Age and sex specific thresholds for risk stratification of cardiovascular disease and clinical decision making: prospective open cohort study by Matthew Sperrin, Angela M Wood, Lois Kim, Zhe Xu, Emanuele Di Angelantonio, Stephen Kaptoge, Juliet Usher-Smith, Matthew Arnold, Lisa Pennells, Ryan Chung

“…Such gains should be weighed against the costs of treating more younger people with statins for longer.…”
Get full text

Comparative clinical characteristics among different age group of adult COVID‐19 patients: A multicenter study by Wei Cheng †, Yating Peng †, Aiyuan Zhou, Ling Lin, Xin Liao, Dingding Deng, Peng Huang, Wenlong Liu, Mingyan Jiang, Xudong Xiang, Qingcui Shuang, Shan Cai, Ping Chen, Xucai Liao

“…Abstract Background Coronavirus disease (COVID‐19) is a global infectious disease with a large burden of illness and high health care costs. This study aimed to compare clinical features among adult COVID‐19 patients in different age groups. …”
Get full text

A new gridded offshore wind profile product for US coasts using machine learning and satellite observations by J. Frech, J. Frech, K. Saha, K. Saha, P. D. Lavin, P. D. Lavin, H.-M. Zhang, J. Reagan, B. Fung

“…In situ wind profiles have sparse geospatial coverage and are costly to obtain en masse, whereas satellite-derived 10 m wind speeds have vast coverage at high resolution. …”
Get full text

Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

“…Blinded independent central review is usually used as a supplemental or monitor to local assessment but is costly. The aim of this study is to investigate whether systematic bias existed in RCTs by comparing the treatment effects of efficacy endpoints between central and local assessments.Design Literature review, pooling analysis and correlation analysis.Data sources PubMed, from 1 January 2010 to 30 June 2017.Eligibility criteria for selecting studies Eligible articles are phase III RCTs comparing anticancer agents for advanced solid tumours. …”
Get full text

Use of intrauterine dextrose as an alternative to systemic antibiotics for treatment of clinical metritis in dairy cattle: a microbiome perspective by Jennine Lection, Jennine Lection, Jennine Lection, Emily Van Syoc, Emily Van Syoc, Emily Van Syoc, Asha Miles, Asha Miles, Julia Hamilton, Marcela Martinez, Santiago Bas, Justin Silverman, Justin Silverman, Justin Silverman, Adrian Barragan, Erika Ganda, Erika Ganda, Erika Ganda

“…IntroductionClinical metritis (CM) has significant costs to dairy producers. Current treatment strategy involves systemic antibiotics; however, there is increasing concern about judicious antibiotic use. …”
Get full text

Exploring the relationship between predicted negative energy balance and its biomarkers of Holstein cows in first-parity early lactation by Hongqing Hu, Sébastien Franceschini, Pauline Lemal, Clément Grelet, Yansen Chen, Hadi Atashi, Katrien Wijnrocx, Hélène Soyeurt, Nicolas Gengler

“…Direct measurement of NEB is impractical for large-scale use due to costs, necessitating reliance on indirect predictors such as milk mid-infrared (MIR) spectrometry-based predicted biomarkers. …”
Get full text

‘Making Moves’: Protocol for a hybrid effectiveness-implementation pre-post trial of a co-designed online physical activity program for childhood cancer survivors by Lauren Ha, Claire E. Wakefield, Jacqueline Jacovou, Karen Johnston, Donna Drew, Mark W. Donoghoe, David Mizrahi, Richard De Abreu Lourenco, Richard J. Cohn, Natalie Taylor, Christina Signorelli, Kiarn Roughley, Callum Joyner, Aj Wright

“…To judge the potential implementation success of Making Moves, we will collect implementation data (feasibility, acceptability, costs) for our process evaluation throughout the trial. …”
Get full text

Estimation and prediction on the economic burden of schistosomiasis in 25 endemic countries by Xian-Fa Chen, Qin Li, Robert Bergquist, Jin-Xin Zheng, Su-Ying Guo, Qiu-Feng Lan, Zheng-Ze He, Li-Juan Zhang, Chun-Li Cao, Jing Xu, Xiao-Nong Zhou

“…The HAM model considered: (i) the impact of schistosomiasis mortality and morbidity on labor supply; (ii) age and gender differences in education and work experience among schistosomiasis patients; and (iii) the impact of schistosomiasis treatment costs on physical capital accumulation. To be able to compare the purchasing power of different countries, we used international dollars (INT$), a hypothetical currency unit based on purchasing power parity. …”
Get full text

Effectiveness of a brief multicomponent intervention to improve physical activity level and functional capacity in fibromyalgia and chronic fatigue syndrome (Synchronize+) by Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Gemma González Serra, Gemma González Serra, Noèlia Carrasco-Querol, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Nerea Bueno Hernández, Pau Bestraten del Pino, Pau Bestraten del Pino, Marta Pastor Cazalla, Marta Pastor Cazalla, Rosa Caballol Angelats, Rosa Caballol Angelats, Pilar Montesó-Curto, Pilar Montesó-Curto, Pilar Montesó-Curto, Elisabet Castro Blanco, Macarena Pozo Ariza, José Fernández-Sáez, José Fernández-Sáez, M. Rosa Dalmau Llorca, M. Rosa Dalmau Llorca, Alessandra Queiroga Gonçalves, Alessandra Queiroga Gonçalves, Carina Aguilar Martín, Carina Aguilar Martín

“…Long-term follow-up will determine whether the changes are maintained over time and their impact on quality of life and healthcare costs.…”
Get full text

A double-layer model for improving the estimation of wheat canopy nitrogen content from unmanned aerial vehicle multispectral imagery by Zhen-qi LIAO, Yu-long DAI, Han WANG, Quirine M. KETTERINGS, Jun-sheng LU, Fu-cang ZHANG, Zhi-jun LI, Jun-liang FAN

“…However, the determination of CNC from field sampling data for leaf area index (LAI), canopy photosynthetic pigments (CPP; including chlorophyll a, chlorophyll b and carotenoids) and leaf nitrogen concentration (LNC) can be time-consuming and costly. Here we evaluated the use of high-precision unmanned aerial vehicle (UAV) multispectral imagery for estimating the LAI, CPP and CNC of winter wheat over the whole growth period. …”
Get full text

Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies by Yunqing Lin, Ziyun Xiao, Fangxiao Hu, Xiujuan Zheng, Chenyuan Zhang, Yao Wang, Yanhong Liu, Dehao Huang, Zhiqian Wang, Chengxiang Xia, Qitong Weng, Leqiang Zhang, Yaoqin Zhao, Hanmeng Qi, Yiyuan Shen, Yi Chen, Fan Zhang, Jiaxin Wu, Pengcheng Liu, Jiacheng Xu, Lijuan Liu, Yanping Zhu, Jingliao Zhang, Wenbin Qian, Aibin Liang, Xiaofan Zhu, Tongjie Wang, Mengyun Zhang, Jinyong Wang

“…Additionally, engineering CARs into human tissue-derived NK cells demonstrates heterogeneity, low transduction efficiency, and high manufacturing costs. Methods The human pluripotent stem cells (hPSCs) were genetically modified by knocking out the CD7 gene and introducing the CD7 CAR expression cassette to generate CD7 KO-CD7 CAR-hPSCs. …”
Get full text

Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms by Aleksandr M. Reznik, Olga A. Karpenko, Elena A. Shumakova, Aleksandr V. Mudrak, Andrey V. Sokolov, Svetlana V. Nazimova, Alina M. Saifulina, Anton M. Eliseenko, Tatjana K. Matvievskaya, Angelina N. Khannanova, Vladimir I. Revenko, Dmitriy V. Scherbakov, Yuriy L. Martynyuk, Aleksandr L. Arbuzov, Oleg A. Yacenko, Polina N. Alekseeva, Aleksandr B. Berdalin, Larisa A. Burygina

“…Studies have shown that the correct selection of target groups for such therapy can reduce the frequency of relapses requiring hospitalization, lower the costs of inpatient care, and shift the focus of therapy from multiple drug administrations to psychosocial work. …”
Get full text

Bacteriostatic Activity and Resistance Mechanism of <i>Artemisia annua</i> Extract Against <i>Ralstonia solanacearum</i> in Pepper by Tiantian Du, Weiping Zhu, Chenning Zhang, Xiaomin Liang, Yinghua Shu, Jingyun Zhou, Mengyu Zhang, Yuxuan He, Jincai Tu, Yuanjiao Feng

“…Considering the development costs, the application of <i>A. annua</i> extract at a concentration of 0.75 g·mL⁻¹ demonstrates great potential for green control measures against bacterial wilt in peppers.…”
Get full text

Synthesis of Mixed Metal Nano-Oxides (MMNOs) for Cu (II) adsorption with remarkable removal efficiency: Isothermal, kinetics, and thermodynamics studies by Asmaa.M. Farid, Ahmed abdelkhalek, Ahmed A. Allam, Haifa E. Alfassam, Rehab Mahmoud, Fatma Mohamed

“…MMNOs possess distinctive properties, including a large surface area, enhanced stability, superior adsorption capabilities, low production costs, and straightforward separation processes. …”
Get full text

The effect of Artificial Intelligence Health Education Accurately Linking System on childhood asthma: study protocol for a pilot randomized controlled trial by Huan-Fang Wang, Yun-Hua Li, Qiaoling Zhang, Lihong Han, Lirong Wang, Lifang Zhang, Xue Bai, Mingyue Cheng, Ting Zhang, Fang Zhao, Hui Li, Xiao-Yun Wang

“…Based on it, we have designed an AI Health Education Accurately Linkage System (AI-HEALS) to explore whether AI-driven interventions can improve self-management capabilities of families with asthmatic children, thereby helping them control the disease and reduce medical costs.MethodsThis research is a pilot single-blind randomized controlled trial (RCT) intended to gauge the efficacy of the AI-HEALS intervention delivered via the WeChat platform in enhancing the self-management abilities of families with asthmatic children. …”
Get full text

Nephrometry Scores Based on Three-dimensional Virtual Models Improve the Accuracy of Predicting Postoperative Complications After Robotic Partial Nephrectomy: Results from a Collab... by Daniele Amparore, Federico Piramide, Paolo Verri, Enrico Checcucci, Alberto Piana, Giuseppe Basile, Alessandro Larcher, Andrea Gallioli, Angelo Territo, Josep Maria Gaya, Pietro Piazza, Stefano Puliatti, Antonio Andrea Grosso, Andrea Mari, Riccardo Campi, Laura Zuluaga, Ucpinar Burak, Badani Ketan, Sergio Serni, Umberto Capitanio, Francesco Montorsi, Alexandre Mottrie, Cristian Fiori, Andrea Minervini, Peter Wiklund, Alberto Breda, Francesco Porpiglia

“…Limitations include the risk of interobserver variability in evaluating nephrometry scores and categories, production costs for the 3DVMs, and the experience of the surgeons involved, with potential impacts on diffusion of this technology. …”
Get full text

Enhancing Sustainable Manufacturing in Industry 4.0: A Zero-Defect Approach Leveraging Effective Dynamic Quality Factors by Rouhollah Khakpour, Ahmad Ebrahimi, Seyed Mohammad Seyed Hosseini

“…One of the important factors that affects TBL sustainability in manufacturing firms is defect (<a href="#_ENREF_4">Goyal, Agrawal, &amp; Saha, 2019</a>), where the issues such as scrap generation (<a href="#_ENREF_11">Lindstr&ouml;m et al., 2019</a>), costs of consumption/waste of resources (<a href="#_ENREF_5">Grobler-Dębska, Kucharska, &amp; Baranowski, 2022</a>), and customer satisfaction level (<a href="#_ENREF_16">Mourtzis, Angelopoulos, &amp; Panopoulos, 2021</a>) are examples of sustainability criteria which are affected by defects. …”
Get full text

Clinical Prediction of Secondary Bloodstream Infections in Patients with Cerebral Infarction: A Nomogram-Driven Risk Assessment Model Based on LASSO Regression by Zhang L, Li X, Cai D, Mei C, Lu L

“…The model’s performance was validated through the area under the Receiver Operating Characteristic curve (AUC), calibration curves, and decision curve analysis (DCA).Results: Patients with BSI had significantly prolonged hospital stays (median of 17 days versus 11 days, p&lt; 0.001), higher costs (median of 34,859 yuan compared to 16,921 yuan, p&lt; 0.001), and increased adverse outcomes (34.4% versus 1.6%, p&lt; 0.001). …”
Get full text

Impact of In-Person and Mobile Exercise Coaching on Psychosocial Factors Affecting Exercise Adherence in Inactive Women With Obesity: 20-Week Randomized Controlled Trial by Christina Gjestvang, John Magne Kalhovde, Elene Mauseth Tangen, Hege Clemm, Lene Annette Hagen Haakstad

“…Thus, integrating web-based coaching could be a more economically sustainable option, offering both flexibility and reduced costs compared with in-person coaching only. Yet, research is needed to assess the effect of hybrid models in improving psychosocial factors among women with obesity. …”
Get full text

Integrating hepatitis C testing and treatment into routine HIV care in Cameroon is feasible by Mathurin Pierre Kowo, Liza Coyer, Victor Sini, Carole Assontsa Kafack, Gabriella Yelheen Metomo, Guy S. Wafeu, Richard Njouom, Alexander Boers, Roel Coutinho, Oudou Njoya, Charles Kouanfack, the DHEPC project team

“…Yet, HCV prevalence among people with HIV in Cameroon remains unknown, with HCV diagnosis and treatment largely inaccessible due to care centralization by specialists with high out‐of‐pocket costs. Integration of HCV services into routine HIV care by general practitioners could improve diagnosis and treatment coverage. …”
Get full text