Insights from the trial innovation network’s initial consultation process by Paul A. Harris, Nan Kennedy, Consuelo H. Wilkins, Karen Lane, Gordon R. Bernard, Jonathan D. Casey, Daniel E. Ford, Salina P. Waddy, Ken L. Wiley, Terri L. Edwards, Nichol McBee, Dixie D. Thompson, Mary Stroud, Emily S. Serdoz, Sarah J. Nelson, Michelle Jones, Lindsay M. Eyzaguirre, Leslie R. Boone, Jessica Baird, Colleen E. Lawrence, Elizabeth Holthouse, Sarah K. Cook, Maeve Tischbein, Natalya Amrine, Tiffany Chen, Jodie Cohen, LaShondra Deyampert, Natalie A. Dilts, Delicia Burts, Amna Baig, Joseph G. Christodoulou, Mariela Rodriguez, Edgar R. Miller, James F. Casella, W. Andrew Mould, J. Michael Dean, Daniel K. Benjamin, Harry P. Selker, Marisha E. Palm, Lori Poole, Jeri S. Burr, Sara Hassani, Angeline Nanni, Meghan Hildreth, Daniel F. Hanley

“…The TIN offers a scientific consultation process, providing access to clinical trial and disease experts who provide input and recommendations throughout the trial’s duration, at no cost to investigators. This approach aims to improve trial design, accelerate implementation, foster interdisciplinary teamwork, and spur innovations that enhance multicenter trial quality and efficiency. …”
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[18F]FET PET-Guided management of pseudoprogression in glioblastoma (FET POPPING): the study protocol for a diagnostic randomized clinical trial by V.J. Ruijters, T.J. Snijders, J.A.J. van der Pol, E.M. van de Giessen, J.M. Niers, M.P.G. Broen, M.M. Anten, S.E.M. Veldhuijzen van Zanten, M. Geurts, A.I.J. Arens, D.J.H.A. Henssen, J.M. Gijtenbeek, M. van der Meulen, A.E.J. Sijben, E. Ghariq, M.J. Vos, J. Tim, I.B. Bosma, G.N. Stormezand, G.W.J. Frederix, J.W. Dankbaar, P.A. Robe, J.J.C. Verhoeff, F.Y.F.L. de Vos, M.G.E.H. Lam, R.M.T. ten Ham, N. Tolboom

“…Still, this diagnostic tool is not used frequently in The Netherlands due to costs, logistics and uncertainty about clinical benefit. …”
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Managing Social Condominiums by Luz María Vergara d´Alençon

“…In Chile, subsidies and credit facilities, combined with the massive construction of low-cost housing, enabled low income groups to access homeownership, and social condominiums are a significant part of the affordable owner-occupied housing stock, however after decades of occupancy, this housing stock shows signs of deterioration and devaluation due to neglected maintenance. …”
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The relationship between a numbers of administrative instructions in implementation the process of reducing employees by Agreen Abdoulla Azeez, Tarik Atan

“…Busenitz. (2004) The Effects of Cost and Asset Retrenchment on the Firm Performance, Journal of management, 30 (2), pp. 189-208. …”
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Genomic analysis and lysogenic conversion of novel RAP44-like phages in Riemerella anatipestifer by Junxuan Zhang, Xiaolu He, Jinzhen Hao, Yefan Wang, Jinyang Su, Xiaoxin Chen, Liying Deng, Yizhang Zheng, Zixing Guo, Mianzhi Wang, Yongxue Sun

“…We aimed to characterize the prophages of R. anatipestifer and explore their role in lysogenic conversion and fitness cost to host bacteria based on the interactive infection of 110 wild-type strains and ATCC 11845. …”
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MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation studyStrengths and Li... by Christian J. Barton, Michelle Dowsey, Anne Smith, Ilana N. Ackerman, Zanfina Ademi, Samantha Bunzli, Peter Choong, Kay M. Crossley, Joanne Kemp, Jason A. Wallis, Alison Gibbs, Vincent Lengkong, Allison M. Ezzat, Juanita Low, Zhomart Orman, Nicholas F. Taylor, Anna Wong Shee, Natasha A. Lannin, Ewa M. Roos, Raph Hau, Angela Cochrane, Mia Pithie, Emma Draffin, David Mitchell, Trevor Russell, Danilo De Oliveira Silva

“…The effectiveness of improving access to first-line care will be determined through propensity score methods. The cost-effectiveness of improving access to first-line care will be also be determined, and semi-structured interviews (1:1 and focus groups) involving participants, health professionals, administrators, and research team will inform a comprehensive process evaluation. …”
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Study protocol for a pragmatic randomised controlled trial in Belgian primary care and hospital settings on the effectiveness of an eHealth self-management support programme consis... by Josefien van Olmen, An De Groef, Nele Devoogdt, Lore Dams, Bart Morlion, Mira Meeus, G Lorimer Moseley, Louise K Wiles, Peter Hibbert, Patrick Neven, Ines Nevelsteen, Steffen Fieuws, Geert Crombez, Michel Mertens, Ceren Gursen, Wiebren Tjalma, Lander Willem, Lauren C Heathcote, Mark Catley, Anna Vogelzang, Marthe Van Overbeke, Emma Tack, Sophie Van Dijck, Annick L De Paepe, Rani Vanhoudt, Davina Wildemeersch, Femke De Backere

“…This delivery mode is believed to reduce barriers to pain self-management by providing timely, safe and cost-effective assistance addressing the biopsychosocial needs of patients. …”
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Exploring Site‐Specific Carbon Dioxide Removal Options With Storage or Sequestration in the Marine Environment – The 10 Mt CO2 yr−1 Removal Challenge for Germany by W. Yao, T. M. Morganti, J. Wu, M. Borchers, A. Anschütz, L.‐K. Bednarz, A. Bhaumik, M. Böttcher, K. Burkhard, T. Cabus, A. S. Chua, I. Diercks, M. Esposito, M. Fink, M. Fouqueray, F. Gasanzade, S. Geilert, J. Hauck, F. Havermann, I. Hellige, S. Hoog, M. Jürchott, H. T. Kalapurakkal, J. Kemper, I. Kremin, I. Lange, J. M. Lencina‐Avila, M. Liadova, F. Liu, S. Mathesius, N. Mehendale, T. Nagwekar, M. Philippi, G. L. N. Luz, M. Ramasamy, F. Stahl, L. Tank, M.‐E. Vorrath, L. Westmark, H.‐W. Wey, R. Wollnik, M. Wölfelschneider, W. Bach, K. Bischof, M. Boersma, U. Daewel, M. Fernández‐Méndez, J. K. Geuer, D. P. Keller, A. Kopf, C. Merk, N. Moosdorf, N. Oppelt, A. Oschlies, J. Pongratz, A. Proelss, G. J. Rehder, L. Rüpke, N. Szarka, D. Thraen, K. Wallmann, N. Mengis

“…This serves as an entry point to discuss main uncertainty factors and research needs beyond technology readiness, and, where possible, cost estimates, expected environmental effects, and monitoring approaches. …”
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flexZhouse by Mohd Zairul

“…The term touches upon interconnected elements that cover many issues ranging from demand (housing needs, demographics, household income, quality housing) to supply (the authorities’ requirements, design, cost, sustainability and procurement). In this thesis, we discuss some of the problems related to the supply and demand issues and examine a possible intervention to solve the problem. …”
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Multi-Comparison of Different Ocular Imaging Modality-based Deep Learning Models for Visually Significant Cataract Detection by Jocelyn Hui Lin Goh, BEng, Xiaofeng Lei, MSc, Miao-Li Chee, MPH, Yiming Qian, PhD, Marco Yu, PhD, Tyler Hyungtaek Rim, MD, PhD, Simon Nusinovici, PhD, David Ziyou Chen, MBBS, FRCOphth, Kai Hui Koh, BSc, Samantha Min Er Yew, BSc, Yibing Chen, BEng, Victor Teck Chang Koh, MBBS, MMed, Charumathi Sabanayagam, MD, PhD, Tien Yin Wong, MD, PhD, Xinxing Xu, PhD, Rick Siow Mong Goh, PhD, Yong Liu, PhD, Ching-Yu Cheng, MD, PhD, Yih-Chung Tham, PhD

“…Because retinal photography is routine in diabetic retinopathy screening, this approach could enable opportunistic cataract screening with minimal add-on cost. Financial Disclosure: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.…”
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Rationale and design of the HERZCHECK trial: Detection of early heart failure using telemedicine and cardiovascular magnetic resonance in structurally weak regions (NCT05122793) by Sebastian Kelle, Anna Clara Nolden, Maximilian Leo Müller, Rebecca Elisabeth Beyer, Henning Steen, Bjoern Andrew Remppis, Johannes Wieditz, Hannah Kentenich, Alex Tuit, Mina Cvetkovic, Undine Ella Witt, Florian André, Sein Schmidt, Alexander Huppertz, Dusan Simic, Dirk Müller, Arim Shukri, Matthias Issing, Andre Glardon, Katrin Christiane Reber, Ulf Landmesser, Norbert Frey, Burkert Pieske, Stephanie Stock, Volkmar Falk, Tim Friede, Gisela Thiede

“…The HERZCHECK trial, conducted in structurally underserved rural regions of North-Eastern Germany, aims to close this gap by evaluating the feasibility, diagnostic efficacy, and cost-effectiveness of a fully mobile, telemedically-supervised screening approach, combining cardiovascular magnetic resonance (CMR) imaging and laboratory testing as central elements. …”
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Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease by I. K. Dzhumaniiazova, A. N. Meshkov, A. N. Meshkov, V.V. Daniel, M. V. Ezhov, E. A. Zelenova, U. V. Chubykina, D.A. Kashtanova, M. V. Ivanov, L. R. Matkava, O. I. Blinova, N. A. Kumar, A. Y. Fedorov, H. U. Ibragimova, T. A. Lavrikova, Y. O. Aksenova, T. M. Gurciev, N. V. Gomyranova, Y. S. Vorobeva, Z. B. Hasanova, V. S. Yudin, V. V. Makarov, A. A. Keskinov, S. A. Kraevoy, S. A. Boytsov, S. M. Yudin, V. I. Skvortsova

“…However, further research is needed to assess the clinical applicability and cost-effectiveness of such screening programs.…”
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Modern railway for 21st Century by Editorial Foreword

“…According to a recent study by the International Union of Railways, the rail transport has about four times less external costs per passengerkilometer than road or air transport. …”
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Differences in care delivery for children and adolescents with cancer in Europe – Results from the SIOPE OCEAN project by Maria Otth, Teresa de Rojas, Kerstin K. Rauwolf, Miguel Martins, Uta Dirksen, Delphine Heenen, Lejla Kameric, Pamela Kearns, Ruth Ladenstein, Cormac Owens, Caroline Queiroz, Richard Sullivan, Carmelo Rizzari, Gilles Vassal

“…Public health insurances reimburse standard of care treatments in most countries (35/37); however, they do not cover all costs and additional funding is reported to be needed in up to one fifth of countries. …”
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Future Scenarios of Global Fisheries and Ocean Alkalinity Enhancement Under Socio‐Economic and Climate Pathways by Hans Sloterdijk, Caroline Grünhagen, Rudi Voss, Patricia Grasse, David P. Keller, Linda Kleemann, Lotta Clara Kluger, Kira Lancker, Wilfried Rickels, Ulf Riebesell, Renato Salvatteci, Andreas Oschlies, Jörn O. Schmidt, Natascha Oppelt, Katrin Rehdanz, Marie‐Catherine Riekhof

“…By integrating ecological, economic, societal, and technological perspectives, we develop scenario narratives and quantify key bio‐economic parameters, including technological progress, fishing costs, fisheries management, marine aquaculture, and ecosystem carrying capacity. …”
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Jak inhibitors in the treatment of alopecia areata - a literature review by Paulina Krzeszowska, Aleksandra Kujawa, Karolina Krochmal, Wojciech Pisarek, Adrianna Samoraj, Jakub Zajączkowski, Kacper Stępniak, Jan Wilk, Karolina Marrodán-Wojtczak, Radosław Kuźma

“…Ongoing research aims to develop more selective JAK inhibitors and maintenance strategies while addressing high treatment costs. …”
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Barriers and opportunities related to access to oncology care in Benin: a qualitative study on breast cancer by Clémence Schantz, Freddy Houéhanou Rodrigue Gnangnon, Moufalilou Aboubakar, Anthelme Kouessi Agbodande, Paloma Puig, Justin Lewis Denakpo, Angéline Tonato Bagnan, Marie Bottin, Komi Mena Agbodjavou, Hélène Robin Sacca, Luis Teixeira, Valéry Ridde, the SENOVIE group

“…Abstract Background Breast cancer is the most prevalent cancer among women globally, including in Africa. …”
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Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children by Irena Cristina Grierosu, Iuliana Magdalena Starcea, Wael Jalloul, Maria Adriana Mocanu, Roxana Alexandra Bogos, Tudor Ilie Lazaruc, Madalina Andreea Beldie, Ruxandra Tibu, Teodor Marian Ionescu, Cati Raluca Stolniceanu, Brindusa Casiana Acsinte, Cipriana Stefanescu, Alexandra Saviuc, Vlad Ghizdovat

“…Structural anomalies were the most common type of malformations (73% from all patients), featuring a significant variety of cortical modifications. …”
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Effects of community action on animal vaccination uptake, antimicrobial usage, and farmers’ wellbeing in Ghana: study protocol for a cluster-randomized controlled trial by Francis Sena Nuvey, Günther Fink, Jan Hattendorf, Daniel T. Haydon, Gilbert Fokou, Kennedy Kwasi Addo, Jakob Zinsstag, Clemence Esse-Dibby, Bassirou Bonfoh

“…Recent studies identified Contagious Bovine Pleuropneumonia (CBPP) and Peste des Petits Ruminants (PPR) as the diseases most negatively affecting ruminant livestock productivity and farmers’ wellbeing in Ghana. …”
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Development and validation of a risk nomogram predicting pneumothorax requiring chest tube placement post-percutaneous CT-guided lung biopsy by Masha Bondarenko, Jianxiang Zhang, Ulysis Hugo Baal, Brian Lam, Gunvant Chaudhari, Yoo Jin Lee, Jamie Schroeder, Maya Vella, Brian Haas, Thienkhai Vu, Kimberly Kallianos, Jonathan Liu, Shravan Sridhar, Brett Elicker, Jae Ho Sohn

“…Abstract Background Pneumothorax requiring chest tube after CT-guided transthoracic lung biopsy presents added clinical risk and costs to the healthcare system. Identifying high-risk patients can prompt alternative biopsy modes and/or better preparation for more focused post-procedural care. …”
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