A spatial transcriptomic atlas of the host response to oropharyngeal candidiasis by Sunna Nabeela, Hayden McSwiggin, Rubens Daniel Miserani Magalhaes, Eliciane Cevolani Mattos, Mohammad Mannan, John T. Dillon, Ashley Barbarino, Eman G. Youssef, Shakti Singh, Wei Yan, Ashraf S. Ibrahim, Heather R. Conti, Priya Uppuluri

“…Additionally, M2 macrophages are important for resistance to OPC. Most notably, we identified a new family of antimicrobial proteins with strong antifungal properties, presenting promising therapeutic potential. …”
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Interiorização da educação universitária paranaense: política de expansão ou real submissão aos desígnios do capital internacional? by Edélcio José Stroparo, Maria Elisabeth Blanck Miguel

“…Abstract The aim of this article is to analyze the motivations that most significantly contributed to the governmental decision that led to the internalization of University Education in the State of Paraná, promoted by the concomitant creation of the State Universities of Londrina, Maringá and Ponta Grossa in 1969. …”
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Identification of tRF-29-79MP9P9NH525 as a biomarker and tumor suppressor of gastric cancer via regulating KIF14/AKT pathway by Jiaxin Ge, Ji Dai, Haoqiang Ji, Jie Guo, Xiaoban Shen, Desen Sun, Qiang Chen, Pan Chen, Guoliang Ye, Junming Guo, Shuangshuang Zhang

“…Abstract Gastric cancer (GC) is one of the most common malignancies with a poor prognosis. The development of novel biomarkers is of utmost importance to screen patients with GC. …”
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Antimicrobial photodynamic therapy in onychomycosis management: A systematic review of clinical trials by Renata de Oliveira Alves, Lara Oliveira Ribeiro Urzedo, Priscila Toninatto Alves de Toledo, Carla Ferreira-Baptista, Matheus Henrique Faccioli Ragghianti, Thais Cristina Pereira, Larissa Pereira Nunes, Rui Damazio Alvites, Gabriel Pereira Nunes

“…Results: Eighteen studies involving 591 participants (mean age: 54.2 years) met inclusion criteria. The most common light source was diode laser (450–700 nm), and photosensitizers included methylene blue, aminolevulinic acid, and methyl-5-aminolevulinate. aPDT significantly reduced onychomycosis severity (30–90 % OSI reduction) and achieved mycological cure rates up to 100 % when combined with fractional CO2 laser. …”
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3D spectral CT-based fusion model predicts prognosis and postoperative adjuvant chemotherapy benefit in locally advanced rectal cancer by Shuxuan Fan, Jiaxin Liu, Xiaomeng Yang, Lisha Qi, Xiaomei Lu, Haiwei Liu, Xiaonan Cui

“…Moreover, SDCT-derived 3D quantitative biomarker displayed as the most important feature in SHAP, indicating the importance of quantitative radiological features in personalized risk stratification. …”
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A Novel 3D Convolutional Neural Network-Based Deep Learning Model for Spatiotemporal Feature Mapping for Video Analysis: Feasibility Study for Gastrointestinal Endoscopic Video Cla... by Mrinal Kanti Dhar, Mou Deb, Poonguzhali Elangovan, Keerthy Gopalakrishnan, Divyanshi Sood, Avneet Kaur, Charmy Parikh, Swetha Rapolu, Gianeshwaree Alias Rachna Panjwani, Rabiah Aslam Ansari, Naghmeh Asadimanesh, Shiva Sankari Karuppiah, Scott A. Helgeson, Venkata S. Akshintala, Shivaram P. Arunachalam

“…Despite advances in DL, most existing models in medical AI focus on static images, overlooking critical temporal cues present in video data. …”
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Atención de emergencia a migrantes en el Hierro: un análisis observacional descriptivo del desafío humanitario by Eugenia Julia Cuesta Aguirre, Angelica Ingelmo Cenador, Raquel Broncano Garcia, Raimundo de Dompablo Guerrero

“…A total of 76 cases of acute conditions were recorded, with the most frequent being wounds/injuries (26.32%) and "patera foot" (11.84%). …”
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Protective mechanism of weathering steel rust layers in atmospheric environments and their stabilization treatment technologies by Junyi GAO, Weichen XU, Binbin ZHANG, Canming LI, Guobao LI, Baorong HOU

“…Additionally, the impact of traditional elements like Cr, Cu, and Ni, as well as other elements such as Sn, Mo, and rare earth elements, on the formation of effective corrosion products, the nucleation of rust layers, and the compactness and bonding strength of the rust has also been analyzed. Most alloying elements enhance the protective properties of rust layers by improving their compactness, stability, and ionic selectivity. …”
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Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study by Michael Smith, Ignacio Garrido-Laguna, Aung Naing, Lance Leopold, Jason J Luke, Kai Ding, Solmaz Sahebjam, Ryan Geschwindt, John D Powderly, John J Nemunaitis, Aaron S Mansfield, Wells A Messersmith, Patricia M LoRusso, Jordan D Berlin

“…One dose-limiting toxicity of serious, grade 3 aseptic meningitis was reported in a patient receiving itacitinib 300 mg once a day plus parsaclisib 10 mg once a day, which resolved when the study drugs were withdrawn. The most common treatment-related adverse events among patients treated with itacitinib plus epacadostat included fatigue, nausea, pyrexia, and vomiting, and for patients treated with itacitinib plus parsaclisib were fatigue, pyrexia, and diarrhea. …”
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Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer by Raffaello Roesel, Francesco Strati, Camilla Basso, Samantha Epistolio, Paolo Spina, Julija Djordjevic, Elisa Sorrenti, Martina Villa, Agnese Cianfarani, Francesco Mongelli, Jacopo Galafassi, Sotirios G. Popeskou, Federica Facciotti, Cecilia Caprera, Federica Melle, Pietro Edoardo Majno-Hurst, Alessandra Franzetti-Pellanda, Sara De Dosso, Ferdinando Bonfiglio, Milo Frattini, Dimitrios Christoforidis, Giandomenica Iezzi

“…A minority of patients show complete response (CR) to nCRT and may avoid surgery and its functional consequences. Instead, most patients show non-complete response (non-CR) and may benefit from additional treatments to increase CR rates. …”
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Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over... by Ronald R Grunstein, Bandana Saini, Christopher J Gordon, Anastasia Suraev, Angela L D'Rozario, Chris Irwin, Camilla M Hoyos, Iain McGregor, Brendon Yee, Isobel Lavender, Danielle McCartney, Nathaniel Marshall

“…Objective Insomnia is the most prevalent sleep disorder, with few effective pharmacotherapies. …”
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MdUGT88F4 involved in the synthesis of isosalipurposide positively regulates the salt stress response of apple plants by Ying Ye, Yanrong Hu, Yuan Liu, Cheng Yu, Kun Zhou, Fengwang Ma, Xiaoqing Gong

“…MdUGT88F4 failed to promote the accumulation of isosalipurposide in vivo, and it was involved in isosalipurposide synthesis. Most of the flavonoid metabolites accumulated to a greater degree in OX plants than in WT plants. …”
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Abstract 116: Reversal of Acute Ocular Ischemic Syndrome Following Rescue Carotid Revascularization: A Case Report by Abhiram Parameswaran Pillai

“…Carotid artery atherosclerosis is the most common etiology. Majority of OIS (∼90%) present with gradual vision loss and approximately 40% present with ocular pain. …”
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Temporal association of antimicrobial use in livestock with antimicrobial resistance in non-typhoid Salmonella human infections in the Netherlands, 2008–2019 by Linda E. Chanamé Pinedo, Anouk P. Meijs, Huifang Deng, Sabine C. de Greeff, Engeline van Duijkeren, Cindy M. Dierikx, Kees T. Veldman, Pim Sanders, Maaike J.C. van den Beld, Bart Wullings, Eelco Franz, Roan Pijnacker, Lapo Mughini-Gras

“…Results: For SE, only a positive association between penicillins use in broilers and resistance to ampicillin among human isolates was significant. For ST/STM, most associations between AMU in livestock and AMR among human isolates were significantly positive, overall and per class-specific antimicrobials, namely for penicillins-ampicillin, tetracyclines-tetracycline and sulfonamides/trimethoprim-sulfamethoxazole/trimethoprim. …”
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Changes in the soil and rhizosphere microbiomes associated with bacterial wilt decline in the tomato monoculture field by Junwei Peng, Jinfeng Hou, Hong Liu, Dmitri V. Mavrodi, Olga V. Mavrodi, Feifei Sun, Minchong Shen, Xia Wang, Keke Dang, Min Yan, Hui Liang, Yuanhua Dong, Jiangang Li

“…The wilt incidence steadily increased, culminating in the most severe outbreak in the fifth cropping cycle. …”
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EFFECTIVENESS OF RMT-BASED LEARNING TRAJECTORIES TO SUPPORT RELATIONAL UNDERSTANDING by Bernika Indrialis Ifana, Nyimas Aisyah, Ely Susanti

“…The learning trajectory developed is able to support students' relational understanding, where in the learning process, students are directed to utilize the various knowledge they have, determine the most effective and efficient strategies, provide detailed solutions, and believe in the truth of the answers they use in solving problems. …”
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Effects of replacing fish oil with shrimp waste, canola, and camelina oils on growth and fillet lipid quality in juvenile rainbow trout fed low-fishmeal diets by Rosendo L. Azcuy, Adrián J. Hernández, Lorenzo Márquez, Matías E. Casaretto, Gabriel A. Morales, Patricio Dantagnan

“…Lipid content was higher in SHCA (37.36 %) and COCA (37.28 %) diets, while FO (35.03 %) and SH (34.63 %) diets had lower levels. Protein was most digestible in FO (92.6 ± 0.56 %) and SHCA (92.5 ± 0.58 %) diets. …”
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The patient, diagnostic, and treatment intervals in adult patients with cancer from high- and lower-income countries: A systematic review and meta-analysis. by Dafina Petrova, Zuzana Špacírová, Nicolás Francisco Fernández-Martínez, Ana Ching-López, Dunia Garrido, Miguel Rodríguez-Barranco, Marina Pollán, Daniel Redondo-Sánchez, Carolina Espina, Camila Higueras-Callejón, Maria José Sánchez

“…Estimates for the diagnostic and treatment intervals came mostly from high-income countries that have powerful health information systems in place to record such information.…”
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CYP2C9 rs1057910 Genotype and Its Association with Paraclinical Characteristics in Gout Patients in the Northeast Region of Vietnam by Lan Thi Vu, Yen Thi Thu Hoang, Yen Thi Nguyen, Vien Van Nguyen, Hien Thu Nguyen, Thanh Ha Do, Tuan Phan Hoang

“…No significant differences in most paraclinical parameters were observed between genotype groups, except for HDL-C levels, which were significantly higher in CYP2C9*3 carriers (p=0.000). …”
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

“…Metabolomic integration pinpointed perturbations within glycine-serine-threonine (Gly-Ser-Thr) metabolism as the most significantly perturbed pathway (P < 0.001), with cross-omics validation identifying GLUL as a pivotal regulatory gene through. …”
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