Optimized Amino Acid-Enhanced Medium for Efficient L-Asparaginase II Production in <i>E. coli</i>: From Shake Flask to Bioreactor by Nicolás Lefin, Javiera Miranda, Iris Munhoz Costa, Alejandro Pedroso Reynaldo, Gisele Monteiro, Mauricio Zamorano, Adalberto Pessoa, Jorge G. Farias

“…Advances in recombinant protein production have improved yields and reduced costs, enabling large-scale production. However, optimizing culture conditions remains crucial for maximizing production. …”
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Overview of drugs approved by the FDA in 2022 by D. V. Kurkin, E. I. Morkovin, D. A. Bakulin, Yu. V. Gorbunova, Yu. A. Kolosov, M. A. Dzhavakhyan, I. E. Makarenko, R. V. Drai, A. V. Zaborovsky, O. V. Shatalova, A. V. Strygin, V. I. Petrov, A. P. Pleten, A. A. Prokopov, T. Yu. Tatarenko-Kozmina

“…The discovery and development of medications are among the most crucial scientific processes in healthcare. …”
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Plastics pollution: pathways, impacts, and regulatory challenges in marine environments by Malika Bel Hassen, Amel Bellaaj Zouari, Moufida Abdennadher, Jean-Claude Assaf, Mantoura Nakad, Rami Abboud, Yosra Khammeri, Mohamed Banni, Alberto Panzeri, Leonardo Gomes, Wael Hamd

“…Microplastics impair blue carbon ecosystems, reducing their carbon sequestration capacity and exacerbating the economic costs associated with climate regulation and coastal protection. …”
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A Review of Postoperative Complications in Colon Cancer Surgery: The Need for Patient-Centered Therapy by Adrian Silaghi, Dragos Serban, Corneliu Tudor, Bogdan Mihai Cristea, Laura Carina Tribus, Irina Shevchenko, Alexandru Florin Motofei, Crenguta Sorina Serboiu, Vlad Denis Constantin

“…Unfortunately, postoperative complications have been shown to negatively impact short-term patient outcomes, long-term oncological prognosis, and overall healthcare costs. The risk factors of postoperative complications are multiple, being linked to the patient’s general condition (lifestyle, comorbidities, etc.), the state of the neoplastic disease, as well as the drug and surgical treatments applied. …”
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Reducing oral corticosteroids in severe asthma (ROSA Project): a nationwide Portuguese consensus by Claudia Chaves Loureiro, Manuel Branco Ferreira, Jorge Ferreira, Ricardo Lima, João Marques, Anna Sokolova, Fernanda S. Tonin, Filipa Duarte Ramos

“…Monitoring patients’ comorbidities was rated as imperative by all experts.Conclusions : These results can guide an update on asthma management in Portugal and should be supplemented by studies on therapy access, patients’ adherence, and costs.…”
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Prediction of barite scale formation and inhibition in hydrocarbon reservoirs using AI modeling: Focus on different optimization algorithms by Ouafa Belkacem, Ahmed Rezrazi, Kamel Aizi, Lokmane Abdelouahed, Maamar Laidi, Abdelhafid Touil, Leila Cherifi, Salah Hanini

“…The ELM model emerged as the most precise (RMSE = 0.0005, R² = 0.999), closely followed by the SVR-PSO model (RMSE = 0.0008, R² = 0.999). …”
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Influence of Aging Conditions on the Dynamic Stiffness of EPDM and EVA Rail Pads by Isaac Rivas, Jose A. Sainz-Aja, Diego Ferreño, Isidro Carrascal, Jose Casado, Soraya Diego

“…Mechanical aging increases stiffness across all pads, with Pad C (EVA) exhibiting the most pronounced increase (27%). The effects of UV exposure vary by material, leading to a stiffness reduction of up to 11.5% in Pad B (EPDM), whereas Pad C (EVA) experiences a 9.5% increase under prolonged exposure. …”
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The way home: a scoping review of public health interventions to increase the utilization of home dialysis in chronic kidney disease patients by Natcha Yongphiphatwong, Yot Teerawattananon, Pitsinee Supapol, Denla Pandejpong, Tanainan Chuanchaiyakul, Jiratorn Sutawong, Naline Gandhi, Nutthawongse Kiatkrissada, Saudamini Vishwanath Dabak, Thunyarat Anothaisintawee

“…Conclusion Education and service provision enhancements may represent the most effective public health interventions for increasing initiation, utilization, and retention rates of HoD in dialysis-requiring patients. …”
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Healthcare-Associated <i>Clostridioides difficile</i> Infection: A Hospital-Based Retrospective Study in North Eastern Romania by Lidia Oana Stămăteanu, Ionela Larisa Miftode, Claudia Elena Pleşca, Mihnea Eudoxiu Hurmuzache, Doina Carmen Manciuc, Daniela Leca, Egidia Gabriela Miftode

“…<i>Clostridioides difficile</i> infection (CDI), the most common cause of nosocomial diarrhea, presents with a wide spectrum of clinical manifestations, ranging from mild diarrhea to severe, life-threatening conditions such as pseudomembranous colitis and toxic megacolon. …”
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Organising general practice for care homes: a multi-method study by Barbara Hanratty, Rachel Stocker, David Sinclair, Katie Brittain, Karen Spilsbury, Daniel Stow, Louise Robinson, Fiona E Matthews

“…Plain language summary Most people who live in care homes are older adults. …”
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Enhancing Quality Control: A Study on AI and Human Performance in Flip Chip Defect Detection by Wannisa Cheamsiri, Anuchit Jitpattanakul, Paisarn Muneesawang, Konlakorn Wongpatikaseree, Narit Hnoohom

“…The model serves as a valuable tool for failure analysis (FA) engineers working with Chip-on-Wafer (CoW) products by enhancing inspection precision and accuracy, save time and costs, reduce human error, and ensure reliability. …”
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Saffron (Crocus sativus L.): The golden spice — management, challenges, and opportunities for sustainable production in the United States by Bharat Sharma Acharya, Arash Ghalehgolabbehbahani, Said Hamido, Gladis Zinati, Arianna Bozzolo, Leigh Archer, Kristie Wendelberger, Saurav Das, Resham Thapa, Dinesh Panday

“…Nicknamed “red gold”, saffron is consistently one of the most expensive spices by weight on the global market. …”
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Microbial contamination of unsterile vs sterilized 3M™ Micropore™ tape on full-thickness skin graft donor wound: Clinical trial and evaluation by Graciella Novian Triana Wahjoe Pramono, Betha E. Riestiano, Hardisiswo Soedjana, Leonardus Widyatmoko, Sandy Sopandi

“…Sterile tapes in developing countries are harder to find and more costly. Whether unsterile tape is safe to use on fresh wounds is an ongoing debate. …”
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Usage of the mobile phone on agricultural farm enterprise development by women in rural Bangladesh by Md. Sadekur Rahman, Md. Enamul Haque, Md. Safiul Islam Afrad, Shaikh Shamim Hasan, Md. Abiar Rahman, Md. Rubayet Al Ferdous Noman

“…The mobile phone is one of the most accessible and transformative communication technologies globally and a staple in modern life. …”
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Preliminary results of colostrum quality and passive immunity transfer in calves under tropical conditions by A. E. Guerrero-Pincay, S. A. Guamán-Rivera, C. D. Guilcapi-Carrillo, A. D. Feijoo-Leon, L. A. Moreira-García, J. Llivi-Marcatoma, C. O. Guerra Flores, A. F. Inca Falconí, B. R. Vaca Barahona, V. F. Noboa Silva

“…Abstract Inadequate management of livestock practices causes low colostrum quality and failure in passive transfer of immunity in calves, which increases mortality and production costs for farmers. Therefore, a study has been conducted in order to determine the effectiveness of passive transfer of immunity in the province of Orellana, Amazonian Ecuador. …”
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Multi-View Data Augmentation to Improve Wound Segmentation on 3D Surface Model by Deep Learning by R. Niri, E. Gutierrez, H. Douzi, Y. Lucas, S. Treuillet, B. Castaneda, I. Hernandez

“…This view provides the most accurate segmentation and the real wound bed area even on non planar wounds. …”
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AI-based nanotoxicity data extraction and prediction of nanotoxicity by Eunyong Ha, Seung Min Ha, Zayakhuu Gerelkhuu, Hyun-Yi Kim, Tae Hyun Yoon

“…Among toxicity assessment methods, computational models for predicting nanotoxicity are emerging as alternatives to traditional in vitro and in vivo assays, which involve high costs and ethical concerns. As a result, the qualitative and quantitative importance of data is now widely recognized. …”
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Analysis of characteristics of children with unintentional injuries admitted in Pediatric Intensive Care Unit from 2017 to 2022 in Shanghai, China by Xiaohong Li, Limin Wang, Miaomiao Chen, Xuemei Zhu, Jicui Zheng, Weiming Chen, Ping Xue

“…Injury patterns varied with age, situational characteristics and involved substantial medical costs. Tailored interventions based on injury patterns are essential to improve child safety and well-being.…”
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MFEM-CIN: A Lightweight Architecture Combining CNN and Transformer for the Classification of Pre-Cancerous Lesions of the Cervix by Peng Chen, Fobao Liu, Jun Zhang, Bing Wang

“…<italic>Goal:</italic> Cervical cancer is one of the most common cancers in women worldwide, ranking among the top four. …”
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“Going vaccine hunting”: Multilevel influences on COVID-19 vaccination among racialized sexual and gender minority adults—a qualitative study by Peter A. Newman, Duy Anh Dinh, Notisha Massaquoi, Charmaine C. Williams, Ashley Lacombe-Duncan, Suchon Tepjan, Thabani Nyoni

“…Findings suggest that the uncritical application of “vaccine hesitancy” to unilaterally explain undervaccination among marginalized populations risks conflating structural and institutional barriers with individual-level psychological factors, in effect placing the onus on those most disenfranchised to overcome societal and institutional processes of marginalization. …”
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