Use of intrauterine dextrose as an alternative to systemic antibiotics for treatment of clinical metritis in dairy cattle: a microbiome perspective by Jennine Lection, Jennine Lection, Jennine Lection, Emily Van Syoc, Emily Van Syoc, Emily Van Syoc, Asha Miles, Asha Miles, Julia Hamilton, Marcela Martinez, Santiago Bas, Justin Silverman, Justin Silverman, Justin Silverman, Adrian Barragan, Erika Ganda, Erika Ganda, Erika Ganda

“…IntroductionClinical metritis (CM) has significant costs to dairy producers. Current treatment strategy involves systemic antibiotics; however, there is increasing concern about judicious antibiotic use. …”
Get full text

History and development direction of iterative upgrading of deep coalbed methane reservoir reconstruction technology：Taking the Daji Block in the eastern margin of the Ordos Basin... by Fengyin XU, Huaibin ZHEN, Shuguang LI, Feng WANG, Lei ZHANG, Yubin WANG, Weichu YU, Weiping ZHU, Borui XU, Yun YANG, Haifeng ZHAO, Kunsen BAI

“…Practical application of finely tailored fracturing designs based on geological characteristics has yielded remarkable results.However, the paper identifies five key challenges and areas for improvement in deep coal reservoir stimulation: High water consumption and difficulties in managing flowback fluids during ultra-large-scale fracturing; The need for breakthroughs in intelligent fracturing technologies; Immaturity of collaborative fracturing methods; The urgent requirement to establish fracturing technology systems for deep, medium-to-low-rank coal seams; Incomplete functionality of fracturing fluids.To address these challenges, six development directions are proposed:① Advancing water-reducing fracturing techniques; ② Conducting research on fishbone horizontal wells combined with matrix acidizing for large-scale water-reduction and production enhancement; ③ Expanding the application of artificial intelligence in intelligent fracturing and post-fracturing evaluation; ④ Developing and implementing collaborative fracturing techniques to optimize well-to-fracture network integration; ⑤ Strengthening research and development and application of stimulation technologies for deep, medium-to-low-rank coal reservoirs; ⑥ Innovating new fracturing materials to further reduce costs, improve efficiency, and enhance recovery rates for deep CBM.…”
Get full text

Exploring the relationship between predicted negative energy balance and its biomarkers of Holstein cows in first-parity early lactation by Hongqing Hu, Sébastien Franceschini, Pauline Lemal, Clément Grelet, Yansen Chen, Hadi Atashi, Katrien Wijnrocx, Hélène Soyeurt, Nicolas Gengler

“…Direct measurement of NEB is impractical for large-scale use due to costs, necessitating reliance on indirect predictors such as milk mid-infrared (MIR) spectrometry-based predicted biomarkers. …”
Get full text

Perceptions about chronic health conditions, multimorbidity and self-management practices in rural northeast South Africa: findings from a qualitative study by Edward Fottrell, Stephen Tollman, F Xavier Gómez-Olivé, Rochelle Burgess, Alisha N Wade, Audry Dube, Nicola Joan Christofides, Belinda J Njiro, Chodziwadziwa Whiteson Kabudula

“…Participants also highlighted the role of religion in the control of chronic disease risk factors and traditional treatments for uncommon conditions such as epilepsy. Costs associated with lifestyle changes and equipment to manage and monitor health were highlighted as barriers to self-management of chronic health conditions.Conclusions Our findings contribute to emerging research on chronic health conditions and self-management approaches. …”
Get full text

Analysis of options for using oxygen-helium mixture in complex therapy and rehabilitation of patients with various diseases of the respiratory organs (review of literature) by Yu. A. Khatuntseva, V. M. Manuylov, A. N. Shcherbyuk, Ya. E. Nemstsveridze, A. A. Andrushchenko, G. I. Kurnakin

“…The development and implementation of innovative rehabilitation methods during treatment and at the posthospital stage is an urgent task of healthcare aimed at reducing labor losses, the level of disability and economic costs.Materials and methods. A systematic analysis of domestic and foreign literature for 2000-2024, published in leading peer-reviewed scientific journals and indexed in the PubMed, Scopus, Web of Science and RSCI databases, was conducted. …”
Get full text

‘Making Moves’: Protocol for a hybrid effectiveness-implementation pre-post trial of a co-designed online physical activity program for childhood cancer survivors by Lauren Ha, Claire E. Wakefield, Jacqueline Jacovou, Karen Johnston, Donna Drew, Mark W. Donoghoe, David Mizrahi, Richard De Abreu Lourenco, Richard J. Cohn, Natalie Taylor, Christina Signorelli, Kiarn Roughley, Callum Joyner, Aj Wright

“…To judge the potential implementation success of Making Moves, we will collect implementation data (feasibility, acceptability, costs) for our process evaluation throughout the trial. …”
Get full text

Estimation and prediction on the economic burden of schistosomiasis in 25 endemic countries by Xian-Fa Chen, Qin Li, Robert Bergquist, Jin-Xin Zheng, Su-Ying Guo, Qiu-Feng Lan, Zheng-Ze He, Li-Juan Zhang, Chun-Li Cao, Jing Xu, Xiao-Nong Zhou

“…The HAM model considered: (i) the impact of schistosomiasis mortality and morbidity on labor supply; (ii) age and gender differences in education and work experience among schistosomiasis patients; and (iii) the impact of schistosomiasis treatment costs on physical capital accumulation. To be able to compare the purchasing power of different countries, we used international dollars (INT$), a hypothetical currency unit based on purchasing power parity. …”
Get full text

Effectiveness of a brief multicomponent intervention to improve physical activity level and functional capacity in fibromyalgia and chronic fatigue syndrome (Synchronize+) by Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Gemma González Serra, Gemma González Serra, Noèlia Carrasco-Querol, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Nerea Bueno Hernández, Pau Bestraten del Pino, Pau Bestraten del Pino, Marta Pastor Cazalla, Marta Pastor Cazalla, Rosa Caballol Angelats, Rosa Caballol Angelats, Pilar Montesó-Curto, Pilar Montesó-Curto, Pilar Montesó-Curto, Elisabet Castro Blanco, Macarena Pozo Ariza, José Fernández-Sáez, José Fernández-Sáez, M. Rosa Dalmau Llorca, M. Rosa Dalmau Llorca, Alessandra Queiroga Gonçalves, Alessandra Queiroga Gonçalves, Carina Aguilar Martín, Carina Aguilar Martín

“…Long-term follow-up will determine whether the changes are maintained over time and their impact on quality of life and healthcare costs.…”
Get full text

A double-layer model for improving the estimation of wheat canopy nitrogen content from unmanned aerial vehicle multispectral imagery by Zhen-qi LIAO, Yu-long DAI, Han WANG, Quirine M. KETTERINGS, Jun-sheng LU, Fu-cang ZHANG, Zhi-jun LI, Jun-liang FAN

“…However, the determination of CNC from field sampling data for leaf area index (LAI), canopy photosynthetic pigments (CPP; including chlorophyll a, chlorophyll b and carotenoids) and leaf nitrogen concentration (LNC) can be time-consuming and costly. Here we evaluated the use of high-precision unmanned aerial vehicle (UAV) multispectral imagery for estimating the LAI, CPP and CNC of winter wheat over the whole growth period. …”
Get full text

Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies by Yunqing Lin, Ziyun Xiao, Fangxiao Hu, Xiujuan Zheng, Chenyuan Zhang, Yao Wang, Yanhong Liu, Dehao Huang, Zhiqian Wang, Chengxiang Xia, Qitong Weng, Leqiang Zhang, Yaoqin Zhao, Hanmeng Qi, Yiyuan Shen, Yi Chen, Fan Zhang, Jiaxin Wu, Pengcheng Liu, Jiacheng Xu, Lijuan Liu, Yanping Zhu, Jingliao Zhang, Wenbin Qian, Aibin Liang, Xiaofan Zhu, Tongjie Wang, Mengyun Zhang, Jinyong Wang

“…Additionally, engineering CARs into human tissue-derived NK cells demonstrates heterogeneity, low transduction efficiency, and high manufacturing costs. Methods The human pluripotent stem cells (hPSCs) were genetically modified by knocking out the CD7 gene and introducing the CD7 CAR expression cassette to generate CD7 KO-CD7 CAR-hPSCs. …”
Get full text

Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms by Aleksandr M. Reznik, Olga A. Karpenko, Elena A. Shumakova, Aleksandr V. Mudrak, Andrey V. Sokolov, Svetlana V. Nazimova, Alina M. Saifulina, Anton M. Eliseenko, Tatjana K. Matvievskaya, Angelina N. Khannanova, Vladimir I. Revenko, Dmitriy V. Scherbakov, Yuriy L. Martynyuk, Aleksandr L. Arbuzov, Oleg A. Yacenko, Polina N. Alekseeva, Aleksandr B. Berdalin, Larisa A. Burygina

“…Studies have shown that the correct selection of target groups for such therapy can reduce the frequency of relapses requiring hospitalization, lower the costs of inpatient care, and shift the focus of therapy from multiple drug administrations to psychosocial work. …”
Get full text

Bacteriostatic Activity and Resistance Mechanism of <i>Artemisia annua</i> Extract Against <i>Ralstonia solanacearum</i> in Pepper by Tiantian Du, Weiping Zhu, Chenning Zhang, Xiaomin Liang, Yinghua Shu, Jingyun Zhou, Mengyu Zhang, Yuxuan He, Jincai Tu, Yuanjiao Feng

“…Considering the development costs, the application of <i>A. annua</i> extract at a concentration of 0.75 g·mL⁻¹ demonstrates great potential for green control measures against bacterial wilt in peppers.…”
Get full text

Synthesis of Mixed Metal Nano-Oxides (MMNOs) for Cu (II) adsorption with remarkable removal efficiency: Isothermal, kinetics, and thermodynamics studies by Asmaa.M. Farid, Ahmed abdelkhalek, Ahmed A. Allam, Haifa E. Alfassam, Rehab Mahmoud, Fatma Mohamed

“…MMNOs possess distinctive properties, including a large surface area, enhanced stability, superior adsorption capabilities, low production costs, and straightforward separation processes. …”
Get full text

The effect of Artificial Intelligence Health Education Accurately Linking System on childhood asthma: study protocol for a pilot randomized controlled trial by Huan-Fang Wang, Yun-Hua Li, Qiaoling Zhang, Lihong Han, Lirong Wang, Lifang Zhang, Xue Bai, Mingyue Cheng, Ting Zhang, Fang Zhao, Hui Li, Xiao-Yun Wang

“…Based on it, we have designed an AI Health Education Accurately Linkage System (AI-HEALS) to explore whether AI-driven interventions can improve self-management capabilities of families with asthmatic children, thereby helping them control the disease and reduce medical costs.MethodsThis research is a pilot single-blind randomized controlled trial (RCT) intended to gauge the efficacy of the AI-HEALS intervention delivered via the WeChat platform in enhancing the self-management abilities of families with asthmatic children. …”
Get full text

Poisoning Epidemiology, Clinical Outcomes and Management Decisions for General Public Calls: A Cross-Sectional Analysis of a Nationwide Telehealth Toxicology Consultation Service D... by Abdullah A. Alharbi, Mohammed A. Muaddi, Meshary S. Binhotan, Ahmad Y. Alqassim, Ali K. Alsultan, Mohammed S. Arafat, Abdulrahman Aldhabib, Yasser A. Alaska, Eid B. Alwahbi, Meshari A. Almutairi, Mobarak Alharthi, M. Mahmud Khan, Mohammed Alabdulaali, Nawfal A. Aljerian

“…The large proportion of cases safely managed by the TCS demonstrates the feasibility and healthcare value of expanding remote toxicology services to improve efficiency and reduce costs. Data-driven insights could inform preventative initiatives, clinical guidance development, and strategic policies to curb poisoning incidence by targeting highest-risk demographics.…”
Get full text

Nephrometry Scores Based on Three-dimensional Virtual Models Improve the Accuracy of Predicting Postoperative Complications After Robotic Partial Nephrectomy: Results from a Collab... by Daniele Amparore, Federico Piramide, Paolo Verri, Enrico Checcucci, Alberto Piana, Giuseppe Basile, Alessandro Larcher, Andrea Gallioli, Angelo Territo, Josep Maria Gaya, Pietro Piazza, Stefano Puliatti, Antonio Andrea Grosso, Andrea Mari, Riccardo Campi, Laura Zuluaga, Ucpinar Burak, Badani Ketan, Sergio Serni, Umberto Capitanio, Francesco Montorsi, Alexandre Mottrie, Cristian Fiori, Andrea Minervini, Peter Wiklund, Alberto Breda, Francesco Porpiglia

“…Limitations include the risk of interobserver variability in evaluating nephrometry scores and categories, production costs for the 3DVMs, and the experience of the surgeons involved, with potential impacts on diffusion of this technology. …”
Get full text

Epidemiology and prediction of non-targeted bacteria by the filmarray pneumonia plus panel in culture-positive ventilator-associated pneumonia: a retrospective multicentre analysis by F. Berteau, A. Kouatchet, Y. Le Gall, C. Pouplet, A. Delbove, C. Darreau, J. Lemarie, F. Jarousseau, F. Reizine, C. Giacardi, G. Allo, C. Aubron, M. Eveillard, V. Dubee, R. Mahieu

“…Abstract Background Ventilator-associated pneumonia (VAP) is a prevalent nosocomial infection in intensive care units (ICUs) with significant impacts on patient outcomes and healthcare costs. Multiplex PCR could allow for personalized empirical treatment of VAP and optimize antibiotic therapy. …”
Get full text

Enhancing Sustainable Manufacturing in Industry 4.0: A Zero-Defect Approach Leveraging Effective Dynamic Quality Factors by Rouhollah Khakpour, Ahmad Ebrahimi, Seyed Mohammad Seyed Hosseini

“…One of the important factors that affects TBL sustainability in manufacturing firms is defect (<a href="#_ENREF_4">Goyal, Agrawal, &amp; Saha, 2019</a>), where the issues such as scrap generation (<a href="#_ENREF_11">Lindstr&ouml;m et al., 2019</a>), costs of consumption/waste of resources (<a href="#_ENREF_5">Grobler-Dębska, Kucharska, &amp; Baranowski, 2022</a>), and customer satisfaction level (<a href="#_ENREF_16">Mourtzis, Angelopoulos, &amp; Panopoulos, 2021</a>) are examples of sustainability criteria which are affected by defects. …”
Get full text

Clinical Prediction of Secondary Bloodstream Infections in Patients with Cerebral Infarction: A Nomogram-Driven Risk Assessment Model Based on LASSO Regression by Zhang L, Li X, Cai D, Mei C, Lu L

“…The model’s performance was validated through the area under the Receiver Operating Characteristic curve (AUC), calibration curves, and decision curve analysis (DCA).Results: Patients with BSI had significantly prolonged hospital stays (median of 17 days versus 11 days, p&lt; 0.001), higher costs (median of 34,859 yuan compared to 16,921 yuan, p&lt; 0.001), and increased adverse outcomes (34.4% versus 1.6%, p&lt; 0.001). …”
Get full text

Impact of In-Person and Mobile Exercise Coaching on Psychosocial Factors Affecting Exercise Adherence in Inactive Women With Obesity: 20-Week Randomized Controlled Trial by Christina Gjestvang, John Magne Kalhovde, Elene Mauseth Tangen, Hege Clemm, Lene Annette Hagen Haakstad

“…Thus, integrating web-based coaching could be a more economically sustainable option, offering both flexibility and reduced costs compared with in-person coaching only. Yet, research is needed to assess the effect of hybrid models in improving psychosocial factors among women with obesity. …”
Get full text