Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-... by Waqas Ahmad, Kyonghwan Choe, Kyonghwan Choe, Riaz Ahmad, Tae Ju Park, Myeong Ok Kim, Myeong Ok Kim

“…Alzheimer’s disease (AD) is the most common and costly chronic progressive neurodegenerative disorder, with the highest impact on public health worldwide. …”
Get full text

Antioxidant related to nutrition, stomatal density, and yield in cilantro (Coriandrum sativum L.) nourished with leachate from compost based on vegetable waste by D. D. Cruz Nieto, N. E. Muguruza Crispín, J. U. Romero Menacho, O. O. Osso Arriz, B. L. Mamani Salcedo, F. V. Luperdi Rios, C. P. Alvarez Quinteros, J. O. Nicho Vargas, M. I. Martinez Loli, R. W. Dextre Mendoza, M. N. Morales Alberto, C. M. Caira Mamani, R. Aguilar Anccota, G. P. Lacherre Rodriguez, J. R. Ramos Vera, M. V. Bautista Espinoza, G. C. Pesantes Arriola, J. R. Reaño Rivera

“…Abstract The food crisis in Peru has intensified due to the increase in the costs of raw materials, such as energy sources, fertilizers, and other industrial inputs, as a result of global socioeconomic instability. …”
Get full text

Development and Evaluation of a Machine Learning Model for Predicting 30-Day Readmission in General Internal Medicine by Abdullah M. Al Alawi, Mariya Al Abdali, Al Zahraa Ahmed Al Mezeini, Thuraiya Al Rawahia, Eid Al Amri, Maisam Al Salmani, Zubaida Al-Falahi, Adhari Al Zaabi, Amira Al Aamri, Hatem Al Farhan, Juhaina Salim Al Maqbali

“…<b>Background/Objectives:</b> Hospital readmissions within 30 days are a major challenge in general internal medicine (GIM), impacting patient outcomes and healthcare costs. This study aimed to develop and evaluate machine learning (ML) models for predicting 30-day readmissions in patients admitted under a GIM unit and to identify key predictors to guide targeted interventions. …”
Get full text

A comparative assessment of two rooftop hybrid energy systems in an Ecuadorian academic complex by Ruben Hidalgo-Leon, Jaqueline Litardo, Scarleth Vasconcelos, Frank Porras, Miguel Torres, Christopher Varela, Jorge Vega, Vicente Macas-Espinosa, Pritpal Singh, Guillermo Soriano

“…In addition, net present costs over 25 years were USD 491,519.71 and USD 1079,532.58. …”
Get full text

Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study by Karen J. Bosma, Claudio M. Martin, Karen E. A. Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E. Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji, Gaëtan Beduneau, Francois Beloncle, Guillaume Carteaux, Emmanuel Charbonney, Alexandre Demoule, Martin Dres, Vito Fanelli, Anna Geagea, Ewan Goligher, François Lellouche, Tommaso Maraffi, Alain Mercat, Pablo O. Rodriguez, Jason Shahin, Stephanie Sibley, Savino Spadaro, Katerina Vaporidi, M. Elizabeth Wilcox, Laurent Brochard, On behalf of the Canadian Critical Care Trials Group and, the REVA Network

“…Discussion Meta-analyses comparing PAV+ to PSV suggest PAV+ may benefit patients and decrease healthcare costs but no powered study to date has targeted the difficult to wean patient population most likely to benefit from the intervention, or used consistent timing for the implementation of PAV+. …”
Get full text

Rationale and Design of the REPEAT Trial: A Multicenter Randomized Trial Comparing Redo Surgical Aortic Valve Replacement to Valve‐in‐Valve Transcatheter Aortic Valve Replacement... by Matthias Raschpichler, Suzanne de Waha, Stefan Blankenberg, Marcio A. Diniz, Emilia Bagiella, Annetine C. Gelijns, Vinicius F. Calsavara, Aakriti Gupta, Niklas Schofer, Tsuyoshi Kaneko, Mohamed Abdel‐Wahab, Holger Thiele, Raj Makkar, Michael A. Borger

“…Secondary end points include each of the individual components of the primary composite end point, Valve Academic Research Consortium‐3–based conduction disturbances and arrhythmia, Valve Academic Research Consortium‐3–based wound and bleeding complications, functional status (ie, 6‐minute walk test, Kansas City Cardiomyopathy questionnaire), and treatment costs. Conclusions The REPEAT trial has been designed to test the hypothesis that redo surgical aortic valve replacement is superior to ViV‐TAVR regarding clinical outcomes at 5 years in patients with degenerated surgical aortic bioprostheses and low to intermediate surgical risk.…”
Get full text

Use of powdered immunized insects for inhibiting Pectobacterium carotovorum infestation and promoting growth in lettuce by Youngwoo CHO, Jun Ho LEE, Jangwoo PARK, Ki-Byung PARK, Mijeong KIM, Sung Su PARK, Sejung HWANG, Saeyoull CHO

“…Thus, our study proposes a novel method for the use of freeze-dried and powdered forms of insects immunized in mass rearing as effective functional fertilizers on a large scale that can also be effective in inhibiting microbial infections, overcoming the limitation of high production costs of such insect fertilizers using conventional methods.…”
Get full text

Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

“…Biopsy, although considered the gold standard, is invasive, costly, and unsuitable for routine monitoring. Traditional biomarkers, such as creatinine and troponin, offer limited predictive value owing to their low specificity, and conventional imaging techniques often fail to detect early organ damage, increasing the risk of undiagnosed rejection episodes. …”
Get full text

Prevalence and risk factors of Chlamydia trachomatis genital infection among military personnel of the Armed Forces of Serbia: A cross-sectional study by Jadranin Željko, Ristanović Elizabeta, Atanasievska Sonja, Dedić Gordana, Šipetić-Grujičić Sandra, Bokonjić Dubravko, Grillo Michael, Mladenović Jovan, Bančević Vladimir, Košević Branko, Šuljagić Vesna

“…Studies conducted in many armed forces worldwide showed that CTI is common within military population and generate significant healthcare costs. The aim of this study was to estimate the prevalence of CTI among members of the Serbian Armed Forces (SAF) and to determine risk factors for this infection. …”
Get full text

Rumen metagenome as a genomic selection target to reduce enteric methane emissions by B.J. Sepulveda, O. González-Recio, A.J. Chamberlain, M. Khansefid, B.G. Cocks, J. Wang, C.P. Prowse-Wilkins, L.C. Marett, S.R.O. Williams, J.L. Jacobs, A. García-Rodríguez, J.A. Jiménez-Montero, J.E. Pryce

“…Reducing enteric methane emissions (EME) through breeding decisions is theoretically possible, yet measuring these emissions on commercial farms is currently challenging and costly. It is common for EME to be measured using different technologies, which may show weak correlations between them, complicating the combination of reference populations, especially between countries. …”
Get full text

Apparent soil electrical conductivity and gamma-ray spectrometry to map particle size fraction in micro-irrigated citrus orchards in California by Elia Scudiero, Elia Scudiero, Michael P. Schmidt, Todd H. Skaggs, Jorge F. S. Ferreira, Daniele Zaccaria, Alireza Pourreza, Dennis L. Corwin

“…Integrating multi-sensor data is a viable means for reducing ground-truthing requirements and related costs, and improving the quality and accuracy of soil maps in agriculture.…”
Get full text

Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…Given the global prevalence and impact of upper respiratory tract infections (URTIs) on productivity and healthcare costs, YBG has shown promise as a potential therapeutic and preventive strategy for recurrent respiratory tract infections. …”
Get full text

Participatory science to complement professional data: Towards conservation of declining native freshwater fish, the crucian carp by Kiran Thomas, Lukáš Kalous, Marek Brabec, Petr Velenský, Milan Gottwald, Daniel Bartoň, Sandip Tapkir, Yevdokiia Stepanyshyna, Zuzana Šmejkalová, Marek Šmejkal

“…Abstract The participatory science approach helps to gather relevant ecological data with high coverage and reduce time and costs to solve intriguing conservation issues. However, the precision and additional value of using participatory science for monitoring freshwater fish species with similar appearances is not well understood. …”
Get full text

Performance assessment of sustainable cooling strategies in canarian Greenhouses: Evaluating earth-to-air heat exchanger and rock-bed systems by Fatima Ezzahra Allali, Hicham Fatnassi, Hassan Demrati, Ahmed Wifaya, Ahmed Aharoune

“…These conditions often require intensive cooling, which is typically reliant on fossil fuel-based energy sources. This increases costs and environmental impact, highlighting the need for sustainable, energy-efficient cooling solutions.This study evaluates the performance of two passive, sustainable cooling strategies, Earth-to-Air Heat Exchanger (EAHE) and Rock-Bed System (RBS), which exploit subsurface thermal properties to control the canarian greenhouse microclimate.A comparative experimental study was conducted using two identical greenhouses equipped with either EAHE or RBS, alongside an uncooled control greenhouse. …”
Get full text

Co-inoculation maintains yields and lowers N2O emission by affecting rhizosphere bacterial diversity in common bean grown on a C-rich clayey Ferralsol by Pablo Schulman, Marcia Thais de Melo Carvalho, Raquel Neves de Mello, Beata Emoke Madari, Pedro Luiz Oliveira de Almeida Machado, Enderson Petronio de Brito Ferreira, Tatiana Maris Ferraresi, Tereza Cristina de Oliveira Borba, Rodrigo Mendes, Edson Hirose, Wilker Alves de Araujo, Matheus Mentone de Britto Siqueira, Ryan Rodrigues da Silva, Pedro Augusto de Oliveira Morais

“…Despite being a N-fixing legume, common bean (Phaseolus vulgaris) cultivation using diazotrophic bacteria is not commonly adopted by Brazilian farmers, who instead rely on mineral nitrogen sources like urea, increasing environmental and economic costs. Diversified systems that enhance soil quality may improve the crop’s ability to depend solely on biological nitrogen fixation. …”
Get full text

Sickness absence trajectories among young employees in their first full-time employment and subsequent long-term sickness absence: a Danish register-based cohort study by Naja Hulvej Rod, Tea Lallukka, Ida Madsen, Ute Bültmann, Maria Melchior, Reiner Rugulies, Jacob Pedersen, Stephen Stansfeld, Jeppe Karl Sørensen, Karl Bang Christensen, Jimmi Mathisen

“…Background Sickness absence (SA) poses an important and costly societal and public health challenge. However, no previous studies have investigated SA trajectories among individuals in their first full-time employment, delving into the contribution of early SA to future long-term absence among young employees. …”
Get full text

Effect of citric waste fermented with yeast waste pellet and roughage-to-concentrate ratio on gas production, digestibility, and fermentation characteristics using an in vitro gas... by Natdanai Kanakai, Sawitree Wongtangtintharn, Chaichana Suriyapha, Rittikeard Prachumchai, Chanon Suntara, Areerat Lunpha, Ruangyote Pilajun, Pin Chanjula, Anusorn Cherdthong

“…Abstract Background Agro-industrial byproducts offer promising solutions for reducing feed costs and mitigating environmental pollution. Efficient waste management through recycling and reuse not only minimizes environmental impact but also opens avenues for innovative animal feed products. …”
Get full text

Donor Perceptions and Preferences of Telemedicine and In-Person Visits for Living Kidney Donor Evaluation by Ellie Kim, Hannah C. Sung, Katya Kaplow, Victoria Bendersky, Carolyn Sidoti, Abimereki D. Muzaale, Jasmine Akhtar, Macey Levan, Suad Esayed, Amir Khan, Christina Mejia, Fawaz Al Ammary

“…Access to transplant centers, travel costs, lost wages, and dependent care arrangements are barriers to willing donors initiating evaluation. …”
Get full text

Silencing of RpATG8 impairs the biogenesis of maternal autophagosomes in vitellogenic oocytes, but does not interrupt follicular atresia in the insect vector Rhodnius prolixus. by Jéssica Pereira, Calebe Diogo, Ariene Fonseca, Larissa Bomfim, Pedro Cardoso, Anna Santos, Uilla Dittz, Kildare Miranda, Wanderley de Souza, Adriana Gioda, Enrique R D Calderon, Luciana Araripe, Rafaela Bruno, Isabela Ramos

“…Nevertheless, regarding major macromolecule degradation and adaptations to the fitness costs imposed by triggering an immune response, we found that autophagic organelles are not essential for follicle atresia in R. prolixus.…”
Get full text

Addressing SARS-CoV-2 evolution: neutralization of emerging variants of concern by the AVX/COVID-12 ‘Patria’ vaccine based on HexaPro-S ancestral Wuhan spike or its updated BA.2.75... by Gregorio Carballo-Uicab, Gregorio Carballo-Uicab, Gregorio Carballo-Uicab, Gabriela Mellado-Sánchez, Gabriela Mellado-Sánchez, Edith González-González, Edith González-González, Juana Salinas-Trujano, Juana Salinas-Trujano, Ivette Mendoza-Salazar, Ivette Mendoza-Salazar, Ivette Mendoza-Salazar, Karina López-Olvera, Karina López-Olvera, Keyla M. Gómez-Castellano, Keyla M. Gómez-Castellano, Ma. Isabel Salazar, Jesús M. Torres-Flores, Héctor Elías Chagoya-Cortés, Georgina Paz-De la Rosa, Ignacio Mena, Oscar Rojas-Martínez, Jesús Horacio Lara-Puente, Gustavo Javier Peralta-Sánchez, David Sarfati-Mizrahi, Alejandro Torres-Flores, Alejandro Torres-Flores, Weina Sun, Florian Krammer, Florian Krammer, Florian Krammer, Florian Krammer, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Peter Palese, Constantino López-Macías, Bernardo Lozano-Dubernard, Sonia M. Pérez-Tapia, Sonia M. Pérez-Tapia, Sonia M. Pérez-Tapia, Juan C. Almagro, Juan C. Almagro, Juan C. Almagro

“…In low- and middle-income countries (LMICs), vaccine access is hindered by high costs and inequitable distribution. To tackle these issues, Mexico developed the AVX/COVID-12 (V-Wu) vaccine, a recombinant Newcastle disease virus (NDV)-based platform expressing a stabilized ancestral Wuhan spike protein (HexaPro-S). …”
Get full text