Prospective Study on Kidney Dysfunction Markers and Risk for Mortality among South Asians by Ram Jagannathan, Shuchi Anand, Dimple Kondal, Jialin Han, Maria Montez-Rath, Mohammed K. Ali, Shivani A. Patel, Kavita Singh, Roopa Shivashankar, RM Anjana, Ruby Gupta, Sailesh Mohan, Glenn M. Chertow, Viswanathan Mohan, Nikhil Tandon, K.M. Venkat Narayan, Dorairaj Prabhakaran

“…Introduction: Associations between markers of impaired kidney function and adverse outcomes among South Asians is understudied and could differ from existing data derived mostly from North American or European cohorts. Methods: We conducted a prospective analysis of 9797 participants from the ongoing cardiometabolic risk reduction study in South Asia, India. …”
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A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches... by Nguyen Van De, Pham Ngoc Minh, Thanh Hoa Le, Do Trung Dung, Tran Thanh Duong, Bui Van Tuan, Le Thanh Dong, Nguyen Van Vinh Chau, Pablo F. Cuervo, M. Dolores Bargues, M. Adela Valero, Albis Francesco Gabrielli, Antonio Montresor, Santiago Mas-Coma

“…It started in the central coast, including 53,109 patients, mostly adults and females. Seasonality, linked to vegetable consumption, peaks in June, although the intensity of this peak differs according to relief/climatic zones. …”
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Interictal suppression in patients with mesial temporal lobe epilepsy: A simultaneous PET/fMRI study by Jie Hu, Liwei Sun, Kun Guo, Bixiao Cui, Chenyang Yao, Jingjuan Wang, Hui Ouyang, Xu Zhang, Chunlin Li, Jie Lu

“…At the whole-brain level, there was significant increase of inward MCM connectivity to the SOZs, which mostly came from mesial-temporo-limbic, anterior and posterior midline regions of the default mode network (DMN) and subcortical nuclei. …”
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Egg desensitization is achieved effectively and safely through a low maintenance dose protocol by Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD

“…Adverse reactions occurred in 15.6% of 5971 doses, mostly mild. Skin prick test wheal diameters decreased significantly (P < .001); s-IgE levels declined whereas s-IgG4 levels increased (P < .001), and sIgG4/sIgE ratios improved. …”
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Structural Brain Morphometry in Children with Attention Deficit Hyperactivity Disorder and Comorbid Mild Cognitive Impairments by George A. Karkashadze, Alexey I. Firumyants, Nikita S. Shilko, Nataliya S. Sergienko, Yulia V. Nesterova, Leonid M. Yatsyk, Elena N. Rudenko, Mikhail I. Polle, Tatiana A. Salimgareeva, Tinatin Yu. Gogberashvili, Nataliya E. Sergeeva, Tatiana A. Konstantinidi, Safarbegim Kh. Sadilloeva, Marina A. Kurakina, Viktor V. Dyachenko, Inessa A. Povalyaeva, Evgeniy V. Bogdanov, Anastasia I. Rykunova, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva, Leyla S. Namazova-Baranova

“…MCI without ADHD group has shown bilateral enlargement of lateral ventricles, decrease in the volume of right pallidum and seven gyri cortex, mostly on the right side, as well as decrease in the volume of four cerebellar lobules. …”
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Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial by Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Xuemei Song, Marisa Lopez-Cruzan, Leslie Linehan, Candice E. Van Skike, Gabriel A. De Erausquin, Veronica Galvan, Miranda E. Orr, Nicolas Musi, Yingxin He, Randall J. Bateman, Chen-Pin Wang, Sudha Seshadri, Ellen Kraig, Dean Kellogg

“…After treatment, we find that twenty, mostly mild adverse events occur, systolic blood pressure and hemoglobin A1c increase, multiple erythrocyte parameters decrease, and there are no significant cognitive changes. …”
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Clinical characteristics and risk factors for recurrence of Kikuchi-Fujimoto disease in children: a case-control study by Bing Liu, Yi Sun, Wen-yuan Shi, Bing Hu, Ling-yun Guo, Tian-ming Chen, Xiao-ming Ge, Yun-yan Wu, Gang Liu

“…Conclusions KFD in children is more common in males and mostly occurs at school age. KFD in children is characterized by tenderness in the lymph node and leukopenia with less multiple lymph node involvement. …”
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Longer-term virologic outcomes on tenofovir-lamivudine-dolutegravir in second-line ART by Jennifer K. van Heerden, Ying Zhao, Claire M. Keene, Rulan Griesel, Zaayid Omar, René Goliath, Kayla Delaney, Gert van Zyl, Gary Maartens, Graeme Meintjes

“…Eligible participants had two consecutive HIV-1 RNA ≥ 1000 copies/mL on first-line ART, mostly tenofovir-emtricitabine-efavirenz. Participants were switched to tenofovir-lamivudine-dolutegravir (TLD) with lead-in 50 mg dolutegravir twice daily in stage one (n = 62), and randomised to TLD with additional lead-in 50 mg dolutegravir or placebo for the first 14 days in stage two (n = 130). …”
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ImageNomer: Description of a functional connectivity and omics analysis tool and case study identifying a race confound by Anton Orlichenko, Grant Daly, Ziyu Zhou, Anqi Liu, Hui Shen, Hong-Wen Deng, Yu-Ping Wang

“…Most packages for the analysis of fMRI-based functional connectivity (FC) and genomic data are used with a programming language interface, lacking an easy-to-navigate GUI frontend. …”
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An expert patient program for people living with multiple sclerosis improves knowledge and empowerment: a pre-test, post-test multicenter implementation study by Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Paloma Amil-Bujan, Cristina Bosch-Farré, Clàudia Coll-Martínez, Clàudia Coll-Martínez, María Jesús Arévalo, Elisenda Anglada-Clofent, Rebeca Menéndez-Díaz, Montserrat Aroca-Alsina, Montserrat Aroca-Alsina, Miguel Merchan-Ruiz, Miguel Merchan-Ruiz, Santiago Pérez-Hoyos, Santiago Pérez-Hoyos, Ángel Guillermo Arévalo-Bernabé, Ángel Guillermo Arévalo-Bernabé, Xavier Montalban, Ana Hernando, Sara LLufriú, Silvia Peralta-Moncusí, Lluís Brieva, Cristina Ramo-Tello, Mariona Carabí, Nuria Solà-Valls, Maria Cinta Zabay, Maria Alba Mañé-Martínez, Jaume Sastre-Garriga, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Carmen Bertran-Noguer

“…Lifestyle habits remained mostly unchanged, except for medication self-management and diet, whereas visits to nurses and other professionals in MS units significantly decreased. …”
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Open-Label Phase 1/2 Study of Daratumumab-Based Desensitization Before Kidney Transplantation by Caroline Pilon, Nizar Joher, Cédric Usureau, Emmanuelle Boutin, Anna Boueilh, Jean-Luc Taupin, Allan Thiolat, José L. Cohen, Vissal David Kheav, Florence Canoui-Poitrine, Maryvonnick Carmagnat, Philippe Grimbert, Marie Matignon

“…Safety analysis showed 4 serious non-treatment-emergent adverse events (non-TEAEs), 36 mild TEAEs, mostly infusion-related reactions, grade 1 and 2 (causing 2 temporary drug discontinuations), but no serious TEAEs. …”
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3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis by G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli

“…Abstract Background Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, mostly due to the paracrine activity of their secretome, exerting pro-angiogenic, antinflammatory and immunosuppressive effects. …”
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Factors associated with health-related quality of life in women with paid work at breast cancer diagnosis: a German repeated cross-sectional study over the first five years after p... by Batoul Safieddine, Siegfried Geyer, Stefanie Sperlich, Johannes Beller, Dorothee Noeres

“…At that stage, income was mostly associated with physical (ß=0.002; CI:0.0002, 0.003) and mental wellbeing (ß=0.002; CI:0.0005, 0.003) with higher summary scores for higher income especially in women aged ≤ 61 years. …”
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Engagement with healthcare providers and healthcare system navigation among Australians with chronic conditions: a descriptive survey study by Jeffrey Braithwaite, Yvonne Zurynski, Joanna Holt, Louise A Ellis, Chiara Pomare, James Ansell, James Gillespie, Jo Root, Isabelle Meulenbroeks, Leanne Wells

“…Logistic regression analyses (estimating ORs) determined the associations between having a chronic condition and the navigation and engagement scores, while controlling for age, gender, level of education and income.Participants 1024 Australians aged 18–88 years (mean=46.6 years; 51% female) recruited from the general population.Results Over half (n=605, 59.0%) of the respondents had a chronic condition, mostly back pain, mental disorders, arthritis and asthma. …”
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Isolation and identification of a matrine-producing fungal strain from petroleum-contaminated soil by Mao Dongxia, Guo Dandan, Wu Lingling, Tian Xiaoxue, Zhang Shengxiang, Liu Tao, Ma Xiaokui

“…The sporangiophores were conical, mostly solitary, showing to grow directly from the hyphae. …”
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Policy Spotlight Effects on Critical Time-Sensitive Diseases: Nationwide Retrospective Cohort Study on Taiwan’s Hospital Emergency Capability Categorization Policy by Chih-Yuan Lin, Chih-Ching Liu, Yu-Tung Huang, Yue-Chune Lee

“…ResultsIn our cohort of 9923 patients, refined through 1:1 propensity score matching, 5566 (56.09%) were male and were mostly older adults. Our analysis revealed that the CHEC policy effectively improved system efficiency and patient outcomes, resulting in significant reductions in medical orders (–7.29 items, 95% CI –10.09 to –4.48; P<.001), short-term mortality rates (–0.09%, 95% CI –0.17% to –0.02%; P=.01) and long-term mortality rates (–0.09%, 95% CI –0.15% to –0.04%; P=.001), and total medical expenses (–5328.35 points per case, 95% CI –10,387.10 to –269.60; P=.04), despite a modest increase in diagnostic fees (376.37 points, 95% CI 92.42-660.33; P=.01). …”
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Influence of structural surface roughness on the strength of layered fill bodies based on PFC2D by Jinxing WANG, Zongsheng HU, Huazhe JIAO, Xiaolin YANG, Qi ZHANG, Xiaohui LIU, Ping XU, Junqiang XU, Xun CHEN

“…The backfill at the lower part of the stratified plane remains mostly intact. As the cemented surface roughness increases, the failure gradually becomes more uniform across the backfill specimens, mainly in the form of overall penetrating tension failure. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Although it was postulated that sEVs can traverse the highly restrictive BBB via transcytosis—data mostly based on the indirect detection of transported cargo—direct evidence for sEV transport across the BBB remains elusive due to challenges in sEV labelling, detection limits, and inherent limitations of existing in vitro BBB models. …”
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Aortic isthmus flow reversal in fetal coarctation of the aorta and the associated factors by Guihong Chen, Yongfeng Han, Congxin Sun, Wei Xiang, Wei Zhao, Pei Zhou, Tianxiao Yu, Zhuo Chen, Bulang Gao, Shuping Ge, Jie Mi

“…Aortic isthmus flow reversal was mostly in the full systole (n = 17 or 60.7%) or late systole and early‐middle diastole (n = 10 or 35.7%) in the CoA‐positive fetuses (n = 27 or 96.4%), significantly (p < 0.001) different from that in the false‐positive or control group. …”
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Effectiveness of myocarditis therapy depending on the diagnosis approach (with or without myocardial biopsy) by O. V. Blagova, A. V. Nedostup, V. P. Sedov, A. Yu. Zaitsev, V. M. Novosadov, E. A. Kogan

“…If it is impossible to perform a biopsy, complex non-invasive strategy makes it possible to diagnose myocarditis with different probability rate and conduct an effective IST, the refusal of which mostly is not justified.…”
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