Low-dose rituximab followed by mycophenolate mofetil for steroid-dependent/frequently relapsing nephrotic syndrome in children: a case series by Jide Song, Hong Chang, Yi Lin, Chunrong Shan, Jia Liu, Ranran Zhang, Nana Nie, Cui Bai, Shan Gao, Qiuye Zhang, Dahai Wang

“…Compared with the calculated standard dose of RTX, low-dose RTX followed by MMF was less costly. No serious adverse reactions were observed during RTX use or follow-up, except for one death due to delayed treatment of severe infection.ConclusionLow-dose RTX followed by MMF can extend the remission duration of FRNS/SDNS in children, and decrease the economic burden on families, while offering good safety.…”
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Impact of the Use of 2-Phospho-L Ascorbic Acid in the Production of Engineered Stromal Tissue for Regenerative Medicine by David Brownell, Laurence Carignan, Reza Alavi, Christophe Caneparo, Maxime Labroy, Todd Galbraith, Stéphane Chabaud, François Berthod, Laure Gibot, François Bordeleau, Stéphane Bolduc

“…This protocol could significantly reduce the costs associated with tissue production by reducing preparation time and use of materials. …”
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Resilience investments under climate change: a regional case study in Southeast Australia by Paul J. Box, Stefanos Xenarios, Stefanos Xenarios, Russell M. Wise, Russell M. Wise, Peter Heinmiller, Chandrama Sarker, Petina L. Pert, Seona Meharg, Gemma Edwards, Russell Gorddard, Sofia Azevedo, Dianne Flett, Nic Mesic, Maryam Ahmad, John Marinopoulos, Greg Parish, Jacqui Montgomery

“…The approach involves: collectively identifying values and vulnerabilities in a hazard-prone region in south-east Australia; prioritizing focal infrastructure asset types for investigation, in this case transport but relevant to all forms of critical infrastructure including nature; identifying suitable interventions for resilience planning under scenarios of change; and formulating RICs by assessing the effectiveness, costs, and benefits of bundles of resilience interventions under scenarios of change. …”
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REMAP Periop: a randomised, embedded, multifactorial adaptive platform trial protocol for perioperative medicine to determine the optimal enhanced recovery pathway components in co... by Brian Williams, Jennifer Holder-Murray, Kathirvel Subramaniam, Kert Viele, Oscar C Marroquin, Scott Berry, Aman Mahajan, Luca La Colla, Charles Luke, Alison R Althans, Stephen A Esper, Joshua Knight, Joseph Derenzo, Ryan Ball, Shawn Beaman, Nicholas Schott, Elizabeth Lorenzi, Lindsay R Berry, Miranda Masters, Katie A Meister, Todd Wilkinson, William Garrard

“…Introduction Implementation of enhanced recovery pathways (ERPs) has resulted in improved patient-centred outcomes and decreased costs. However, there is a lack of high-level evidence for many ERP elements. …”
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Development and validation of AI-based automatic segmentation and measurement of thymus on chest CT scans by Yusheng Guo, Bingxin Gong, Guowei Jiang, Wang Du, Shuangfeng Dai, Qi Wan, Dongyong Zhu, Chanyuan Liu, Yi Li, Qing Sun, Qianqian Fan, Bo Liang, Lian Yang, Chuansheng Zheng

“…Conclusion Thy-uNET can provide reliable automatic segmentation and automatic measurement information of the thymus or thymic region on routine CT, reducing time costs and improving the consistency of evaluations.…”
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Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development by Mengxue He, Dongxue Wang, Yong‐Jiang Xu, Jiachen Shi, Aiyang Liu, Xiaoxi Zhao, Yunlai Gao, Yuan He, Yu Zhang, Ru‐Xing Wang, Yuanfa Liu

“…Abstract Background Coronary atherosclerosis (CA) is a leading cause of cardiovascular diseases with the high morbidity and mortality; however, the current diagnostic methods, primarily based on symptoms, signs, lab examination and imaging, are often inadequate for detecting subclinical or early‐stage CA, costly, and inaccessible in many cases. The objective of this study was to discover sensitive and specific biomarkers for the diagnosis of CA severity. …”
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Effects of animal-assisted therapy on dental anxiety, behavior, and perceptions in young pediatric patients: a blinded randomized controlled trial by Grace Kapov, Kasey Linton, Christopher Gatewood, Chuwen Liu, Timothy Strauman, Eric Hodges, Christina Graves, Caroline Sawicki, Di Wu, Kimon Divaris, Laura Anne Jacox

“…Pharmacological methods of anxiety management are costly, carry risks of adverse outcomes, and may not be acceptable to some families. …”
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Incidence, in-hospital mortality and risk factors for hospital-acquired pneumonia in patients with intra-abdominal surgical procedures hospitalized in a tertiary hospital in Belgra... by Taušan Đorđe, Kostić Zoran, Slavković Damjan, Nešković Branimir, Bokonjić Dubravko, Šipetić-Grujičić Sandra, Ratković Nenad, Šuljagić Vesna

“…Hospital-acquired pneumonia (HAP) in a surgical population significantly increases morbidity and mortality, prolongs hospitalization and increases total treatment costs. In the present study, we aimed to determine incidence, in-hospital mortality and risk factors (RFs) of HAP in patients with intra-abdominal surgical procedures hospitalized in a tertiary hospital in Belgrade (Serbia). …”
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Effects of community action on animal vaccination uptake, antimicrobial usage, and farmers’ wellbeing in Ghana: study protocol for a cluster-randomized controlled trial by Francis Sena Nuvey, Günther Fink, Jan Hattendorf, Daniel T. Haydon, Gilbert Fokou, Kennedy Kwasi Addo, Jakob Zinsstag, Clemence Esse-Dibby, Bassirou Bonfoh

“…The main idea is the platforms enabling information exchange on livestock vaccines, enhancing service scheduling, and sharing vaccination costs among farmers living in the same locality. …”
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The anterior intercrest line is a novel, accurate surface marking for identifying the L4/5 disc level: a prospective agreement study with fluoroscopy by Matthew H. Claydon, MBBS, BMedSci, FRACS, Dean T. Biddau, BBiomedSc, Stephanie G Claydon, Dean P McKenzie, BA (Hons), PhD, Gregory M. Malham, BSc, MB, ChB, DMed, FRACS

“…Using this line would reduce radiation exposure, overall operative times, and costs.…”
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Enhancing xanthan biosynthesis in aerobic granular sludge for resource recovery: The role of organic loading rate, carbon-to-nitrogen ratio, and feeding strategy by Manveer Kaur, Rebecca N. Vesuwe, André Bezerra dos Santos, Kalindi D. Morgan, Oliver Terna Iorhemen

“…This study is the first to examine xanthan biosynthesis and recovery in aerobic granular sludge (AGS) wastewater treatment systems, providing an alternative to conventional carbohydrate-rich fermentation, which is energy-intensive, feedstock-dependent, and costly. Valorizing xanthan from wastewater supports circular economy principles and integrated water–resource management. …”
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Digitally delivered cognitive behavioral therapy for insomnia (CBT-I) for patients with chronic pain and insomnia (The Back2Sleep Trial): study protocol for a randomized controlled... by Maria Louise Stage Olsen, Jonas Bloch Thorlund, Robert Zachariae, Werner Vach, Laila Bendix, Julie Jespersen, Preben Kidmose, Christine Parsons, Kristian Kidholm, Henrik Bjarke Vægter

“…Medium-term and long-term secondary outcomes (ISI, pain intensity, EQ5D-5L, health care costs, and use of sleep and pain medication) will be collected after 24 and 52 weeks. …”
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Revision Total Hip Arthroplasty — What Are We to Expect? by Igor I. Shubnyakov, Andrey A. Korytkin, Alexey O. Denisov, Alisagib A. Dzhavadov, Aymen Riahi, Maksim S. Guatsaev, Rashid M. Tikhilov

“…There is a sharp increase in the number of revision procedures, a growing proportion of complex revisions requiring advanced and costly implants, and an exceptionally rapid rise in the number of infection-related revisions. …”
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Universal conditional networks (UniCoN) for multi-age embryonic cartilage segmentation with sparsely annotated data by Nishchal Sapkota, Yejia Zhang, Zihao Zhao, Maria Jose Gomez, Yuhan Hsi, Jordan A. Wilson, Kazuhiko Kawasaki, Greg Holmes, Meng Wu, Ethylin Wang Jabs, Joan T. Richtsmeier, Susan M. Motch Perrine, Danny Z. Chen

“…Tackling this segmentation task with deep learning (DL) methods is laborious due to the big burden of manual image annotation, expensive due to the high acquisition costs of 3D micro-CT images, and difficult due to embryonic cartilage’s complex and rapidly changing shapes. …”
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Knowledge and Views of Patients With Cardiovascular Disease Toward Pharmacogenomics in The United Arab Emirates by Maram O. Abbas, Azhar T. Rahma, Iffat Elbarazi, Bassam R. Ali, George P. Patrinos, Farah Nagy, Alya Osman, Reem K. Alneyadi, Anwar S. Alshamsi, Mohamed Alraqabani, Zeina Al‐Mahayri, Fatma Al‐Maskari

“…Participants were grouped into three PGx perception clusters: Cluster 1 (33.17%) concerned about risks but valued PGx, Cluster 2 (40.23%) worried about privacy/costs, and Cluster 3 (26.58%) confident in PGx benefits. …”
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SeaConvNeXt: A Lightweight Two-Branch Network Architecture for Efficient Prediction of Specific IHC Proteins and Antigens on Hematoxylin and Eosin (H&E) Images by Yuli Chen, Guoping Chen, Guoying Shi, Yao Zhou, Jiayang Bai, Germán Corredor, Cheng Lu, Xiujuan Lei

“…Immunohistochemistry (IHC) is a vital technique for detecting specific proteins and antigens in tissue sections using antibodies, aiding in the analysis of tumor growth and metastasis. However, IHC is costly and time-consuming, making it challenging to implement on a large scale. …”
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TPL-DA: A Novel Threshold-Free Pseudolabel Learning Framework for Domain Adaptive Semantic Segmentation of High-Resolution Remote Sensing Images by Yan Ren, Jie Long, Xiaowen Gao, Ming Zhang, Guoqing Liu, Nan Su

“…Domain adaptive semantic segmentation (DASS) has been proposed to mitigate the reliance on dense and costly annotations, typically using stagewise training. …”
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Development and validation of a risk nomogram predicting pneumothorax requiring chest tube placement post-percutaneous CT-guided lung biopsy by Masha Bondarenko, Jianxiang Zhang, Ulysis Hugo Baal, Brian Lam, Gunvant Chaudhari, Yoo Jin Lee, Jamie Schroeder, Maya Vella, Brian Haas, Thienkhai Vu, Kimberly Kallianos, Jonathan Liu, Shravan Sridhar, Brett Elicker, Jae Ho Sohn

“…Abstract Background Pneumothorax requiring chest tube after CT-guided transthoracic lung biopsy presents added clinical risk and costs to the healthcare system. Identifying high-risk patients can prompt alternative biopsy modes and/or better preparation for more focused post-procedural care. …”
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Kenya’s National Action Plan on antimicrobial resistance: measuring implementation progress by Joseph Mukoko, Evelyn Wesangula, Nkatha Gitonga, Ndinda Kusu, Cynthia Odhiambo, Emmanuel Tanui, Allan Azegele, Romona Ndanyi, Mohan P. Joshi, Tamara Hafner, Niranjan Konduri

“…Major learnings and recommendations from the review—strengthening governance arrangements at the national and county level; costing of the NAP-AMR; and ramping up advocacy efforts to political leadership to gather further support for actions on AMR—were integrated into the next iteration of the NAP-AMR (2023–2027), which was released during the World AMR Awareness Week in November 2023. …”
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Assessing the reliability of woody vegetation structural characterisation from UAV-LS in a tropical savanna by Rafael Bohn Reckziegel, Thomas Lowe, Timothy Devereux, Stephanie M. Johnson, Ellen Rochelmeyer, Lindsay B. Hutley, Tanya Doody, Shaun R. Levick

“…Terrestrial laser scanning (TLS) represents the gold standard in remote quantification of woody vegetation structure and volume, but is costly and time consuming to acquire. TLS data is typically collected at spatial scales of 1 ha or smaller, which limits its suitability for representing heterogeneous landscapes, and for training and validating satellite-based models which are needed for larger area monitoring. …”
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