ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers wi... by Kenny A Rodriguez-Wallberg, Jonas Bergh, Antonis Valachis, Per Frisk, Theodoros Foukakis, Per Ljungman, Sandra Eloranta, Hanna Pauline Nilsson, Johan Malmros, Christina Linder Stragliotto, Erika Isaksson Friman, Barbro Linderholm, Anne Andersson, Sara Harrysson, Lovisa Vennström, Helena Mörse

“…Background Gonadotropin-releasing hormone agonists (GnRHa) cotreatment used to transiently suppress ovarian function during chemotherapy to prevent ovarian damage and preserve female fertility is used globally but efficacy is debated. Most clinical studies investigating a beneficial effect of GnRHa cotreatment on ovarian function have been small, retrospective and uncontrolled. …”
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The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analys... by Andria Mousa, Abdullah Al-Taiar, Nicholas M Anstey, Cyril Badaut, Bridget E Barber, Quique Bassat, Joseph D Challenger, Aubrey J Cunnington, Dibyadyuti Datta, Chris Drakeley, Azra C Ghani, Victor R Gordeuk, Matthew J Grigg, Pierre Hugo, Chandy C John, Alfredo Mayor, Florence Migot-Nabias, Robert O Opoka, Geoffrey Pasvol, Claire Rees, Hugh Reyburn, Eleanor M Riley, Binal N Shah, Antonio Sitoe, Colin J Sutherland, Philip E Thuma, Stefan A Unger, Firmine Viwami, Michael Walther, Christopher J M Whitty, Timothy William, Lucy C Okell

“…<h4>Background</h4>Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as 'test-and-treat' policies administered by community health workers (CHWs). …”
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Phenotypic and genotypic characterization of antimicrobial resistance and virulence profiles of Salmonella enterica serotypes isolated from necropsied horses in Kentucky by Ajran Kabir, William G. Kelley, Cheyenne Glover, Erdal Erol, Yosra A. Helmy

“…Salmonella Typhimurium was the most prevalent serotype with 19.2% prevalence. All of the isolates were identified as biofilm producers and motile. …”
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Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress by Muwen Yang, Dongni Shi, Jianbo Lyu, Yibing Pan, Yiyang Lyv, Xiangfu Chen, Ying Ouyang, Yajie Liu, Yue Li, Libing Song

“…ER-localized HSP90B1 accelerates the clearance of radiotherapy-induced misfolded proteins and upregulates the PERK-EIF2α-ATF4 pathway, which further transcriptionally upregulates antioxidant factors, such as SLC1A5, GCLC, and CTNS, to inhibit radiotherapy-induced ROS accumulation, ultimately leading to radiotherapy resistance, and poor clinical outcomes. Most importantly, sialic acid analogs (SAA) 3Fax-NeuAc inhibited the sialylation of HSP90B1 and its transport to the ER, thereby effectively overcomed radiotherapy resistance in TNBC. …”
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"<i>Festina lente</i>" — a multicenter study on the outcomes of carotid endarterectomy, depending on vessel suturing speed by M. S. Sautina, A. S. Sokolova, A. S. Butorina, L. I. Puchnina, R. M. Rylsky, D. V. Shmatov, A. V. Korotkikh, O. V. Lebedev, S. V. Artyukhov, O. Sh. Mukhtorov, R. Yu. Leader, Sh. Wang, L. V. Roshkovskaya, M. A. Khetagurov, V. M. Unguryan, M. P. Chernyavin, G. Sh. Bagdavadze, P. D. Palagin, A. A. Sirotkin, A. N. Kazantsev

“…According to Kaplan-Meier curves, restenosis was most often revealed 6 months after CEA in the general sample.Conclusion. 1. …”
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Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting by Mikhail Popov, Siarhei Dabravolski, Vladislav Dontsov, Sergei Vzvarov, Evgeniy Agafonov, Dmitriy Zybin, Olga Radchenkova, Dmitriy Saveliev, Victoria Pronina, Natalia Kashirina, Liudmila Lipatova, Mikhail Peklo, Pavel Rutkevich, Elena Yanushevskaya, Alisa Sokolovskaya, Arkadiy Metelkin, Svetlana Verkhova, Nikita Nikiforov, Dmitriy Shumakov

“…No significant correlation was observed between preoperative MMP9 levels and age or most other baseline laboratory parameters. Conclusions: Our study established an association between 1-year postoperative MMP9 levels and key parameters of left ventricular function during the long-term follow-up period. …”
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Finding New Hot Subdwarf Stars in SDSS Images by Jiangchuan Zhang, Yude Bu, Huili Wu, Yuhang Zhang, Shanshan Li, Zhenxin Lei, Zhenping Yi, Xiaoming Kong, Meng Liu

“…We applied the HsdDet algorithm to some photometric images of SDSS, and detected 29,695 candidates, whose reduced proper motions are primarily concentrated between 5 and 20 mas yr ^−1 . Most of the candidates have distances of 1.5 ∼ 7.5 kpc, while some candidates can be as far as 20 kpc or even more. …”
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Associations of socioeconomic status and health lifestyles with chronic obstructive pulmonary disease: two nationwide population-based studies by Siying Liu, Tingting Liu, Cihang Lu, Jiahui Guo, Jie Li, Hanyu Wang, Bingxin You, Qiqiang Guo, Jing Zhang, Yongze Li

“…Risk factor analysis for COPD revealed that, in addition to a low SES (HR = 2.55, 95% CI = 2.39 to 2.72; OR = 2.08, 95% CI = 1.76 to 2.46) and unhealthy lifestyle (HR = 2.92, 95% CI = 2.73 to 3.12; OR = 3.78, 95% CI = 3.13 to 4.57), smoking (HR = 5.23, 95% CI = 4.87 to 5.61; OR = 3.85, 95% CI = 3.23 to 4.59) was the most significant risk factor for COPD. Conclusions Low SES significantly contributes to COPD risk, but a healthy lifestyle mediating this association. …”
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Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease by Prodromos Parasoglou, Ricardo S. Osorio, Oleksandr Khegai, Zanetta Kovbasyuk, Margo Miller, Amanda Ho, Seena Dehkharghani, Thomas Wisniewski, Antonio Convit, Lisa Mosconi, Ryan Brown

“…Finally, we performed linear regression analysis on 31P-MRS measurements in both cohorts to investigate the relationship of phosphorus metabolism with age. Results: Most regional 31P metabolite ratio and pH inter- and intra-day CVs were well below 10%. …”
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Over 100 years of longitudinal connectivity changes from the perspective of a migratory fish species by Johannes Luca Kowal, Gertrud Haidvogl, Andrea Funk, Johannes Schützenhofer, Paulo Branco, Maria-Teresa Ferreira, Paul Meulenbroek, Rafaela Schinegger, Thomas Hein

“…Our results illustrate that the most significant loss of connectivity has occurred after the beginning of the 20th century. …”
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National and supranational mechanisms for the protection of human rights and freedoms in contemporary conditions by L. A. Terekhova

“…The mechanism of reports, however, is not reliable enough - there are states that ignore it.Regional Conventions are rightly considered the most effective means of protecting human rights. …”
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Incidence and Outcomes of Brain Metastasis in Pleural Mesothelioma in the Era of Immunotherapy by Margaret Stalker, MD, Suzanne L. Walker, PhD, CRNP, AOCN, BC, Emily Lebow, MD, Emily Ling-Lin Pai, MD, PhD, Alex Watts, MS, Wei-Ting Hwang, PhD, Amir Banihashemi, MD, Evan Anderson, MSN, Leonid Roshkovan, MD, Sharyn I. Katz, MD, Leslie Litzky, MD, Andrew R. Haas, MD, PhD, Sunil Singhal, MD, Corey J. Langer, MD, Keith Cengel, MD, PhD, Melina E. Marmarelis, MD, MSCE

“…Conclusions: In this retrospective study, clinically significant BM was most prevalent in those exposed to IO and not seen in those receiving chemotherapy despite similar mOS between the groups. …”
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Cost and effectiveness of differentiated ART service delivery strategies in Zambia: a modelling analysis using routine data by Nkgomeleng A. Lekodeba, Sydney Rosen, Bevis Phiri, Sithabiso D. Masuku, Caroline Govathson, Aniset Kamanga, Prudence Haimbe, Hilda Shakwelele, Muya Mwansa, Priscilla Lumano‐Mulenga, Amy N. Huber, Sophie J. S. Pascoe, Lise Jamieson, Brooke E. Nichols

“…ART cost and laboratory test costs were the most influential parameters on provider costs and the ICERs. …”
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FACTORS ASSOCIATED WITH ANXIETY AND DEPRESSION SPECTRUM DISORDERS IN BEHCHET’S DISEASE by P. S. Ovcharov, T. A. Lisitsyna, D. Yu. Veltishchev, O. F. Seravina, O. B. Kovalevskaya, S. I. Glukhova, Z. S. Alekberova, E. L. Nasonov

“…A total of 116 patients with BD were examined. Most of them were men (69.8%), whose mean age (M±σ) was 33.4±9.82 years; the median duration of BD was 120.0 [70.0; 192.0] months; 51.9% of the patients were natives of the North Caucasus. …”
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RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity by Lin Li, Hui Guo, Jie Hu, Lei Cui, Zining Wang, Feifei Xu, Xiaojuan Wang, Huanling Zhang, Chunyuan Xie, Yongxiang Liu, Xiaojun Xia, Zixuan Guo, Heping Li, Tiantian Wang, Ruhui Yao, Huan Jin, Yanxun Lin

“…Identification of molecular mechanisms by which tumor cells evade from NK cell-mediated killing may offer novel therapeutic strategies for potentiating NK-based cancer immunotherapy.Methods An in vitro tumor-NK cell co-culture system was employed to identify the most significantly altered genes in tumor cells following NK cell interaction. …”
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Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine by Joan Castellsagué, Bernat Gel, Juana Fernández‐Rodríguez, Roger Llatjós, Ignacio Blanco, Yolanda Benavente, Diana Pérez‐Sidelnikova, Javier García‐del Muro, Joan Maria Viñals, August Vidal, Rafael Valdés‐Mas, Ernest Terribas, Adriana López‐Doriga, Miguel Angel Pujana, Gabriel Capellá, Xose S Puente, Eduard Serra, Alberto Villanueva, Conxi Lázaro

“…Sorafenib (a BRAF inhibitor), in combination with doxorubicin or rapamycin, was found to be the most effective treatment for reducing MPNST growth. …”
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Assessment of OLCI absorption coefficients for non-water components across all optical water classes by Astrid Bracher, Astrid Bracher, Andrew Clive Banks, Hongyan Xi, David Dessailly, Juan Gossn, Carole Lebreton, Rüdiger Röttgers, Ewa Kwiatkowska, Spyros Chaikalis, Ehsan Mehdipour, Elli Pitta, Mariana Altenburg Soppa, Jan Wevers, Christina Zeri

“…Furthermore, our study corroborates the skill of the EUMETSAT algorithm to obtain valid information in most of the blue and green spectra, making it of high potential for introduction into the processing of ocean-colour radiometry data from new hyperspectral satellite missions.…”
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Feeding on the move: assessing the effect of feeding during long-distance ferry transport on the physiology, clinical signs of disease and activity of unweaned calves by L.L. van Dijk, S. Siegmann, P. Bennett, K. Sugrue, C.G. van Reenen, E.A.M. Bokkers, G. Sayers, M. Conneely, N.L. Field

“…A subset of calves were equipped with activity sensors and continuous glucose monitors (CGM). Most blood variables differed between FEED and CONT calves on Day 1; glucose was higher (4.8 vs 4.0 mmol/L) and beta-hydroxybutyrate (0.20 vs 0.34 mmol/L), non-esterified fatty acids (0.52 vs 0.71 mmol/L), and lactate (0.85 vs 1.25 mmol/L) were lower for FEED compared to CONT calves; no blood variables showed significant differences at the next timepoint (all P > 0.05). …”
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MODELS OF SYNTACTIC STRUCTURES IN OLD GERMANIC CONCESSIVE SENTENCES by Oleksandra M. Tuhai

“…It has been de- termined that the syntax of concessive sentences with various semantics of concession in the dynamic syn- chrony demonstrates the functioning of the identified syntactic models in most semantic types of conces- sive clauses depending on the specific Old Germanic language. …”
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Entangled in uncertainty: The experience of living with dementia from the perspective of family caregivers. by Els van Wijngaarden, Hugo van der Wedden, Zerline Henning, Rikke Komen, Anne-Mei The

“…<h4>Discussion and conclusion</h4>Our findings show that dealing with what Boss (2011) called 'ambiguous loss-experiences' is one of the most demanding aspects of living with dementia. Based on the findings, we have developed a model that depicts how people handle contingency and seek balance along the continuum of facing and resisting. …”
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