Cementless unicompartmental knee arthroplasty is safe and effective at a minimum follow‐up of 4.2 years: A systematic review by Pierangelo Za, Giuseppe Francesco Papalia, Umberto Cardile, Pietro Gregori, Sebastiano Vasta, Edoardo Franceschetti, Stefano Campi, Rocco Papalia

“…However, several advantages are reported for cementless UKA, such as improved osseointegration, reduced cement‐related costs and complications. The aim of this study was to analyse clinical outcomes, survival, complications, failures and revision rate of cementless UKA. …”
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Early Flap Reconstruction and Infection Rates in Open Lower Extremity Fractures: A Systematic Review and Meta-analysis by Rafael Felix P. Tiongco, BA, Siam K. Rezwan, BA, Sami Alahmadi, MSc, Matthew J. Heron, BS, Scott A. Sylvester, MD, Stella M. Seal, MLS, Tim de Jong, MD, PhD, Ala Elhelali, PhD, MSc, Lily R. Mundy, MD

“…Infection is a common complication of lower extremity flap coverage and is associated with prolonged hospitalization, high costs, and poor patient-reported outcomes. Elapsed time from injury to flap coverage can increase infection risk, but the optimal timing threshold remains debatable. …”
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Enhancing the selectivity and conditional sensitivity of an antimicrobial peptide through cleavage simulations and homoarginine incorporation to combat drug-resistant bacteria by Keyi Yao, Jiachen Liu, Ruize Sun, Yun Wang, Yangyang Jiang, Tao Wang, Xiaoling Chen, Chengbang Ma, Tianbao Chen, Chris Shaw, Mei Zhou, Lei Wang

“…However, their development has been hindered by high manufacturing costs, toxicity, and poor enzyme tolerance. In this study, we employed bioinformatics tools to simulate the trypsin cleavage of Esculentin-2P (E2P), a frog-derived AMP with 37 amino acids and performed functional screening to identify its effective active fragments. …”
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Prospective observational study to assess the performance accuracy of clinical decision rules in children presenting to emergency departments with possible cervical spine injuries:... by Franz E Babl, Simon Craig, Susan M Donath, Meredith L Borland, Natalie Phillips, Amit Kochar, Gavin A Davis, Shane George, Stuart Dalziel, Arjun Rao, Nathan Kuppermann, Stacy Goergen, Sarah Watson, Amanda Williams, Eunicia Tan, Catherine L Wilson, Michelle Davison, Blessy John-Denny, Sonia Singh, Sharon O’Brien, Geoffrey N Askin, Chris J Selman, Julie C Leonard

“…While imaging can be used to determine the presence of injuries, these tests are not without risks and costs, including exposure to radiation and associated life-time cancer risks. …”
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A Review of Soil Constitutive Models for Simulating Dynamic Soil–Structure Interaction Processes Under Impact Loading by Tewodros Y. Yosef, Chen Fang, Ronald K. Faller, Seunghee Kim, Qusai A. Alomari, Mojtaba Atash Bahar, Gnyarienn Selva Kumar

“…Full-scale crash testing remains the benchmark for evaluating barrier performance; however, such tests are costly, logistically demanding, and subject to variability that limits repeatability. …”
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Self-adaptive evolutionary neural networks for high-precision short-term electric load forecasting by Muhammad Abbas, Yanbo Che, Sarmad Maqsood, Muhammad Zain Yousaf, Mustafa Abdullah, Wajid Khan, Saqib Khalid, Mohit Bajaj, Mohammad Shabaz

“…Abstract Reliable short-term electric load forecasting (STLF) is essential for enhancing grid stability, optimizing energy distribution, and minimizing operational costs in modern power systems. However, existing forecasting models, including statistical approaches and deep learning architectures such as multi-layer perceptron (MLP), struggle to capture complex nonlinear load variations while maintaining computational efficiency. …”
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Gestion optimisée des intrants pour une réponse efficace en contexte de pandémie au Cameroun by Joseph Fokam, Cyrille Alain Abega Abega, Ezechiel Ngoufack Jagni Semengue, Aissatou Abba, Désiré Takou, Grace Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Derrick Ayuk Ngwese Tambe, Chenwi Collins, Aude Christelle Ka’e, Michel Carlos Tommo Tchouaket, Rachel Audrey Nayang Mundo, Aurelie Minelle Kengni Ngueko, Naomi-Karell Etame, Larissa Gaelle F. Moko, Evariste Molimbou, Willy Leroi Togna Pabo, Pamela Patricia Tueguem, Nadine Fainguem, Lionele F. Mba, Laeticia Grace Yatchou, Nafissatou Ibnou, Thaddée Bienvenu Onana, Yap Boum II, Alain Georges Etoundi Mballa, Alexis Ndjolo

“…Contribution: Adequate implementation of this logistical strategy would optimize supply management and help to save associated costs while ensuring effective genomic surveillance or response when faced with any public health incident in Cameroon.…”
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Optimising coronary imaging decisions with machine learning: an external validation study by Floor Groepenhoff, Leonard Hofstra, Sophie Heleen Bots, Saskia Haitjema, Imo Hoefer, L. Malin Overmars, Bram van Es, Mark C. H. De Groot, G. Aernout Somsen, I. Igor Tulevski, Hester M. den Ruijter, Wouter W. van Solinge

“…Cardiac CT or coronary angiography is often used but is inefficient and costly and involves risks. Sex-stratified algorithms based on electronic health records (EHRs) could be a non-invasive alternative for excluding coronary stenosis, yet their performance may vary by healthcare settings. …”
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First 100 days outcomes of cryopreserved vs non-cryopreserved stem cells autologous bone marrow transplant in multiple myeloma - a single center experience by Awais Siddiq, Mehreen Ali Khan, Jehanzeb Ur Rehman, Irsa Hidayat, , Qudratullah, Munazza Nabi Awan, Hammad Javed

“…Conclusion: NC stem cell grafts offer comparable efficacy to CryoP grafts while reducing costs and enhancing outcomes, particularly for engraftment speed and hospital stay duration. …”
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Mixed Reality in Undergraduate Nursing Education: A Systematic Review and Meta-Analysis of Benefits and Challenges by Laura Guillen-Aguinaga, Esperanza Rayón-Valpuesta, Sara Guillen-Aguinaga, Blanca Rodriguez-Diaz, Rocio Montejo, Rosa Alas-Brun, Enrique Aguinaga-Ontoso, Luc Onambele, Miriam Guillen-Aguinaga, Francisco Guillen-Grima, Ines Aguinaga-Ontoso

“…The main challenges were cybersickness, usability, high costs, and limited institutional access to MR technology. …”
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HUBUNGAN AGENSI DAN KINERJA PADA PERUSAHAAN KELUARGA DI INDONESIA by D. Agus Harjito

“…If there is a negative relationship between the mechanisms of reducing agency problems means there is an interchangeable (substitution) relationship between the mechanisms of reducing the agency problems that agency costs can be reduced. However, if there is a positive relationship means that the increasing use of one of the mechanisms reducing agency problems will increase the use of other mechanism reducing agency problems. …”
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High-Resolution Mapping of Shallow Water Bathymetry Based on the Scale-Invariant Effect Using Sentinel-2 and GF-1 Satellite Remote Sensing Data by Jiada Guan, Huaguo Zhang, Tong Han, Wenting Cao, Juan Wang, Dongling Li

“…However, the acquisition of high-resolution imagery has been a challenge due to the difficulties and high costs associated with obtaining such data. To address this issue, this study proposes a water depth inversion method based on Gaofen-1 (GF-1) satellite data, which integrates multi-source satellite data to obtain high-resolution bathymetric data. …”
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The Impact of Rapid Molecular Diagnostics for Influenza on Antibiotic Stewardship in the Emergency Department—An Observational Retrospective Study by Elisa Roth, Marco Cattaneo, Yvonne Hollenstein, Maja Weisser, Stefano Bassetti, Sarah Tschudin Sutter, Roland Bingisser, Christian H. Nickel, Adrian Egli

“…Objective: The clinical diagnosis of respiratory tract infections (RTIs) may result in unnecessary antibiotic treatment due to clinical exams’ low sensitivity and specificity to differentiate viral from bacterial infections and costly diagnostic work-ups. Unnecessary antibiotic consumption drives antibiotic resistance. …”
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Production and biochemical characterization of freeze-dried blueberry juice from enzymatically processed berries by E. A. Alekseenko, N. Yu. Karimova, G. V. Semenov, I. S. Krasnova, O. E. Bakumenko

“…This direction allows complex problem solving regarding seasonality of berry processing with optimization of logistics costs, extension of the geography of sources of raw material supply while preserving high sensory properties of a freeze-dried product. …”
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Cultivation of cells in alginate drops as a high-performance method of obtaining cell spheroids for bioprinting by S. Yu. Filippova, T. V. Chembarova, S. V. Timofeeva, I. V. Mezhevova, N. V. Gnennaya, I. A. Novikova, T.  O. Lapteva

“…In addition, the clonal nature of the obtained spheroids leads to an increase in research costs and thus limits their scalability.…”
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Cell Therapy in Neonates by Reza Saeidi

“…However, the success of these therapies depends on overcoming several challenges, including immune rejection, high costs, Ethical Issues and approval processes.…”
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Effect of transcutaneous vagus nerve stimulation with electrical stimulation on generalized anxiety disorder: Study protocol for an assessor-participant blinded, randomized sham-co... by JingLing Lai, Jun Liu, Lei Zhang, JiuDong Cao, Yang Hong, Ling Zhang, JiLiang Fang, XiaoLing Wang

“…In addition, the use of t-VNS devices has substantially decreased time and financial costs, potentially providing a promising option for complementary alternative medicine in the treatment of GAD, thereby advancing treatment decisions for this condition. …”
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Closing-the-loop: a novel care coordination tool to reduce maternal healthcare utilization postpartum and collaboratively build interventions to address community needs by Amanda Terry, Chelsea Arnold, Zackery White, Mary O’Connor, Gillian Feldmeth, Halima Ahmadi-Montecalvo

“…Conclusions Using the Unite Us platform as a digital tool to advance care coordination, the OB Service line within Sarasota Memorial observed statistically significant reductions in postpartum healthcare utilization in Medicaid/Medicare beneficiaries indicating that addressing non-medical, health-related needs may improve postpartum outcomes and reduce costs. These referral data are also used to facilitate community discussions on ways to build a more supportive network to improve maternal and child health outcomes.…”
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Multi-input PINN Surrogate Model for Digital Twin of Lead-cooled Fast Reactor Main Pump by GUO Yiwen, LI Liangxing, XIANG Zutao, GUI Jiabin, SHI Shang, LEI Zhenxin, XU Xiangyang

“…This approach results in high computational costs and prolonged design cycles. To address the issues, a physics-informed neural network (PINN) surrogate model with a multi-input structure was developed and applied it for rapid prediction of the flow field of the MPC in LFR under different operating conditions, to be used in the state tracking module of a digital twin system. …”
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Which Surgical Hand Preparation Method Is More Effective? A Comparative Study of Hand Rub and Hand Scrub by Claudia Olivia, Kusman Ibrahim, Titis Kurniawan

“…Surgical Site Infection (SSI) can be a devastating complication, leading to increased morbidity, mortality, and healthcare costs. Pre-surgical hand preparation is an effective strategy to prevent SSI. …”
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