Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstiti... by Tomoyuki Araya, Toshiyuki Kita, Tsukasa Ueda, Nanao Terada, Tamami Sakai, Kenta Yamamura, Koji Kurokawa, Yuka Uchida, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

“…Although a combination of carboplatin and paclitaxel is most frequently used for patients with advanced NSCLC and ILD, the safety and efficacy of carboplatin plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) are yet to be elucidated. …”
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Global metabolome changes induced by environmentally relevant conditions in a marine-sourced Penicillium restrictum by Le, Van-Tuyen, Bertrand, Samuel, Brandolini-Bunlon, Marion, Gentil, Emmanuel, Robiou du Pont, Thibaut, Rabesaotra, Vony, Wielgosz-Collin, Gaëtane, Mossion, Aurélie, Grovel, Olivier

“…This revealed that fatty acid composition of lipids was the most altered part of the explored metabolisms whether looking to the effect of water or of environmentally relevant conditions. …”
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The interactive influence of gender and ergonomic factors, alongside psychosocial associations, on work-related musculoskeletal disorders in Saudi dental students: a cross-sectiona... by Saba Kassim, Hawazin Mohammad Alblehshi, Hala Bakeer, Manuel Barbosa Almeida, Doaa S. Al-Harkan, Safa Jambi, Doaa Felemban, Wafa Alaajam, Nebras Althagafi, Hani T. Fadel, Alla Alsharif

“…Of the participants, 71% (95% confidence interval (CI) [64.3–76.7]) self-reported WMSDs in at least one area of body over the past 12 months, with the most reported WMSDs being in the lower back, followed by the neck, wrists/hands, and shoulders at 48%, 45%, 31% and 30%, respectively. …”
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Assessment of need and practice for assistive technology and telecare for people with dementia—The ATTILA (Assistive Technology and Telecare to maintain Independent Living At home... by Kirsty Forsyth, Catherine Henderson, Lucy Davis, Anusua Singh Roy, Barbara Dunk, Eleanor Curnow, Rebecca Gathercole, Natalie Lam, Emma Harper, Iracema Leroi, John Woolham, Chris Fox, John O'Brien, Andrew Bateman, Fiona Poland, Peter Bentham, Alistair Burns, Anna Davies, Richard Gray, Rosie Bradley, Martin Knapp, Stanton Newman, Rupert McShane, Craig Ritchie, Emma Talbot, Emma Hooper, Rachel Winson, Bethany Scutt, Victoria Ordonez, Samantha Nunn, Grace Lavelle, Robert Howard

“…ATT assessments showed 52% fidelity to the ATT assessment standard. Areas of assessment most frequently leading to identifying ATT need were daily activities (93%), memory (89%), and problem‐solving (83%). …”
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TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER by A. D. Zikiryakhodzhaev, M. A. Frolova, E. A. Rasskazova, E. V. Glazkova

“…The rate of triple-negative breast cancer is 10–24  %, and in recent years it’s one of the most studied subtypes of breast cancer due to its clinical aggressiveness and a small number of molecular targets.The study objective is to evaluate effectiveness of different NAPCT regimens including their dependence on the presence of mutations in the ВRСА 1, 2, СHEK2 genes.Materials and methods. …”
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E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease by V. I. Podzolkov, A. E. Bragina, N. A. Druzhinina, L. N. Mohammadi

“…According to the results of multivariate regression analysis the hsCRP level was related with only the smoking experience (B=0.91±0.19, p=0.000005), AU level with the daily inhaled nicotine dose (B=1.59±0.7, p=0.0121) and smoking experience (B=3.07±1.23, p=0.0179), and ABI level with only smoking experience (B=-0.09±0.004, p=0.0419).Conclusion: In smokers, both traditional and vapers, the levels of hsCRP, AU are significantly higher, and the ABI is lower than in healthy young nonsmokers. The most significant influence on the level of hsCRP is exerted by the experience of  tobacco  and  vape  smoking;  to  the  AU  level  – the experience of tobacco and vaping and the daily inhaled nicotine dose, and by the value of the ABI – the experience of vaping.…”
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Prevalence and associated factors of chronic pain among nurses: a national cross-sectional study by Zhenhui Ren, Jiaxin Yang, Chongmei Huang, Qiang Yu, Xuting Li, Zengyu Chen, Dan Zhang, Chunhui Bin, Meng Ning, Yiting Liu, Jianghao Yuan, Yamin Li, Yusheng Tian

“…Results The prevalence of chronic pain among the participants was 8.2%, with the most common sites of pain being the low back (55.8%), neck and shoulder (40.0%), and head (37.6%). …”
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Intelligent decision-making and regulation method of gas extraction “borehole-pipe network” system by Kai WANG, Dongxu WANG, Aitao ZHOU, Junwen ZHANG, Fangzhou SONG, Chang’ang DU, Yushuang HAO, Xihui FAN, Wei ZHAO

“…Therefore, in order to regulate the negative pressure of gas extraction system reasonably and accurately, four prediction algorithms are compared and analyzed, and the most excellent prediction algorithm is selected and improved according to its own shortcomings. …”
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Noninvasive Ventilation Weaning in Acute Hypercapnic Respiratory Failure due to COPD Exacerbation: A Real-Life Observational Study by Paola Faverio, Anna Stainer, Federica De Giacomi, Grazia Messinesi, Valentina Paolini, Anna Monzani, Paolo Sioli, Irdi Memaj, Oriol Sibila, Paolo Mazzola, Alberto Pesci

“…The most recent British Thoracic Society/Intensive Care Society (BTS/ICS) guidelines on the use of noninvasive ventilation (NIV) in acute hypercapnic respiratory failure (AHRF) suggest to maximize NIV use in the first 24 hours and to perform a slow tapering. …”
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Carbohydrate antigen-125 (CA125): a marker of right ventricular dysfunction and poor prognosis in heart failure with preserved ejection fraction by Sher May Ng, Geert H.D. Voordes, Michelle Lobeek, Michiel Rienstra, Adriaan A. Voors, Elke S. Hoendermis, Dirk J. van Veldhuisen, Thomas M. Gorter

“…The Olink proteomic analysis identified carbohydrate antigen 125 (CA125) as the most differentially abundant in plasma of patients with HFpEF and RVD as compared to those without RVD, which corroborated with further immunoassay analysis − median CA125 in patients with RVD was 23 kU/L [21–47] vs. 16 [12–20] in patients without RVD (p < 0.001). …”
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A retrospective study of the antimicrobial susceptibility patterns of Klebsiella pneumoniae isolated from urine samples over a decade in South India by Mahadevaiah Neelambike Sumana, Yogeesh D. Maheshwarappa, Kalyani G., Kalyani G., Rashmi P. Mahale, Sowmya G. S, Morubagal Raghavendra Rao, Ranjitha Shankaregowda, Vidyavathi B. Chitaragi, Deepashree R., Sujatha S. R., Neetha S. Murthy, Badveti Satyasai, Vasimalli Vinay Kumar, Supreeta R. Shettar

“…This study aimed to assess the antimicrobial susceptibility (AST) patterns of Klebsiella pneumoniae (KPN) isolated from urine samples over a decade (2014–2023).MethodsThe study analyzed Klebsiella pneumoniae isolates AST pattern from urine samples at a tertiary care hospital in Mysuru (Karnataka), South India using the VITEK-2 (bioMérieux, France) database.ResultsOf 73,283 urine samples, 21,362 (29.15%) showed significant bacterial growth. The most frequently isolated organism was Escherichia coli (n = 9,211, 43.11%), followed by Pseudomonas aeruginosa (n = 1,108, 5.18%) and K. pneumoniae (n = 920, 4.30%). …”
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Molecular biological subtypes of breast cancer in BRCA1 mutation carriers by N. I. Pospekhova, D. A. Golovina, M. G. Filippova, A. V. Semyanikhina, S. L. Dranko, A. M. Danishevich, A. M. Stroganova

“…According to the literature, BRCA1-associated breast cancer (BC) most often belongs to the triple negative (TNBC) molecular subtype. …”
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Remdesivir Use in Pediatric Patients with Acute SARS-CoV-2 Infection Is Safe and Well Tolerated by Delma J. Nieves, M. Tuan Tran, Jasjit Singh, Negar Ashouri, Tricia Morphew, Jennifer G. Lusk, Felice C. Adler-Shohet, Rachel Marano, Stephanie Osborne, Jennifer Strickland, Antonio C. Arrieta

“…In total, 62% of cases were Hispanic. The most common reasons for Remdesivir treatment included respiratory distress (201; 63%) and having high-risk underlying conditions (109; 34%). …”
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Combining Transcriptome Analysis and Comparative Genomics to Identify Key Components of the Lignin Biosynthesis Gene Network in <i>Sorghum bicolor</i> by Hao Niu, Yanbo Wang, Ruizhen Liu, Xiaoqiang Cheng, Yao Wang, Yubin Wang, Xin Lv, Fangfang Fan, Lan Ju, Jianqiang Chu, Haisheng Yan, Hongru Wang, Hetan Chang, Yancong Zhang, Yongfu Tao, Junai Ping

“…The 104 lignin biosynthesis candidates were significantly enriched (<i>p</i>-value < 0.01) in these differentially expressed genes, with most differentially expressed candidate genes related to monolignol biosynthesis and polymerization being up-regulated in high-lignin accessions. …”
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Expression and characterization of a codon-optimized butyrylcholinesterase for analysis of organophosphate insecticide residues by Jing-jing TIAN, Xiang-ning CHEN, Yuan-hong XIE, Yong LU, Wen-tao XU, Li XU, Bin DU

“…All values of the half maximal inhibitory concentration of a substance (IC50) for hBChE were lower than those for HoBChE, but most IC50 for hBChE were lower than those for EeAChE except dichlorvos. …”
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Evaluating birthing individual and infant healthcare utilization and costs among individuals experiencing perinatal mood and anxiety disorders by Ashlee J. Vance, Clayton J. Shuman, Sarah Bell, Anca Tilea, Anna Courant, Karen M. Tabb, Kara Zivin

“…Results The sample consisted of 101,306 birthing individuals and 108,438 infants representing 108,438 unique dyads. Most birthing individuals were between the ages of 25–39 and categorized as White (71.7% of deliveries). …”
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Use of upadacitinib in the treatment of moderate to severe atopic dermatitis: patient profiling, dose selection, and therapy modulation, what does real-life teach us? by Edoardo Mortato, Niccolò Gori, Giacomo Caldarola, Marina Talamonti, Claudia Paganini, Luisa Boeti, Filomena Russo, Teresa Grieco, Ersilia Tolino, Gaia Moretta, Flavia Pigliacelli, Rosa Coppola, Domenico Giordano, Camilla Chello, Concetta Potenza, Maria Concetta Fargnoli, Vincenzo Panasiti, Barbara Cocuroccia, Ketty Peris, Marco Galluzzo

“…The safety profile was consistent with prior reports, with acneiform eruption, elevated creatine phosphokinase (CPK), and dyslipidemia being the most common adverse events. No reactivation of atopic keratoconjunctivitis was observed.Conclusions These findings support the efficacy, safety, and flexibility of upadacitinib dosing in clinical practice.…”
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Evaluation of a Digital Media Campaign to Promote Knowledge and Awareness of the GPFirst Program for Nonurgent Conditions: Repeated Survey Study by Rebecca Ong Hui Shan, Hong Choon Oh, Priscilla Goh Sook Kheng, Lyndia Lee Sze Hui, Mas Riza Bte Mohd Razali, Edris Atikah Ahmad, Jagadesan Raghuram, Choon How How, Steven Lim Hoon Chin

“…ResultsThe Facebook posts generated 38,404 engagements within 5 months, with “#ThankYourGP” posts being the most viewed (n=24,602) and engaged (n=2618). Overall, 1191 and 1161 participants completed CS1 and CS2 respectively. …”
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OsLB2.2 negatively regulates rice disease resistance at seedling stage in rice by Tianze Ma, Mengge Wang, Shupeng Xie, Shupeng Xie, Chengxin Li, Jingguo Wang, Hualong Liu, Luomiao Yang, Longnan Men, Zhonghua Sun, Tianpeng Zong, Detang Zou, Hongliang Zheng, Wei Xin, Wei Xin

“…BackgroundRice blast disease, caused by the fungal pathogen Magnaporthe oryzae, stands as the most destructive diseaset of rice, negatively impacting yield and quality. …”
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Effect of hydrogen on the corrosion and stress corrosion cracking behavior of additively manufactured Ti–6Al–4V compared with traditional process by Jing Li, Tao Zhang, Li Li, Zimin Li, Jiajing Peng, Yimian Chen, Wanqing You, Changsheng Fu, Bright O. Okonkwo, Chao Xiang, Zhiming Zhang, Jianqiu Wang, En-Hou Han

“…Following electrochemical hydrogen charging, the corrosion resistance of forged Ti–6Al–4V experienced the most significant degradation in corrosion resistance. …”
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