Research Priorities in the Field of Posttraumatic Pain and Disability: Results of a Transdisciplinary Consensus-Generating Workshop by David M. Walton, James M. Elliott, Joshua Lee, Eldon Loh, Joy C. MacDermid, Siobhan Schabrun, Walter L. Siqueira, Brian D. Corneil, Bill Aal, Trevor Birmingham, Amy Brown, Lynn K. Cooper, James P. Dickey, S. Jeffrey Dixon, Douglas D. Fraser, Joseph S. Gati, Gregory B. Gloor, Gordon Good, David Holdsworth, Samuel A. McLean, Wanda Millard, Jordan Miller, Jackie Sadi, David A. Seminowicz, J. Kevin Shoemaker, Gunter P. Siegmund, Theodore Vertseegh, Timothy H. Wideman

“…The Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis (IMHA) has recently identified better understanding of causal mechanisms as one of three priority foci of their most recent strategic plan. Objectives. A 2-day invitation-only active participation workshop was held in March 2015 that included 30 academics, clinicians, and consumers with the purpose of identifying consensus research priorities in the field of trauma-related MSK pain and disability, prediction, and prevention. …”
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Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization by Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo

“…These results demonstrate the added value of anti-CyaA antibodies elicited by intranasal application of the rPrn-RTX908 fusion antigen in the protection of the airway against B. pertussis infection.IMPORTANCEDespite high vaccine coverage, unexpectedly massive whooping cough outbreaks are currently resurging in the most developed countries using the acellular pertussis (aP) vaccine. …”
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The examination of physical function and cognitive outcomes in middle-to-older high-risk adults: an unsupervised clustering method by Joshua L. Gills, Joshua L. Gills, Megan D. Jones, Anthony Campitelli, Anthony Campitelli, Sally Paulson, Sally Paulson, Cody Diehl, Charles Rodgers, Charles Rodgers, Erica Madero, Jennifer R. Myers, Kelsey Bryk, Omonigho Michael Bubu, Omonigho Michael Bubu, Omonigho Michael Bubu, Jordan M. Glenn, Michelle Gray

“…Physical function index (PFI) declines with age; additionally, higher PFI is associated with better cognitive functioning in middle-to-older age individuals. However, most studies utilize one domain of PFI to examine associations with cognition. …”
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Epidemiological characteristics and hospital outcomes of hospitalized Lassa fever cases during the 2022-2023 outbreak in Liberia [version 2; peer review: 1 approved, 2 approved wit... by Emmanuel Dwalu, Pryanka Relan, Julius S. M. Gilayeneh, Patrick N. Kpanyen, Peter Adewuyi, Godwin E. Akpan, Ibrahim Franklyn Kamara, George W. Goteh, Shermarke Hassan, Philip Owiti, Fahn Tarweh, Benjamin T. Vonhm, Bode I. Shobayo, Ralph W. Jetoh, Louis Ako-Egbe, Chukwuma D. Umeokonkwo, Darius B. Lehyen, Mher Beglaryan, Hannock Tweya

“…Fever, 128 (93%), malaise, 121 (88%), headache, 114 (83%) and myalgia, 114 (83%) were the most common clinical characteristics. There were 83 (19%) deaths among hospitalized suspected LF cases - 42 deaths (15%) among 278 individuals who tested negative and 41 among confirmed cases with 30% case fatality rate (CFR). …”
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Internet addiction and its influencing factors among middle school students in Hunan province: a cross-sectional study by Fei WANG, Lixi QIN, Zhuoga NIMA, Yaqing TAN, Miyang LUO, Yanhua CHEN, Jiayou LUO

“…Among the middle school students identified as having internet addiction, the most frequent symptoms were withdrawal symptoms (87.75%), tolerance symptoms (83.09%), and internet control disorders (79.45%). …”
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A systematic review and network meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from randomi... by Sophie E. Beese, Malcolm J. Price, Claire Tomlinson, Pawana Sharma, Isobel M. Harris, Ada Adriano, Lauren M. Quinn, Ritu Gada, Thomas J. Horgan, Fiona Maggs, Martin Burrows, Krishnarajah Nirantharakumar, G. Neil Thomas, Robert C. Andrews, David J. Moore, Parth Narendran

“…These results have identified the 11 most promising therapies trialled and help to direct future head-to-head clinical trials to support approvals for interventions to treat those newly diagnosed with type 1 diabetes. …”
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International Probabilistic Workshop 2022 by Editorial, Foreword

“…Organising institutions: Stellenbosch University is one the most prestigious universities in South Africa and its students add to the exciting life of the town. …”
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Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution by Ioanna Papatheodorou, Gabriela Blažková, Veronika Bosáková, Zuzana Tomášiková, Erin Spearing, Robin Klieber, Pavel Ostašov, Julie Štíchová, Martina Dvončová, Alexandra Mýtniková, Jan Emmer, Kamila Bendíčková, Tomáš Tomáš, Vladimír Šrámek, Petros Kolovos, Monika Holubová, Martin Helán, Marcela Vlková, Jan Frič, Marcela Hortová-Kohoutková

“…These changes were attenuated in the presence of TNF-α, thus showing a unique role of IL-18 when acting alone without its most frequent paired cytokine TNF-α. We further confirmed that IL-18 induces monocyte-macrophage transition and migration using human intestinal organoids. …”
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Sistem Pendukung Keputusan untuk Pemilihan Pupuk Padi Berbasis AHP dan Pembobotan ROC Dengan Pengujian User Validation by Mayang Anglingsari Putri, Risqy Siwi Pradini, Agung Setia Budi, Denisha Trihapningsari Trihapningsari

“…Testing results indicate that most respondents agree with the weight of criteria and the relevance of fertilizer alternatives. …”
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Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023) by Xiaolei Wu, Haiyin Hu, Yuetong Wang, Alice Josephine Fauci, Yazi Zhang, Wenting Song, Fengwen Yang, Boli Zhang, Junhua Zhang, Zhaochen Ji

“…The sample sizes ranged from 18 to 3 777 participants, and most studies were conducted at a single center. Methodologically, the implementation of allocation concealment and blinding remained insufficiently emphasized. …”
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Glutaraldeído: avaliação das condições sanitárias da solução em uso para o reprocessamento de endoscópios [Glutaraldehyde: evaluation of sanitary conditions of the solution in use... by Francine Vieira Pires, Anaclara Ferreira Veiga Tipple, Jackeline Maciel Barbosa, Adenicia Custódia Silva e Souza, Luana Cássia Miranda Ribeiro, Heliny Carneiro Cunha Neves

“…Data were collected through a script about sanitary conditions, by pH assessment, and concentration of glutaraldehyde in use. Most services performed neither concentration control nor pH of glutaraldehyde. …”
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Hemispheric Asymmetry of Relative Sunspot Numbers during Solar Cycles 17–25 by Wenhua Wang, Linhua Deng, Zuo Jiang, Jinlei Li, Xinhua Zhao, Tingting Xu, Miao Wan, Jie Cao, Nanbin Xiang, Xuewen Tan, Wei Zhou, Weihong Zhou

“…By combining normalized asymmetry indices, cumulative deviation tracking, and year-by-year significance testing, we identify four key results: (1) the northern hemisphere consistently dominates during the ascending phases of most cycles, suggesting a preferential emergence of magnetic flux at the northern hemisphere; (2) the hemispheric asymmetry significantly diminishes during polarity reversal periods, indicating a balancing effect of global magnetic reconfiguration; (3) solar cycles 23 and 25 exhibit remarkably similar asymmetry patterns, implying solar cycle 25 is likely to be similar to solar cycle 23; and (4) the strength of hemispheric dominance correlates with the overall solar activity level, with stronger asymmetries observed during high-activity phases and weaker signals near solar minima. …”
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Trends in Group A <i>Streptococcus</i> Pharyngitis and Co-Infection with Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Observational Study by Hidenori Takahashi, Yugo Satake, Saori Shimizu, Satomi Fujihara, Syunsuke Takano, Suzuko Fukasawa, Kaeyong Park, Naoya Toba, Takahiko Yano, Hiroki Nagamatsu, Ryutaro Hirose, Mio Toyama-Kousaka, Shinichiro Ota, Miwa Morikawa, Masaharu Shinkai

“…Among 151 patients tested for GAS and SARS-CoV-2, 14 (9.3%) had co-infections, which were identified exclusively after July 2022. Most patients exhibited mild symptoms, primarily fever and sore throat, with decreased lymphocyte counts despite normal white blood cell counts. …”
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Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming by Jing Chu, Rong Qin, Shu-Jing Wang, Qiang Wang, Qiang Wu

“…Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood and frequently presents with bone marrow (BM) metastasis, particularly in high-risk cases. …”
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Lignocellulose adaptation drives polysaccharide biosynthesis in Tremella fuciformis: metabolomic and proteomic insights into CAZyme regulation by Yingyin Xu, Yingyin Xu, Qian Dong, Qian Dong, Shilin Zhang, Shilin Zhang, Liyuan Xie, Liyuan Xie, Qian Zhang, Qian Zhang, Xueqin Shu, Xueqin Shu, Jie Zhou, Jie Zhou, Weihong Peng, Weihong Peng

“…Among the 21 identified metabolic pathways with enriched proteins, carbohydrate metabolism was the most enriched. The Carbohydrate-Active Enzyme (CAZyme) database was used to annotate 161 carbohydrate enzymes, and 67 of them were differentially expressed proteins. …”
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Insights from fifteen years of real-world development, testing and implementation of youth digital mental health interventions by Shane Cross, Shaminka Mangelsdorf, Lee Valentine, Shaunagh O'Sullivan, Carla McEnery, Isabelle Scott, Tamsyn Gilbertson, Shona Louis, Jon Myer, Ping Liu, Niel Mac Dhonnagáin, Tom Wren, Eleanor Carey, Daniela Cagliarini, Ross Jacobs, Roos Pot-Kolder, Imogen Bell, Jennifer Nicholas, Lucia Valmaggia, John Gleeson, Mario Alvarez-Jimenez

“…Drawing on the work of Orygen Digital, we outline the evolution of interventions including the Moderated Online Social Therapy (MOST) platform, the Mello app, and a suite of virtual reality-based therapies; all developed to meet the complex clinical, developmental, and service needs of youth aged 12 to 25.We identify ten key challenges and opportunities encountered in designing, developing and implementing these DMHIs: (1) meaningful co-design; (2) sustained user engagement; (3) personalization and transdiagnostic targeting; (4) optimizing intensities of human support; (5) leveraging peer support and social networking; (6) embedding DMHIs in clinical services; (7) blending digital and face-to-face care; (8) building data infrastructure and learning health systems; (9) developing sustainable and scalable business models; and (10) preparing DMHIs for large language models. …”
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A survey on the perception of health degree students on the use of Instagram and TikTok as learning tools by Silvia Garrido, Beatriz Losa, María Caballero, Alexandra Alvarez, Genny Raffaeli, Giacomo Cavallaro, Maria-Lorella Gianni, Felipe Garrido

“…Results: Students identified Instagram (68%) and YouTube (39%) as the most comfortable social networks for learning. Seventy-five percent of students indicated that they followed Instagram accounts about medicine or nursing, with 47% of these accounts lacking apparent university affiliations. …”
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Trajectories to HIV Viral Suppression and Nonsuppression: Case Studies From Rural East African Adolescents and Young Adults in the SEARCH-Youth Trial by Jason Johnson-Peretz MAOM, MPhil (Oxon), Anjeline Onyango BA, Cecilia Akatukwasa MPH, BSc, Fredrick Atwine BA, Titus M. O. Arunga BSc, Lawrence Owino BSc, Florence Mwangwa MBChB, MPH, Marilyn Nyabuti MBChB, Jane Kabami MPH, Laura B. Balzer PhD, MPhil, Diane V. Havlir MD, James Ayieko MBChB, MPH, PhD, Theodore Ruel MD, Elizabeth A. Bukusi MBChB, MMed, MPH, PhD, Edwin D. Charlebois PhD, MPH, Moses Robert Kamya MBChB, MMed, PhD, Carol S. Camlin PhD, MPH

“…We also found that several factors combine to have effects beyond each individual factor taken singly, for example, medication side effects were influenced by food insecurity; disclosure was most effective with individuals around whom one may potentially take medication, such as co-resident partners; and mobility compromised adherence when patients did not know how or where to access care in new places. …”
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Development and Breeding of Herbicide‐Resistant Sorghum for Effective Cereal‐Legume Intercropping by Sanyuan Tang, Jiayang Shi, Xuefeng Li, Mingliang Yang, Chao Li, Dan Zhang, Sen Yang, Cuo Mei, Zuyong Luo, Li Zhang, Wanke Zhang, Chunrui Zhang, Chenbo Zhu, Xiaowei Ma, Ran Xia, Yuhang Chen, Jinsong Zhang, Qingshan Chen, Shouyi Chen, Qi Xie, Feifei Yu

“…Abstract Weeds bring a serious challenge to crop production, and herbicides is the most effective and economic way to manage it in field. …”
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Knowledge, Attitude, and Practice Toward Antitubercular Agents Among Pulmonary Tuberculosis Patients in Southwestern China: A Cross-Sectional Study by Pi Y, Tan J, Yang P, Pan J, Yang X, Xiang M, Li T

“…Non-adherent behaviors (18.1%) and missed dose compensation (47.3%) were more common in males (P=0.005), older adults (P=0.026), low-income (P=0.022), less-educated (P&lt; 0.001), farmers (P&lt; 0.001), and single-drug users (P=0.014).Conclusion: This study reveals significant differences and deficiencies in knowledge, attitude, and practice of first-line antitubercular drugs among patients with active pulmonary TB, with the most pronounced gaps observed among older adults, lower educational attainment, and farmers.Plain Language Summary: What Did We Study?…”
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