The ruminal and faecal microbiota, digestion processes, and milk composition of dairy cows are modified by the botanical biodiversity of pastures by M. Musati, M. Coppa, C. Delbès, I. Verdier-Metz, M. Popova, V. Niderkorn, M. Bouchon, Y. Farizon, F. Enjalbert, M. Renna, C. Lussiana, G. Mangione, B. Martin, A. Ferlay

“…After a 5-week pre-experimental period on a common permanent grassland plot, the two groups of cows grazed for 4 weeks (experimental period) on two plots characterised by contrasting levels of plant biodiversity: low diversity (LD; 19 species, mainly grasses) and high diversity (HD; 56 species, mostly dicots). Samples of simulated bites, rumen fluid, faeces, and milk were collected at the end of the pre-experimental and experimental periods. …”
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Interictal suppression in patients with mesial temporal lobe epilepsy: A simultaneous PET/fMRI study by Jie Hu, Liwei Sun, Kun Guo, Bixiao Cui, Chenyang Yao, Jingjuan Wang, Hui Ouyang, Xu Zhang, Chunlin Li, Jie Lu

“…At the whole-brain level, there was significant increase of inward MCM connectivity to the SOZs, which mostly came from mesial-temporo-limbic, anterior and posterior midline regions of the default mode network (DMN) and subcortical nuclei. …”
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Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi‐Ethnic Study of Atherosclero... by Sarah Nomura, Weihua Guan, Yixin Zhang, Geoffrey H. Tison, Hiroaki Ikezaki, Margaret R. Diffenderfer, Ching‐Ti Liu, Ron C. Hoogeveen, Christie M. Ballantyne, Ernst J. Schaefer, Michael Y. Tsai

“…Conclusions Elevated Lp(a) levels are associated with HF risk among White, but not Black individuals, and associations appears to be mostly mediated by a history of myocardial infarction.…”
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Ceftazidime–Avibactam Versus Polymyxin-Based Combination Therapies: A Study on 30-Day Mortality in Carbapenem-Resistant Enterobacterales Bloodstream Infections in an OXA-48-Endemic... by Rıdvan Dumlu, Meyha Şahin, Okan Derin, Özlem Gül, Sedef Başgönül, Rehile Zengin, Çiğdem Arabacı, Funda Şimşek, Serap Gençer, Ayşe Sesin Kocagöz, Ali Mert

“…Research comparing the effectiveness of CAZ-AVI and PBCT in CRE blood stream infections (CRE-BSIs) is limited, mostly focusing on <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing isolates. …”
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Compassion fatigue and satisfaction among frontline staff in long term care facilities: psychometric properties of the Serbian version of the professional quality of life scale by Milutin Vracevic, Milutin Vracevic, Vedrana Pavlovic, Natasa Todorovic, Natasa Todorovic, Natasa M. Milic, Natasa M. Milic, Bojana Matejic, Predrag Brkic, Nikola V. Milic, Marko Savic, Srdjan Masic, Andrija Pavlovic, Vladislav Stanisic, Ana Tasic, Dragan Spaic, Sandra Matovic, Danijela Tiosavljevic, Danijela Tiosavljevic, Dejana Stanisavljevic

“…The following standardized instruments were also distributed: Secondary Traumatic Stress Scale (STSS), Depression Anxiety and Stress Scale 21 (DASS-21) and 12-Item Short-Form Health 36 Survey (SF-12).ResultsA total of 300 LTC workers participated, mostly women (86.3%), with an average age of 45.4 ± 10.5 years and a median work experience of 15 years (range: 1 to 42 years). …”
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Egg desensitization is achieved effectively and safely through a low maintenance dose protocol by Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD

“…Adverse reactions occurred in 15.6% of 5971 doses, mostly mild. Skin prick test wheal diameters decreased significantly (P < .001); s-IgE levels declined whereas s-IgG4 levels increased (P < .001), and sIgG4/sIgE ratios improved. …”
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Structural Brain Morphometry in Children with Attention Deficit Hyperactivity Disorder and Comorbid Mild Cognitive Impairments by George A. Karkashadze, Alexey I. Firumyants, Nikita S. Shilko, Nataliya S. Sergienko, Yulia V. Nesterova, Leonid M. Yatsyk, Elena N. Rudenko, Mikhail I. Polle, Tatiana A. Salimgareeva, Tinatin Yu. Gogberashvili, Nataliya E. Sergeeva, Tatiana A. Konstantinidi, Safarbegim Kh. Sadilloeva, Marina A. Kurakina, Viktor V. Dyachenko, Inessa A. Povalyaeva, Evgeniy V. Bogdanov, Anastasia I. Rykunova, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva, Leyla S. Namazova-Baranova

“…MCI without ADHD group has shown bilateral enlargement of lateral ventricles, decrease in the volume of right pallidum and seven gyri cortex, mostly on the right side, as well as decrease in the volume of four cerebellar lobules. …”
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Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial by Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Xuemei Song, Marisa Lopez-Cruzan, Leslie Linehan, Candice E. Van Skike, Gabriel A. De Erausquin, Veronica Galvan, Miranda E. Orr, Nicolas Musi, Yingxin He, Randall J. Bateman, Chen-Pin Wang, Sudha Seshadri, Ellen Kraig, Dean Kellogg

“…After treatment, we find that twenty, mostly mild adverse events occur, systolic blood pressure and hemoglobin A1c increase, multiple erythrocyte parameters decrease, and there are no significant cognitive changes. …”
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Evaluation of molecular and serological testing for imported urogenital schistosomiasis screening in a referral tropical medicine centre in Barcelona, Spain by Patricia Martínez-Vallejo, Alejandro Mediavilla, Aroa Silgado, Francesc Zarzuela, Lidia Goterris, Carles Rubio Maturana, Nuria Serre-Delcor, Inés Oliveira-Souto, Fernando Salvador, Joan Joseph-Munne, María Luisa Aznar, Diana Pou, Begoña Treviño, Israel Molina, Javier Sotillo, Elena Sulleiro

“…It is estimated that more than 200 million people are affected worldwide, mostly in Africa. The gold standard diagnosis of urogenital schistosomiasis (UGS) is the microscopic visualisation of Schistosoma haematobium eggs in concentrated urine; however, its sensitivity is low. …”
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Clinical characteristics and risk factors for recurrence of Kikuchi-Fujimoto disease in children: a case-control study by Bing Liu, Yi Sun, Wen-yuan Shi, Bing Hu, Ling-yun Guo, Tian-ming Chen, Xiao-ming Ge, Yun-yan Wu, Gang Liu

“…Conclusions KFD in children is more common in males and mostly occurs at school age. KFD in children is characterized by tenderness in the lymph node and leukopenia with less multiple lymph node involvement. …”
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Cellular and Molecular Atlas of Peripheral Blood Mononuclear Cells from a Pregnant Woman After Recovery from COVID-19 by Lili Du, Yingyu Liang, Xiaoyi Wang, Lijun Huang, Xingfei Pan, Jingsi Chen, Dunjin Chen, Dandan Shi

“…After reclustering and Augur analysis, we found that CD16 monocytes and mucosal-associated invariant T (MAIT) cells were mostly affected within different myeloid, T, and NK cell subtypes in our COVID_RS patient. …”
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Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling by Aseervatham Anusha Amali, Douglas Jie Wen Tay, Douglas Jie Wen Tay, Yiqi Seow, Marie Loh, Marie Loh, Marie Loh, Sharada Ravikumar, Jocelyn Jin Yu, Shaun Seh Ern Loong, Siew Wai Fong, Chang Jie Mick Lee, Jonathan Jordon Cailu Lim, Louis Hanqiang Gan, Winston Lian Chye Koh, Ying Ding, Qi Hui Sam, Zhaohong Tan, Rachel Ying Min Tan, Chong Boon Lua, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Amit Singhal, Shyam Prabhakar, Wee Joo Chng, Wee Joo Chng, Laurent Renia, Laurent Renia, David Chien Boon Lye, David Chien Boon Lye, Lisa F. P. Ng, Lisa F. P. Ng, Kai Sen Tan, Kai Sen Tan, Roger Foo, Roger Foo, Chang Chuan Melvin Lee, Chang Chuan Melvin Lee, Barnaby Young, Barnaby Young, Louis Yi Ann Chai, Louis Yi Ann Chai

“…To date, these studies have yielded loci mostly in non-functional domains of unknown biological significance and invariably require large sample sizes, potentially missing lower frequency variants, especially in under-represented or minority populations.MethodsTo identify unique genetic traits predisposing to severe COVID-19 in Asians, we employed an alternative strategy using whole exome sequencing of representative cohort of severe versus mild COVID-19 patients. …”
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Longer-term virologic outcomes on tenofovir-lamivudine-dolutegravir in second-line ART by Jennifer K. van Heerden, Ying Zhao, Claire M. Keene, Rulan Griesel, Zaayid Omar, René Goliath, Kayla Delaney, Gert van Zyl, Gary Maartens, Graeme Meintjes

“…Eligible participants had two consecutive HIV-1 RNA ≥ 1000 copies/mL on first-line ART, mostly tenofovir-emtricitabine-efavirenz. Participants were switched to tenofovir-lamivudine-dolutegravir (TLD) with lead-in 50 mg dolutegravir twice daily in stage one (n = 62), and randomised to TLD with additional lead-in 50 mg dolutegravir or placebo for the first 14 days in stage two (n = 130). …”
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ImageNomer: Description of a functional connectivity and omics analysis tool and case study identifying a race confound by Anton Orlichenko, Grant Daly, Ziyu Zhou, Anqi Liu, Hui Shen, Hong-Wen Deng, Yu-Ping Wang

“…Most packages for the analysis of fMRI-based functional connectivity (FC) and genomic data are used with a programming language interface, lacking an easy-to-navigate GUI frontend. …”
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An expert patient program for people living with multiple sclerosis improves knowledge and empowerment: a pre-test, post-test multicenter implementation study by Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Paloma Amil-Bujan, Cristina Bosch-Farré, Clàudia Coll-Martínez, Clàudia Coll-Martínez, María Jesús Arévalo, Elisenda Anglada-Clofent, Rebeca Menéndez-Díaz, Montserrat Aroca-Alsina, Montserrat Aroca-Alsina, Miguel Merchan-Ruiz, Miguel Merchan-Ruiz, Santiago Pérez-Hoyos, Santiago Pérez-Hoyos, Ángel Guillermo Arévalo-Bernabé, Ángel Guillermo Arévalo-Bernabé, Xavier Montalban, Ana Hernando, Sara LLufriú, Silvia Peralta-Moncusí, Lluís Brieva, Cristina Ramo-Tello, Mariona Carabí, Nuria Solà-Valls, Maria Cinta Zabay, Maria Alba Mañé-Martínez, Jaume Sastre-Garriga, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Carmen Bertran-Noguer

“…Lifestyle habits remained mostly unchanged, except for medication self-management and diet, whereas visits to nurses and other professionals in MS units significantly decreased. …”
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Clinical activity of durvalumab for patients with advanced mismatch repair-deficient and repair-proficient endometrial cancer. A nonrandomized phase 2 clinical trial by Linda Mileshkin, Elizabeth Barnes, Tarek Meniawy, Kristy Robledo, Michael Friedlander, Geraldine Goss, Jermaine Coward, Yoland Antill, Michelle Cummins, Sally Baron-Hay, Martin R Stockler, Catherine Shannon, Philip Beale, Peey-Sei Kok, Deborah Smith, Sonia Yip, Amanda Spurdle, Yeh Chen Lee, Janine Lombard, John Andrews

“…Immune-related adverse events occurred in 14 women, mostly grades 1–2.Conclusion Durvalumab monotherapy showed promising activity and acceptable safety in AEC with dMMR regardless of prior lines of chemotherapy, but activity was limited in AEC with pMMR.Trial registration numbers ANZGOG1601, ACTRN12617000106336, and NCT03015129.…”
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Open-Label Phase 1/2 Study of Daratumumab-Based Desensitization Before Kidney Transplantation by Caroline Pilon, Nizar Joher, Cédric Usureau, Emmanuelle Boutin, Anna Boueilh, Jean-Luc Taupin, Allan Thiolat, José L. Cohen, Vissal David Kheav, Florence Canoui-Poitrine, Maryvonnick Carmagnat, Philippe Grimbert, Marie Matignon

“…Safety analysis showed 4 serious non-treatment-emergent adverse events (non-TEAEs), 36 mild TEAEs, mostly infusion-related reactions, grade 1 and 2 (causing 2 temporary drug discontinuations), but no serious TEAEs. …”
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Toxicity, Half-Life and Antitumor Activity of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as Novel Antimitotic CYP1A1-Targeted Prodrugs in Female Mouse Models by Atziri Corin Chavez Alvarez, Chahrazed Bouzriba, Vincent Ouellette, Mathieu Gagné-Boulet, Alexandre Patenaude, Sylvie Pilote, René C.-Gaudreault, Chantale Simard, Sébastien Fortin

“…PAIB-SOs are prodrugs bioactivated into potent antimitotics by the cytochrome P450 1A1 (CYP1A1), which is a frequent enzyme in resistant BC cells, but mostly missing in normal cells. Our screening program studies of PAIB-SO chemolibraries selected three prototypical PAIB-SOs as antimitotic prodrugs amenable for studies using BC animal models. …”
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Impact of hematopoietic cell transplantation and quizartinib in newly diagnosed patients with acute myeloid leukemia and FMS-like tyrosine kinase 3–internal tandem duplications in... by Richard F. Schlenk, Pau Montesinos, Hee-Je Kim, Antonio Romero-Aguilar, Radovan Vrhovac, Elżbieta Patkowska, Pavel Žak, Po-Nan Wang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Herve Dombret, Sergio Amadori, Jianxiang Wang, Alexander E. Perl, Mark J. Levis, Harry P. Erba

“…Patients who underwent protocol-specified allo-HCT in CR1/CRc1 experienced post-allo-HCTQrelated complications, mostly grade ≥2 graft-versus-host disease, as expected. …”
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Evaluation of eco-driving performance of electric vehicles using driving behavior-enabled graph spectrums: A naturalistic driving study in China by Hui Zhang, Yiyue Luo, Naikan Ding, Toshiyuki Yamamoto, Chenming Fan, Chunhui Yang, Wei Xu, Chaozhong Wu

“…However, current researches on ecological driving behavior mostly use structured data to reflect the characteristics of ecological driving behavior, and it is difficult to accurately reveal the recessive relationship between driving behavior and energy consumption. …”
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