based on rodent models. The goal of this study was to further characterize RF by applying advanced multimodal hemodynamic imaging in stroke patients.MethodsPatients from the IMPreST study with LVO stroke and successful recanalization [corresponding to thrombolysis in cerebral ischemia grade (TICI) 2b-3] were included. …”
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Minimal residual ascites 3 months after TIPS implantation implicates worse clinical outcomes in patients with cirrhosis by Jim Benjamin Mauz, Lukas Hartl, Andrea Kornfehl, Sarah Lisa Schütte, Paul Hemetsberger, Theresa Müllner-Bucsics, Mathias Jachs, Anja Tiede, Hannah Rieland, Michael Schwarz, Nina Dominik, Georg Kramer, Bernhard Meyer, Lukas Reider, Michael Trauner, Heiner Wedemeyer, Mattias Mandorfer, Benjamin Maasoumy, Thomas Reiberger, Tammo Lambert Tergast

“…Results: Overall, 292 patients with male predominance (71.7%) and mostly alcohol-related liver disease (71.7%) were included. …”
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Study of Low-Level Wind Shear and Its Evolution Based on LIDAR and Aircraft Reports Identification by Jie DING, Lei ZHANG, Zeyong HU, Jiemin WANG, Kaijun ZHANG, Jiening LIANG, Yuan WANG, Zhida ZHANG, Lili XU, Jin WANG, Tao CAI

“…Low-level wind shear significantly impacts aviation safety and operational efficiency.Zhongchuan Airport， located in a mountainous inland region， experiences the influence of complex terrain and weather systems.Wind shear is frequently observed during the summer season.This study analyzes the spatial and temporal characteristics of low-level wind shear events at Zhongchuan Airport using aircraft reports spanning from 2009 to 2018.During the observation period from May 2016 to November 2017， a total of 18 low-level wind shear events were confirmed through aircraft verification.Two methods， namely the fixed and adaptive window methods， were compared to identify wind shear events using LIDAR data from the Windcube 400s-at instrument.The study also explored the continuous evolution and spatial characteristics of the three-dimensional wind shear structure.The results indicate that the frequency of low-level wind shear events has increased at a faster rate compared to the flight volume at Zhongchuan Airport over the past ten years.The peak months for low-level wind shear events at Zhongchuan Airport are April-July and August-October， influenced by local weather patterns.The peak months for low-level wind shear events at Zhongchuan Airport are April-July and August-October， influenced by local weather patterns.Wind shear induced by convective weather occurs in the weak or non-echo region surrounding the convective cloud， resulting from the convergence of updrafts and downdrafts outside the cloud， or the formation of a gust front following the downdraft's contact with the ground.The wind shear factor is correlated with the intensity of radar echoes.Compared to the fixed window method， the adaptive window method had a larger recognition range due to the different data sets included in the recognition window.Therefore， the adaptive window method was found to be more suitable for studying the three-dimensional evolution of wind shear structures.Therefore， the adaptive window method is better suited for studying the evolution of the three-dimensional wind shear structure.The wind shear in the vicinity of Zhongchuan Airport is characterized by a low spatial distribution， small horizontal scale， and short duration， primarily concentrated in the small-scale and γ mesoscale.In other words， the wind shear events occurred at relatively low altitudes， with horizontal scales mostly ranging between 1000~1500 m and 2000~2600 m， lasting less than 20 minutes.Furthermore， 40.5% of the wind shear events were attributed to the movement of the wind， primarily influenced by the background wind.The findings of this study contribute to a better understanding of the characteristics of wind shear， offering valuable insights for the identification， mechanisms， forecasting， and early warning of low-level wind shear events at Zhongchuan Airport.…”
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Comprehensive management strategy of interstitial lung disease induced by trastuzumab deruxtecan by ZHANG Jian, HAN Qian, XU Fei, GAN Lu, CHEN Zhanhong, MA Li, WANG Hao, LIU Jieqiong, WU Xiaohong, CAI Li, ZHAO Bing, LÜ Zheng, LI Li, NI Sujie, HU Xichun

“…T-DXd-induced ILD is mostly Grades 1-2, and implementing a standardized clinical management protocol can reduce the incidence of severe ILD events, improve patient prognosis, and help maximize the clinical benefits of T-DXd. …”
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Upper Oligocene to Pleistocene planktonic foraminifera stratigraphy at North Atlantic DSDP Site 407, Reykjanes Ridge: diversity trends and biozonation using modern Neogene taxonomi... by T. M. Weitkamp, T. M. Weitkamp, M. J. Razmjooei, M. J. Razmjooei, P. N. Pearson, H. K. Coxall, H. K. Coxall

“…This ca. 300 m sequence provides a nearly continuous record of planktonic foraminifera with mostly good preservation quality, aiding the study of pelagic diversity changes over the past 25 million years as the modern North Atlantic Ocean system evolved. …”
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Measles Outbreak in Sverdlovsk Region by S. V. Skryabina, S. A. Kovyazina, S. V. Kuzmin, A. I. Yurovskikh, O. V. Tsvirkun, A. G. Gerasimova, N. T. Tikhonova, L. N. Malyamova, S. S. Smirnova, A. N. Kharitonov, E. A. Rybinskova

“…During the period c from 40 to 51 week of 2016 measles ill 76 people, mostly (66 persons) residents of the city of  Yekaterinburg. …”
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Exploring the changes in functional connectivity of the limbic system in Patients with amnestic mild cognitive impairment treated by acupuncture based on fMRI by Han Yingmei, Li Yijie, Zhang Heng, Feng Ze, Li Weiqing, Zhang Hanxi, Yang Ming, Chu Bingyuan, Wang Feng

“…There were differences in the FC of Seed4, Seed29, and Seed30 in the sham-acupoint group, indicating that there were baseline differences among aMCI patient groups. (2) After acupuncture in the true-acupoint group, the FC between multiple seed points and brain regions decreased, while the differences before and after the intervention in the sham-acupoint group mostly did not pass the Family-Wise Error (FEW) correction. (3) Compared with the HC group, the FC of seed points in both the true-acupoint group and the sham-acupoint group mainly decreased after acupuncture. …”
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Optimization of the treatment of patients with severe chronic urticaria by Ye.M. Dytiatkovska, N.O. Nedohybchenko

“…According to our data, patients with SCU are mostly people of working age, more than half of whom have a history of the disease for five years or more, in 70% of cases of a valid study, they are characterized by an increased content of total IgE and have a low level of indicators according to the questionnaire SKINDEX-29 at the level of physical symptoms, emotional sphere and functioning. …”
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Karakteristik Ibu pada Penderita Abortus dan Tidak Abortus di RS Dr. M. Djamil Padang Tahun 2011-2012 by Resya I Noer, Ermawati Ermawati, Afdal Afdal

“…Pregnant women with abortion were mostly at the age 20 years and above 35 years, parity more than 3,  had previous abortions, gestational age less than 12 weeks, does not work and elementary school, junior and senior high as their latest education compared to pregnant women without abortion. …”
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Factors Influencing the Implementation of Non‐Pharmacological Interventions for Behavioural and Psychological Symptoms of Dementia in Residential Aged‐Care Homes: A Systematic Revi... by Hunduma Dinsa Ayeno, Gizat M. Kassie, Mustafa Atee, Tuan Nguyen

“…These studies spanned the period from 2010 to 2022 and were mostly conducted in the United Kingdom, Australia, the United States and Canada. …”
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Expression Analysis and SNP Mining of the Parkin Co-Regulated Gene (PACRG) and parkin in Penaeus vannamei Against White Spot Syndrome Virus by Qian XUE, Xupeng LI, Yang LI, Sheng LUAN, Kun LUO, Jie KONG, Qun XING, Xianhong MENG

“…The location of PACRG mRNAs mostly overlapped with the WSSV replication site in the shrimp muscle, suggesting that PACRG plays a functional role in the interaction between P. vannamei and WSSV. …”
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Perfil socioeconômico e cultural do estudante ingressante no curso de graduação em enfermagem [Social, economic, and cultural profile of incoming undergraduate students at the scho... by Norma Valéria Dantas de Oliveira Souza, Lucia Helena Garcia Penna, Luana dos Santos Cunha, Amanda de Almeida Sant’anna Baptista, Iraneide Ferreira Mafra, Débora Cristina de Almeida Mariano

“…Results were treated on the basis of simple statistics and showed that freshmen are teenagers and mostly women. Results showed 12.50% of the participants had no basic sanitation facilities at home and had low family income. …”
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El estilo de vida del estudiantado de Pedagogía en Educación Física de una universidad del centro sur de Chile (The lifestyle of the Pedagogy in Physical Education students at a un... by Alex Garrido-Méndez, Carlos Matus Castillo, Catalina Pereira Araneda, Pablo Luna Villouta, Rafael Zapata Lamana, Oscar Andrades Ramírez, Carol Flores Rivera, Rodrigo Carrillo Monsalve, Carlos Celis Morales

“…However, 45.4% frequently use drugs, mostly men (χ²=17.203; p=0.002). 25% stated that they always sleep well, while 64.8% said sometimes. …”
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Effectiveness of Glecaprevir/Pibrentasvir in Patients with Chronic HCV-infection Genotypes 1 to 6 in the real-world settings in Russia (EVEREST study) by О. I. Sagalova, V. S. Adonieva, S. V. Zotov, D. A. Gusev, E. A. Strebkova, R. B. Galbraikh, V. G. Morozov, I. M. Khayertynova, I. V. Krasilnikova, I. V. Sannikova, A. Bhagat, D. O. Milenin, A. P. Efremova

“…The results of clinical trials showed good tolerability of GLE/PIB and high virologic response rate (mostly >95%) among different patient populations. …”
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