Immunogenicity and safety of Ad26.RSV.preF/RSV preF protein vaccine at predicted intermediate- and end-of-shelf-life as an evaluation of potency throughout shelf life by Tessa Hosman, Roy van Heesbeen, Arangassery Rosemary Bastian, Weihong Hu, Christy Comeaux, Nynke Ligtenberg, Bart van Montfort, Benoît Callendret, Esther Heijnen

“…RSV preF-binding antibody concentrations were also similar 6 months post-vaccination. Solicited AEs were mostly mild to moderate in intensity, and a decreased reactogenicity was observed from the Release group to the ISL and EoSL group. …”
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Genome-wide identification and analysis of the WRKY gene family in Sainfoin (Onobrychis viciifolia) and their response to drought, salt, and alkali stress by Wenxiang Li, Yinuo Yan, Yanxia Liang, Shiyao Yue, Yaling Liu, Feng Yuan, Mengrong Xu, Dengxia Yi, Jun Li, Yan Zhao, Lili Nan, Wenbo Jiang

“…Transcriptome analysis revealed that highly expressed genes under drought, salt, and alkali stress mostly belonged to groups I, III, IId, IIa, and IIb. …”
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Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV by Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson

“…Conclusions: WG in PLWH on ART is mostly influenced by pre-existing weight and low physical activity, rather than switch to INSTI.…”
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Exploring mental health professionals’ emotional responses with individuals diagnosed with antisocial personality disorder or psychopathy: a scoping review by Gabriele Lo Buglio, Leonardo Zaninotto, Renan Göksal, Uyangakhishig Bayasgalan, Alice Barsanti, Brad D. Booth, Brad D. Booth, Nicola Carone, Anmar Mighri, Alessandro Miola, Alessandro Miola, Laura Muzi, Vittorio Lingiardi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Tommaso Boldrini, Tommaso Boldrini

“…PubMed, Web of Science, and EBSCO/PsycINFO were searched for studies published from 01/01/1990 to 06/12/2023, including clinicians providing clinical care to individuals with antisocial or psychopathy traits or disorders assessed via standardized and validated tools and focusing on their cognitive, emotional and behavioral responses, with no restriction regarding context/location and study design (protocol: https://osf.io/eaquj).ResultsTwelve studies were included, mostly from Europe, mainly focusing on clinicians working with individuals with ASPD. …”
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Identifying Causative Agents of a Paretic Syndrome in Waterbirds in Southern Portugal by María V. Mena Casero, Andrew D. Turner, Begoña Ben-Gigirey, Ryan P. Alexander, Karl J. Dean, Robert G. Hatfield, Benjamin H. Maskrey, Christelle Mazuet, Kobey Karamendin, Rafael Mateo

“…In the Iberian Peninsula, a paretic clinical picture without known etiology affecting mostly gulls has been reported during the last few decades. …”
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Mapping the role of vaccines in combating AMR in the WHO African region: a scoping review and implications for research and policy by Chinwe Iwu-Jaja, Laetitia Gahimbare, Akhona V. Mazingisa, Walter Fuller, Degefaw Y. Mazengiya, Joseph Okeibunor, Olushayo O. Olu, Patrick de Marie C. Katoto, Ali A. Yahaya, Kwasi Nyarko, Charles S. Wiysonge

“…Seven studies either focused on Africa as a whole or were multi-regional studies that included Africa, with country-specific studies mostly from South Africa and Ethiopia. Four studies focused on pneumococcal conjugate vaccines (PCV), while others examined influenza, rotavirus, respiratory syncytial virus, tuberculosis, and Klebsiella pneumoniae vaccines. …”
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Stereotactic body radiotherapy with carbon ions as local ablative treatment in patients with primary liver cancer by Paula Hoffmeister-Wittmann, Philipp Hoegen-Saßmannshausen, Livia Wicklein, Fabian Weykamp, Katharina Seidensaal, Christoph Springfeld, Michael T. Dill, Thomas Longerich, Peter Schirmacher, Arianeb Mehrabi, René Michael Mathy, Bruno C. Köhler, Jürgen Debus, Klaus Herfarth, Jakob Liermann

“…Promising effects of CIRT have been described in several studies during the past decades, mostly in Japan. To date, no standardized treatment protocol has been established and European data on CIRT for liver cancer is lacking. …”
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Multimodal deep learning for predicting neoadjuvant treatment outcomes in breast cancer: a systematic review by Eriseld Krasniqi, Lorena Filomeno, Teresa Arcuri, Gianluigi Ferretti, Simona Gasparro, Alberto Fulvi, Arianna Roselli, Loretta D’Onofrio, Laura Pizzuti, Maddalena Barba, Marcello Maugeri-Saccà, Claudio Botti, Franco Graziano, Ilaria Puccica, Sonia Cappelli, Fabio Pelle, Flavia Cavicchi, Amedeo Villanucci, Ida Paris, Fabio Calabrò, Sandra Rea, Maurizio Costantini, Letizia Perracchio, Giuseppe Sanguineti, Silvia Takanen, Laura Marucci, Laura Greco, Rami Kayal, Luca Moscetti, Elisa Marchesini, Nicola Calonaci, Giovanni Blandino, Giulio Caravagna, Patrizia Vici

“…Results Fifty-one studies, mostly retrospective (90.2%, median cohort 281), were included. …”
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Mapping regional implementation of ‘Making Every Contact Count’: mixed-methods evaluation of implementation stage, strategies, barriers and facilitators of implementation by Gregory Maniatopoulos, Tracy Finch, Deborah Harrison, Catherine Haighton, Jill Harland, Rob Wilson, Angela M Rodrigues, Craig Robson, Bethany Nichol, Caroline Charlton, Beckie Gibson, Emma Giles, Denise Orange

“…Overall, the implementation of MECC within the region was at an early stage, with training mostly delivered between, rather than within, organisations. …”
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West Nile Virus Outbreak in Israel 2024 Compared with Previous Seasons: A Retrospective Study by Guy Katzenellenbogen, Michal Canetti, Ili Margalit, Yonatan Shusterman, Alon Simchovitz-Gesher, Lior Naveh, Nadav Baharav, Miki Goldenfeld, Ana Belkin, Marina Brod, Anat Wieder-Finesod, Eyal Leshem, Erez Magiel, Itzchak Levy, Yaniv Lustig, Victoria Indenbaum, Nicola Maggio, Shahar Dekel, Bella Mechnik, Yovel Peretz, Noam Barda, Amir Tafesh, Dafna Yahav, Gili Regev-Yochay

“…The majority (109/134, 81%) had neuroinvasive disease, mostly encephalitis. In 2024, patients were older, with a lower functional state, and a higher proportion were severely immunocompromised. …”
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Dietary protein/carbohydrate ratio and swimming activity modulate mitochondrial performance and oxidative metabolism in gilthead sea bream (Sparus aurata) juveniles by Isabel García-Pérez, Lucía Aragón-Serrano, Manel Montblanch, Albert Sánchez-Moya, Miquel Perelló-Amorós, Jaume Fernández-Borràs, Joaquim Gutiérrez, Josefina Blasco

“…Exercise reduced plasma triglyceride levels and upregulated mfn1, glut4, and ucp2 expression in red muscle, while liver and white muscle function remained mostly unaffected by swimming activity. Gilthead sea bream juveniles demonstrated notable metabolic adaptation to a carbohydrate-rich diet, presenting minor diet-induced changes at the molecular level, with skeletal muscles showing high metabolic plasticity. …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Spike density, falling number and thousand kernel weight were positively and significantly altered by biochar amendment, whilst the remaining parameters mostly differed between cultivars only. By contrast, biochar application did not alleviate nitrogen reduction in grains and straw in both cultivars neither increase grain protein content, although it remained sufficient for pasta making under all treatment combinations. …”
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Prognostic significance of tumor size for primary invasive cutaneous melanoma: A population‐based study, 2004‐2016 by Qiuying Ma, Huinan Suo, Li Zhu, Yue Qian, Xiaoyan Sun, Jun Xie, Qianru Li, Yangxue Fu, Jun Li, Juan Tao

“…After adjusting for age, sex, primary site, histopathologic cell type, Breslow thickness, ulceration, mitotic rate, regional metastasis, and distant metastasis, the hazard ratio (HR) of MSS increased with increasing tumor size until a peak at 31‐42 mm (HRs, 1.33, 1.59, 2.41, respectively; all P < .0001), and then decreased when tumor size was larger than 42 mm using tumor size ≤ 6 mm as the reference (HR, 2.11; 95% confidence interval [CI], 1.84 −2.42; P < .0001). This pattern mostly remained after stratification by T subcategories from T1 to T4 in localized primary CM except that tumor size >42 mm subgroup had the shortest MSS in T4. …”
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Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database by Alexandre O. Gérard, Diane Merino, Nouha Ben Othman, Alexandre Destere, Delphine Viard, Elliot Ewig, Fanny Rocher, Antoine Sicard, Milou-Daniel Drici

“…However, the European Medicines Agency (EMA) Summary of Product Characteristics (SmPC) includes a broad range of adverse drug reactions (ADRs), mostly identified in small clinical trials with cyclosporine as a control, in patients exposed to other immunosuppressants. …”
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Research progress of combined treatment of western medicine in children with allergic purpura (儿童过敏性紫癜西药联合治疗的研究进展) by HU Yuan (胡园), CHEN Xiuying (陈秀英), LIU Lili (刘莉莉)

“…Allergic purpura, as an allergic microvascular allergic disease, mostly occurs in children. Clinical manifestations include skin purpura, joint pain, abdominal pain and kidney damage. …”
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Ceftazidime-Avibactam versus Polymyxin-Based Therapies: A Study on 30-Day Mortality in Carbapenem-Resistant Enterobacterales Bloodstream Infections in an OXA-48 Endemic Region by Rıdvan Dumlu, Meyha Şahin, Okan Derin, Özlem Gül, Sedef Başgönül, Rehile Zengin, Çiğdem Arabacı, Funda Şimşek, Serap Gencer, Sesin Kocagöz, Ali Mert

“…BACKGROUND-AIM: Ceftadizime-avibactam(CAZ-AVI) is recommended as the primary treatment for bloodstream infections (BSI) caused by OXA-48 β-Lactamase producing Carbapenem-resistant Enterobacterales (CRE), while polymyxin-based-combination-therapies(PBT) are considered a last resort if in-vitro susceptible and CAZ-AVI is unavailable.Research comparing effectivenes of CAZ-AVI and PBT in CRE-BSI is limited, mostly focusing on KPC-producing isolates. In Turkey, OXA-48 is endemic and OXA-48-Like is common.Globally, there is limited studies on this topic. …”
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Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questio... by Bjørn Bjorvatn, Frances Chung, Kentaro Matsui, Christian Benedict, Damien Léger, Giuseppe Plazzi, Yuichi Inoue, Yves Dauvilliers, Colin Espie, Fang Han, Luigi De Gennaro, Markku Partinen, Brigitte Holzinger, Charles M Morin, Thomas Penzel, Courtney J Bolstad, Jonathan Cedernaes, Rachel Ngan Yin Chan, Ana Suely Cunha, Ilona Merikanto, Sergio Mota-Rolim, Michael Nadorff, Jules Schneider, Mariusz Sieminski, Yun-Kwok Wing

“…In the fully adjusted logistic regression models, results (weighted and stratified by country) were adjusted for gender, age, marital status, educational level, ethnicity, presence of sleep problems before COVID-19 and severity of the COVID-19 pandemic in each country at the time of the survey.Results The responders were mostly women (64%) with a mean age 41.8 (SD 15.9) years (median 39, range 18–95). …”
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The Impact of the COVID-19 Pandemic on Medical Training at the Greek National Health Service: A Cross-Sectional Study by Ioannis Moutsos, Dimitrios Lamprinos, Evangelia-Georgia Kostaki, Panagiotis Georgakopoulos, Gerasimos Siasos, Evangelos Oikonomou, Kostas A. Papavassiliou, Philippos Orfanos, Georgios Marinos

“…Two out of five medical students reported that their medical training was mostly affected during the first wave of the pandemic, from March to June 2020 (<i>n</i> = 201, 43.2%). …”
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Adverse childhood experiences and internalizing symptoms: the moderating role of neural responses to threat by Carola Dell’Acqua, Claudio Imperatori, Rita B. Ardito, Benedetto Farina, Mauro Adenzato, Giuseppe Carbone, Aurelia Lo Presti, Daniela Palomba, Simone Messerotti Benvenuti

“…Another mechanism could be a stress-induced disruption in the processing of pleasant stimuli, which is mostly linked with depressive symptoms. In this study, we examined how ACEs and neural correlates of different emotional processing stages (affective engagement, anticipation, elaboration) interact in the association with internalizing symptoms in a sample of university students (n = 46, 28 females). …”
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Risk factors associated with non-communicable diseases among government employees in Nepal: insights from a cross-sectional study by Durga Datta Chapagain, Durga Datta Chapagain, Kennedy Mensah Osei, Danik Iga Prasiska, Heejin Kimm, Vasuki Rajaguru, Sunjoo Kang, Tae Hyun Kim, Sang Gyu Lee, Whiejong Han

“…Significance was set at p &lt; 0.05 and 95% CI.ResultsParticipants’ mean age was 33.1 ± 9.1 years, with 82.1% (n = 796) male, mostly from aged 30–39 (n = 397, 41%), and Brahmin/Chhetri (n = 454, 46.9%). …”
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