Soil variation response is mediated by growth trajectories rather than functional traits in a widespread pioneer Neotropical tree by Levionnois, Sébastien, Tysklind, Niklas, Nicolini, Eric, Ferry, Bruno, Troispoux, Valérie, Le Moguedec, Gilles, Morel, Hélène, Stahl, Clément, Coste, Sabrina, Caron, Henri, Heuret, Patrick

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Identification of Plasmodium falciparum and host factors associated with cerebral malaria: description of the protocol for a prospective, case-control study in Benin (NeuroCM) by Valentin Joste, Laurine Maurice, Gwladys I Bertin, Agnès Aubouy, Farid Boumédiène, Sandrine Houzé, Daniel Ajzenberg, Nicolas Argy, Achille Massougbodji, Ida Dossou-Dagba, Maroufou Jules Alao, Michel Cot, Philippe Deloron, Jean-François Faucher, Dissou Affolabi, Hélène Authier, Linda Ayedadjou, Bibiane Biokou, Agnès Coste, Jean-Eudes Degbelo, Latifou Dramane, Sayeh Jafari-Guemouri, Claire Kamaliddin, Elisée Kinkpe, Anaïs Labrunie, Yélé Ladipo, Thomas Lathiere, Audrey Mowendabeka, Jade Papin, Bernard Pipy, Pierre-marie Preux, Marie Raymondeau, Jade Royo, Darius Sossou, Brigitte Techer, Bertin Vianou

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Efficacy of corticosteroids addition to multimodal cocktail periarticular injection in total knee arthroplasty with hemophilic arthropathy by Hai Su, Shenxu Yu, Lei Chen, Haojing Zhou, Yichen Gong, Hua Huang, Shuaijie Lv, Peijian Tong, Xun Liu, Jun Ying

“…A three-month follow-up study was conducted to compare the postoperative outcomes in the above groups, including Visual Analogue Scale (VAS) scores, knee range of motion (ROM), Knee Society Score (KSS), inflammatory markers (C-reactive protein, CRP, and Interleukin- 6, IL- 6), and hospitalization parameters (body temperature, length of hospital stay, hospitalization costs, and perioperative usage of coagulation factor VIII). …”
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Genetic Polymorphisms on TNFA, TNFRSF1A, and TNFRSF1B Genes Predict the Effectiveness of Anti-TNF-α Treatment in Inflammatory Bowel Disease Patients by Michelangelo Rottura, Igor Pirrotta, Domenico Antonio Giorgi, Natasha Irrera, Vincenzo Arcoraci, Federica Mannino, Rosario Campisi, Chiara Bivacqua, Laura Patanè, Giuseppe Costantino, Socrate Pallio, Walter Fries, Anna Viola, Giovanni Pallio

“…<b>Conclusions:</b> These results suggest that the evaluation of SNPs in <i>TNF-α</i>, <i>TNFR1A</i>, and <i>TNFR1B</i> genes could improve the management of IBD, leading to more effective, individualized treatment plans and a reduction in healthcare costs associated with ineffective therapies and disease complications.…”
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Genetic Parameter Estimation of Body Weight and <i>Vp</i>_AHPND Resistance in Two Strains of <i>Penaeus vannamei</i> by Guixian Huang, Jie Kong, Jiteng Tian, Sheng Luan, Mianyu Liu, Kun Luo, Jian Tan, Jiawang Cao, Ping Dai, Guangfeng Qiang, Qun Xing, Juan Sui, Xianhong Meng

“…These findings also suggest that infection frequency and observation time influence resistance performance and breeding selection, emphasizing the need for a tailored resistance evaluation program to improve breeding efficiency and reduce costs.…”
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Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context by Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala

“…Summary: Background: Although terminal complement inhibitors transformed the prognosis of atypical haemolytic uraemic syndrome (aHUS) from dismal to favourable, treatment approaches vary due to the intermittent disease nature and high costs. Occasionally, complement inhibition is applied in infectious (i)HUS. …”
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Ecological, biological and biotechnological aspects of Saccharomyces Cerevisiae biomass production by Temirlan A. Serikov, Gulya А. Jamalova, Khadichakhan S. Rafikova, Bakhytzhan K. Yelikbayev, Aliya K. Yernazarova, Kurbanova L. Serikovna, Alexey G. Zazybin, Vladislav S. Sakhanin, Vladimir Yu. Egutkin

“…The enrichment of molasses with nutrients based on the use of cereals, glucose syrup obtained from corn, date syrup, whey, cassava, forestry, and agricultural waste has commercial potential, since these approaches do not require special processing requirements and provide low production costs (exception: forestry waste). In the technology of Saccharomyces Cerevisiae biomass production, a population of diploid cells is used, since compared with haploid cells they are genetically more stable, characterized by faster and more active metabolism, and larger sizes.…”
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Repurposing FDA-Approved Agents to Develop a Prototype <i>Helicobacter pylori</i> Shikimate Kinase (HPSK) Inhibitor: A Computational Approach Using Virtual Screening, MM-GBSA Calcu... by Abdulaziz H. Al Khzem, Tagyedeen H. Shoaib, Rua M. Mukhtar, Mansour S. Alturki, Mohamed S. Gomaa, Dania Hussein, Nada Tawfeeq, Mohsina Bano, Mohammad Sarafroz, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o

“…While current therapies face challenges from rising antibiotic resistance, particularly to clarithromycin, alongside treatment complexity and costs, the World Health Organization has prioritized the development of new antibiotics to combat this high-risk pathogen. …”
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Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness by Karamoko Niaré, Karamoko Niaré, Rebecca Crudale, Abebe A. Fola, Abebe A. Fola, Neeva Wernsman Young, Victor Asua, Victor Asua, Melissa D. Conrad, Pierre Gashema, Anita Ghansah, Stan Hangi, Deus S. Ishengoma, Deus S. Ishengoma, Jean-Baptiste Mazarati, Ayalew Jejaw Zeleke, Philip J. Rosenthal, Abdoulaye A. Djimdé, Abdoulaye A. Djimdé, Jonathan J. Juliano, Jonathan J. Juliano, Jonathan J. Juliano, Jeffrey A. Bailey, Jeffrey A. Bailey

“…While whole-genome sequencing (WGS) is optimal in terms of assessing the entire genome, it is costly for numerous samples. Targeted approaches selectively enriching for the sequence of interest are more affordable and have higher throughput but sometimes lack adequate information content for key analyses.MethodsWe have developed a highly multiplexed molecular inversion probe (MIP) panel (IBC2FULL) targeting 4,264 single-nucleotide polymorphisms (SNPs) with ≥5% minor allele frequency (MAF) in Sub-Saharan African regions from publicly available Plasmodium falciparum WGS (n = 3,693). …”
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Effects of partial silage replacement with corn stover pellets on the rumen microbiota and serum metabolome of breeding cows by Chenyue Jiao, Changze Cui, Youpeng Qi, Meixian Zhang, Pengcheng Zhao, Shaopeng Chen, Xiangyan Wang, Jiang Hu, Jiang Hu, Bingang Shi, Bingang Shi, Ting Liu, Ting Liu, Zhidong Zhao, Zhidong Zhao, Fangfang Zhao, Fangfang Zhao

“…IntroductionStraw pellet ration replacing part of silage is of great significance for farmers to save farming costs and solve the lack of feed resources. A comprehensive analysis of rumen microbial and serum metabolite compositions is conducted to promote the development of the modern breeding cows-feeding industry.MethodsIn this study, 18 healthy 2-year-old Simmental breeding cows weighing 550 ± 20 kg were selected and randomly divided into two groups. …”
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Design and evaluation of novel triazole derivatives as potential anti-gout inhibitors: a comprehensive molecular modeling study by Mohammed Er-rajy, Mohammed Er-rajy, Mohamed El fadili, Sara Zarougui, Somdutt Mujwar, Mourad Aloui, Mohammed Zerrouk, Belkheir Hammouti, Larbi Rhazi, Rachid Sabbahi, Mohammed M. Alanazi, Khalil Azzaoui, Khalil Azzaoui, Rachid Salghi, Menana Elhallaoui

“…These computational approaches facilitate drug discovery while reducing research costs.MethodsOur work focuses on a series of synthesized anti-xanthine oxidase inhibitors, aiming to develop new inhibitors. …”
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<i>In vivo</i> evaluation of tropism and biodistribution of synthetic and natural adeno-associated viral vectors by next-generation sequencing by D. O. Maksimov, D. A. Naumova, E. A. Astakhova, V. V. Artemev, S. A. Biryukov, I. S. Abramov, A. A. Navoikova, N. V. Rudev, S. G. Feoktistova, O. V. Glazova, O. N. Mityaeva, P. Yu. Volchkov

“…The optimal solution to minimise the time and costs associated with gene therapy development lies in the improvement of methods aimed at assessing AAV vector biodistribution and transduction efficiency in vivo.AIM. …”
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Identifying the predictors of ultra early neurological improvement and its role in functional outcome after endovascular thrombectomy in acute ischemic stroke by Yuzheng Lai, Mohammad Mofatteh, José Fidel Baizabal-Carvallo, José Fidel Baizabal-Carvallo, Jianfeng He, Wenhao Wu, Daohong Wang, Wenshan Yan, Jicai Ma, Sijie Zhou, Yu Sun, Yu Sun, Yi He, Shumei Li, Hao Sun

“…In addition, lower hospitalization costs were associated with patients who had UENI, compared to No-UENI (p = 0.003). …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Further studies are however needed for an early treatment in order to increase the patients’ quality of life [9] and to reduce the direct and indirect costs for the healthcare systems. Furthermore, the psychophysical evaluation of olfactory impairments associated with some treatments, such as radiotherapy and chemotherapy, and with several types of rhinitis could help address patients’ complaints, and increase the patient’s quality of life [10, 11]. …”

Agricultural Policies and Practices: Pathways for Transformation by Hari Sharma Neupane, Bikram Acharya, Pradeep Wagle, Buddhi Raj Gyawali

“…Similarly, the Technology and Infrastructure Development theme focused on varied avenues of innovative technology (such as UAV, GIS, and Remote Sensing), farm mechanization, and smart and efficient irrigation practices to optimize costs of production, labor, fertilizer shortages, and monitoring of plant and soil health Finally, the Governance theme underpinned coherence and discordance between the policy frameworks and governing structures/mechanisms of three levels of government and opportunities for realignment for agricultural transformation as well as a local governance framework for agricultural service delivery at a municipality level. …”
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A Study on the Yield Stability of Oilseed Sunflower Genotypes under Drought Stress by Nasrin Akbari, Reza Darvishzadeh

“…Therefore, taking into account the quantitative control, and the effects of the environment and the interaction of the genotype × environment, selection for this trait is complex, costly, and time-consuming. Therefore, understanding the genotype × environment interaction is essential for the development of high-yielding and stable genotypes. …”
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Comparison of Subconjunctival Triamcinolone with Topical Prednisolone for Routine Anti-Inflammatory Prophylaxis in Manual Small Incision Cataract Surgery: A Single-Center, Randomiz... by Papa-Vettorazzi R, Shorstein NH, Peterson B, Yee Melgar M, Silva Linares L, O'Brien KS

“…Recent studies have shown superior effectiveness of the injection technique compared with topical drops in phacoemulsification surgery, a more costly procedure. This will be the first study of this technique in MSCIS.Keywords: cystoid macular edema, intraocular pressure rise, rebound iritis, triamcinolone acetonide injection, dropfree cataract surgery…”
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CP Violation: Differing Binding Energy Levels of Quarks and Antiquarks, and Their Transitions in Λ-Baryons and B-Mesons by Dimitris M. Christodoulou, Demosthenes Kazanas

“…The wider quark range stems from the flip <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="normal">s</mi><mo>→</mo><mi mathvariant="normal">b</mi></mrow></semantics></math></inline-formula>, which costs 283 MeV more (or <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>3</mn><mo>×</mo></mrow></semantics></math></inline-formula> more) than the corresponding antiquark flip <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi mathvariant="normal">s</mi><mo>¯</mo></mover><mo>→</mo><mover><mi mathvariant="normal">b</mi><mo>¯</mo></mover></mrow></semantics></math></inline-formula>. …”
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Acceptability and Feasibility of Using Hair Samples for Chronic Stress Measurement Among Transgender Women in Brazil by Sophia Zamudio‐Haas, Paula Galdino Cardin de Carvalho, Alexander Marr, A. Rain Mocelle, Antonio Moscatelli, Katia Cristina Bassichetto, Gustavo Santa Roza Saggese, Patric V. Prado, Roy Gerona, Sheri A. Lippman, Maria Amélia Veras, Jae M. Sevelius

“…Participants were reimbursed for travel costs. Results Between April and December 2022, we messaged with 143 individuals out of the 180 sampled (79%) and invited them to participate in the study. …”
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The Distance to Mental Health Services and the Use of Public Transportation: A Challenge for Timely Care by Julio Torales, Mainor Márquez, Iván Barrios

“…Implementing policies that subsidize transportation costs for patients, such as free or reduced-fare bus passes for medical appointments, could help mitigate barriers related to transportation (7). …”
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