Can theory-driven implementation interventions help clinician champions promote opioid stewardship after childbirth? Protocol for a pragmatic implementation study by Michelle H. Moniz, Michelle H. Moniz, Michelle H. Moniz, Amy M. Kilbourne, Amy M. Kilbourne, Alex F. Peahl, Alex F. Peahl, Alex F. Peahl, Jennifer F. Waljee, Jennifer F. Waljee, Jennifer F. Waljee, Shelytia Cocroft, Carey Simpson, Carey Simpson, Lisa Kane Low, Lisa Kane Low, Lisa Kane Low, Mark C. Bicket, Mark C. Bicket, Mark C. Bicket, Michael J. Englesbe, Michael J. Englesbe, Michael J. Englesbe, Molly J. Stout, Molly J. Stout, Vidhya Gunaseelan, Vidhya Gunaseelan, Althea Bourdeau, Althea Bourdeau, May Hu, Carrie Miller, Carrie Miller, Shawna N. Smith, Shawna N. Smith, Shawna N. Smith

“…., acceptability, feasibility, costs, needed REP and E-REP adaptations) using clinician and patient surveys and qualitative methods (ClinicalTrials.gov identifier: NCT06285123).DiscussionFindings will inform refinements to the REP and E-REP interventions and add to the literature on the effectiveness of facilitation to promote uptake of evidence-based clinical practices in maternity care.…”
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Improving the accuracy of Respiratory Syncytial Virus (RSV) incidence estimates among hospitalised adults in Bristol, UK by Katie Lihou, Robert Challen, Anastasia Chatzilena, George Qian, Glenda Oben, Jade King, Serena McGuinness, Begonia Morales-Aza, Kaltun Duale, Ainhoa Rodriguez Pereira, William Healy, Jennifer Oliver, Nick Maskell, Adam Finn, Leon Danon, Catherine Hyams, Avon C. A. P. Research Group

“…The implementation of effective RSV vaccines could reduce morbidity, mortality and associated costs of disease. Adult RSV burden accuracy is improved by adjustment for test characteristics due to the impact of imperfect specificity when positivity-rates are low, and this is particularly important for out-of-season estimates. …”
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Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair by Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer

“…Currently, the only FDA cell-based therapy for articular cartilage injury is Autologous Chondrocyte Implantation (ACI); however, this procedure is costly, time-intensive, and requires multiple treatments. …”
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Transient simulation of multi-product pipeline driven by flow mechanisms and operational data by Jian DU, Haochong LI, Qi LIAO, Kaikai LU, Jianqin ZHENG, Xiao YU

“…Most existing transient estimation methods rely on precise and reliable physical models, which involve high computational costs to address multi-condition and multi-parameter combinations. …”
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Artificial Intelligence for Detecting COVID-19 With the Aid of Human Cough, Breathing and Speech Signals: Scoping Review by Mouzzam Husain, Andrew Simpkin, Claire Gibbons, Tanya Talkar, Daniel Low, Paolo Bonato, Satrajit S. Ghosh, Thomas Quatieri, Derek T. O'Keeffe

“…<italic>Goal:</italic> Official tests for COVID-19 are time consuming, costly, can produce high false negatives, use up vital chemicals and may violate social distancing laws. …”
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A retrospective multi-site examination of chronic kidney disease using longitudinal laboratory results and metadata to identify clinical and financial risk by Mark Fung, Aya Haghamad, Elizabeth Montgomery, Kathleen Swanson, Myra L. Wilkerson, Kimon Stathakos, Richard VanNess, Sarah A. Nowak, Clayton Wilburn, Haluk Kavus, Mohammed Amer Swid, Nkemakonam Okoye, Yonah C. Ziemba, Girish Ramrattan, Jonathan Macy, John McConnell, Mary Jane Lewis, Beth Bailey, Khosrow Shotorbani, James M. Crawford

“…The imputed lost reimbursement under risk-adjusted payment systems for under-documentation of CKD in this subset of patients was $2.85 M for the three institutions combined, representing lost opportunity for both identification and proactive clinical management of these patients, and financial recovery for the costs of providing that care. Conclusions Clinical laboratories can provide value beyond routine diagnostics, helping to close gaps in care for identification and management of CKD, stratifying subgroups of patients to identify risk, and capturing missed reimbursement through risk adjustment factors.…”
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Comparison of treatment patterns, efficacy and safety between generic and branded atorvastatin users in China: a multicenter, retrospective propensity score-matched cohort study by Xiaoxuan Xing, Zhizhou Wang, Ke Wang, Yiming Hua, Xiaoxi Li, Kejia Le, Wenbing Ma, Yingyun Guan, Aiping Deng, Xiong Yun, Hongfu Cai, Yongning Lyu, Guoying Xiong, Min Yang, Siyang Wang, Chaojun Xue, Jing Zhang, Qiushi Guo, Song Hu, Jing Li, Xianzhe Dong, Lan Zhang

“…Conclusion Generic atorvastatin had higher adherence and persistence and lower costs vs the branded drug, with no significant differences in efficacy and safety. …”
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Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers by Stephen M. Rao, Alexandria L. Chorba, M. J. Helppi, Alina Tuladhar, Amanda L. Penko, Sarah Holley, Brandon Nehls, Sabrina Paulino, Matthew C. Streicher, Audrey Zhu, Kellie Bruening, Sally Durgerian, Katherine Koenig, Mark Lowe, Wanyong Shin, Stephen E. Jones, Rachel Galioto, Jagan A. Pillai, Lynn M. Bekris, James B. Leverenz, Anson B. Rosenfeldt, Tamanna Singh, Gerald J. Beck, J. Carson Smith, Jay Alberts, Jay Alberts

“…Secondary outcomes include comprehensive neurocognitive and physical function test batteries, MRI scans including structural and functional connectivity measures, and blood-based biomarkers.HypothesesOver an 18-month interval, physically inactive ε4 carriers who engage in high-intensity aerobic exercise will demonstrate less cognitive decline and hippocampal atrophy than physically inactive ε4 carriers who did not participate in a formal exercise program.ConclusionSuccessful demonstration of a scalable, home-based, high-intensity aerobic exercise intervention in altering the trajectory of AD pathophysiology and its effects on cognitive functioning will transform AD treatment, improve patient outcomes and quality of life, and reduce healthcare costs.…”
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An explainable unsupervised learning approach for anomaly detection on corneal in vivo confocal microscopy images by Ningning Tang, Qi Chen, Yunyu Meng, Daizai Lei, Li Jiang, Yikun Qin, Xiaojia Huang, Fen Tang, Shanshan Huang, Qianqian Lan, Qi Chen, Lijie Huang, Rushi Lan, Xipeng Pan, Huadeng Wang, Fan Xu, Wenjing He

“…The proposed method enhances screening efficiency, reduces annotation costs, and holds great potential for scalable intelligent diagnosis of corneal diseases.…”
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Preventing adverse events during paediatric cancer treatment: protocol for a multi-site hybrid randomised controlled trial of catheter lock solutions (the CLOCK trial) by Paul Monagle, Andrew Wood, Robert Ware, Adam Irwin, Joshua Byrnes, Natalie Bradford, Susan Moloney, Michelle Martin, Tricia Kleidon, Andrew Moore, Roni Cole, Fiona Newall, Victoria Gibson, Samantha Keogh, David Eisenstat, Amanda Ullman, Mari Takashima, Elouise Comber, Eloise Borello, Nicole Henson, Philippa Howard, Karen McCleary, Jordana McLean, Michelle Noyes, Gemma Rowan, Amanda St John, Joshua Wolf

“…Secondary outcomes will include CABSI, CVAD-associated-thrombosis, CVAD failure, incidental asymptomatic CVAD-associated-thrombosis, other adverse events, health-related quality of life, healthcare costs and mortality. To achieve 90% power (alpha=0.05) for the primary outcome, data from 720 recruitments are required. …”
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The SmartNTx-study: a prospective, randomized controlled trial to investigate additional interventional telemedical management versus standard aftercare in kidney transplant recipi... by Mario Schiffer, Lars Pape, Julia K. Wolff, Julia K. Wolff, Raoul Gertges, Vanessa Visconti, Karen Reichert, Anja Pfau, Anne Dieterle, Katja Sauerstein, Andreas Kribben, Kristina Boss, Sinem Karaterzi, Felix Nensa, Philipp Winneckens, Mario Cypko, Mario Cypko, Wiebke Duettmann, Bianca Zukunft, Eva Schrezenmeier, Marcel G. Naik, Fabian Halleck, Roland Roller, Sebastian Möller, Sebastian Möller, Oliver Amft, Oliver Amft, Klemens Budde

“…In the interventional arm, the iBox score will be used to better detect patients at risk for early graft failure and drug-drug interactions will be regularly checked with certified software.DiscussionThe study aims to prolong patient and graft survival through additional telemedical services in order to reduce avoidable hospitalizations, improve treatment of co-morbidities, and improve adherence through patient empowerment, which should result in lower health care costs, and better quality of life of patients after kidney transplantation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT05897047.…”
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T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles by Jacek Lubelski, Eline van Diest, Ator Ashoti, Christina Zotou, Hanneke Rijssemus, Raymond Schiffelers, Zhiyong Lei, Maurits Geerlings, Jaime Fernández Bimbo, Daniel E Murphy, Martijn J W Evers, Suneel A Narayanavari, Diana Pereira Vaz, Nadine Saber, Peter Mayrhofer

“…However, treatment accessibility is hindered by high costs, long manufacturing times, and the need for specialized centers and inpatient care. …”
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Assessment of bone mineral density in epileptic patients with long-term antiepileptic therapy: pilot data by N. A. Sivakova, I. V. Abramova, V. P. Rybasova, O. D. Bolshunova, E. D. Kasyanov, G. V. Rukavishnikov, M. A. Khobeysh, M. Yu. Sorokin, L. V. Lukina, N. I. Ananyeva, R. F. Nasyrova, V. A. Mikhailov, G. E. Mazo

“…The problem of decreased bone mineral density and frequent fractures in patients with epilepsy is an important and understudied issue that significantly reduces quality of life and involves significant economic costs for the treatment and rehabilitation of epileptic patients. …”
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Critical care nurses’ knowledge regarding prevention of central venous catheter-related infection in Saudi Arabia: A cross-sectional study by Bassam Shyhan Alshammari, Salman Hamdan Alsaqri, Sameer A. Alkubati, Jordan H. Llego, Ahmad K. Al-Sadi, Aziza Z. Ali, Wessam A. Elsayed, Anas Mahmoud Balawi, Shaimaa Mohamed Nageeb, Laila A. Hamed

“…Background: Central venous catheter-related infections (CVC-RIs) are a significant concern in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare costs. Nurses play a crucial role in preventing these infections through proper catheter care, adherence to aseptic techniques, and early detection of complications. …”
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Application Practice of AI Empowering Post-discharge Specialized Disease Management in Postoperative Rehabilitation of the Lung Cancer Patients Undergoing Surgery by Mei LI, Hongbing ZHANG, Chunqiu XIA, Yuqi ZHANG, Huihui JI, Yi SHI, Liran DUAN, Lingyu GUO, Jinghao LIU, Xin LI, Ming DONG, Jun CHEN

“…This study followed 463 lung cancer surgery patients using an AI-based platform, aiming to identify common postoperative issues, propose solutions, improve quality of life, reduce recurrence-related costs, and promote AI integration in healthcare. …”
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Delivering a national de-adoption programme: a documentary analysis of local commissioning policy compliance with England's Evidence-based Interventions programme (EBI) by Carmel Conefrey, Nicola Farrar, Maeve Coyle, Mike Bell, Jane Blazeby, Christopher Burton, Jenny Donovan, Andy Gibson, Joel Glynn, Tim Jones, Angus McNair, Josie Morley, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, William Hollingworth, Leila Rooshenas

“…Abstract Background In 2019 the English National Health Service (NHS) launched a national de-adoption programme to stop or limit access to surgical procedures considered to have little, or uncertain, evidence of benefit to justify their risks and/or costs: the Evidence-Based Interventions (EBI) programme. …”
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Post-harvest processing methods have critical roles on the contents of active metabolites and pharmacological effects of Astragali Radix by Xiaoyan Zhang, Shengnan Jiang, Tingting Sun, Wenbing Zhi, Kairu Ding, Ziyao Qiao, Hong Zhang, Hong Zhang, Ye Li, Yang Liu, Yang Liu

“…The fresh processing method effectively prevents the loss and degradation of metabolites, common in traditional drying and softening processes, while also reducing production costs. Astragali Radix (AR), a leguminous botanical drug, is widely utilized in clinical practice and functional foods. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…This co-creation platform for network-wide systems-based activities would reduce inefficiencies in AMR-related activities around agrifood, providing a cross-cutting, cohesive community to deliver transformational guidance on relevant, practical agrifood solutions that add value by reducing AMR, antimicrobial usage and associated costs, and decreasing resultant environmental contamination by prioritising challenges, sharing knowledge and best practice, and co-creating practical solutions with key stakeholders. …”
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Catabolic pathway acquisition by rhizosphere bacteria readily enables growth with a root exudate component but does not affect root colonization by Stephan Christel, Alyssa A. Carrell, Leah H. Hochanadel, Manuel I. Villalobos Solis, Paul E. Abraham, Sara S. Jawdy, Julie E. Chaves, Nancy L. Engle, Timkhite-Kulu Berhane, Tao Yao, Jin-Gui Chen, Wellington Muchero, Timothy J. Tschaplinski, Melissa A. Cregger, Joshua K. Michener

“…The likelihood of a successful transfer event is expected to depend on the precise balance of costs and benefits resulting from pathway acquisition. …”
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Eco-friendly pest management in integrated rice-fish farming systems using plant-derived biopesticides to promote sustainable agriculture by Wiratno , I.M. Trisawa, I. Taufik, I. Ardi, L. Thesiana, E. Kusrini, D. Susanti, E.W. Minarni, A. Nurawan, A. Jufri, Sukamto , Y. Apriyana, N. Sutrisna, Y. Surdianto, B. Susanto, U. Susanto

“…Economically, the slightly higher input costs of botanical sprays were offset by improved rice yields, reduced post-harvest losses, and higher fish survival rates, resulting in significant gains in net farm income. …”
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