Enhanced rational protein engineering to reduce viscosity in high-concentration IgG1 antibody solutions by Tyler J. Lefevre, Jenna G. Caldwell, Austin Gallegos, Qun Du, Erin Houston, Gilad Kaplan, Reza Esfandiary

“…Subcutaneous (SC) delivery of therapeutic antibodies can offer multiple benefits to patients and healthcare providers, including convenience, time savings, and cost reduction. To improve the SC injection experience, drug developers may seek a low injection volume (1–2 mL), which for some antibody drugs necessitates a high concentration solution (≥100 mg/mL) to meet dosage requirements. …”
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Digital biomarkers for interstitial glucose prediction in healthy individuals using wearables and machine learning by Xinyu Huang, Franziska Schmelter, Christian Seitzer, Lars Martensen, Hans Otzen, Artur Piet, Oliver Witt, Torsten Schröder, Ulrich L. Günther, Lisa Marshall, Marcin Grzegorzek, Christian Sina

“…However, invasiveness, high cost, and limited lifecycle of continuous glucose monitoring (CGM) devices restrict their widespread use. …”
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Construction of a programmed activation nanosystem based on intracellular hypoxia in cisplatin-resistant tumor cells for reversing cisplatin resistance by Yurong Liu, Longqing Si, Yunheng Liu, Song Li, Xiaokang Zhang, Shaojing Jiang, Wenjing Liu, Xiaolin Li, Lianguo Zhang, Hongxia Zheng, Zhonghao Liu, Jinghui Hu, Jing Chen

“…Our previous study revealed that cisplatin resistance in cancer cells comes at the cost of increased intracellular hypoxia. In this study, we used 2-nitroimidazole modified hyaluronic acid (HA-NI) as the carrier. …”
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Experimental Model of Recurrent Corneal Erosion by A. N. Kulikov, S. V. Churashov, I. O. Gavrilyuk, V. A. Tarabrina, N. I. Platonov, O. A. Muravyeva, R. L. Troianovskiy

“…The disadvantages of such models are the labour intensity of their implementation and a relatively high cost. The proposed method makes it possible to create the necessary conditions for local inflammation and destruction of adhesive molecules using the energy of ultraviolet (UV) irradiation. …”
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Yield and water productivity of rice as influenced by crop establishment and irrigation methods under temperate environment by Tasneem Mubarak, Intikhab Aalum Jehangir, Ashaq Hussain, Eajaz Ahmad Dar, Zahoor Ahmad Shah, Aabid H. Lone, Mohd Salim Mir, Salah El-Hendawy, Mohamed A. Mattar, Ali Salem

“…While irrigation method did not significantly impact growth or yield, conventional flooding led to a 28% reduction in water productivity compared to the saturation method and a 25% reduction compared to the alternate wetting and drying method. In terms of benefit-cost ratio, while the differences were modest, the saturation method recorded slightly higher values. …”
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A versatile HPLC method collaborated with NaDES-ultrasound-assisted LLE and machine learning for purity testing and trace analysis of 1,4-benzodiazepines in crime scene evidence, h... by Walaa Nabil Abd-AlGhafar, Rasha Abo Shabana, Rania El-Shaheny, Manar M. Tolba

“…However, efficient extraction from such complex matrices usually requires large volumes of toxic organic solvents, lengthy time, and high cost. For the first time, microwave-driven synthesis of novel natural deep eutectic solvent (NaDES) in just two min was conducted in this study for efficient and green ultrasound-assisted liquid-liquid extraction of BNZs. …”
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Adsorption of Amorphous Silica Nanoparticles onto Hydroxyapatite Surfaces Differentially Alters Surfaces Properties and Adhesion of Human Osteoblast Cells. by Priya Kalia, Roger A Brooks, Stephen D Kinrade, David J Morgan, Andrew P Brown, Neil Rushton, Ravin Jugdaohsingh

“…Here we investigated the direct adsorption of silicate species onto an HA coated surface as a cost effective method of incorporating silicon on to HA surfaces for improved implant osseointegration, and determined changes in surface characteristics and osteoblast cell adhesion. …”
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A comparison of participatory science seining and electrofishing for sampling fish assemblages in an urban river by Olivia F. Williams, Sally Petrella, Lauren Eaton, Robert Muller, Philip Kukulski, Paul Seelbach, Catherine Riseng, Karen M. Alofs

“…Friends of the Rouge, a non‐profit, has collected fish assemblage data throughout the river network for 10 years by seining, a sampling method they selected due to low cost, safety and fit to the organization's volunteer‐based monitoring program. …”
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Viper Venom and Synthetic Peptides: Emerging Active Ingredients in Anti-Ageing Cosmeceuticals by Dana Georgiana Moisă, Anca Maria Juncan, Luca-Liviu Rus, Andreea Loredana Vonica-Țincu, Gabriela Cormoș, Felicia Gabriela Gligor

“…The high percentage of cosmetics categorized under the Mass-Market segment could be attributed to the use of synthetic peptides, given the high cost of natural viper venom as an anti-ageing ingredient, a price likely reflected in the final cosmetic product. …”
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Machine Learning-Based Identification of Plastic Types Using Handheld Spectrometers by Hedde van Hoorn, Fahimeh Pourmohammadi, Arie-Willem de Leeuw, Amey Vasulkar, Jerry de Vos, Steven van den Berg

“…Plastic-type identification with a low-cost, handheld spectral approach could help in parts of the world where high-end spectral imaging systems on conveyor belts cannot be implemented. …”
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A robust in-vitro and ex-vitro Agrobacterium rhizogenes-mediated hairy root transformation system in mungbean for efficient visual screening of transformants using the RUBY reporte... by Sanjeev Kumar, Sakshi Prakash, Priti Kumari, Neeti Sanan-Mishra

“…Conclusion We have developed a simple, rapid, low-cost, and labor-efficient Agrobacterium rhizogenes-mediated mungbean transformation protocol using both in-vitro and ex-vitro approaches, with RUBY as a reporter gene. …”
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Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C–H bonds with TON over 1000000 by Zong-Rui Li, Kun Zhan, Yi-Jie Wang, Liang-Liang Wu, Guo-Lin Lu, Hao-Yang Wang, Xiao-Long Wan, Zhen-Jiang Xu, Kam-Hung Low, Chi-Ming Che

“…A formidable challenge in the field is to increase the turnover numbers (TONs) for catalytic C-H functionalization reactions reported in the literature (generally <10,000) to reasonably high levels to reduce the cost of the reaction. Another challenge is the selective functionalization of less reactive primary C(sp3)-H bonds compared to other types of more reactive C-H bonds. …”
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A Biomechanical Analysis of Weighted Lifting With an Active Knee Exoskeleton by Margaret A. Meagher, Grace R. Hunt, Brendon Ortolano, Rosemarie Murray, Lukas Gabert, Kenneth Bo Foreman, Tommaso Lenzi

“…Previous studies have indicated that powered knee exoskeletons can reduce muscle activation and metabolic cost while lifting. However, no prior studies have conducted comprehensive biomechanical analyses using motion capture during exoskeleton-assisted lifting, which is crucial for examining joint-level effects of the assistance. …”
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InfraredStereo3D: Breaking Night Vision Limits with Perspective Projection Positional Encoding and Groundbreaking Infrared Dataset by Yuandong Niu, Limin Liu, Fuyu Huang, Juntao Ma, Chaowen Zheng, Yunfeng Jiang, Ting An, Zhongchen Zhao, Shuangyou Chen

“…In this paper, a stereo matching network combined with transformer and cost volume is constructed. The existing work in the positional encoding of the transformer usually uses a parallel projection model to simplify the calculation. …”
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Determining Optimal Processing Conditions for Fabricating Industrial Moulds with Additive Manufacturing by Daniel Moreno Nieto, Francisco Javier Puertas Morales, Julia Rivera Vera, Pedro Burgos Pintos, Daniel Moreno Sanchez, Sergio I. Molina

“…Among Material Extrusion (ME) techniques, the Fused Granular Fabrication (FGF) method has enabled the development of Large Format Additive Manufacturing (LFAM) using polymeric materials, which has also established its presence in industries working with large prototypes, molds, and tools. This cost-efficient process has proven its applicability and success in manufacturing molds for composites, particularly in short and medium production runs, significantly reducing production times and costs. …”
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Study assessing the effectiveness of overdose prevention centers through evaluation research (SAFER): an overview of the study protocol by Magdalena Cerdá, Bennett L. Allen, Alexandra B. Collins, Czarina N. Behrends, Michele Santacatterina, Victoria Jent, Brandon D. L. Marshall

“…Fourth, we estimate the costs and cost savings associated with starting up and operating OPCs. …”
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Investigating the Effect of Bamboo Fibers on The Engineering Properties of Laterite Soils in Road Construction. by Kiiza, Obed

“…The growing cost of conventional stabilizing agents and the need for the economical utilization of industrial and agricultural wastes for beneficial highway construction purposes encouraged the investigation into the stabilizing potential of bamboo fibre in lateritic soils. …”
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Access to Primary Education By Children With Physical Disabilities in Bwambara Sub-County Rukungiri District. by Akatukunda, Faith

“…The recommendations that came out of the study were that schools should give admission to CWPD at a free cost, and Schools should put up a special desk for CWD so that when they come for admission they don't wait for long hours. …”
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Assessing The Impact of Tea Production on The Economic Development of Local Community: A Case Study of Kayonza Tea Factory in Kayonza Sub- County Kanungu District. by Tukwasibwe, Joab

“…The study findings show that the factors that have favoured tea production were land availability which is a major factor consisting 90% of the respondents, farm labour, relief, agro-input use and the growing promotion as a strategic agricultural enterprise, the contributions of tea production in Kayonza sub-county Kanungu District were a source of income which is the major contribution of tea production (97%), employment opportunities, foreign exchange earner for the county, contributing to food security, infrastructural development, and the challenges affecting tea production in Kayonza sub-county Kanungu District were pest and diseases which is the major challenge to tea production (90%) cost of production, lack of comprehensive policies, , poor road networks and infrastructures, poor agricultural technology, marketing and value¬addition constraints, climatic changes and seasonal effects and poor access to information. …”
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Assessing the Impact of Social Media Usage and Performance of the Selected Small and Medium Businesses in Ntungamo District. by Nyamwija, Bonitah

“…The study further revealed the impact of social media on the performance of small-scale and medium businesses which the effects included; increased brand awareness, customer engagement and relationship building, opportunities for collaboration and partnerships, targeted marketing and advertising, and cost-effective marketing channels in the Ntungamo district. …”
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