The PRINCIPLE randomised controlled open label platform trial of hydroxychloroquine for treating COVID19 in community based patients at high risk by F. D. Richard Hobbs, Jienchi Dorward, Gail Hayward, Ly-Mee Yu, Benjamin R. Saville, Christopher C. Butler, the PRINCIPLE Investigators

“…We found no evidence from this treatment arm of the PRINCIPLE trial, stopped early and therefore under-powered for reasons external to the trial, that hydroxychloroquine reduced hospital admission or death in people with suspected, but mostly unconfirmed COVID-19.…”
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Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy. by Sylvain Rheims, Michel Cucherat, Alexis Arzimanoglou, Philippe Ryvlin

“…<h4>Background</h4>Despite guidelines establishing the need to perform comprehensive paediatric drug development programs, pivotal trials in children with epilepsy have been completed mostly in Phase IV as a postapproval replication of adult data. …”
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A comparison of participatory science seining and electrofishing for sampling fish assemblages in an urban river by Olivia F. Williams, Sally Petrella, Lauren Eaton, Robert Muller, Philip Kukulski, Paul Seelbach, Catherine Riseng, Karen M. Alofs

“…Differences in the species captured are mostly driven by rare and benthic species. Species accumulation curves were not significantly different at the watershed or subwatershed scale. …”
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Farmers’ Perception of the Impacts of Climate Variability and Change on Food Security in Rubanda District, South Western Uganda by Willbroad, Byamukama, Bello N.J, Omoniyi T.E

“…Climate variability adversely impacts crop production and imposes a major constraint on farming planning, mostly under rain fed conditions across developing countries. …”
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The Contribution of Micro Finance Institutions on the Growth of Small and Medium Business : A Case Study of North Kigezi Diocese Sacco In Rukungiri Municipality. by Ainembabazi, Wensi

“…The study was set to find out the contribution of micro finance institutions mostly (SA CC Os) to the financial performance of small scale enterprises in Uganda while considering a case study of North Kigezi SACCO, found in Rukungiri Municipality and to the neighbouring areas of Kihindi, Kinyasano, Nyakibale, and other divisions. …”
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Racial and ethnic disparities in human papillomavirus (HPV) vaccine uptake among United States adults, aged 27–45 years by Natalie L. Rincon, Kelsey Rae McDowell, Darien Weatherspoon, Tiarney D. Ritchwood, Daniel J. Rocke, Eric Adjei Boakye, Nosayaba Osazuwa-Peters

“…Logistic regression models estimated the odds of vaccine uptake (receipt of ≥1 vaccine dose) based on sociodemographic factors. Participants were mostly Non-Hispanic Whites (60.7%) and females (50.9%). …”
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Effects of eustress induced by low concentrations of salinity on broccoli (Brassica oleracea) and purslane (Portulaca oleracea) microgreens by Gretchen Plocek, Shivani Kathi, Catherine Simpson

“…Most controlled environments utilize municipal water for crop irrigation. …”
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Mechanistic insights into the cardiovascular effects of acute heat exposure: A multi-omics analysis based on a randomized crossover trial by Xinlei Zhu, Xihao Du, Yixiang Zhu, Lu Zhou, Cong Liu, Yue Niu, Qingli Zhang, Yixuan Jiang, Haidong Kan, Renjie Chen

“…Multi-omics analyses indicated heat-induced perturbations in pathways were mostly related to systemic inflammation, oxidative stress, coagulation, and lipid metabolism disorder. …”
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Fat embolism and COVID-19 infection: autopsy and post-mortem laboratory findings in SARS-CoV-2 positive patients by Adriana Gavronova, Lukas Hamerlik, Margita Bartkova, Vaclav Svrchokryl, Veronika Kralikova, Katerina Vranova, Peter Ondra, Martin Dobias

“…Causes of death of studied subjects were natural, mostly from respiratory failure (in 12 cases, 75%). …”
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HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1 by María de Lourdes Mora-García, Sofía López-Cisneros, Vianey Gutiérrez-Serrano, Rosario García-Rocha, Benny Weiss-Steider, Jorge Hernández-Montes, Héctor I. Sánchez-Peña, Luis Roberto Ávila-Ibarra, Christian Azucena Don-López, Ricardo Muñóz-Godínez, Daniela Berenice Torres Pineda, Rommel Chacón-Salinas, Luis Vallejo-Castillo, Sonia Mayra Pérez-Tapia, Alberto Monroy-García

“…These results suggest that persistent infection with HR-HPV, mostly HPV-16, in CIN-1 patients may promote the expression of CD39 and CD73 through the production of TGF-β in precursor lesions to generate an immunosuppressive microenvironment and allow its progression to CeCa.…”
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Host metabolites explain microbiome variation between different rice genotypes by Pin Su, Houxiang Kang, Qianze Peng, Weiye Peng, Shu’e Sun, Xiaohua Du, Chi Zhang, Ziling Lei, Lianyang Bai, Qianjun Tang, Yong Liu, Tomislav Cernava, Deyong Zhang

“…Host-related factors causing this variation are mostly unknown. Microbiome genes, or M genes in short, are host genes that are involved in shaping the microbiome. …”
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First M87 Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole by The Event Horizon Telescope Collaboration, Kazunori Akiyama, Antxon Alberdi, Walter Alef, Keiichi Asada, Rebecca Azulay, Anne-Kathrin Baczko, David Ball, Mislav Baloković, John Barrett, Dan Bintley, Lindy Blackburn, Wilfred Boland, Katherine L. Bouman, Geoffrey C. Bower, Michael Bremer, Christiaan D. Brinkerink, Roger Brissenden, Silke Britzen, Avery E. Broderick, Dominique Broguiere, Thomas Bronzwaer, Do-Young Byun, John E. Carlstrom, Andrew Chael, Chi-kwan Chan, Shami Chatterjee, Koushik Chatterjee, Ming-Tang Chen, Yongjun Chen, Ilje Cho, Pierre Christian, John E. Conway, James M. Cordes, Geoffrey B. Crew, Yuzhu Cui, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Jason Dexter, Sheperd S. Doeleman, Ralph P. Eatough, Heino Falcke, Vincent L. Fish, Ed Fomalont, Raquel Fraga-Encinas, William T. Freeman, Per Friberg, Christian M. Fromm, José L. Gómez, Peter Galison, Charles F. Gammie, Roberto García, Olivier Gentaz, Boris Georgiev, Ciriaco Goddi, Roman Gold, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Michael H. Hecht, Ronald Hesper, Luis C. Ho, Paul Ho, Mareki Honma, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Michael Janssen, Britton Jeter, Wu Jiang, Michael D. Johnson, Svetlana Jorstad, Taehyun Jung, Mansour Karami, Ramesh Karuppusamy, Tomohisa Kawashima, Garrett K. Keating, Mark Kettenis, Jae-Young Kim, Junhan Kim, Jongsoo Kim, Motoki Kino, Jun Yi Koay, Patrick M. Koch, Shoko Koyama, Michael Kramer, Carsten Kramer, Thomas P. Krichbaum, Cheng-Yu Kuo, Tod R. Lauer, Sang-Sung Lee, Yan-Rong Li, Zhiyuan Li, Michael Lindqvist, Kuo Liu, Elisabetta Liuzzo, Wen-Ping Lo, Andrei P. Lobanov, Laurent Loinard, Colin Lonsdale, Ru-Sen Lu, Nicholas R. MacDonald, Jirong Mao, Sera Markoff, Daniel P. Marrone, Alan P. Marscher, Iván Martí-Vidal, Satoki Matsushita, Lynn D. Matthews, Lia Medeiros, Karl M. Menten, Yosuke Mizuno, Izumi Mizuno, James M. Moran, Kotaro Moriyama, Monika Moscibrodzka, Cornelia Müller, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Ramesh Narayan, Gopal Narayanan, Iniyan Natarajan, Roberto Neri, Chunchong Ni, Aristeidis Noutsos, Hiroki Okino, Héctor Olivares, Gisela N. Ortiz-León, Tomoaki Oyama, Feryal Özel, Daniel C. M. Palumbo, Nimesh Patel, Ue-Li Pen, Dominic W. Pesce, Vincent Piétu, Richard Plambeck, Aleksandar PopStefanija, Oliver Porth, Ben Prather, Jorge A. Preciado-López, Dimitrios Psaltis, Hung-Yi Pu, Venkatessh Ramakrishnan, Ramprasad Rao, Mark G. Rawlings, Alexander W. Raymond, Luciano Rezzolla, Bart Ripperda, Freek Roelofs, Alan Rogers, Eduardo Ros, Mel Rose, Arash Roshanineshat, Helge Rottmann, Alan L. Roy, Chet Ruszczyk, Benjamin R. Ryan, Kazi L. J. Rygl, Salvador Sánchez, David Sánchez-Arguelles, Mahito Sasada, Tuomas Savolainen, F. Peter Schloerb, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, Fumie Tazaki, Paul Tiede, Remo P. J. Tilanus, Michael Titus, Kenji Toma, Pablo Torne, Tyler Trent, Sascha Trippe, Shuichiro Tsuda, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jan Wagner, John Wardle, Jonathan Weintroub, Norbert Wex, Robert Wharton, Maciek Wielgus, George N. Wong, Qingwen Wu, Ken Young, André Young, Ziri Younsi, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Guangyao Zhao, Shan-Shan Zhao, Ziyan Zhu, Juan-Carlos Algaba, Alexander Allardi, Rodrigo Amestica, Jadyn Anczarski, Uwe Bach, Frederick K. Baganoff, Christopher Beaudoin, Bradford A. Benson, Ryan Berthold, Jay M. Blanchard, Ray Blundell, Sandra Bustamente, Roger Cappallo, Edgar Castillo-Domínguez, Chih-Cheng Chang, Shu-Hao Chang, Song-Chu Chang, Chung-Chen Chen, Ryan Chilson, Tim C. Chuter, Rodrigo Córdova Rosado, Iain M. Coulson, Thomas M. Crawford, Joseph Crowley, John David, Mark Derome, Matthew Dexter, Sven Dornbusch, Kevin A. Dudevoir, Sergio A. Dzib, Andreas Eckart, Chris Eckert, Neal R. Erickson, Wendeline B. Everett, Aaron Faber, Joseph R. Farah, Vernon Fath, Thomas W. Folkers, David C. Forbes, Robert Freund, Arturo I. Gómez-Ruiz, David M. Gale, Feng Gao, Gertie Geertsema, David A. Graham, Christopher H. Greer, Ronald Grosslein, Frédéric Gueth, Daryl Haggard, Nils W. Halverson, Chih-Chiang Han, Kuo-Chang Han, Jinchi Hao, Yutaka Hasegawa, Jason W. Henning, Antonio Hernández-Gómez, Rubén Herrero-Illana, Stefan Heyminck, Akihiko Hirota, James Hoge, Yau-De Huang, C. M. Violette Impellizzeri, Homin Jiang, Atish Kamble, Ryan Keisler, Kimihiro Kimura, Yusuke Kono, Derek Kubo, John Kuroda, Richard Lacasse, Robert A. Laing, Erik M. Leitch, Chao-Te Li, Lupin C.-C. Lin, Ching-Tang Liu, Kuan-Yu Liu, Li-Ming Lu, Ralph G. Marson, Pierre L. Martin-Cocher, Kyle D. Massingill, Callie Matulonis, Martin P. McColl, Stephen R. McWhirter, Hugo Messias, Zheng Meyer-Zhao, Daniel Michalik, Alfredo Montaña, William Montgomerie, Matias Mora-Klein, Dirk Muders, Andrew Nadolski, Santiago Navarro, Joseph Neilsen, Chi H. Nguyen, Hiroaki Nishioka, Timothy Norton, Michael A. Nowak, George Nystrom, Hideo Ogawa, Peter Oshiro, Tomoaki Oyama, Harriet Parsons, Scott N. Paine, Juan Peñalver, Neil M. Phillips, Michael Poirier, Nicolas Pradel, Rurik A. Primiani, Philippe A. Raffin, Alexandra S. Rahlin, George Reiland, Christopher Risacher, Ignacio Ruiz, Alejandro F. Sáez-Madaín, Remi Sassella, Pim Schellart, Paul Shaw, Kevin M. Silva, Hotaka Shiokawa, David R. Smith, William Snow, Kamal Souccar, Don Sousa, T. K. Sridharan, Ranjani Srinivasan, William Stahm, Anthony A. Stark, Kyle Story, Sjoerd T. Timmer, Laura Vertatschitsch, Craig Walther, Ta-Shun Wei, Nathan Whitehorn, Alan R. Whitney, David P. Woody, Jan G. A. Wouterloot, Melvin Wright, Paul Yamaguchi, Chen-Yu Yu, Milagros Zeballos, Shuo Zhang, Lucy Ziurys

“…They also present a new tool to explore gravity in its most extreme limit and on a mass scale that was so far not accessible.…”
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The Impact of Cardiac Output Methods on the Classification of Pulmonary Hypertension by Léon Genecand, Gaëtan Simian, Mona Lichtblau, Jean‐Marc Fellrath, Julian Klug, Hugues Turbé, Christian Lovis, Stéphane Noble, Julie Wacker, Julian Müller, Roberto Desponds, Maurice Beghetti, Benoit Lechartier, David Montani, Olivier Sitbon, Silvia Ulrich, Frédéric Lador

“…., between 1 and 3 WU), mostly concerning patients with IpcPH and unclassified PH, exhibited a higher risk of diagnostic error.…”
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Comparison of emergency department throughput and process times between male and female patients: A retrospective cohort investigation by the Reducing Disparities Increasing Equity... by Ege G. Onal, Kit Knier, Alexander W. Hunt, John M. Knudsen, David M. Nestler, Ronna L. Campbell, Kristine M. Thompson, Kharmene L. Sunga, Laura E. Walker, Bo E. Madsen, Annie T. Sadosty, Alyson J. McGregor, Aidan F. Mullan, Molly M. Jeffery, Venkatesh R. Bellamkonda

“…Conclusion Numerous statistically significant differences were identified in throughput and care measures—mostly these differences favored male patients. Few of these comparisons met our criteria for clinical significance.…”
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Sphenopalatine ganglion stimulation for the treatment of trigeminal neuropathic pain by Paweł Sokal, Sara Kierońska-Siwak, Marcin Rusinek, Magdalena Jabłońska, Antoni Nehring, Oskar Puk, Damian Palus, Renata Jabłońska

“…All patients had previously been treated with RF rhizotomy, microvascular decompression, or stereoradiosurgery without a satisfactory long-term therapeutic effect and had recurrent, mostly constant TNP. An electrode lead was implanted in the pterygopalatine fossa of all patients to stimulate the SPG under guidance of neuronavigation with an implantable pulse generator inserted after a two-week trial period.ResultsPreoperatively, the mean visual analog scale score was 9. …”
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The urinary microbiome distinguishes symptomatic urinary tract infection from asymptomatic older adult patients presenting to the emergency department by Evan S. Bradley, Celina Stansky, Abigail L. Zeamer, Ziyuan Huang, Lindsey Cincotta, Abigail Lopes, Linda Potter, Theresa Fontes, Doyle V. Ward, Vanni Bucci, Beth A. McCormick, John P. Haran

“…Machine learning classifiers combining clinical covariates other than specific signs and symptoms and microbiome features (taxa, metabolic pathways, or virulence factors) revealed mostly microbiome features as predictive of symptomatic UTI over clinical features.…”
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Genetic deregulation of REL in germinal center B cells induces generation of a pool of lymphoma precursor cells by Léa Prévaud, Karima Ferhat, Dilara Sensoy, Ophélie Téteau, Tiffany Marchiol, Quentin Lemasson, Catherine Ouk, Claire Carrion, Michel Cogné, Jean Feuillard, Christelle Vincent-Fabert, Nathalie Faumont

“…Abstract: In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B-cell DLBCL subtype (GCB-DLBCL) for which c-Rel is the pivotal Rel/NF−κΒ subunit. …”
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Acquired right-sided diaphragmatic hernia after pediatric living donor transplantation: a guide for the non-transplant pediatric surgeon by Francesca Palmisani, Hannah N. Stundner-Ladenhauf, Judith Pichler, Denise Aldrian, Andreas Heilos, Philipp Steinbauer, Martin L. Metzelder, Janina M. Patsch, Wolf-Dieter Huber, Rupert Oberhuber, Wilfried Krois

“…All the cases presented with a defect in the posteromedial aspect of the diaphragm, potentially related to thermal effects in the bare area of the diaphragm during transplantation.ConclusionsAcquired diaphragmatic hernia is a rare complication of pLDLT, that mostly occurs in the long-term postoperative follow-up. …”
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Care and decision-making at the end of life for migrants living in the Netherlands: An intersectional analysis by Marieke Torensma, Xanthe de Voogd, Roukayya Oueslati, Irene G.M. van Valkengoed, Dick L. Willems, Bregje D. Onwuteaka-Philipsen, Jeanine L. Suurmond

“…Intersecting gendered care roles determine that mostly daughters are involved.Considering the interplay of aspects of social identity and their effect on social positioning, and pro-active enquiry into values, goals and preferences for end-of-life care of patients and their relatives are paramount to achieve person centred and family-oriented care responsive to the needs of diverse communities.…”
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Association of ambient air pollution with incident rheumatoid arthritis, subsequent respiratory diseases, and death: A multi-state analysis of a prospective cohort by Bin-Bin Feng, Yu-Xuan Zhang, Xing-Yue Dai, Mei-Qin Nie, Yong-Yong Liu, Ruo-Wei Ma, Lin Zhu, Yu-Ye Zuo, Hai-Feng Pan, Guo-Cui Wu

“…Background: Previous studies have mostly examined the separate effects of air pollution exposure on the onset of rheumatoid arthritis (RA) or respiratory diseases. …”
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