Genetic Differentiation of Abies alba Outside Its Main Range Under Warm Meso‐ and Sub‐Mediterranean Conditions in Italy and Switzerland by Sevil Coşgun, Jérémy Gauthier, Giuliano Bonanomi, Gabriele Carraro, Paolo Cherubini, Marco Conedera, Erika Gobet, Maria‐Chiara Manetti, Gianluigi Mazza, Christoph Schwörer, Christoph Sperisen, Nadir Alvarez, Felix Gugerli, Willy Tinner

“…ABSTRACT Abies alba is an important European tree species currently mostly found at cool and humid sites in the montane zone. …”
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Fediša Modikologo: breaking the intergenerational cycle of violence against women and children. Theoretical framework and protocol for a prospective cohort study [version 1; peer r... by Leane Ramsoomar, Rachel Jewkes, Samantha Willan, Jani Nothling, Esnat Chirwa, Venice Mbowane, Maureen Phakoe, Shibe Mhlongo, Louis Sibiya, Desiree Pass, Charntel Paile, Ishen Seocharan, Nataly Woollett, Laura Washington, Nwabisa Jama-Shai, Bianca Dekel, Pinky Mahlangu, Mercilene Machisa, Amanda Zembe, Boitumelo Seepamore, Tracy Glass, Nicola Christofides, Stanley Carries, Darshini Govindasamy, Naeemah Abrahams, Asiphe Ketelo

“…The primary cohort will enrol 12,000 women experiencing severe IPV, recruited using non-probabilistic methods (mostly referral from services and community members, and chain-recruitment). …”
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Single and two-dose typhoid conjugate vaccine safety and immunogenicity in HIV-exposed uninfected and HIV-unexposed uninfected Malawian children by Nginache Nampota-Nkomba, Osward M. Nyirenda, Victoria Mapemba, Rhoda Masonga, Priyanka D. Patel, Theresa Misiri, Felistas Mwakiseghile, Richard Wachepa, John M. Ndaferankhande, Bright Lipenga, Pratiksha Patel, Happy Banda, Jennifer Oshinsky, Marcela F. Pasetti, Robert S. Heyderman, Leslie P. Jamka, Divya Hosangadi, Shrimati Datta, Melita A. Gordon, Kathleen M. Neuzil, Matthew B. Laurens

“…Cohort 2 (100 participants) enrollment began 25 March 2020. Solicited AEs were mostly mild, with no significant differences between HEU and HUU participants or one- and two-dose groups. …”
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Clinical Outcomes According to Aortic Stenosis Management: Insights From Real‐World Practice by Augustin Coisne, David Montaigne, Samy Aghezzaf, Sandro Ninni, Gilles Lemesle, Arnaud Sudre, Nicolas Lamblin, Thomas Modine, André Vincentelli, Francis Juthier, Martin B. Leon, Juan F. Granada, Christophe Bauters

“…Patients with untreated severe AS experienced high mortality rates, mostly cardiovascular for patients who declined AVR. …”
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Decoding MUC1 and AR axis in a radiation-induced neuroendocrine prostate cancer cell-subpopulation unveils novel therapeutic targets by Catarina Macedo-Silva, Ângela Albuquerque-Castro, Iris Carriço, Joana Lencart, Isa Carneiro, Lucia Altucci, João Lobo, Vera Miranda-Gonçalves, Rui Henrique, Margareta P. Correia, Carmen Jerónimo

“…Abstract Despite the initial efficacy of radiotherapy (RT) in treating prostate adenocarcinoma (PCa), disease progression can lead to the emergence of neuroendocrine prostate cancer (NEPC) - a highly aggressive malignancy for which standard therapies are mostly ineffective. Although oncogenic MUC1-C is a leading driver of NEPC and of PCa lineage plasticity, its putative role in response to RT, including RT-induced neuroendocrine transdifferentiation (tNED), has not been explored. …”
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Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways by Jemma J. Taitz, Jemma J. Taitz, Jian Tan, Jian Tan, Duan Ni, Duan Ni, Camille Potier-Villette, Camille Potier-Villette, Georges Grau, Georges Grau, Ralph Nanan, Ralph Nanan, Ralph Nanan, Laurence Macia, Laurence Macia, Laurence Macia

“…Epidemiological analysis revealed a positive correlation between global antibiotic consumption and IBD incidence.DiscussionOur findings demonstrate that antibiotic-mediated dysbiosis results in significantly altered short-chain fatty acid levels but immune homeostasis in spleen and MLNs at steady state is mostly preserved. Non-specific activation of splenocytes ex vivo, however, revealed mice with perturbed microbiota had significantly elevated production of TNF. …”
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Prediction and zoning evaluation of in-situ stress field in deep tight sandstone reservoirs of Western Sichuan Depression, Sichuan Basin: a case study of the second member of Xujia... by Tao HUANG, Ruixue LI, Hucheng DENG, Jianhua HE, Kesai LI, Yan LIU, Zehou XIANG, Yifei DU, Tairan YE

“…The results show that the current maximum horizontal principal stress direction in the Xu 2 Member of the Xinchang structural belt mostly ranges from N85° to 108°E, with an overall counterclockwise rotation as burial depth increases. …”
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Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models by Jian Ye, Brian A Belt, Shuyang S Qin, Rachel Jewell, Laura M Calvi, Bradley N Mills, Tara G Vrooman, Carl J Johnston, Scott A Gerber, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles, Nadia Luheshi, Noah A Salama, Sidney Lesser, Sarah L Eckl, Lauren Benoodt, Edith Lord, David Linehan

“…The beneficial effects of triple therapy were mostly abrogated by depletion of CD8+ T cells. In addition, triple therapy downregulated pathways related to tumor stemness, proliferation, and metabolism, and reduced EMT. …”
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Paradigm shift of respiratory viruses causing lower respiratory tract infection in children during COVID-19 pandemic in India by Mannat Kang, Subhabrata Sarkar, Suresh Kumar Angurana, Pankaj Singh, Meenakshi Rana, Ishani Bora, Rishi Chetanya, Bharatendu Singh, Jayashree Muralidharan, Radha Kanta Ratho

“… Introduction: Acute lower respiratory tract infections (ALRTIs) are the commonest cause of mortality in children mostly attributed to respiratory viruses. During the coronavirus disease 2019 (COVID-19) pandemic, the dynamics and transmission of infections changed worldwide due to widespread public health measures. …”
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Differentiating Main-Duct IPMN from Chronic Pancreatitis Using Next-Generation Sequencing of Main Pancreatic Duct Fluid: A Pilot Study by Daniel Schmitz, Stefan Prax, Martin Kliment, Felix Gocke, Daniel Kazdal, Michael Allgäuer, Roland Penzel, Martina Kirchner, Olaf Neumann, Holger Sültmann, Jan Budczies, Peter Schirmacher, Frank Bergmann, Jörg-Peter Ritz, Raoul Hinze, Felix Grassmann, Jochen Rudi, Albrecht Stenzinger, Anna-Lena Volckmar

“…Twenty-two patients (mean MPD diameter of 12.4 (7–31) mm) with a definitive, mostly surgically confirmed diagnosis were included in the analysis. …”
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Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia by Genevieve E. Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y. C. Tong, David Boettiger, Benjamin Cowie, Joshua S. Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies, on behalf of the Hep B PAST Partnership

“…Using the 2024 World Health Organisation guidelines, this increased to 50% due mostly to fibrosis and population prevalence of diabetes. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…Motor functions and body weight improved mostly in female mice with sustained estrogen levels, whereas males had to compensate for the ongoing, disease-related testis atrophy and the loss of androgen production.Our study underscores the beneficial therapeutic effects of FTY on HD involving endogenous steroid hormones and their important anabolic effects. …”
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Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) by Antonio Bernabe-Ortiz, Neil Pearce, Hans Kromhout, Pablo Perel, Liam Smeeth, Cristina O’Callaghan-Gordo, Jason Glaser, Kristina Jakobsson, Dorothea Nitsch, Ben Caplin, Nalika Gunawardena, Adeera Levin, Vidhya Venugopal, Marvin Gonzalez-Quiroz, Sophie Hamilton, Cristina O'Callaghan Gordo, Rajiv Saran, Ricardo Correa-Rotter, Ajay Singh, Giuseppe Remuzzi, Emmanuel Burdmann, Rick Johnson, Phabdheep Kaur, Pronpimolk Kongtip, Magdalena Madero Rovalo, Moffat Nyirenda, Dorairaj Prabhkaran, Narayan Prasad, Nalika Gunawardenan

“…Introduction A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. …”
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MUSEQuBES: The Column Density, Covering Fraction, and Mass of O vi-bearing Gas in and Around Low-redshift Galaxies by Sayak Dutta, Sowgat Muzahid, Joop Schaye, Nicolas F. Bouché, Sebastiano Cantalupo, Hsiao-Wen Chen, Sean Johnson

“…Combining 253 star-forming galaxies (mostly more massive) from the literature with 176 star-forming galaxies from MUSEQuBES, we find that both $\left\langle N({\rm{O}}\,{\rm\small{VI}})\right\rangle $ and the average covering fraction peak at ${\mathrm{log}}_{10}({M}_{\star }/{M}_{\odot })$ ≈ 9.5. …”
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Safety and efficacy of combined trastuzumab-deruxtecan and concurrent radiation therapy in breast cancer. The TENDANCE multicentric French study by K. Debbi, M.A. Benderra, J. Medioni, C. Durdux, N.H. To, C. Boukhobza, N. Grellier, A. Benmaziane, L. Monnier, J. Gligorov, E. Assaf, Y. Belkacemi

“…Indications consisted mostly of palliative bone irradiation (46.3 %) and stereotactic radiosurgery (SRS) (25.9 %). …”
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Multiparameter flow cytometric and transcriptional analyis of CD20 positive T-cells in bone marrow in patients of multiple myeloma and monoclonal gammopathy of undetermined signifi... by Barbara Forró, Béla Kajtár, Ágnes Lacza, László Kereskai, Livia Vida, Balázs Kőszegi, Péter Urbán, József Kun, József Kun, Attila Gyenesei, Szabolcs Kosztolányi, Dániel Kehl, Pál Jáksó

“…Increased PD-1 expression indicates T-cell exhaustion which was mostly detected in the samples of patients with a higher tumor percentage. …”
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Effectiveness of combining psychological prevention interventions with interventions that address the social determinants of mental health in low- and middle-income countries: a sy... by Crick Lund, Katherine Sorsdahl, Marianna Purgato, Corrado Barbui, Nagendra Luitel, Mark Jordans, Emily Garman, Rakesh Singh, Emiliano Albanese, Eleonora Prina, Beatrice Bano, Daniela Trujillo, Maria Cecilia Dedios Sanguineti

“…No data were available on the incidence of anxiety.Conclusions Combined task-shared interventions are effective in mostly short-term prevention of CMHCs in LMICs. Combining strategies targeting social determinants with psychological prevention approaches offers a potential opportunity to reduce the global mental health burden. …”
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The heterozygous mutation COL4A4 c.817-1G>A causes Alport syndrome in a Chinese family: a case report by Dayan Wang, Dayan Wang, Xiaobing Li, Xiaobing Li, Kaichao Cheng, Kaichao Cheng, Lanjin Zheng, Lanjin Zheng, Pengfei Yu, Pengfei Yu, Panjian Lai, Panjian Lai

“…BackgroundAlport syndrome is an inherited glomerular disease that leads to progressive kidney failure, hearing loss, and eye problems. Diagnosis mostly relies on tests of tissue pathology and genetic analysis. …”
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PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing by Michael H. Lee, Araceli Perez-Lopez, Leigh A. Knodler, Grace Nguyen, Gregory T. Walker, Judith Behnsen, Steven Silva, Jean Celli, Melissa A. Tamin, Michael H. Liang, Karine Melchior, Felix A. Argueta, Sean-Paul Nuccio, Manuela Raffatellu

“…However, these activities have mostly been observed with mutant, avirulent strains with a truncated O-antigen that renders bacteria sensitive to complement killing. …”
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Identifying and assessing the capacity and experience of trial sites in low- and middle-income countries for high-quality randomised drug trials in maternal and perinatal health by Ahmet Metin Gülmezoglu, Pisake Lumbiganon, Shivaprasad S Goudar, Jenny Cao, Joshua Peter Vogel, Maureen Makama, Anna Shalit, Annie RA McDougall, Ben Sanderson, Tahlia Guneratne, Kate Mills, Anne Ammerdorffer, Jennifer A Scott, Lindsay Keir

“…Of these 52 trials, 16 (30.8%) were Good Clinical Practice-compliant, 22 (42.3%) were phase III and one was a regulatory trial. 14 trials were conducted by a collaborative group established mostly for a specific trial or a small group of related trials. …”
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