CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…Meanwhile, the down-regulated genes were mostly enriched in the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. …”
Get full text

Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series by Olav Dajani, Iain Philips, Ester Kristine Størkson, Trude R. Balstad, Leo R. Brown, Asta Bye, Ross Dolan, Christine Greil, Marianne Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Inger Ottestad, Judith Sayers, Melanie Simpson, Mariana S. Sousa, Ola Magne Vagnildhaug, Michael S. Yule, Barry J. A. Laird, Richard J. E. Skipworth, Tora S. Solheim, Mark Stares, Jann Arends, the Cancer Cachexia Endpoints Working Group

“…Conclusion In CC trials, oncological endpoints were mostly secondary and only few significant findings have been reported. …”
Get full text

Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients by Estefania Simoes, Ricardo Uchida, Mariana P. Nucci, Fabio L. S. Duran, Joanna D. C. C. Lima, Leonardo R. Gama, Naomi A. Costa, Maria C. G. Otaduy, Fang C. Bin, Jose P. Otoch, Paulo Alcantara, Alexandre Ramos, Alessandro Laviano, Mauricio Berriel Diaz, Margaret M. Esiri, Gabriele C. DeLuca, Stephan Herzig, Geraldo Busatto Filho, Marilia Seelaender

“…Conclusions Our results indicate that cachexia compromises CNS morphology mostly causing changes in the GM of cachectic patients, leading to alterations in regional volume patterns, functional connectivity, neuronal morphology, neuroglia profile and inducing neuroinflammation, all of which may contribute to the loss of homeostasis control and to deficient information processing, as well as to the metabolic and behavioural derangements commonly observed in human cachexia. …”
Get full text

Ozone trends in homogenized Umkehr, ozonesonde, and COH overpass records by I. Petropavlovskikh, I. Petropavlovskikh, J. D. Wild, J. D. Wild, K. Abromitis, K. Abromitis, P. Effertz, P. Effertz, K. Miyagawa, L. E. Flynn, E. Maillard Barras, R. Damadeo, G. McConville, G. McConville, B. Johnson, P. Cullis, S. Godin-Beekmann, G. Ancellet, R. Querel, R. Van Malderen, D. Zawada

“…In the lower stratosphere, trends derived from Umkehr and ozonesonde records are mostly negative (except for positive ozonesonde trends at OHP); however, the uncertainties are quite large. …”
Get full text

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer by Jeffrey Schlom, Carl H. June, George A. Fisher, John J. Nemunaitis, Kristen M. Hege, Emily K. Bergsland, Robert S. Warren, James G. McArthur, Andy A. Lin, Stephen A. Sherwin

“…Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (≤14 weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48 weeks. …”
Get full text

Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation by Wuyan Zheng, Wanyu Wu, Yuhan Li, Bo Qin, Yuping Wang, Yunhan Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong

“…Nevertheless, the specific role of microglia in the inflammatory response triggered by IS remains mostly unclear. The primary target of this investigation is to study the neuroinflammatory impact of lycorine (LYC) during the IS process. …”
Get full text

Investigation of two different PACAP-38 (Pituitary Adenylate Cyclase Activating Polypeptide) formulated feeds on Atlantic salmon (Salmo salar) immune responses with Enteric Red Mou... by E Fajei, L Rivera Méndez, SK Whyte, J Velazquez, P Dantagnan, M Soto-Davila, T Rodríguez-Ramos, E Proskos, B Dixon, Y Carpio, M Estrada, MD Fast

“…Furthermore, PACAP diets induced some inflammatory gene expression in the head kidney, intestine and spleen, mostly at 3 and 7 dpi (il10 and hepc). These data suggest that both amidated and non-amidated PACAP had induced il1ß, hepc and il10, and the timing suggests protection against infection and stress, possibly by inhibiting inflammatory pathways and reducing oxidative stress. …”
Get full text

Integrating anamnestic and lifestyle data with sphingolipid levels for risk-based prostate cancer screening by Caterina Peraldo-Neia, Paola Ostano, Melissa Savioli, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Guana, Francesca Crivelli, Francesco Montagnani, Michele Dei-Cas, Rita Paroni, Antonella Sinopoli, Francesco Ferranti, Nicolò Testino, Marco Oderda, Andrea Zitella, Chiara Fiameni, Amedeo Gagliardi, Alessio Naccarati, Luca Clivio, Paolo Gontero, Stefano Zaramella, Giovanna Chiorino

“…Univariable logistic regression was applied to identify ananmestic and lifestyle variables mostly associated with PCa. Penalized logistic regression models predictive of PCa or ISUP > 1 PCa were built both using the 814 subjects with complete information for such variables, applying a 10-fold cross validation approach, and dividing the dataset into a training (n = 445: 132 PCa, 313 non-PCa) and a test (n = 369: 147 PCa, 222 non-PCa) set. …”
Get full text

Real-World Analysis of Short-Term Effectiveness of Oral Semaglutide: Impact on Glycometabolic Control and Cardiovascular Risk by Sara Palazzi, Federica Sentinelli, Antonella Zugaro, Sara Morgante, Livia Santarelli, Sandra Melanzi, Annamaria De Mutiis, Deamaria Piersanti, Barbara Macerola, Marco Iezzi, Pietro Mercuri, Alessandro Ferranti, Daniele Tienforti, Maria Gisella Cavallo, Arcangelo Barbonetti, Marco Giorgio Baroni

“…<b>Results</b>: Among 167 participants (mean age 66.5 years, mostly obese, baseline HbA1c 8.4% ± 1.5), 83.2% received a 7 mg dose. …”
Get full text

Supplement-driven iron overload accelerates phenotypic aging via inflammatory biomarkers: Potential counteraction through anti-inflammatory or antioxidant diets by Bin Li, Zhu Ming, Yina Wang, Yingfeng Zhang, Runyi Zhou, Can Zhang, Yue Wu, Guoliang Wang, Hongquan Xie, Ying Li, Ran Li

“…Cluster analysis split participants into two groups: dietary iron reference (DIR), mostly below the UL (45 mg/day) with minimal supplemental iron; and supplement-driven iron overload (SDIO), all exceeding the UL, with supplemental iron comprising 83.44 % of total intake on average. …”
Get full text

Utilization of cervical cancer screening and its associated factors among women living with HIV in East Africa: a systematic review and meta-analysis by Gebrie Getu Alemu, Getaneh Awoke Yismaw, Habtamu Abebe Getahun, Habtamu Wagnew Abuhay, Mekuriaw Nibret Aweke, Meron Asmamaw Alemayehu, Nebiyu Mekonnen Derseh, Tigist Kifle Tsegaw, Tilahun Yemanu Birhan, Banchlay Addis, Berhanie Addis Ayele, Emebet Birhanu Lealem, Eyob Akalewold Alemu, Fetlework Gubena Arage

“…Abstract Background Women living with HIV (WLHIV), mostly in East Africa, are six times more likely to develop cervical cancer and are a priority population for secondary prevention. …”
Get full text

Spinal metastases at the thoracolumbar junction – Influencing factors for surgical decision-making according to a multicentric registry by Vanessa Hubertus, Arthur Wagner, Arian Karbe, Leon-Gordian Leonhardt, Beate Kunze, Susanne Borchert, Fatma Kilinc, Michelle Mariño, Nitzan Nissimov, Charlotte Buhre, Marcus Czabanka, Marc Dreimann, Sven O. Eicker, Lennart Viezens, Hanno S. Meyer, Peter Vajkoczy, Bernhard Meyer, Julia S. Onken

“…Reoperations were necessary in 65 cases (16%), mostly due to SSI (n = 19, 29%), local recurrence (n = 15, 23%), and hardware failure (HWF) during follow-up (n = 9, 18%, i-iii, p = 0.7853). …”
Get full text

Facilitators, barriers, and guidance to successful implementation of multidisciplinary transitional care interventions: A qualitative systematic review using the consolidated frame... by Romain Collet, Juul van Grootel, Marike van der Leeden, Marike van der Schaaf, Johanna van Dongen, Suzanne Wiertsema, Edwin Geleijn, Mel Major, Raymond Ostelo

“…We identified 79 factors, mostly linked to three domains of the Consolidated Framework for Implementation Research: Innovation, Inner setting, and Individuals involved. …”
Get full text

Sex-Dimorphic Differential Expression Profiles in the Brain of the Adult Chinese Soft-Shelled Turtle, <i>Pelodiscus sinensis</i> by Pan Liu, Yanchao Liu, Junxian Zhu, Chen Chen, Liqin Ji, Xiaoli Liu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Qiaoqing Xu, Jiang Zhou, Wei Li

“…However, the underlying molecular mechanisms of this phenomenon have mostly been investigated in the gonadal tissues of <i>P. sinensis</i>, and there are no articles on sex differentiation from the brain of <i>P. sinensis</i>. …”
Get full text

Pulsed field ablation using a circular electrode array catheter in patients with atrial fibrillation: A workflow optimization study evaluating the role of mapping by Melanie A. Gunawardene, Jens Hartmann, Jannis Dickow, Rahin Wahedi, Tim Harloff, Johanna Jezuit, Eike P. Tigges, Mario Jularic, Borislav Dinov, Nele Gessler, Stephan Willems

“…Insufficient PV ablation with remaining conduction occurred mostly anterior (n = 8/15, 53 %) and at the carina (n = 4/15; 27 %). …”
Get full text

514 A systematic review on sleep duration and Alzheimer’s disease fluid biomarkers: Preliminary findings by Vanessa Young, Vanessa M. Young, Joy Zeynoun, Christine Gaspard, Christopher R Frei, Jayandra Jung Himali, Antonio L. Teixeira, Tiffany Kautz, Sudha Seshadri, Andree-Ann Baril

“…For the 14 studies using CSF biomarkers, lower Aβ42 (3/14), Aβ40 (1/14), or the ratio (1/14) were associated with either short or long sleep duration; t-tau (3/14) and p-tau181 (4/14) levels were mostly associated with short sleep. For the 7 blood-based biomarker studies, Aβ42 (2/7), Aβ40 (2/7), and the ratio (3/7) had mixed results with either short or long sleep. …”
Get full text

Piloting a team-based telemedicine care for hypertension focused on Black patients by Srista Manandhar, Sunit Chhetri, Danielle Sutton, Animita C. Saha, Suneet Kaur, Josh Brown, Jeff Williamson, Kathryn E. Callahan, Justin B. Moore, Yhenneko J. Taylor, Hayden B. Bosworth, Yashashwi Pokharel

“…We provided social support to 11 patients 19 times including support at home visits by CHWs, mostly for food and medications. There were challenges in supporting other social needs like housing. …”
Get full text

Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma by Linlin Zhang, Chuanying Zhu, Shuo Huang, Miaomiao Xu, Chao Li, Hongliang Fu, Yafu Yin, Sheng Liang, Hui Wang, Zhilei Cui, Lei Huang

“…The Anlotinib-BSA nano-capsule (nBSA) showed a mostly uniform size distribution centering at 21–23 nm, and the nano-drug had a characteristic absorption peak at the wavelength of 325 nm. …”
Get full text

Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data. by Laura Slade, Maya Blackman, Hiten D Mistry, Jeffrey N Bone, Milly Wilson, Nuhaat Syeda, Lucilla Poston, Peter von Dadelszen, Laura A Magee, SCOPE Consortium

“…<h4>Methods and findings</h4>Included were pregnancies in the international SCOPE cohort with birth at ≥20 weeks' gestation, 2004 to 2008. Women were mostly of white ethnicity, in their 20s, and of normal-to-overweight body mass index (BMI). …”
Get full text

Comparison of the efficacy and safety of various anti-inflammatory drugs in urate-lowering therapy initiation in patients with gout (preliminary data) by M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina

“…Nasonova Research Institute of Rheumatology, 97 (94%), mostly men, entered a single-center prospective study. …”
Get full text