TransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis by Haitao Li, Haitao Li, Yuanyuan Chu, Yuanyuan Chu, Liyuan Jiang, Liyuan Jiang, Lei Li, Lei Li, GuoDong Lv, Yuansheng Liu, Chunhou Zheng, Chunhou Zheng, Yansen Su, Yansen Su

“…Traditional methods of identifying drug combinations via biological experimentation is costly and time-consuming. Besides, the scarcity of existing drug combinations for echinococcosis hinders the development of computational methods. …”
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Supporting Access to HIV Pre-Exposure Prophylaxis in a Shifting Financial and Insurance Landscape by Connor Eichenwald, MD, MPH, Robin T. Higashi, PhD, Timothy P. Hogan, PhD, Jacqueline Naeem, MD, Julia L. Marcus, PhD, MPH, Douglas Krakower, MD, Ank E. Nijhawan, MD, MPH, MSCS

“…Community-based organizations reported difficulty in sustainably providing pre-exposure prophylaxis to uninsured clients because of fewer funds to cover unreimbursed costs for pre-exposure prophylaxis care. Many community-based organizations have diverted resources away from client outreach for pre-exposure prophylaxis and toward helping clients to enroll in commercial insurance plans that cover pre-exposure prophylaxis. …”
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Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli by Jing Sun, Yiming Liu, Jiashen Chang, Ying Liu, Luqi Li, Ran Jiang, Yihan Luo, Shuo Yang, Mei Yang, Xinglong Wang, Juan Wang, Xi Xia, Kangkang Guo, Zengqi Yang, Dongyang Ye

“…While developing novel antibiotics is an effective approach to eradicate resistance genes/bacteria, it entails considerable costs and a lengthy timeframe. This study discovered that exogenous adenosine can effectively restore the sensitivity of tet(X3)-positive Escherichia coli to tigecycline through metabolic reprogramming based on a non-targeted metabolomics strategy. …”
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High-throughput mesoscopic optical imaging data processing and parsing using differential-guided filtered neural networks by Hong Zhang, Zhikang Lu, Peicong Gong, Shilong Zhang, Xiaoquan Yang, Xiangning Li, Zhao Feng, Anan Li, Chi Xiao

“…However, obtaining a batch of raw array mouse brain data at a resolution of $$0.65 \times 0.65 \times 3 \,\upmu \hbox {m}^{3}$$ 0.65 × 0.65 × 3 μ m 3 can reach 220TB, and the cropping of the outer contour areas in the disjointed processing still relies on manual visual observation, which consumes substantial computational resources and labor costs. In this paper, we design an efficient deep differential guided filtering module (DDGF) by fusing multi-scale iterative differential guided filtering with deep learning, which effectively refines image details while mitigating background noise. …”
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Identification of sweetpotato virus disease-infected leaves from field images using deep learning by Ziyu Ding, Fanguo Zeng, Haifeng Li, Jianyu Zheng, Junzhi Chen, Biao Chen, Wenshan Zhong, Xuantian Li, Zhangying Wang, Lifei Huang, Xuejun Yue, Xuejun Yue

“…Current diagnostic methods are either costly or labor-intensive, limiting both efficiency and scalability.MethodsThe segmentation algorithm proposed in this study can rapidly and accurately identify SPVD lesions from field-captured photos of sweetpotato leaves. …”
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Deep learning-assisted diagnosis of liver tumors using non-contrast magnetic resonance imaging: a multicenter study by Shihui Zhen, Shihui Zhen, Shihui Zhen, Peng Zhang, Hanxiao Huang, Zhiyu Jiang, Yankai Jiang, Yankai Jiang, Jihong Sun, Liqing Zhang, Mei Ruan, Qingqing Chen, Yujun Wang, Yubo Tao, Weizhi Luo, Ming Cheng, Zhetuo Qi, Wei Lu, Hai Lin, Xiujun Cai

“…It provides a potential alternative for screening liver tumors with the advantage of reducing costs, scanning time and contrast-agents risks. It is more suitable for benign tumours follow-up, surveillance of HCC and liver metastasis that need periodic repetitive examinations.…”
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A deep learning model based on chest CT to predict benign and malignant breast masses and axillary lymph node metastasis by Jingxiang Sun, Xiaoming Xi, Mengying Wang, Menghan Liu, Xiaodong Zhang, Haiyan Qiu, Youxin Zhang, Taian Fu, Yanan Du, Wanqing Ren, Dawei Wang, Guang Zhang

“…This study aims to develop a deep learning model based on chest CT imaging to improve the preliminary assessment of breast lesions, potentially reducing the need for costly follow-up procedures such as magnetic resonance imaging (MRI) or positron emission tomography-CT and alleviating the financial and emotional burden on patients. …”
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Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis by Noppachai Siranart, Pannathorn Nakaphan, Thanathip Suenghataiphorn, Panisara Fangsaard, Tanattida Phanthong, Patavee Pajareya, Somkiat Phutinart, Pawaris Tirakunwichcha, Suwit Paksin, Pornnicha Sowalertrat, Sakkarin Chirapongsathorn, Kittithat Tantitanawat

“…Conclusion Gastroparesis is associated with SLE, contributing to longer hospitalizations, higher costs, and increased need for invasive interventions. …”
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Protocol for implementation of intraoperative adverse event recording during WHO checklist sign-out by Guy Haller, Lauren Clack, Christian Schindler, Luzius A Steiner, Salome Dell-Kuster, Dieter Hahnloser, Jörn-Markus Gass, Christoph S Burkhart, Andreas P Vogt, Katrin Burri-Winkler, Anne C Auderset, Valentin Neuhaus, Giorgio Prouse, Judith Winkens, Amanda Van Vegten, Zuzanna Kita, Monika Finsterwald, Nico Streit, Lisa M Willms

“…Introduction & aim Intraoperative adverse events (iAEs) increase postoperative complications, which are devastating to patients and costly to healthcare systems. To optimise patient outcomes, the WHO Surgical Safety Checklist (WHO SSC) was introduced in 2008, but adherence, especially to its third part (sign-out), is low, and iAEs are currently not routinely assessed. …”
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Preventing Proximal Femur Pathologic Fractures Improves Outcomes in Patients with Metastatic Bone Disease: A Clinical Study Based on a Single Center Experience by Joana Páscoa Pinheiro, Mariana Nabais, André Spranger, Paulo Almeida, José Portela, Joaquim Soares do Brito

“…This study aimed to evaluate oncologic outcomes, surgical complications, and associated healthcare costs in surgically treated patients with proximal femur bone metastases. …”
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Sustainable lipid production from Chlorella vulgaris USU1 strain using packed absorption column-derived effluent as carbon source for biomass generation by Bambang Trisakti, Rivaldi Sidabutar, Irvan Irvan, Erman Munir, Maya Sarah, Farida Hanum, Mhd. Rivaldi Syahputra, Michael Michael, Vanness Vanness, Gloria Clarita Sinamo, Renata Ambarita, Mawardyah Sidauruk, Selvia Geraldine Silaban, Yasmin Nabilah, Hiroyuki Daimon, Mohd. Sobri Takriff, Peer Mohamed Abdul

“…Economic analysis established favorable metrics with capital costs of IDR 4505/L, operating expenses of IDR 1155/L, and profit gained of IDR 8991/L, yielding a net profit of IDR 3331/L. …”
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High-adhesive and conductive AMPSs-TA-Fe hydrogels via E-beam-assisted rapid one-pot synthesis for strain sensor by Eunhye Kim, Heewoong Park, Ngo Thi Hang, Daewoo Kim, Seunghan Shin, Kiok Kwon

“…However, TA's radical scavenging effect complicates polymerization by UV or thermal curing, leading prior studies to adopt time-intensive, costly approaches, such as post-polymerization soaking or pre-formed polymers. …”
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Current status of generalized pustular psoriasis: Findings from a multicenter hospital-based survey of 127 Chinese patients by Haimeng Wang, Jiaming Xu, Xiaoling Yu, Siyu Hao, Xueqin Chen, Bin Peng, Xiaona Li, Ping Wang, Chaoyang Miao, Jinzhu Guo, Qingjie Hu, Zhonglan Su, Sheng Wang, Chen Yu, Qingmiao Sun, Minkuo Zhang, Bin Yang, Yuzhen Li, Zhiqiang Song, Songmei Geng, Aijun Chen, Zigang Xu, Chunlei Zhang, Qianjin Lu, Yan Lu, Xian Jiang, Gang Wang, Hong Fang, Qing Sun, Jie Liu, Hongzhong Jin, Lishao Guo

“…This score showed significant differences between patients with and without systemic symptoms; it demonstrated correlations with both depression and anxiety scores. Treatment costs caused financial hardship in 55.9% of patients, underscoring the burden associated with GPP. …”
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Mortality and its predictors among patients undergoing hemodialysis in Ethiopia: A systematic review and meta-analysis by Bekalu Mekonen Belay, Melese Kebede Hailu, Yeshiambaw Eshetie Ayenew, Mengistu Ewunetu, Tigabu Minuye Aytenew, Ayenew Genet Kebede, Belayneh Dessie Kassa, Addisu Assfaw Ayen, Yirgalem Abere

“…Background: Patients are forced to discontinue therapy due to unaffordable hemodialysis costs in low-income countries, which frequently results in death. …”
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Human resources and curricula content for early child development implementation: multicountry mixed methods evaluation by Karim Manji, Esther Goh, Kate M Milner, Rob Hughes, Maya Kohli-Lynch, Victoria Ponce Hardy, James Radner, Sonia Sharma, Joy E Lawn, Vanessa Cavallera, Raquel Bernal Salazar, Alexandra Brentani, Karlee L Silver, Sunil S Bhopal, Jena D Hamadani

“…Larger studies, which also examine impact, including high-quality process and costing evaluations with comparable data, are required to further inform decisions for implementation of RCEL projects at national and regional scales.…”
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Demonstration of Terabit/s LAN-WDM for the Evolution of B5G/6G Fronthaul Networks by Jiao Zhang, Qingsong Wang, Junhao Zhang, Xiang Liu, Bingchang Hua, Jian Chen, Zhigang Xin, Yuancheng Cai, Mingzheng Lei, Yucong Zou, Liang Tian, Guo Zhao, Meihua Bi, Min Zhu

“…IM/DD has more mature commercial deployment applications for short-reach applications with lower costs and simpler configurations compared with coherent solutions. …”
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Clinical factors associated with severe coronary stenosis in patients undergoing cardiac surgery by Rui Wang, Wei Gao, Xinyu Che, Ruopei Shen, Chunfeng Dai, Yan Xia, Ao Chen, Danbo Lu, Jiaqi Ma, Hungju Chen, Chenguang Li, Zhangwei Chen, Juying Qian, Junbo Ge

“…Although informative, CAG is costly and exposes patients to significant radiation. …”
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Fine-Mapping of Tomato <i>male sterile-24</i> Locus and Marker Development for <i>ms-24</i> and Its Alleles, <i>ms-10</i>, <i>ms-35</i>, and <i>ms-36</i> by Li Zhang, Mengxia Yang, Kai Wei, Wencai Yang, Shanshan Li, Xiaoxuan Wang, Yanmei Guo, Lei Liu, Can Zhu, Yongchen Du, Junming Li, Xin Li, Zejun Huang

“…Male sterility is an essential trait for minimizing costs and ensuring seed purity in the production of tomato hybrid seeds. …”
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Estimating double burden of malnutrition among rural and urban children in Amazonia using Bayesian latent models by Jesem Douglas Yamall Orellana, Luke Parry, Luke Parry, Francine Silva Dos Santos, Laísa Rodrigues Moreira, Patricia Carignano Torres, Antônio Alcirley da Silva Balieiro, Fernanda Rodrigues Fonseca, Paula Moraga, Erick Albacharro Chacón-Montalván

“…The DBM is associated with increased risks of non-communicable diseases, childbirth complications, and healthcare costs related to obesity in adulthood. However, evaluating low prevalence outcomes in relatively small populations is challenging using conventional frequentist statistics. …”
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State-of-the-art literature review of Recovery College evaluative studies between 2013-2024 by Catherine Briand, Catherine Briand, Catherine Vallée, Catherine Vallée, Francesca Luconi, Joanie Thériault, Joanie Thériault, Anick Sauvageau, Anick Sauvageau, Julie Bellemare, Julie Bellemare

“…Articles then moved on to outcomes evaluation (2015-2024) and service utilization and costs (2019-2024). Finally, articles focused on documenting an international scope of the RC and providing a status report and global multicenter comparisons (2019-2023).DiscussionThese groups of articles capture the scope and richness of the studies, but also the progression in study quality over the past 10 years. …”
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