Applications of augmented reality in cardiology till 2024: a comprehensive review of innovations and clinical impacts by Ibthisam Ismail Sharieff, Diviya Bharathi Ravikumar, Shashvat Joshi, Barath Prashanth Sivasubramanian, Rajat Gupta, Yash Garg, Umabalan Thirupathy, Ragavendar Saravanabavanandan, Siva Naga Yarrarapu, Vikramaditya R. Samala Venkata

“…However, widespread clinical adoption of AugR in many healthcare institutions is limited by technical challenges and high costs related to specialized hardware, software, and maintenance.ConclusionAugR holds great promise in transforming cardiac care, but its clinical integration depends on rigorous trials to validate its effectiveness. …”
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Biomarkers of Response to Internet-Based Psychological Interventions: Systematic Review by Giulia Gotti, Chiara Gabelli, Sophia Russotto, Fabio Madeddu, Philippe Courtet, Jorge Lopez-Castroman, Patrizia Zeppegno, Carla Maria Gramaglia, Raffaella Calati

“… BackgroundInternet-based psychological interventions provide accessible care to a wide range of users, overcoming some obstacles—such as distance, costs, and safety—that might discourage seeking help for mental issues. …”
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Parenthood stressfulness and intensity in the students’ views by I. V. Tikhonova, Yu. V. Misiyuk, U. Yu. Sevastyanova

“…Students oriented on having many children demonstrate a balanced view on parenthood stressfulness in terms of resources and costs. Students, focused on having few children, have an idea of moderate parental stressfulness. …”
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TRIM study protocol - a prospective randomized multicenter Trial to assess the Role of Imaging during follow-up after radical surgery of stage IIB-C and III cutaneous malignant Mel... by Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson, Ulf Dyrke, Dimitrios Papantoniou, Anders Sundin, Gustav J. Ullenhag

“…However, imaging has drawbacks, including resources required (costs, personnel, equipment) and the radiation exposure. …”
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Telemonitoring for Chronic Heart Failure: Narrative Review of the 20-Year Journey From Concept to Standard Care in Germany by Sebastian Spethmann, Gerhard Hindricks, Kerstin Koehler, Stefan Stoerk, Christiane E Angermann, Michael Böhm, Birgit Assmus, Sebastian Winkler, Martin Möckel, Mirja Mittermaier, Monika Lelgemann, Daniel Reuter, Ralph Bosch, Alexander Albrecht, Stephan von Haehling, Thomas M Helms, Stefan Sack, Tarek Bekfani, Jan Wolfgang Gröschel, Magdalena Koehler, Christoph Melzer, Jan Wintrich, Bettina Zippel-Schultz, Georg Ertl, Claus Vogelmeier, Nikolaos Dagres, Jasmin Zernikow, Friedrich Koehler

“…The concept of telemedicine for CHF was first introduced in the late 1990s, and since 2010, studies have demonstrated its potential to improve patient outcomes and reduce health care costs. Over the following decade, technological advancements and changes in health care policy led to the development of more sophisticated telemedicine solutions for CHF, including remote patient management through invasive or noninvasive telemonitoring devices, mobile apps, and virtual consultations. …”
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Cas9-expressing cattle using the PiggyBac transposon all-in-one system by Dong-Hyeok Kwon, Gyeong-Min Gim, Soo-Young Yum, Kyeong-Hyeon Eom, Song-Jeon Lee, Sang-Eun Han, Hee-Soo Kim, Hyeong-Jong Kim, Woo-Sung Lee, Woo-Jae Choi, Ji-Hyun Lee, Do-Yoon Kim, Dae-Jin Jung, Dae-Hyun Kim, Jun-Koo Yi, Byeong-Ho Moon, Won-You Lee, Goo Jang

“…However, genetic engineering in cattle has lagged due to long gestation periods, single embryo pregnancies, and high rearing costs. Additionally, the slow validation of germline transmission and the absence of germline-competent embryonic stem cells hinder progress. …”
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The effect of a systematic multi-dimensional assessment in severe uncontrolled asthma: a literature review and protocol for an investigator-initiated, open-label, randomized-contro... by L. Bult, G. J. Braunstahl, J. G. J. V. Aerts, D. Bänffer, J. S. J. A. van Campen, M. S. van Daalen, Y. van Dooren, U. Flanders, E. S. Geurts, P. P. Hekking, R. Heller - Baan, M. J. A. Jans, J. H. Kappen, R. C. A. Mies, B. Oppedijk, M. de la Roij - Hartmans, S. Van der Sar - Van der Brugge, Y. Türk, E. Vis, R. Wolters, E. C. Vasbinder, J. C. C. M. in ‘t Veen

“…These patients are eligible for treatment with biologicals, which provide significant benefits but are costly and need precise indication. However, identifying all individual treatable traits before diagnosing severe asthma is challenging. …”
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Hospital frailty risk score in predicting outcomes after simultaneous colon and liver resection for colorectal cancer liver metastasis in older adults: Evidence from the Nationwide... by Haohao Huang, Weidong Jin, Huiling Sun, Bo Diao, Ping Wang, Jiankun Jia, Dandan Ma, Yi Zhang

“…Frailty was significantly associated with increased risks of in-hospital mortality (adjusted odds ratio [aOR] = 3.65, 95% confidence interval [CI]: 2.52, 5.28), non-routine discharge (aOR = 2.44, 95% CI: 2.08, 2.87), prolonged LOS (aOR = 3.07, 95% CI: 2.60, 3.61), overall complications (aOR = 3.47, 95% CI: 3.03, 3.97), sepsis (aOR = 13.73, 95% CI: 9.76, 19.31), respiratory failure (aOR = 4.99, 95% CI: 3.80, 6.57), acute kidney injury (AKI) (aOR = 6.42, 95% CI: 4.83, 8.52), and acute liver failure (aOR = 2.10, 95% CI: 1.38, 3.21), as well as 32.69 thousand USD higher total hospital costs (95% CI: 28.41, 36.97) than no frailty. Incorporating frailty with traditional demographic and clinical risk factors improved in-hospital mortality prediction (area under ROC curve [AUC]: 0.765 to 0.799). …”
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Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context by Germán Peñalva, Rafael Cantón, María Teresa Pérez-Rodríguez, Juan José González-López, Jesús Rodríguez-Baño, Ester del Barrio-Tofiño, Cristina Kirkegaard-Biosca, Isabel Sánchez-Romero, Andrea Gutiérrez-Villanueva, Teresa Marrodán-Ciordia, José Manuel Guerra-Laso, Cristóbal del Rosario-Quintana, Laura Suárez-Hormiga, Jordi Cámara, Mireia Puig-Asensio, Eva Heredero, María Antonia Sepúlveda, Juan Carlos Rodríguez-Díaz, Esperanza Merino, Emilia Cercenado, Sofia de la Villa, María Siller, Francisco Arnaiz, Cristina Seral, José Antonio Lepe, José Miguel Cisneros, José Ramón Paño-Pardo

“…Funding: The management costs of this study were funded by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). …”
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Virtual Intervention for Vertebral frActures (VIVA): protocol for a feasibility study of a multicentre randomized controlled trial by Ada Sevinc, Alexandra Papaioannou, Suzanne N. Morin, Jennifer A. Watt, Raheem B. Kherani, Sheila Brien, Larry Funnell, Lehana Thabane, Lauren A. Beaupre, Jenna C. Gibbs, Heather Keller, Caitlin McArthur, Matteo Ponzano, Sonia Singh, Sharon Straus, Jenny Thain, Zachary J. Weston, Timothy H. Wideman, Christopher D. Witiw, Lora Giangregorio

“…The secondary outcomes include costs relative to benefit, effects on health-related outcomes (e.g. 30-s chair stand, Brief Pain Inventory, Quality of Life Questionnaire of the European Foundation for Osteoporosis-41, SCREEN-14), and outcomes related to implementation (e.g. participant and provider experience using semi-structured interviews, fidelity, number of screened and enrolled participants by referral source, fracture verification process). …”
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Can theory-driven implementation interventions help clinician champions promote opioid stewardship after childbirth? Protocol for a pragmatic implementation study by Michelle H. Moniz, Michelle H. Moniz, Michelle H. Moniz, Amy M. Kilbourne, Amy M. Kilbourne, Alex F. Peahl, Alex F. Peahl, Alex F. Peahl, Jennifer F. Waljee, Jennifer F. Waljee, Jennifer F. Waljee, Shelytia Cocroft, Carey Simpson, Carey Simpson, Lisa Kane Low, Lisa Kane Low, Lisa Kane Low, Mark C. Bicket, Mark C. Bicket, Mark C. Bicket, Michael J. Englesbe, Michael J. Englesbe, Michael J. Englesbe, Molly J. Stout, Molly J. Stout, Vidhya Gunaseelan, Vidhya Gunaseelan, Althea Bourdeau, Althea Bourdeau, May Hu, Carrie Miller, Carrie Miller, Shawna N. Smith, Shawna N. Smith, Shawna N. Smith

“…., acceptability, feasibility, costs, needed REP and E-REP adaptations) using clinician and patient surveys and qualitative methods (ClinicalTrials.gov identifier: NCT06285123).DiscussionFindings will inform refinements to the REP and E-REP interventions and add to the literature on the effectiveness of facilitation to promote uptake of evidence-based clinical practices in maternity care.…”
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Improving the accuracy of Respiratory Syncytial Virus (RSV) incidence estimates among hospitalised adults in Bristol, UK by Katie Lihou, Robert Challen, Anastasia Chatzilena, George Qian, Glenda Oben, Jade King, Serena McGuinness, Begonia Morales-Aza, Kaltun Duale, Ainhoa Rodriguez Pereira, William Healy, Jennifer Oliver, Nick Maskell, Adam Finn, Leon Danon, Catherine Hyams, Avon C. A. P. Research Group

“…The implementation of effective RSV vaccines could reduce morbidity, mortality and associated costs of disease. Adult RSV burden accuracy is improved by adjustment for test characteristics due to the impact of imperfect specificity when positivity-rates are low, and this is particularly important for out-of-season estimates. …”
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Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair by Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer

“…Currently, the only FDA cell-based therapy for articular cartilage injury is Autologous Chondrocyte Implantation (ACI); however, this procedure is costly, time-intensive, and requires multiple treatments. …”
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A retrospective multi-site examination of chronic kidney disease using longitudinal laboratory results and metadata to identify clinical and financial risk by Mark Fung, Aya Haghamad, Elizabeth Montgomery, Kathleen Swanson, Myra L. Wilkerson, Kimon Stathakos, Richard VanNess, Sarah A. Nowak, Clayton Wilburn, Haluk Kavus, Mohammed Amer Swid, Nkemakonam Okoye, Yonah C. Ziemba, Girish Ramrattan, Jonathan Macy, John McConnell, Mary Jane Lewis, Beth Bailey, Khosrow Shotorbani, James M. Crawford

“…The imputed lost reimbursement under risk-adjusted payment systems for under-documentation of CKD in this subset of patients was $2.85 M for the three institutions combined, representing lost opportunity for both identification and proactive clinical management of these patients, and financial recovery for the costs of providing that care. Conclusions Clinical laboratories can provide value beyond routine diagnostics, helping to close gaps in care for identification and management of CKD, stratifying subgroups of patients to identify risk, and capturing missed reimbursement through risk adjustment factors.…”
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Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers by Stephen M. Rao, Alexandria L. Chorba, M. J. Helppi, Alina Tuladhar, Amanda L. Penko, Sarah Holley, Brandon Nehls, Sabrina Paulino, Matthew C. Streicher, Audrey Zhu, Kellie Bruening, Sally Durgerian, Katherine Koenig, Mark Lowe, Wanyong Shin, Stephen E. Jones, Rachel Galioto, Jagan A. Pillai, Lynn M. Bekris, James B. Leverenz, Anson B. Rosenfeldt, Tamanna Singh, Gerald J. Beck, J. Carson Smith, Jay Alberts, Jay Alberts

“…Secondary outcomes include comprehensive neurocognitive and physical function test batteries, MRI scans including structural and functional connectivity measures, and blood-based biomarkers.HypothesesOver an 18-month interval, physically inactive ε4 carriers who engage in high-intensity aerobic exercise will demonstrate less cognitive decline and hippocampal atrophy than physically inactive ε4 carriers who did not participate in a formal exercise program.ConclusionSuccessful demonstration of a scalable, home-based, high-intensity aerobic exercise intervention in altering the trajectory of AD pathophysiology and its effects on cognitive functioning will transform AD treatment, improve patient outcomes and quality of life, and reduce healthcare costs.…”
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An explainable unsupervised learning approach for anomaly detection on corneal in vivo confocal microscopy images by Ningning Tang, Qi Chen, Yunyu Meng, Daizai Lei, Li Jiang, Yikun Qin, Xiaojia Huang, Fen Tang, Shanshan Huang, Qianqian Lan, Qi Chen, Lijie Huang, Rushi Lan, Xipeng Pan, Huadeng Wang, Fan Xu, Wenjing He

“…The proposed method enhances screening efficiency, reduces annotation costs, and holds great potential for scalable intelligent diagnosis of corneal diseases.…”
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Preventing adverse events during paediatric cancer treatment: protocol for a multi-site hybrid randomised controlled trial of catheter lock solutions (the CLOCK trial) by Paul Monagle, Andrew Wood, Robert Ware, Adam Irwin, Joshua Byrnes, Natalie Bradford, Susan Moloney, Michelle Martin, Tricia Kleidon, Andrew Moore, Roni Cole, Fiona Newall, Victoria Gibson, Samantha Keogh, David Eisenstat, Amanda Ullman, Mari Takashima, Elouise Comber, Eloise Borello, Nicole Henson, Philippa Howard, Karen McCleary, Jordana McLean, Michelle Noyes, Gemma Rowan, Amanda St John, Joshua Wolf

“…Secondary outcomes will include CABSI, CVAD-associated-thrombosis, CVAD failure, incidental asymptomatic CVAD-associated-thrombosis, other adverse events, health-related quality of life, healthcare costs and mortality. To achieve 90% power (alpha=0.05) for the primary outcome, data from 720 recruitments are required. …”
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The SmartNTx-study: a prospective, randomized controlled trial to investigate additional interventional telemedical management versus standard aftercare in kidney transplant recipi... by Mario Schiffer, Lars Pape, Julia K. Wolff, Julia K. Wolff, Raoul Gertges, Vanessa Visconti, Karen Reichert, Anja Pfau, Anne Dieterle, Katja Sauerstein, Andreas Kribben, Kristina Boss, Sinem Karaterzi, Felix Nensa, Philipp Winneckens, Mario Cypko, Mario Cypko, Wiebke Duettmann, Bianca Zukunft, Eva Schrezenmeier, Marcel G. Naik, Fabian Halleck, Roland Roller, Sebastian Möller, Sebastian Möller, Oliver Amft, Oliver Amft, Klemens Budde

“…In the interventional arm, the iBox score will be used to better detect patients at risk for early graft failure and drug-drug interactions will be regularly checked with certified software.DiscussionThe study aims to prolong patient and graft survival through additional telemedical services in order to reduce avoidable hospitalizations, improve treatment of co-morbidities, and improve adherence through patient empowerment, which should result in lower health care costs, and better quality of life of patients after kidney transplantation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT05897047.…”
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Critical care nurses’ knowledge regarding prevention of central venous catheter-related infection in Saudi Arabia: A cross-sectional study by Bassam Shyhan Alshammari, Salman Hamdan Alsaqri, Sameer A. Alkubati, Jordan H. Llego, Ahmad K. Al-Sadi, Aziza Z. Ali, Wessam A. Elsayed, Anas Mahmoud Balawi, Shaimaa Mohamed Nageeb, Laila A. Hamed

“…Background: Central venous catheter-related infections (CVC-RIs) are a significant concern in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare costs. Nurses play a crucial role in preventing these infections through proper catheter care, adherence to aseptic techniques, and early detection of complications. …”
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Post-harvest processing methods have critical roles on the contents of active metabolites and pharmacological effects of Astragali Radix by Xiaoyan Zhang, Shengnan Jiang, Tingting Sun, Wenbing Zhi, Kairu Ding, Ziyao Qiao, Hong Zhang, Hong Zhang, Ye Li, Yang Liu, Yang Liu

“…The fresh processing method effectively prevents the loss and degradation of metabolites, common in traditional drying and softening processes, while also reducing production costs. Astragali Radix (AR), a leguminous botanical drug, is widely utilized in clinical practice and functional foods. …”
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