The effect of a systematic multi-dimensional assessment in severe uncontrolled asthma: a literature review and protocol for an investigator-initiated, open-label, randomized-contro... by L. Bult, G. J. Braunstahl, J. G. J. V. Aerts, D. Bänffer, J. S. J. A. van Campen, M. S. van Daalen, Y. van Dooren, U. Flanders, E. S. Geurts, P. P. Hekking, R. Heller - Baan, M. J. A. Jans, J. H. Kappen, R. C. A. Mies, B. Oppedijk, M. de la Roij - Hartmans, S. Van der Sar - Van der Brugge, Y. Türk, E. Vis, R. Wolters, E. C. Vasbinder, J. C. C. M. in ‘t Veen

“…These patients are eligible for treatment with biologicals, which provide significant benefits but are costly and need precise indication. However, identifying all individual treatable traits before diagnosing severe asthma is challenging. …”
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Chlorhexidine-alcohol versus Povidone-iodine plus Alcohol as Preoperative Antiseptic for Prevention of Surgical Site Infection in Caesarean Section: A Randomised Controlled Trial by Shravanthi Swamy, Aruna M Biradar, Ekta Chhabra, Shailaja Rajendra Bidri, Neelamma Patil, Shreedevi Kori, Shilpa Lakshmi, Preethi Malapure

“…Surgical Site Infection (SSI) remains a significant complication, impacting maternal recovery and healthcare costs. Aim: To evaluate the efficacy of chlorhexidine-alcohol versus Povidone-Iodine (PI) plus alcohol in preventing SSI in patients undergoing CS. …”
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Hospital frailty risk score in predicting outcomes after simultaneous colon and liver resection for colorectal cancer liver metastasis in older adults: Evidence from the Nationwide... by Haohao Huang, Weidong Jin, Huiling Sun, Bo Diao, Ping Wang, Jiankun Jia, Dandan Ma, Yi Zhang

“…Frailty was significantly associated with increased risks of in-hospital mortality (adjusted odds ratio [aOR] = 3.65, 95% confidence interval [CI]: 2.52, 5.28), non-routine discharge (aOR = 2.44, 95% CI: 2.08, 2.87), prolonged LOS (aOR = 3.07, 95% CI: 2.60, 3.61), overall complications (aOR = 3.47, 95% CI: 3.03, 3.97), sepsis (aOR = 13.73, 95% CI: 9.76, 19.31), respiratory failure (aOR = 4.99, 95% CI: 3.80, 6.57), acute kidney injury (AKI) (aOR = 6.42, 95% CI: 4.83, 8.52), and acute liver failure (aOR = 2.10, 95% CI: 1.38, 3.21), as well as 32.69 thousand USD higher total hospital costs (95% CI: 28.41, 36.97) than no frailty. Incorporating frailty with traditional demographic and clinical risk factors improved in-hospital mortality prediction (area under ROC curve [AUC]: 0.765 to 0.799). …”
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Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context by Germán Peñalva, Rafael Cantón, María Teresa Pérez-Rodríguez, Juan José González-López, Jesús Rodríguez-Baño, Ester del Barrio-Tofiño, Cristina Kirkegaard-Biosca, Isabel Sánchez-Romero, Andrea Gutiérrez-Villanueva, Teresa Marrodán-Ciordia, José Manuel Guerra-Laso, Cristóbal del Rosario-Quintana, Laura Suárez-Hormiga, Jordi Cámara, Mireia Puig-Asensio, Eva Heredero, María Antonia Sepúlveda, Juan Carlos Rodríguez-Díaz, Esperanza Merino, Emilia Cercenado, Sofia de la Villa, María Siller, Francisco Arnaiz, Cristina Seral, José Antonio Lepe, José Miguel Cisneros, José Ramón Paño-Pardo

“…Funding: The management costs of this study were funded by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). …”
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Virtual Intervention for Vertebral frActures (VIVA): protocol for a feasibility study of a multicentre randomized controlled trial by Ada Sevinc, Alexandra Papaioannou, Suzanne N. Morin, Jennifer A. Watt, Raheem B. Kherani, Sheila Brien, Larry Funnell, Lehana Thabane, Lauren A. Beaupre, Jenna C. Gibbs, Heather Keller, Caitlin McArthur, Matteo Ponzano, Sonia Singh, Sharon Straus, Jenny Thain, Zachary J. Weston, Timothy H. Wideman, Christopher D. Witiw, Lora Giangregorio

“…The secondary outcomes include costs relative to benefit, effects on health-related outcomes (e.g. 30-s chair stand, Brief Pain Inventory, Quality of Life Questionnaire of the European Foundation for Osteoporosis-41, SCREEN-14), and outcomes related to implementation (e.g. participant and provider experience using semi-structured interviews, fidelity, number of screened and enrolled participants by referral source, fracture verification process). …”
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Improving the accuracy of Respiratory Syncytial Virus (RSV) incidence estimates among hospitalised adults in Bristol, UK by Katie Lihou, Robert Challen, Anastasia Chatzilena, George Qian, Glenda Oben, Jade King, Serena McGuinness, Begonia Morales-Aza, Kaltun Duale, Ainhoa Rodriguez Pereira, William Healy, Jennifer Oliver, Nick Maskell, Adam Finn, Leon Danon, Catherine Hyams, Avon C. A. P. Research Group

“…The implementation of effective RSV vaccines could reduce morbidity, mortality and associated costs of disease. Adult RSV burden accuracy is improved by adjustment for test characteristics due to the impact of imperfect specificity when positivity-rates are low, and this is particularly important for out-of-season estimates. …”
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Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair by Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer

“…Currently, the only FDA cell-based therapy for articular cartilage injury is Autologous Chondrocyte Implantation (ACI); however, this procedure is costly, time-intensive, and requires multiple treatments. …”
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Transient simulation of multi-product pipeline driven by flow mechanisms and operational data by Jian DU, Haochong LI, Qi LIAO, Kaikai LU, Jianqin ZHENG, Xiao YU

“…Most existing transient estimation methods rely on precise and reliable physical models, which involve high computational costs to address multi-condition and multi-parameter combinations. …”
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Artificial Intelligence for Detecting COVID-19 With the Aid of Human Cough, Breathing and Speech Signals: Scoping Review by Mouzzam Husain, Andrew Simpkin, Claire Gibbons, Tanya Talkar, Daniel Low, Paolo Bonato, Satrajit S. Ghosh, Thomas Quatieri, Derek T. O'Keeffe

“…<italic>Goal:</italic> Official tests for COVID-19 are time consuming, costly, can produce high false negatives, use up vital chemicals and may violate social distancing laws. …”
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A retrospective multi-site examination of chronic kidney disease using longitudinal laboratory results and metadata to identify clinical and financial risk by Mark Fung, Aya Haghamad, Elizabeth Montgomery, Kathleen Swanson, Myra L. Wilkerson, Kimon Stathakos, Richard VanNess, Sarah A. Nowak, Clayton Wilburn, Haluk Kavus, Mohammed Amer Swid, Nkemakonam Okoye, Yonah C. Ziemba, Girish Ramrattan, Jonathan Macy, John McConnell, Mary Jane Lewis, Beth Bailey, Khosrow Shotorbani, James M. Crawford

“…The imputed lost reimbursement under risk-adjusted payment systems for under-documentation of CKD in this subset of patients was $2.85 M for the three institutions combined, representing lost opportunity for both identification and proactive clinical management of these patients, and financial recovery for the costs of providing that care. Conclusions Clinical laboratories can provide value beyond routine diagnostics, helping to close gaps in care for identification and management of CKD, stratifying subgroups of patients to identify risk, and capturing missed reimbursement through risk adjustment factors.…”
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Comparison of treatment patterns, efficacy and safety between generic and branded atorvastatin users in China: a multicenter, retrospective propensity score-matched cohort study by Xiaoxuan Xing, Zhizhou Wang, Ke Wang, Yiming Hua, Xiaoxi Li, Kejia Le, Wenbing Ma, Yingyun Guan, Aiping Deng, Xiong Yun, Hongfu Cai, Yongning Lyu, Guoying Xiong, Min Yang, Siyang Wang, Chaojun Xue, Jing Zhang, Qiushi Guo, Song Hu, Jing Li, Xianzhe Dong, Lan Zhang

“…Conclusion Generic atorvastatin had higher adherence and persistence and lower costs vs the branded drug, with no significant differences in efficacy and safety. …”
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Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers by Stephen M. Rao, Alexandria L. Chorba, M. J. Helppi, Alina Tuladhar, Amanda L. Penko, Sarah Holley, Brandon Nehls, Sabrina Paulino, Matthew C. Streicher, Audrey Zhu, Kellie Bruening, Sally Durgerian, Katherine Koenig, Mark Lowe, Wanyong Shin, Stephen E. Jones, Rachel Galioto, Jagan A. Pillai, Lynn M. Bekris, James B. Leverenz, Anson B. Rosenfeldt, Tamanna Singh, Gerald J. Beck, J. Carson Smith, Jay Alberts, Jay Alberts

“…Secondary outcomes include comprehensive neurocognitive and physical function test batteries, MRI scans including structural and functional connectivity measures, and blood-based biomarkers.HypothesesOver an 18-month interval, physically inactive ε4 carriers who engage in high-intensity aerobic exercise will demonstrate less cognitive decline and hippocampal atrophy than physically inactive ε4 carriers who did not participate in a formal exercise program.ConclusionSuccessful demonstration of a scalable, home-based, high-intensity aerobic exercise intervention in altering the trajectory of AD pathophysiology and its effects on cognitive functioning will transform AD treatment, improve patient outcomes and quality of life, and reduce healthcare costs.…”
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An explainable unsupervised learning approach for anomaly detection on corneal in vivo confocal microscopy images by Ningning Tang, Qi Chen, Yunyu Meng, Daizai Lei, Li Jiang, Yikun Qin, Xiaojia Huang, Fen Tang, Shanshan Huang, Qianqian Lan, Qi Chen, Lijie Huang, Rushi Lan, Xipeng Pan, Huadeng Wang, Fan Xu, Wenjing He

“…The proposed method enhances screening efficiency, reduces annotation costs, and holds great potential for scalable intelligent diagnosis of corneal diseases.…”
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Preventing adverse events during paediatric cancer treatment: protocol for a multi-site hybrid randomised controlled trial of catheter lock solutions (the CLOCK trial) by Paul Monagle, Andrew Wood, Robert Ware, Adam Irwin, Joshua Byrnes, Natalie Bradford, Susan Moloney, Michelle Martin, Tricia Kleidon, Andrew Moore, Roni Cole, Fiona Newall, Victoria Gibson, Samantha Keogh, David Eisenstat, Amanda Ullman, Mari Takashima, Elouise Comber, Eloise Borello, Nicole Henson, Philippa Howard, Karen McCleary, Jordana McLean, Michelle Noyes, Gemma Rowan, Amanda St John, Joshua Wolf

“…Secondary outcomes will include CABSI, CVAD-associated-thrombosis, CVAD failure, incidental asymptomatic CVAD-associated-thrombosis, other adverse events, health-related quality of life, healthcare costs and mortality. To achieve 90% power (alpha=0.05) for the primary outcome, data from 720 recruitments are required. …”
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T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles by Jacek Lubelski, Eline van Diest, Ator Ashoti, Christina Zotou, Hanneke Rijssemus, Raymond Schiffelers, Zhiyong Lei, Maurits Geerlings, Jaime Fernández Bimbo, Daniel E Murphy, Martijn J W Evers, Suneel A Narayanavari, Diana Pereira Vaz, Nadine Saber, Peter Mayrhofer

“…However, treatment accessibility is hindered by high costs, long manufacturing times, and the need for specialized centers and inpatient care. …”
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Assessment of bone mineral density in epileptic patients with long-term antiepileptic therapy: pilot data by N. A. Sivakova, I. V. Abramova, V. P. Rybasova, O. D. Bolshunova, E. D. Kasyanov, G. V. Rukavishnikov, M. A. Khobeysh, M. Yu. Sorokin, L. V. Lukina, N. I. Ananyeva, R. F. Nasyrova, V. A. Mikhailov, G. E. Mazo

“…The problem of decreased bone mineral density and frequent fractures in patients with epilepsy is an important and understudied issue that significantly reduces quality of life and involves significant economic costs for the treatment and rehabilitation of epileptic patients. …”
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Critical care nurses’ knowledge regarding prevention of central venous catheter-related infection in Saudi Arabia: A cross-sectional study by Bassam Shyhan Alshammari, Salman Hamdan Alsaqri, Sameer A. Alkubati, Jordan H. Llego, Ahmad K. Al-Sadi, Aziza Z. Ali, Wessam A. Elsayed, Anas Mahmoud Balawi, Shaimaa Mohamed Nageeb, Laila A. Hamed

“…Background: Central venous catheter-related infections (CVC-RIs) are a significant concern in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare costs. Nurses play a crucial role in preventing these infections through proper catheter care, adherence to aseptic techniques, and early detection of complications. …”
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Delivering a national de-adoption programme: a documentary analysis of local commissioning policy compliance with England's Evidence-based Interventions programme (EBI) by Carmel Conefrey, Nicola Farrar, Maeve Coyle, Mike Bell, Jane Blazeby, Christopher Burton, Jenny Donovan, Andy Gibson, Joel Glynn, Tim Jones, Angus McNair, Josie Morley, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, William Hollingworth, Leila Rooshenas

“…Abstract Background In 2019 the English National Health Service (NHS) launched a national de-adoption programme to stop or limit access to surgical procedures considered to have little, or uncertain, evidence of benefit to justify their risks and/or costs: the Evidence-Based Interventions (EBI) programme. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…This co-creation platform for network-wide systems-based activities would reduce inefficiencies in AMR-related activities around agrifood, providing a cross-cutting, cohesive community to deliver transformational guidance on relevant, practical agrifood solutions that add value by reducing AMR, antimicrobial usage and associated costs, and decreasing resultant environmental contamination by prioritising challenges, sharing knowledge and best practice, and co-creating practical solutions with key stakeholders. …”
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Catabolic pathway acquisition by rhizosphere bacteria readily enables growth with a root exudate component but does not affect root colonization by Stephan Christel, Alyssa A. Carrell, Leah H. Hochanadel, Manuel I. Villalobos Solis, Paul E. Abraham, Sara S. Jawdy, Julie E. Chaves, Nancy L. Engle, Timkhite-Kulu Berhane, Tao Yao, Jin-Gui Chen, Wellington Muchero, Timothy J. Tschaplinski, Melissa A. Cregger, Joshua K. Michener

“…The likelihood of a successful transfer event is expected to depend on the precise balance of costs and benefits resulting from pathway acquisition. …”
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