Impact of multidimensional assessment on anti-fracture treatment decisions in patients with fragility hip fractures within a Fracture Liaison Service by Chiara Ceolin, Stefania Sella, Cristina Simonato, Ester Bukli, Giulia Bano, Valentina Camozzi, Anna Bertocco, Marco Onofrio Torres, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Maria Grazia Rodà, Michele Cannito, Antonio Berizzi, Andrea Venturin, Vito Cianci, Elisa Pala, Mariachiara Cerchiaro, Deris Gianni Boemo, Maria Vittoria Nesoti, Gaetano Paride Arcidiacono, Paolo Simioni, Pietro Ruggieri, Giuseppe Sergi, Sandro Giannini, Marina De Rui, on behalf of the Hip-POS working group

“…While FLS models effectively reduce refracture risk and maintain cost-effectiveness, it is unclear if these benefits apply equally to all patients, especially those with higher comorbidities and reduced functional capacity, who may face worse prognoses. …”
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Simulation of management practices to reduce nitrogen losses to water and air on well-drained grass-based dairy farms in derogation by G. Lakhanpal, N.B. Basu, D. O'Brien, C. Buckley, B. Horan, K.G. Richards, O. Fenton

“…Although the results observed demonstrate opportunities to reduce N losses from grazing systems from a combination of reduced fertilizer rates, restricted grazing, and use of protected urea, the effects of these mitigations must also be considered in terms of economic cost to farms. On that basis, future system trials should monitor flows and losses from the implementation of such mitigations in addition to the economic effects to chart a way forward for better water and air outcomes while maintaining the profitability of Irish dairy farms.…”
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Comprehensive genomic profiling reveals a unique genomic landscape in solid tumors in an Indian cancer cohort of 1000 patients: a single institutional experience by Mithua Ghosh, Sheela Mysore Lingaraju, Krishna C.R, Gautam Balaram, Ramya Kodandapani, Vijay E, Vijay K, Suhas N, Devika H, Shekar Patil, Satheesh Chiradoni Thungappa, Somorat Bhattacharjee, Sridhar P.S, Roshni Dasgupta, Mohammed Naseer, Srinivas B.J, Vishal Rao, Veena Ramaswamy, Radheshyam Naik, Govind Babu, Aarthi Ravichandran, Urvashi Bahadur, Krithika Murugan, Mahesh B, Lohith Reddy, Ajaikumar Basavalinga S

“…Abstract The use of Comprehensive Genomic Profiling (CGP) in clinical practice to detect broad-spectrum therapeutic, prognostic, and predictive biomarkers, including tumor mutational burden (TMB), microsatellite instability (MSI), somatic BRCA (sBRCA) and other homologous recombination repair genes (HRRs) provides a more cost-efficient and tissue-preserving approach than serial single-biomarker analysis. …”
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Mobile Health Biometrics to Enhance Exercise and Physical Activity Adherence in Type 2 Diabetes (MOTIVATE-T2D): a decentralised feasibility randomised controlled trial delivered ac... by Joel Singer, Helen Jones, Céu Mateus, Charlotte A Jones, Jonathan Little, Victoria S Sprung, Mary E Jung, Robert Andrews, Alison M McManus, Richard Pulsford, Katie Hesketh, Jonathan Low, Matthew Cocks, Benjamin Buckley, Sandra Blitz, Kaja Falkenhain, Jennifer Job, Sarah L Percival, Catherine L Russon

“…Exploratory clinical outcomes showed a potential effect in favour of MOTIVATE-T2D, including proposed primary outcomes HbA1c and systolic BP (between-group mean differences: HbA1c: 6 months: −5% change from baseline, CI −10 to 2: 12 months: −2% change from baseline, CI −8 to −4; systolic BP: 6 months: −1 mm Hg, CI −5 to 3: 12 months: −4 mm Hg, CI −8 to 1).Conclusions Our findings support the feasibility of delivering the MOTIVATE-T2D mHealth-supported PA intervention for people with recently diagnosed T2D and progression to a full RCT to examine its clinical and cost-effectiveness.Trial registration number ISRCTN: 14335124; ClinicalTrials.gov: NCT0465353.…”
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Design of Tri-frequency Combiner Based on Inverted T-stub Combiner Network by LIU Zirui, WANG Haoyu, HUANG Kama

“…Although cavity combiners exhibit lower insertion loss and higher power capacity, their large size and high manufacturing costs hinder their application in modern compact systems. …”
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Reutilization and upcycling of spent graphite for sustainable lithium-ion batteries: Progress and perspectives by Xueqian Li, Chenglong Deng, Mengyao Liu, Jiawei Xiong, Xiaodong Zhang, Qiaoyi Yan, Jiao Lin, Cen Chen, Feng Wu, Yi Zhao, Renjie Chen, Li Li

“…In the development of sustainable lithium-ion batteries, achieving the efficient and cost-effective recycling of all components, particularly spent graphite (SG) anodes, has become a critical requirement. …”
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Evaluation of Technical and Anthropometric Factors in Postures and Muscle Activation of Heavy-Truck Vehicle Drivers: Implications for the Design of Ergonomic Cabins by Esteban Ortiz, Daysi Baño-Morales, William Venegas, Álvaro Page, Skarlet Guerra, Mateo Narváez, Iván Zambrano

“…These findings offer quantitative support for improving cabin ergonomics in low-resource settings through targeted, cost-effective design changes.…”
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An Interdisciplinary Ecosystem for the Prevention of Cardiotoxicity in Older Patients With Breast Cancer: Protocol for a Prospective and Multicentric Study by Gaia Giulia Angela Sacco, Ketti Mazzocco, Anastasia Constantinidou, Andri Papakonstantinou, Davide Mauri, Grigorios Kalliatakis, Manolis Tsiknakis, Domen Ribnikar, Dorothea Tsekoura, Valantis Aidarinis, Kalliopi Keramida, Panagiotis Oikonomopoulos, Athos Antoniades, Cameron Brown, Federica Rizzi, Anca Bucur, Elsa Pacella, Georgia Karanasiou, Daniela Cardinale, Carlo Cipolla, Elisabetta Munzone, Dimitrios Fotiadis, Giuseppe Curigliano, Gabriella Pravettoni

“…Such a health care approach will also benefit the health care system, which currently spends almost 40% of its resources on patients aged >60 years, with long-term care and hospital admissions being the primary cost drivers. Trial RegistrationClinicalTrials.gov NCT06334445; https://clinicaltrials.gov/study/NCT06334445 International Registered Report Identifier (IRRID)DERR1-10.2196/63455…”
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High-risk neuroblastoma in Mexico: from multimodal treatment to immunotherapy. Regarding the first case treated with naxitamab by Alberto Olaya Vargas, Haydee Salazar-Rosales, Marcela Caballero-Palacios, Nideshda Ramírez-Uribe, Gerardo López-Hernández, Erika Morales-Martinez, María Cervantes-Delgado, Liliana Velasco Hidalgo, Araceli Castellanos-Toledo, Rocío Cárdenas-Cardos, Rocío Cárdenas-Cardos, Ana Niembro-Zúñiga, Roberto Rivera-Luna, Alberto Olaya-Nieto, Jesús Ponce-Cruz, Jaime Shalkow-Klincovstein, Yadira Melchor-Vidal, Rodrigo Díaz-Machorro

“…It is worth noting that the current cost of anti-GD2 therapies available in Latin America is estimated to exceed $450,000 USD. …”
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Torreya grandis nut peptides regulate lipid-II inhibitors in high-fat diet-fed mice by Rabia Durrani, Sun Yutian, Hou Bowen, Hammad Ullah, Erwann Durand, Yang Meiyun, Long Yiyang, André Delavault, Muhammad Yasir, Huan Weiwei, Gao Fei, Song Lili

“…Plant-derived bioactive peptides have drawn increasing attention in the field of nutrition and food science due to their biological activities, low cost, safety, and ease of industrial production. …”
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Experimental and numerical evaluation of the two-dimensional dynamics of water and nitrogen within a vegetated filter strip in the Daihai Basin, China by Bokai Yang, Xianyue Li, Fanfan Song, Delong Tian, Jianwen Yan, Ning Chen

“…A 1.7 cm spacing was found to be a threshold for reducing NO-3-N outflow and construction cost.…”
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Performance, Metabolism, and Economic Implications of Replacing Soybean Meal with Dried Distillers Grains with Solubles in Feedlot Cattle Diets by Andrei L. R. Brunetto, Guilherme L. Deolindo, Ana Luiza de F. dos Santos, Luisa Nora, Maksuel Gatto de Vitt, Renato S. de Jesus, Bruna Klein, Luiz Eduardo Lobo e Silva, Roger Wagner, Gilberto V. Kozloski, Aleksandro S. da Silva

“…In terms of economic viability, DDGS-based diets were 10.5% cheaper, reducing the cost of production per animal by 7.67%. Profitability increased by 110% with DDGS compared to soybean meal, despite the high transportation costs. …”
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Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer by Jessica Young, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Sacha Gnjatic, Jianming Wang, Shipra Gandhi, Kristopher Attwood, Tracey O’Connor, Kazuaki Takabe, Victoria Fitzpatrick, Eduardo Cortes Gomez, Stephen Edge, Janine Miller, Ronald T Slomba, Ellis G Levine, Sinem Ozbey, Giorgio Ioannou, Cayla Janes, Igor De Souza, Vladimir Roudko, Prasanna Kumar, Suresh Kalathil, Helen Cappuccino

“…The combination of NAC with pembrolizumab increases the pCR rate but at the cost of immune-related adverse events (irAEs). Based on these considerations, we tested if systemic infusion of the chemokine modulatory regimen (CKM; selective toll-like receptor 3 (TLR3) agonist rintatolimod, interferon (IFN)-α2b, and cyclooxygenase-2 (COX-2) inhibitor celecoxib) regimen can be safely combined with NAC to enhance intratumoral CTL numbers and NAC effectiveness.Methods Phase I study NCT04081389 evaluated nine patients with early-stage TNBC who received 3 weeks of paclitaxel with CKM (dose-escalation of IFN-α2b), followed by 9 weeks of paclitaxel alone, dose-dense doxorubicin and cyclophosphamide, and surgery. …”
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Changes in texture and lignin during different developmental stages of mulberries and transcriptome analysis by WANG Binbin, DAI Xianglong, DU Kaiqun, SHEN Zixin, WANG Hui, GAO Yanxia

“…With the advancement and cost reduction of high-throughput sequencing technologies, transcriptomics and metabolomics have been applied to explore the molecular mechanisms of mulberry ripening and softening. …”
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Quantum machine learning-based electrokinetic mining for the identification of nanoparticles and exosomes with minimal training data by Abhimanyu Thakur, Pedro Correia Santos Bezerra, Abhishek, Shihao Zeng, Kui Zhang, Werner Treptow, Alexander Luna, Urszula Dougherty, Akushika Kwesi, Isabella R. Huang, Christine Bestvina, Marina Chiara Garassino, Fuyu Duan, Yash Gokhale, Bin Duan, Yin Chen, Qizhou Lian, Marc Bissonnette, Jianpan Huang, Huanhuan Joyce Chen

“…As an alternative, the assessment of electrokinetic attributes such as zeta potential or electrophoretic mobility, conductance, and mean count rate, offers a more cost-effective, rapid, and reliable means of characterizing these particles. …”
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Red-emissive carbon dot-cobalt oxyhydroxide nanosystem: A turn-on sensor for α-Glucosidase activity and inhibitor identification by Huihui Sun, Chuanyuan Gao, Yumin Yang, Changqing Liu, Han Qin, Mengyuan Tan, Jin Li, Xiaoxia Li, Kunze Du, Yanxu Chang

“…The development of efficient methods for sensing αlpha-glucosidase (α-Glu) and screening its inhibitors has attracted significant attention due to their pivotal role in discovering therapeutic medicines for Type 2 diabetes. Herein, a low-cost and sensitive fluorometric strategy based on red carbon dots (R-CDs) and cobalt oxyhydroxide nanosheets (CoOOH NSs) had been established to detect α-Glu and screen its inhibitory compounds in natural products. …”
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Pneumatic Compliant End-effector Using Multi-compensation Integrated Nonlinear Active Disturbance Rejection Control by ZHANG Shuzhong, WU Qianxin, DAI Fuquan, WANG Yabing, ZHANG Gong

“…Among various end-effector mechanisms, the pneumatic type is widely adopted due to its lightweight structure, low cost, robustness, and ease of maintenance. This paper focuses on achieving constant force control in a pneumatic end-effector compliant mechanism.MethodsAchieving constant force control in this mechanism is challenging due to nonlinear factors within the pneumatic system (such as gas compression, proportional valve dead zones, and cylinder friction) and the effects of posture changes on output force. …”
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Research training: Validating a key questionnaire on systematic reviews and meta-analysis for medical genetics residents in Mexico by Luis Felipe León Madero, Valentina Martínez Montoya, Franahid Josefina D'silva Signe

“…Key barriers identified were lack of time (56%), insufficient research experience (46%), cost or lack of resources (44%), and the administrative procedures required being very complicated (44%). …”
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Promoting smoking cessation and preventing relapse to tobacco use following a smoke-free mental health inpatient stay (SCEPTRE feasibility study): a multicentre randomised controll... by Simon Gilbody, Catherine Hewitt, John Britton, Lion Shahab, Tim Coleman, Elena Ratschen, Judith Watson, Alex Mitchell, Gregor Russell, Steve Parrott, Lesley Sinclair, Peter A Coventry, Paul Galdas, Michelle Horspool, Samantha Brady, Emily Shoesmith, Petal Petersen Williams, Lisa Huddlestone, Victoria Exley, Fraser Wiggins, Jodi Pervin, Moira Leahy, Claire Paul, Lesley Colley, Simon Hough

“…The aim of this trial is to determine the feasibility of a large-scale clinical trial to test the effectiveness and cost-effectiveness of the SCEPTRE intervention, compared with usual care.Methods and analysis This feasibility study will be an individually randomised, controlled trial in eight National Health Service mental health Trusts recruiting adults (≥18 years) admitted to an acute adult mental health inpatient setting who smoke tobacco on admission, or at any point during their inpatient stay. …”
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Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…BackgroundDespite the curative potential, high cost of manufacturing and the toxicities limits the wider access of Chimeric Antigen Receptor (CAR) T cell therapy in global medicine. …”
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