Life Table Parameters and Digestive Enzyme Activity of <i>Araecerus fasciculatus</i> (Coleoptera: Anthribidae) Feeding on Different Stored Products by Lingyan Jian, Yuping Yang, Songhai Xie, Yibin Lou, Ling Chen, Fanglian Dai, Paraskevi Agrafioti, Yu Cao, Christos G. Athanassiou, Can Li

“…These results indicated that coffee beans were the most suitable host food, while kansui was the least suitable for the development of <i>A. fasciculatus</i>.…”
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Nemvaleukin alfa monotherapy in patients with advanced melanoma and renal cell carcinoma: results from the phase 1/2 non-randomized ARTISTRY-1 trial by Xiaomin He, Emiliano Calvo, David F McDermott, Valentina Boni, Olivier Dumas, Arvind Chaudhry, Sang Joon Shin, Seth D Rosen, Philip R Debruyne, Ulka N Vaishampayan

“…ORR in melanoma and RCC cohorts was 9% (95% CI, 2% to 21%; n=4) and 14% (95% CI, 3% to 35%; n=3), respectively; disease control rate was 50% (95% CI, 35% to 65%; n=23) and 50% (95% CI, 28% to 72%, n=11), respectively, with stable disease ≥6 months observed in 3 (7%) and 2 (9%) patients, respectively. The most common nemvaleukin-related treatment-emergent adverse event of grade 3–4 was neutropenia (melanoma, n=27 (57%); RCC, n=9 (33%)). …”
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Emergence and characteristics of multidrug-resistant Salmonella enterica subspecies enterica serovar Infantis harboring the pESI plasmid in chicken slaughterhouses in South Korea by Jiyeon Jeong, Myeongju Chae, Min-Su Kang, Ji-Youn Lee, Yong-Kuk Kwon, Hye-Jin Lee, So-Hee Lee, Hyeon-Bin Son, Jin-San Moon, Seongbeom Cho

“…The isolates in 2014 were antibiotic susceptible, whereas most isolates from 2021 to 2022 exhibited multidrug-resistance, including resistance to third-generation cephalosporins. …”
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GLUT3 enhances chemosensitivity in glioblastoma by transporting temozolomide and capecitabine by Honglin Diao, Yuxin Sun, Xiaojia Zhou, Qikai Wang, Mingyue Wang, Keyu Chen, Zhihua Huang, Jianlei Wei, Zeping Li, Yaxin Lou, Zebin Mao, Wenhua Yu

“…Abstract Glioblastoma multiforme (GBM), the most aggressive brain cancer, is highly resistant to chemotherapy, which profoundly affects patient survival and prognosis. …”
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Potential causal associations of long-term exposure to PM2.5 constituents and all-cause mortality: Evidence from the Pearl River Cohort study by Huanle Cai, Yuqin Zhang, Jing Wei, Wayne R. Lawrence, Shirui Chen, Huanhuan Cheng, Hui Tang, Dan Chen, Ying Wang, Jing Gu, Wangjian Zhang, Yuantao Hao

“…Individuals < 65 years, unmarried, urban medical insured, not consuming alcohol, or not exercising were potentially more susceptible to the adverse effects for most PM2.5 constituents (P for interaction < 0.10). …”
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Prevalence of and risk factors for postoperative delirium among children after cardiac surgery in a Single-Centre retrospective study by Sophia Schumann, Gerhard Schön, Ida Hüners, Daniel Biermann, Lena Christine Siebel, Friederike Jess, Urda Gottschalk, Carolin Gleitze-Nolting, Jonas Denecke, Johannes Drescher, Dominique Singer, Michael Hübler, Rainer Gerhard Kozlik-Feldmann, Sebastian Hermann Harms

“…Overall, PD and IWS are highly prevalent in paediatric cardiac intensive care units (pCICUs), especially in infants and children with prolonged ventilation durations who require multiple sedatives. This is one of the most extensive single-centre studies in the pCICU population, and the results revealed that IWS and lactatemia in the context of LCOS are novel predictors of PD.…”
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Risk Factors and Severity Indicators of Female Pelvic Organ Prolapse: Insights from a Comprehensive Retrospective Study with a Large Sample Size by Qiao Li, Xiaoyu Niu, Yueyue Chen, Can Luo, Yueting Zhang, Jian Meng, Dongmei Wei

“…Conclusions: Grade II prolapse was most commonly observed in the anterior vaginal wall, whereas grade I prolapse predominantly occurred in the posterior vaginal wall. …”
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Evaluating the Immunogenic Potential of ApxI and ApxII from <i>Actinobacillus pleuropneumoniae</i>: An Immunoinformatics-Driven Study on mRNA Candidates by Yi Deng, Jia-Yong Chen, Yuhan Wang, Yu-Luo Wang, Jiale Liu, Zhiling Peng, Jiayu Zhou, Kun Lu, Xin Wen, Xizhu Chen, Siyu Pang, Dan Wang, Miaohan Li, Senyan Du, San-Jie Cao, Qin Zhao

“…Following challenge with the two most prevalent APP strains in Mainland China, APP 5b and APP 1, the survival rates for ApxI (71.4% and 62.5%) and ApxII (75% and 71.4%) were measured, with notably reduced lung lesions and neutrophil infiltration. …”
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Optimizing seasonal performance of advanced heat mitigation solutions for city-scale thermal management in Greater Kuala Lumpur by Norishahaini Mohamed Ishak, Ansar Khan, Jamalunlaili Abdullah, Siti Aekbal Salleh, Mattheos Santamouris

“…Surface temperature reductions were also most pronounced under the combined strategy, reaching 9.6 °C and 9.8 °C respectively. …”
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Exploring AMR and virulence in Klebsiella pneumoniae isolated from humans and pet animals: A complement of phenotype by WGS-derived profiles in a One Health study in Egypt by Enas A. Soliman, Alaa Saad, Ashraf A. Abd El Tawab, Fatma I. Elhofy, Amira M. Rizk, Manar Elkhayat, Tamara Kozytska, Majdil Ilyas, Marwa Bassiouny, Hanka Brangsch, Mathias W. Pletz, Heinrich Neubauer, Lisa D. Sprague, Gamal Wareth

“…MLST analysis revealed different sequence types among K. pneumoniae isolates, and the most frequent STs were ST29, ST219, and ST37. Three ST23 that are generally known as hypervirulent type were identified but they lacked major discriminatory determinants for hypervirulent K. pneumoniae (hvKp). …”
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<i>pyVPRM</i>: a next-generation vegetation photosynthesis and respiration model for the post-MODIS era by T. Glauch, T. Glauch, J. Marshall, C. Gerbig, S. Botía, M. Gałkowski, M. Gałkowski, S. N. Vardag, S. N. Vardag, A. Butz, A. Butz

“…VPRM is widely used as a biospheric flux model in atmospheric transport modeling, most often on scales ranging from city to continent, but also in studies of biospheric carbon budgets and their changes with climate extremes. …”
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ESTIMATION OF EFFICACY OF THE THREATMENT PREVENTIVE COMPLEX IN PATIENTS WITH GENERALIZED PERIODONTITIS, WORKING IN CONDITIONS OF GREENHOUSES UNDER THE INFLUENCE OF PESTICIDES ON SE... by T. D. Zabolotnyj, N. N. Bandrivska, V. T. Dyryk

“…The periodontal diseases are one of the most common and difficult in the treatment and clinical conduction among the dental diseases. …”
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Composite single-cell protein as a sustainable fishmeal substitute: Enhancing growth and health in largemouth bass (Micropterus salmoides) by Jian Chen, Jianqiang Huang, Ling Pan, Fuping Song, Yonghua Hu, Shuang Zhang, Yan Wang

“…In conclusion, CSCP is a promising FM substitute, improving disease resistance, antioxidant capacity, immune response, digestive function, and intestinal microbiota in largemouth bass, with the FM26 diet yielding the most optimal results. This study provides valuable insights for sustainable aquaculture feed optimization.…”
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Comparison of Factors Affecting Quality of Life in Patients with Acute Ischemic Stroke Across Different Stroke Severities by Yuxuan Lu, Weiping Sun, Yining Huang, Zhaoxia Wang, Zhiyuan Shen, Wei Sun, Ran Liu, Fan Li, Junlong Shu, Qing Peng, Jingjing Jia, Peng Sun, Yijun Song, Haiqiang Jin, CASTOR Investigators

“…In the non-minor stroke cohort, analysis revealed that additional factors include diabetes mellitus, geographical region, speech impairment, and thrombolysis, while in the minor stroke cohort, hypertension, coronary heart disease, cancer, prolonged length of stay, and hemorrhage were found to be relevant factors. The impact of most factors on QoL was mediated by MFRO, while the effects of age, speech impairment, and geographical region were also mediated by NMFRO. …”
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Goals and opportunities of bedside hemostasis screening tests by E. V. Roitman, A. A. Shabalina, M. M. Tanashyan, N. Yu. Dmitrieva

“…Moderately reduced or moderately elevated values of hematocrit and platelet count, which are the most common in practice, do not significantly affect the results of whole citrate blood POC tests. …”
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Comprehensive view on chemotherapy-free management of acute myeloid leukemia by using venetoclax in combination with targeted and/or immune therapies by David Kegyes, Andrei Tat, Alin Stefan Vizitiu, Daiana Vazar-Tripon, Radu Ilie, Adrian Bogdan Tigu, Diana Cenariu, Anamaria Bancos, Sabina Iluta, Ciprian Jitaru, Madalina Nistor, Radu Tomai, Diana Gulei, Mihnea Zdrenghea, Hermann Einsele, Gabriel Ghiaur, Carlo M. Croce, Ciprian Tomuleasa

“…As the modern approach to treating hematological malignancies are the chemotherapy-free regimen, in the current manuscript, we provide a comprehensive view on all available therapies that are considered to be chemotherapy-free, with a special emphasis on acute myeloid leukemia (AML), where phase I-III clinical trials have provided the most data.…”
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Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma by Yalei Wen, Hui Wang, Xiao Yang, Yingjie Zhu, Mei Li, Xiuqing Ma, Lei Huang, Rui Wan, Caishi Zhang, Shengrong Li, Hongling Jia, Qin Guo, Xiaoyun Lu, Zhengqiu Li, Xiangchun Shen, Qiushi Zhang, Lu Si, Chengqian Yin, Tongzheng Liu

“…In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K, which are the most prevalent NRAS mutations in melanoma. The genetic ablation or pharmacological inhibition of CK1δ markedly destabilizes NRAS mutants and suppresses their oncogenic functions. …”
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Lymphoblastoid and Jurkat cell lines are useful surrogate in developing a CRISPR-Cas9 method to correct leukocyte adhesion deficiency genomic defect by Ahmad R. Ramadan, Ahmad R. Ramadan, Noureddine Ben Khalaf, Khaled Trabelsi, Halla Bakheit, Imen Ben-Mustapha, Imen Ben-Mustapha, Mohamed-Ridha Barbouche, M-Dahmani Fathallah

“…Three candidate gRNAs were first predicted in silico using CRISPOR and experimentally tested in wild-type ITGB2-expressing Jurkat cells to identify the gRNA with the highest genomic DNA cleavage efficiency. The most efficient gRNA was then paired with espCas9 and used alongside five homology-directed repair templates (HDRs) (single-stranded donor oligonucleotides, ssODNs) to repair ITGB2 defects in patient-derived lymphoblastoid cell lines. …”
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Validation of SPARCC MRI-RETIC e-tools for increasing scoring proficiency of MRI sacroiliac joint lesions in axial spondyloarthritis by Mikkel Østergaard, Kristyna Bubová, Monika Gregová, Robert GW Lambert, Susanne Juhl Pedersen, Manouk de Hooge, Iris Eshed, Stephanie Wichuk, Adrian Ciurea, Michael S Nissen, Ashish J Mathew, Joel Paschke, Raphael Micheroli, Burkhard Möller, Walter Maksymowych, Nora Vladimirova, Žiga Snoj, Anna Enevold Fløistrup E F Hadsbjerg, Karlo Pintaric, Marie Wetterslev, Karel Gorican

“…Greater enhancement of reader reliability was evident after the use of the structural module and was most consistently evident for the scoring of erosion (ICC status/change: stage 1 (0.42/0.20) to stage 3 (0.50/0.38)) and backfill (ICC status/change: stage 1 (0.51/0.19) to stage 3 (0.69/0.41)). …”
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Time-Lag of Seasonal Effects of Extreme Climate Events on Grassland Productivity Across an Altitudinal Gradient in Tajikistan by Yixin Geng, Hikmat Hisoriev, Guangyu Wang, Xuexi Ma, Lianlian Fan, Okhonniyozov Mekhrovar, Madaminov Abdullo, Jiangyue Li, Yaoming Li

“…Notably, extreme precipitation indices had a significant impact on grassland NPP, with the interaction between Precipitation anomaly (PA) and Max Tmax (TXx) exerting the most pronounced influence on the spatial variation of grassland NPP (q = 0.53). …”
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