Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial. by Jian Zhang, Yanchun Meng, Biyun Wang, Xinhong Wu, Hongmei Zheng, Jing Hu, Wei Liu, Wenyan Chen, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li, Sujie Ni, Zhengyan Yu, Lichun Sun, Yun Wang, Qiang Peng, Song Wang, Xin Hu, Jianfei Wang, Yijia Wu, Xichun Hu

“…Grade 3 or 4 treatment-related adverse events occurred in 68.8% and 12.5% of patients, respectively, mostly myelosuppression. PK analysis showed no major drug accumulation for dalpiciclib or pyrotinib over the treatment period. …”
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中国核桃出口增长驱动因素研究Research on driving factors of China′s walnut export growth by 白丽，杨璇，李锐凯 BAI Li，YANG Xuan，LI Ruikai

“…From 2018 to 2022, the MPR of China′s walnut gradually increased, the TC index was between 0 and 1 and gradually tended to 1, and the RCA index was mostly less than 0.8, indicating that the international competitiveness of China′s walnut was weak, but it was gradually increasing.The CMS model analysis showed that the competitiveness effect was the main factor affecting China′s walnut export. …”
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Mental disorders in antiphospholipid syndrome patients: association with clinical and immunological manifestations of the disease by А. В. Borisova, Т. А. Lisitsyna, D. Yu. Veltishchev, Т. М. Reshetnyak, О. F. Seravina, О. В. Kovalevskaya, F. А. Cheldieva, А. А. Abramkin, А. Е. Zeltyn, Е. L. Nasonov

“…Cognitive impairment (CI), mostly mild and moderate, was found in the vast majority of patients with APS (102 (95.3%)). …”
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Visible-light deep reduction of low concentration CO2 over composite catalyst Ru/CoAl-LDH and the performance enhancement mechanism by Jun DAI, Fengting JIA, Juan YANG, Zhixiang FENG, Dazhao WANG, Chongchong LENG

“…However, the previous reports have mostly used high-purity CO2 as the research object, while the CO2 concentration in the flue gas emitted by coal-fired power plants is only 3%−15%. …”
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الفساد في العراق: من البُنْيَة إلى الظاهرة محاولة للخروج من الحلقة المفرغة للاستدامة (1974-2015) by عماد عبد اللطيف سالم

“…An executive authority to such serious problems of incorporation can not be (in the near term) an essential and serious element in the policy-making necessary to slow down the process of penetrating and penetrating corrupt structural formations into the depth of values and behavior (mostly individual) that continue to resist temptations and gains To get the huge rents of corruption, and very low (social and personal) costs, let alone begin to dismantle the structure of corruption itself (in the longer term). …”
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Construction of a preoperative emotional state and postoperative intra-abdominal pressure based prediction model for early enteral feeding intolerance in postoperative patients wit... by Yingying Xu, Qiongyuan Hu, Dandan Pei, Yin Zhang, Huanhuan Zhu, Yan Hui, Wenxian Guan, Meiling Xu, Li Chen

“…BackgroundThe incidence of enteral feeding intolerance (ENFI) in the early postoperative period is high in patients after gastric cancer resection due to the characteristics of surgical traumatic stress and changes in the physiological structure of the digestive tract, and the current evaluation of ENFI after gastric cancer resection mostly depends on the symptoms and complaints of patients after gastric cancer resection, which is lagging and subjective. …”
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Influence of urokinase gene-knockout in C57BL/6-PlautmI. IBugThisPlau6FDhu/GFDhu mice on growth factors in malignant melanoma by E. M. Frantsiyants, I. V. Kaplieva, I. V. Neskubina, V. A. Bandovkina, L. K. Trepitaki, E. I. Surikova, N. D. Cheryarina, L. A. Nemashkalova, N. S. Lesovaya

“…Levels of VEGFA, VEGFC, sVEGFR1, sVEGFR3, IGF1, IGF2, TGFβ1 and FGF21 were determined by ELISA in the skin, tumor and perifocal tissues isolated on the 21st day of the tumor growth.Results. uPA gene-knockout inhibited the growth (mostly in females) and metastasis (predominantly in males) of melanoma in mice. …”
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Prevalence and factors associated with childhood malaria and anaemia in Osun state, Nigeria: a baseline household malariometric study by Olusola Ajibaye, Semiu Adebayo Rahman, Oluwagbemiga Olanrewaju Aina, Chinazo Ujuju, Chimere Obiora Agomo, Samuel Akindele, Olakiigbe Abiodun, Tolulope Victoria Uzoka, Nnenna Ogbulafor, Olufemi Oroge, Rufai-Ahmed Garba, Michael Ekholuenetale, Kolawole Maxwell, Ridwan Akorede Awosanya, Mary Abosede Adekola, Benjamin Bukky Ilesanmi, Adekemi Ajayi, Olusola Oresanya, James K. Tibenderana, Adeola Yetunde Olukosi

“…Results A total of four hundred children aged 2–18 months were assessed in this study, which was conducted in July 2023. The caregivers were mostly the biological mothers of the children (n = 387, 96.8%). …”
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Tumor gene expression signatures associated with outcome in large B−cell lymphoma treated with CD19-directed CAR T−cell therapy (axicabtagene ciloleucel) by Yuan Tian, Justin Budka, Frederick L. Locke, Jason R. Westin, Christina To, Gayatri Tiwari, Daqin Mao, Davide Bedognetti, Rhine R. Shen, Jorge Andrade, Simone Filosto

“…Herein, we leveraged the ZUMA-7 phase III randomized trial of relapsed/refractory large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (axi-cel; CD19-targeting CAR T cells) to discover tumor gene expression signatures (GES) associated with outcome.MethodsWith tumor transcriptomics from 134 axi-cel patients, we employed multivariate penalized Cox models analyzing event-free survival (EFS), progression-free survival (PFS), and duration of response (DOR).Results and DiscussionWe identified two novel GES, a six-gene/transcript signature (6-GES; CD19, CD45RA, CCL22, KLRK1, SOX11, SIGLEC5) correlated with improved outcome after axi-cel (HR: 0.27, 95% CI: 0.16–0.44 for EFS), representing lymphomas with abundant target antigen (CD19) expression, adhesion molecules, and relatively low immune infiltration mostly composed of cytotoxic lymphocytes (T and NK cells) and DCs, and secondly, a 17-gene/transcript signature (17-GES; CD45RO, BCL2, IL-18R1, TNFSF4 [OX40L], KLRB1 [CD161], KIR3DL2, ITGB8, DUSP5, GPC4, PSMB5, RPS6KB1, SERPINA9, NBN,GLUD1, ESR1, ARID1A, and SLC16A1) correlated with disease progression after axi-cel (HR: 6.12, 95% CI: 3.57–10.50 for EFS), consistent with high immune inflammation and escape mechanisms, such as the upregulation of genes involved in repair of damaged DNA or chromatin remodeling, inhibition of apoptosis, and a metabolically restrictive environment. …”
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A Governance Framework for the Geospatial Information Centres (GICs) in Developing Countries إطار حوكمة مراكز المعلومات الجغرافية المكانية في البلدان النامية... by Muhammad Abdulrahman Seddeek, Hossam Sami

“…There are numerous issues with the process of building GIC databases, especially in developing countries, mostly related to weak governance, one of which is the lack of adequate tools for gathering and arranging data; the absence of standardized information methods and recording; the inability to access this information through a working method; information preservation and recording techniques; the inability to use specialized hardware and software, etc. …”
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Revisión de instrumentos de género para analizar los vínculos del alumnado con la actividad física en edad escolar (Review of gender instruments to analyse student links to physica... by Elisa García Obrero, Jorge Agustín Zapatero-Ayuso, Elena Ramirez Rico

“…The instruments found were mostly questionnaires, which analysed variables on peer treatment, students’ personal situation and motivation, students’ attachment to PE and gender stereotypes. …”
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Mapping of the Literal Regressive and Geospatial–Temporal Distribution of Solar Energy on a Short-Scale Measurement in Mozambique Using Machine Learning Techniques by Fernando Venâncio Mucomole, Carlos Augusto Santos Silva, Lourenço Lázaro Magaia

“…The statistical findings show a high degree of solar energy incidence, with increments <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mfenced separators="|"><mrow><mo>∆</mo><msubsup><mrow><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></mfenced></mrow></semantics></math></inline-formula> in the average order of −0.05 and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></semantics></math></inline-formula> mostly ranging between 0.4 and 0.9. In 2012 and 2014, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></semantics></math></inline-formula> was 0.8956 and 0.6986, respectively, because clear days had a higher incident flux and intermediate days have a higher frequency of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mo>∆</mo><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></semantics></math></inline-formula> on clear days and a higher occurrence density. …”
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Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies by R. F. Kholbobozoda, A. A. Kostin, N. V. Vorobyev, A. O. Tolkachev, A. A. Krasheninnikov, I. A. Taraki, A. D. Kaprin

“…Testicular cancer (TC) mostly affect young men of reproductive age. Several studies have shown correlation between the level of sex hormones in testicular cancer and serum tumor markers. …”
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An integrated approach for very high cardiovascular risk patients. Intermediate results by E. I. Usova, M. V. Ionov, A. S. Alieva, N. G. Avdonina, N. V. Orbeladze, А. A. Khodyreva, A. N. Yakovlev, N. E. Zvartau

“…Both high-density lipoprotein cholesterol (-0,48 mmol/l, p=0,348), office and home BP remained mostly unchanged. The proportion of patients with target office BP levels was almost the same (χ2=3,06, p=0,08). …”
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Efecto de un programa de promoción de hábitos de vida saludables sobre los niveles de actividad física y el comportamiento frente a la actividad física en jóvenes de una universida... by Dayan Gabriela García Laguna, Isis Daniela Garcia Saavedra, Andrés Felipe Zuluaga Gómez, Diana Marcela Ramos Caballero

“…Results: Eighty-one students participated with a mean age of 19.5 years (SD 2.1), mostly women (85.2%). Significant differences were found in the total MET-min/week after implementing the program (p=.032). …”
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Book Review Education Policy: Globalization, Citizenship and Democracy by Çetin Toraman

“…Moreover, a new conception of political formulation based on democracy and education is discussed to summarize the issue.According the reviewer, this book is highly beneficial for researchers in the field of education, especially for those who mostly study on democracy and human rights issues. …”
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A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study. by Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic

“…Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally advanced or metastatic disease, as there are no useful biomarkers for detection in its early stages, when surgery can be curative. …”
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The Development and Implementation of a Simulated Patient Resource for Teaching and Assessment in Optometry Low Vision Rehabilitation by Karas M, Lucas N, Ryan B

“…Even though feedback suggested that the method is mostly acceptable to both assessors and students, we have concluded that having access to a readily available pool of real patients is the more credible option for teaching and assessing this accredited level of low vision practice. …”
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Impact on physical function of the +AGIL Barcelona program in community-dwelling older adults with cognitive impairment: an interventional cohort study by Cristina Arnal, L Monica Pérez, Luís Soto, Álvaro Casas Herrero, Joan Ars, Sonia Baró, Francisco Díaz, Araceli Abilla, M Belén Enfedaque, Matteo Cesari, Marco Inzitari

“…Results 194 participants were included (82 with CI, based on previous diagnosis or the Mini-COG screening tool), 68% women, mean age 81.6 (SD = 5.8) yo. Participants were mostly independent in Activities of Daily Living (mean Barthel = 92.4, SD = 11.1). …”
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Factors associated with suicide risk among Chinese adults: A prospective cohort study of 0.5 million individuals. by Rongqin Yu, Yiping Chen, Liming Li, Junshi Chen, Yu Guo, Zheng Bian, Jun Lv, Canqing Yu, Xianmin Xie, Dan Huang, Zhengming Chen, Seena Fazel

“…The associations with possible suicide deaths were mostly similar to those with suicide deaths, although there was no clear link between possible suicide deaths and psychiatric factors such as depression and generalized anxiety disorders. …”
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