Understanding the future of dengue in Malaysia: Assessing knowledge, attitude, and homeowner practices in mitigating climate-driven risks [version 1; peer review: 2 approved] by Sapna Shridhar Patil, Izzah Athirah Rosli, Fatin Norhasny Leman, Nur Hasnah Ma’amor, Nor Asiah Muhamad, Kulankara Balan Venugopalan, Prabal Bhargava, Mahalingam Dinesh, Weng Keong Yau, Chai Hong Yeong, Eng Hwa Wong, Arasarethinam Mugilarasi, Ameya Ashok Hasamnis, Imam Shaik, Chung Yeng Looi, Pei Pei Chong, Priya Madhavan, Lei Hum Wee, Anitha Ponnupillai, Jo Ann Andoy-Galvan, Yin How Wong

“…This is a cross-sectional study conducted among adult residents of low-cost housing apartments in an urban poor community in Kuala Lumpur, Malaysia involving approximately 16,000 residents. …”
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Exploring β-lactam interactions with DacB1: unraveling optimal therapies for combating drug-resistant Mycobacterium tuberculosis by Mary Nantongo, David C. Nguyen, Eunjeong Shin, Christopher R. Bethel, Magdalena A. Taracila, Khalid M. Dousa, Qing Li, Shane Fletcher, Sebastian G. Kurz, Barry N. Kreiswirth, W. Henry Boom, Steve Holland, Eric J. Rubin, Robert A. Bonomo

“…Current treatment options for drug-resistant TB are costly, toxic, and often ineffective, necessitating the exploration of alternative therapeutic strategies. …”
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Reverse-sequence endoscopic versus conventional open nipple-sparing mastectomy with implant-based breast reconstruction: a single-center prospective cohort study (RECO study) by Tianyuan Li, Qing Zhang, Yanyan Xie, Huanzuo Yang, Kawun Chung, Hui Dai, Xiaoman Cao, Zhenggui Du

“…However, traditional minimal-access NSM is time-consuming, costly, and has a steep learning curve, hindering its widespread adoption. …”
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On the Upper Mid-Band 8 × 8 and 8 × 4 Device MIMO Performance Based on Applying Compact Backcover Four-Antenna Modules for 6G Smartphones With Increased Data Rates by Kin-Lu Wong, Wan-Ting Li, Chin-Lung Wang, Chun-Chi Wen, Wei-Yu Li

“…However, it is worth noting that the <inline-formula> <tex-math notation="LaTeX">$8\times 8$ </tex-math></inline-formula> MIMO requires twice the transmitted power of current fifth-generation (5G) <inline-formula> <tex-math notation="LaTeX">$4\times 4$ </tex-math></inline-formula> MIMO and has a much more complex system architecture. Thus, whether it is cost effective to apply the <inline-formula> <tex-math notation="LaTeX">$8\times 8$ </tex-math></inline-formula> MIMO for increased data rates is not clear. …”
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HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in... by Augustine T Choko, Elizabeth L Corbett, Nigel Stallard, Hendramoorthy Maheswaran, Aurelia Lepine, Cheryl C Johnson, Doreen Sakala, Thokozani Kalua, Moses Kumwenda, Richard Hayes, Katherine Fielding

“…No serious adverse events were reported. Costs per male partner who attended the clinic with a confirmed HIV test result were $23.73 and $28.08 for the HIVST + $3 and HIVST + $10 arms, respectively. …”
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Release Behavior and Bioaccumulation Characteristics of Organophosphate Esters from Plastics in Marine Aquaculture by Zhi YANG, Dongni LIU, Shengnan HUANG, Xuetian DAI, Wei QIAN, Xiaoshan ZHU

“…They are lightweight, durable, and cost-effective. However, the large-scale production and extensive use of plastics in aquaculture have increased concerns about their potential environmental impacts, particularly regarding the pollution of the marine environment and the associated risks to ecosystems. …”
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Crack Tracking in Small-Diameter Metal Pipe Using Controlled Motor Vibrations and Flexible Sensor by Md Rabiul Awal, Nurul Atiqah Tajulmar, Muhammad Syarifuddin Yahya, Nurafnida Afrizal, Wan Hafiza Wan Hassan, Nurul Adilah Abdul Latiff, Shakir Saat

“…Higher strength, durability (along with wear and corrosion resistance), and lower cost make these pipes suitable for extreme weather conditions and hostile environments. …”
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Patient-derived colorectal microtumors predict response to anti-PD-1 therapy by Duy T. Nguyen, Matthew A. Schaller, Krista P. Terracina, Xia Xu, Diego I. Pedro, Alfonso Pepe, Juan M. Urueña, Zadia Dupee, Nickolas Diodati, Ryan A. Smolchek, Jack E. Famiglietti, Nhi Tran Yen Nguyen, Gerik W. Tushoski-Alemán, Kuoyuan Cheng, Lan Chen, Doug Linn, Vania Vidimar, Aquila Fatima, Soon Woo Kwon, Dongyu Sun, Hongmin Chen, Haiyan Xu, Brian Long, Lily Y. Moy, Bonnie J. Howell, George H. Addona, W. Gregory Sawyer

“…To improve efficiency, cost-effectiveness, and clinical outcomes, there is an essential need for a testing platform capable of promptly identifying evidence of anti-PD-1 response to inform treatment strategies. …”
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Safety of creatine supplementation: a scientometrics analysis on the impact of the ‘Creatine For Health’ initiative and introduction to CREAS by Diego A. Bonilla, Drew E. Gonzalez, Gustavo Humeres, Jisun Chun, Kelly Hines, Adriana Gil, Richard B. Kreider

“…For “HCl,” significant associations were found with words like “stomach,” “better,” “bloating,” “superior,” “expensive,” “cost,” and “soluble.”Conclusion While sentiment analysis suggests that a small percentage of the public holds a stronger negative view of creatine supplementation, it remains unclear how misinformation may have influenced these perceptions. …”
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Decentralized Immunization Monitoring: Lessons Learnt from a Pilot Implementation in Kumbotso LGA, Kano State, Nigeria by Adam Attahiru, Yahaya Mohammed, Fiyidi Mikailu, Hyelshilni Waziri, Ndadilnasiya Endie Waziri, Mustapha Tukur, Bashir Sunusi, Mohammed Nasir Mahmoud, Nancy Vollmer, William Vargas, Yusuf Yusufari, Gustavo Corrêa, Heidi W. Reynolds, Teemar Fisseha, Talatu Buba Bello, Moreen Kamateeka, Adefisoye Oluwaseun Adewole, Musa Bello, Imam Wada Bello, Sulaiman Etamesor, Joseph J. Valadez, Patrick Nguku

“…Negative vaccine perceptions (50% delayed, 53.6% ZD) and distrust in health workers (46.4% delayed, 48.2% ZD) were significant barriers, though the caregiver intent to vaccinate was protective (OR: 0.27, <i>p</i> < 0.001). The cost of accessing immunization services appeared to have a minor effect on coverage, as the majority of caregivers of delayed and ZD children reported spending less than 200 Naira (equivalent to USD 0.15) on transport. …”
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Donor-derived CARCIK-CD19 cells engineered with Sleeping Beauty transposon in acute lymphoblastic leukemia relapsed after allogeneic transplantation by Federico Lussana, Chiara F. Magnani, Stefania Galimberti, Giuseppe Gritti, Giuseppe Gaipa, Daniela Belotti, Benedetta Cabiati, Sara Napolitano, Silvia Ferrari, Alex Moretti, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Giuliana Rizzuto, Anna Grassi, Muriel Paganessi, Cristian Meli, Sarah Tettamanti, Giulia Risca, Giulia Pais, Giulio Spinozzi, Fabrizio Benedicenti, Giovanni Cazzaniga, Chiara Capelli, Elisa Gotti, Martino Introna, Josée Golay, Eugenio Montini, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi

“…Abstract Non-viral engineering can ease CAR-T cell production and reduce regulatory and cost requirements. We utilized Sleeping Beauty transposon to engineer donor-derived anti-CD19.CD28.OX40.CD3zeta T cells differentiated in cytokine-induced killer (CARCIK-CD19) for B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients relapsed after allogeneic hematopoietic stem cell transplantation (alloHSCT). …”
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A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Experimental evolution suggested that this P450 duplication is associated with a significant fitness cost, potentially affecting its adaptive value in presence of other resistance alleles. …”
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Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol by Nicola White, James D Chalmers, Salman Siddiqui, Paul H Lee, Cyrus Daneshvar, James Raftery, Charles Roberts, Philip Mitchelmore, Kerensa Thorne, Stefan J Marciniak, Tom Wilkinson, Angelica Cazaly, Gareth Griffiths, Neil J Greening, Anna Freeman, Alexander Allen, Andrew Cook, Karl J Staples, Tommaso Morelli, Jacqueline Nuttall, James Myerson, Olivia Cox, Emma Chamberlain, Tristan William Clark, Martha Purcell, Pedro Rodrigues, Matthew Pavitt, Michael G Crooks, Emma Tilt, Emma Knox, Monica Gil, Max Ellis, Ingrid Seath, Sandy Aitken, Barbara Costa, Sarah Dudley

“…Secondary endpoints include time to recovery and healthcare cost. Exploratory endpoints focus on biomarker profiles associated with virus type and clinical outcomes.Ethics and dissemination The study protocol received ethical approval from the relevant committees (English Ethics Reference Number: 22/WM/0119; Scottish Ethics Reference Number: 22-SS-0101, 20/09/2023). …”
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Clinical evaluation of two pathogen enrichment approaches for next-generation sequencing in the diagnosis of lower respiratory tract infections by Xiao Lei, Xiumei Xu, Chao Liu, Lipeng Zhong, Shupeng Yin, Biaoxian Li, Ling Cao, Zhiting Xie, Jing Li, Xuan Zhang, Yaping Guo, Liang Zhang, Haiyan Lin, Sufeng Zhang, Chengsheng Zhang, Tian Gong

“…Next-generation sequencing (NGS) has emerged as a promising platform for the diagnosis of infectious diseases, albeit with high costs and challenges in result interpretation. Here we evaluated two NGS-based pathogen detection assays for the etiological diagnosis of pneumonia in a prospective cohort of 257 patients. …”
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Indigenous Malolactic Starter Cultures as Innovative Tools to Modify the Sensory Profile of a Wine: An Oenological Challenge by Elizabeth Naiquen Flores, Gabriel Alejandro Rivas, Andrea Cecilia Guillade, Natalia Soledad Brizuela, Marina Edith Navarro, Emma Elizabeth Tymczyszyn, Lucrecia Delfederico, Carolina Fabiana Perez, Liliana Carmen Semorile, Danay Valdes La Hens, Barbara Mercedes Bravo-Ferrada

“…This study evaluated the oenological potential of three innovative native malolactic fermentation starters (MLFS) on a pilot scale, aiming to offer local wineries cost-effective MLFS with native LAB strains. Alcoholic fermentation of Malbec grapes was carried out using a commercial yeast starter, followed by a sequential inoculation of native malolactic starters formulated with (i) mesophilic <i>Lactiplantibacillus plantarum</i> UNQLp11 and <i>Oenococcus oeni</i> UNQOe73.2, both from the Province of Río Negro; (ii) psychrotrophic <i>Lentilactibacillus hilgardii</i> UNQLh1.1 and <i>Oenococcus oeni</i> UNQOe19, both from the Province of Río Negro; (iii) mesophilic <i>Lactiplantibacillus plantarum</i> UNQLp1001, from the Province of Buenos Aires; and (iv) a commercial malolactic started, which served as a control. …”
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Enteric-coated microencapsulation improves the therapeutic effect of cinnamon oil on artificially infected chicken with Escherichia coli by Huanling Xing, Fang Zhou, Jianhao Lin, Junfeng Ban, Junyi Huang, Xinghai Li, Hanjun He, Yanqun Li, Mei Bai, Xiangxiu Liang, Hong Wu

“…These findings suggest enteric microcapsule system for CEO significantly enhances CEO's therapeutic potential, offering a promising strategy for developing more efficient and cost-effective natural antibacterial treatments for colibacillosis.…”
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Characteristics of patients prescribed SGLT-2i and/or GLP-1RA among cardiology clinics in the US: insights from the COORDINATE-diabetes trial by Adam J Nelson, Lisa A. Kaltenbach, Hussein R. Al-Khalidi, Monica Leyva, Laura Webb, Darren K. McGuire, Rodica Pop-Busui, Matthew A Cavender, Vanita R. Aroda, Melissa L. Magwire, Caroline R. Richardson, Ildiko Lingvay, Julienne K. Kirk, Ambarish Pandey, Tanya Gaynor, Jonathan Pak, Alana Washington, Cagri Senyucel, Renato D. Lopes, Jennifer B. Green, Christopher B. Granger, Neha J Pagidipati

“…Contraindications to either agent and high cost were infrequently cited as reasons for not prescribing. …”
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Bioinoculant production composed by Pseudomonas sp., Serratia sp., and Kosakonia sp., preliminary effect on Allium cepa L., growth at plot scale by Andrea Blanco Vargas, Lina Rodríguez Gacha, Natalia Sánchez Castro, Laura Herrera Carlosama, Raúl Poutou Piñales, Lucía Díaz Ariza, Viviana Gutiérrez Romero, Claudia Rivera Hoyos, Leydi Ardila Leal, Aura Pedroza Rodriguez

“…To meet P requirements in agricultural settings, a low-cost culture medium (MT11B) was designed in which a bioinoculant was produced consisting of three bacterial isolates capable of solubilizing P from phosphoric rock (PR). …”
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Global Coffea arabica variety trials reveal genotype-by-environment interactions in resistance to coffee leaf rust (Hemileia vastatrix) by Jorge C. Berny Mier y Teran, Solene Pruvot-Woehl, Solene Pruvot-Woehl, Catherine Maina, Santos Barrera, James Mwita Gimase, Brahim Banda, Albertino Meza, Nathan Aliel Kachiguma, Nathan Aliel Kachiguma, Elijah K. Gichuru, Julio Alvarado, Julio Alvarado, Suresh Kumar, Jonny Alonso Castillo, Beatriz Moreno Lopez, Ariana Karina Román Ruíz, Ari Wibowo, Never Mwatsiya, Jeena Devasia, Divya Kallingapuram Das, Edgardo Alpizar, Melanie Bordeaux, Miftahur Rizqi Akbar, Piet van Asten, Jean Baptiste Kayigamba, Paul Mulemangabo, Godfrey Sseremba, Benit Mate, Hans Alexander Méndez Mendoza, Simon Martin Mvuyekure, Simon Martin Mvuyekure, Jane Jerono Cheserek, Rosalío López Morgado, Chemutai Job Alunga, Nayani Suryprakash Rao, Samson Tarusenga, Tania Humphrey, Christophe Montagnon

“…The use of resistant varieties is the most cost-effective and sustainable strategy for managing coffee leaf rust. …”
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Semantic Reasoning Using Standard Attention-Based Models: An Application to Chronic Disease Literature by Yalbi Itzel Balderas-Martínez, José Armando Sánchez-Rojas, Arturo Téllez-Velázquez, Flavio Juárez Martínez, Raúl Cruz-Barbosa, Enrique Guzmán-Ramírez, Iván García-Pacheco, Ignacio Arroyo-Fernández

“…Large-language-model (LLM) APIs demonstrate impressive reasoning capabilities, but their size, cost, and closed weights limit the deployment of knowledge-aware AI within biomedical research groups. …”
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