Depletion-restitution therapy of autoimmune rheumatic diseases. Part 2. Perspectives on bispecific antibodies by A. L. Maslyanskiy, D. A. Dibrov, A. M. Lila, A. V. Torgashina, E. G. Zotkin, M. Yu. Samsonov, G. A. Togizbayev

“…Recent years have seen attempts to repurpose bsAbs for the treatment of refractory, prognostically unfavorable forms of systemic autoimmune rheumatic diseases (SARDs), supported by theoretical rationale, experimental evidence, and parallels with successful CAR-T cell therapy.Beyond BiTEs, the bsAb platform also enables development of biologics with extended pharmacokinetics, multi-cytokine targeting potential for synergistic suppression of inflammation, and checkpoint-directed modulation of targeted cell functional activity.Advantages such as standardized manufacturing, off-the-shelf availability, predictable pharmacokinetics (with a known and limited half-life), flexible dosing regimens enabling slow escalation of the dose, the possibility of individualizing treatment duration and dosing frequency, the feasibility of repeated treatment cycles, the option to discontinue therapy in case of adverse events, and the significantly lower cost of short low-dose treatment cycles compared to CAR-T cell therapy – all these make bsAb-based strategies a highly attractive priority for next-generation depletion-restitution therapies for SARDs.…”
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An SDR-Based GNSS-R CubeSat Payload: Hardware Development and Optimization of the Onboard Processing by Shah Zahid Khan, Yasir M. O. Abbas, Edwar Edwar, Abdul-Halim Jallad, Adriano Camps

“…This study presents the design and development of a cost-effective and compact 0.5U GNSS-R CubeSat payload that optimizes the GNSS-R data processing technique by using the auxiliary data from the reference signals, such as Pseudo-Random Noise (PRN) codes, and their Doppler frequencies in order to reduce the search space. …”
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Selection of optimal synthesis method of graphene oxide using Multi-Criteria Decision-Making by Trisha Daftari, Divya Shivanand, Urva Dave, Sajith Lapachi Nagarajan, Shamik Misra, Bandaru Kiran, Gade Pandu Rangaiah, Samarshi Chakraborty

“…It thus aims to bridge the gap in the literature by offering an MCDM-based approach to determine the optimal production method for GO, considering selection criteria such as raw material cost, toxicity, operating temperature, and the ratio of reactants to the final product. …”
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Application of robotic technology in surgery (literature review) by D. G. Parfeev, A. M. Morozov, K. I. Khorak, P. G. Kogan, S. V. Zhukov, A. D. Aminova, V. A. Zhezheleva

“…At the same time, there are barriers to the development of robotic technology, such as the high cost of robots and procedures, as well as a shortage of qualified specialists. …”
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Practical and Compact Guided Mode Resonance Sensing System for Highly Sensitive Real-Time Detection by Yen-Song Chen, Devesh Barshilia, Chia-Jui Hsieh, Hsun-Yuan Li, Wen-Hsin Hsieh, Guo-En Chang

“…The proposed detection system not only offers improved user-friendliness and cost efficiency but also delivers an enhanced performance, making it ideal for scientific and industrial applications, including biosensing and optical metrology, where precise polarization control is crucial.…”
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Development of a Broad-Spectrum Antigen-Capture ELISA Using Combined Anti-p26 Polyclonal and Monoclonal Antibodies for Detection of Equine Infectious Anemia Virus by Haibing Liang, Bingqian Zhou, Zhe Hu, Xiaoyu Chu, Xuefeng Wang, Cheng Du, Xiaojun Wang

“…The assay is simple, rapid, and cost-effective, making it suitable for both laboratory research and clinical applications. …”
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Assessing the environmental and economic benefits of integrating solar energy in Nigerian construction by H. C. O. Unegbu, D. S. Yawas, B. Dan-asabe, A. A. Alabi, R. C. Vedad

“…Financial constraints emerged as the most critical barrier, accounting for 40% of reported challenges, particularly due to high initial costs and limited access to financing. Technological limitations, particularly in energy storage and system efficiency, restrict large-scale deployment. …”
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Energy Efficiency of Agroforestry Farms in Angola by Oloiva Sousa, Ludgero Sousa, Fernando Santos, Maria Raquel Lucas, José Aranha

“…A comprehensive understanding of the energy balance allows farmers to assess the true cost-effectiveness of their operations, identify energy inefficiencies, and implement more effective strategies to maximise productivity while minimising environmental impacts.…”
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Integrated thermal and battery management for electric vehicles: Experimental validation and simulation-based optimization of lithium-ion batteries by Pujari Harish Kumar, Gayathri Raju, Mohit Bajaj, Nallolla Chinna Alluraiah, Pasala Gopi, Sunil Kumar Pulumithi, Reshma Gopi Remabhai, Rashmi Gangadhar, Ievgen Zaitsev

“…This novel approach bridges the gap between cutting-edge cooling techniques and intelligent battery management, offering a scalable and cost-effective solution for next-generation EV battery systems. …”
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Bridging Global Disparities in Breast Cancer Care: External Validation Study of the MD Anderson “Nomogram To Predict Positive Sentinel Lymph Nodes After Neoadjuvant Chemotherapy” a... by Vishal Farid Raza FCPS, Ayesha Ehsan FCPS, Amina Iqbal Khan FACS

“…This study externally validates its accuracy in a sample of Pakistani women and assesses its implications for cost effective breast cancer care in a resource limited setting. …”
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Removal of E. coli O157:H7 coliform bacteria from sewage wastewater using silver doped borate bioglass by Bassant I. Elsaba, Ashraf Elsayad, Yasser S. Rammah, Hosam Salaheldin

“…In conclusion, silver-doped BG is a cost-effective, eco-friendly, and highly recommended technology for SWW purification from fecal coliform bacteria and therefore, can be used for reclamation and other non-drinking water.…”
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Development of an Internet of Things (IoT)-based disease forecaster to manage purple spot on asparagus fern by John R. Spafford, Mary K. Hausbeck, Benjamin P. Werling, Stewart F. Tucker, Younsuk Dong

“…We assessed disease control when fungicides (azoxystrobin alternated with chlorothalonil) were applied according to TOMCAST using SpecConnect or the Internet of Things (IoT)-based LOCO-DM (Low-Cost sensor monitoring system for Disease Management) at two thresholds (15 or 20 DSV) or every 10 days. …”
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Assessing the Techno-Economic Feasibility of Bamboo Residue-Derived Hard Carbon by Senqiang Qin, Chenghao Yu, Yanghao Jin, Gaoyue Zhang, Wei Xu, Ao Wang, Mengmeng Fan, Kang Sun, Shule Wang

“…The results demonstrate that bamboo residues are a strategically distributed and underutilized resource for producing cost-competitive hard carbon at scale, particularly in provinces with existing bamboo industries and supply chains.…”
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Relaxation Response and Resiliency Training and Its Effect on Healthcare Resource Utilization. by James E Stahl, Michelle L Dossett, A Scott LaJoie, John W Denninger, Darshan H Mehta, Roberta Goldman, Gregory L Fricchione, Herbert Benson

“…<h4>Conclusion</h4>Mind body interventions such as 3RP have the potential to substantially reduce healthcare utilization at relatively low cost and thus can serve as key components in any population health and health care delivery system.…”
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Development of Polydopamine–Chitosan-Modified Electrochemical Immunosensor for Sensitive Detection of 7,12-Dimethylbenzo[a]anthracene in Seawater by Huili Hao, Chengjun Qiu, Wei Qu, Yuan Zhuang, Zizi Zhao, Haozheng Liu, Wenhao Wang, Jiahua Su, Wei Tao

“…This innovative approach offers a cost-effective and efficient solution for the in situ rapid monitoring of trace carcinogens in marine environments, potentially advancing the field of marine pollutant detection technologies.…”
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Green Synthesis, Characterization, and Potential Antibacterial and Anticancer Applications of Gold Nanoparticles: Current Status and Future Prospects by Md. Amdadul Huq, Md. Rasel Rana, Abdus Samad, Md. Shahedur Rahman, M. Mizanur Rahman, Md Ashrafudoulla, Shahina Akter, Jong-Whi Park

“…Green synthesis of AuNPs using biological agents such as plants and microbes is the most fascinating and attractive alternative to physicochemical synthesis as it offers many advantages, such as simplicity, non-toxicity, cost-effectiveness, and eco-friendliness. Plant extracts contain numerous biomolecules, and microorganisms produce various metabolites that act as reducing, capping, and stabilizing agents during the synthesis of AuNPs. …”
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Implementation of Intensified Tuberculosis Case Finding among People Living with HIV in Kampala, Uganda: A cross sectional study by David Okello, Angela Nakanwagi Kisakye, Justine Namakula, Esther Buryegyeya

“…Introduction: Intensified Case Finding (ICF) is a cost-effective strategy for tuberculosis (TB) control and improving quality of life however, its implementation by health workers is generally reported as low in Uganda. …”
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Can “Attenuation Subtraction”, a Computed Tomography Scan‐Based Factor, be Used as a Predictor of High‐Risk Esophageal Varices in Cirrhotic Patients? A Retrospective Cohort Study... by Mohammad Mersad Mansouri Tehrani, Nasser Bahari, Kian Goudarzi, Faeze Salahshour, Babak Shekarchi, Mohammad Masih Mansouri‐Tehrani, Majid Nouri

“…While current guidelines recommend screening for EVs, existing procedures are often invasive, costly, and occasionally unreliable. This study aims to develop a CT‐based predictor for identifying high‐risk esophageal varices group (HRG) in cirrhotic patients, offering a noninvasive, safe, and cost‐effective alternative that integrates seamlessly into routine follow‐up without requiring additional resources or time. …”
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Identifying areas for action to create healthier diets in the London Borough of Newham: systems mapping with residents by Jessica Renzella, Adeola Agbebiyi, Ruby Nayyar, Saira Malik, Emily Ahmed, Seeromanie Harding, Peter Scarborough, Prachi Bhatnagar

“…Conclusions Online Group Model Building activities represent a comprehensive yet low cost and low burden method for engaging communities in identifying areas for action to improve diets. …”
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Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera by Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan

“…However, challenges persist, including limited degradation precision due to the broad distribution of lysosome‐targeting receptors (LTRs), as well as the high cost and complexity of recombinant protein production or chemical synthesis. …”
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