PO12 | Characterisation and real word clinical data of HEM006, a newly formulated intranasal spray desmopressin (DDAVP) to address a global treatment gap

“…This formulation holds the potential to restore consistent global access to intranasal desmopressin, reduce reliance on costly and invasive therapies, and address a persistent unmet medical need in bleeding disorders. …”
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Layered Production Allocation Method for Dual-Gas Co-Production Wells by Guangai Wu, Zhun Li, Yanfeng Cao, Jifei Yu, Guoqing Han, Zhisheng Xing

“…The synergistic development of low-permeability reservoirs such as deep coalbed methane (CBM) and tight gas has emerged as a key technology to reduce development costs, enhance single-well productivity, and improve gas recovery. …”
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A Hybrid Model of Feature Extraction and Dimensionality Reduction Using ViT, PCA, and Random Forest for Multi-Classification of Brain Cancer by Hisham Allahem, Sameh Abd El-Ghany, A. A. Abd El-Aziz, Bader Aldughayfiq, Menwa Alshammeri, Malak Alamri

“…The proposed ViT-PCA-RF model helps detect early brain tumors, enabling timely intervention, better patient outcomes, and streamlining the diagnostic process, reducing patient time and costs. Our research trained and tested on the Brain Tumor MRI (BTM) dataset for multi-classification of brain tumors. …”
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Fertility intention and its correlates with reproductive-aged married women in Ethiopia: an adapted theory of planned behavior (TPB) by Fitsum Tariku Fantaye, Solomon Abrha Damtew, Kelemua Menegesha Sene

“…In women, fertility intention refers to their preferences regarding the number of children they wish to have in the future, considering factors such as the costs and benefits associated with childbearing. …”
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Exploring the Role of FDG PET CT Scan in Detecting High Grade Diffuse Large B-Cell Lymphoma by Marzieh Azmoun, Mohammad Moeini Nodeh, Maryam Emadzadeh, Kamran Ariana, Habibollah Dadgar, Amirreza Khorosanchi, Emran Askari, Eisa Nazar

“…Currently, the standard method for evaluating patients at the initial stages of cancer diagnosis in Mashhad oncology centers involves computed tomography scans (CT scans), histopathological evaluation of tissue, bone marrow sampling, and cytogenetic studies, all of which are time-consuming and costly. It is worth mentioning that at present, the most recommended approach for determining lymphoma staging is the FDG-PET/CT scan, which combines labeled glucose with CT scan and offers a more accurate alternative. …”
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Pleiotropic effects of PPAR-α – from benchside to bedside by I. V. Shirinsky, V. S. Shirinsky

“…This could reduce risk of polypharmacy and reduce direct treatment costs. It is not unlikely that the use of PPARα agonists in a patient with multimorbidity could prevent acquiring a new disease. …”
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Assessment of Radiological Parameters of Lordosis in Chronic Low Back Pain: A Case-control Study by Sudhir Singh, Sankalp Singh, Vijay Pratap Singh

“…The normal range of lordosis has not yet been agreed upon; hence, the practice of assessing the parameters of lordosis on sagittal radiographs becomes irrelevant, adding to treatment costs and exposing patients to radiation risk. Consequently, the practice of measuring lordosis needs to be re-evaluated. …”
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Analysis of financial and economic indicators, characterizing the activities of organizations in the oil and gas industry by L. A. Chaldaeva, T. I. Chinaeva, A. S. Bogopolskiy

“…By the example of organizations JSC “IDELOIL” and Ltd “NEDRA-K”, a comparative analysis of financial and economic indicators was carried out, directions for increasing gross profit and gross margin indicators were proposed and justified in order to reduce costs and increase revenues.As a result, it was concluded that the oil industry in Russia depends on political and economic factors, in this regard, it is necessary to regularly analyze the activities of organizations in this industry to identify miscalculations, low-active functioning systems, etc., with the purpose of more efficient functioning of the industry.…”
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Incidence, bacteriological profile and predictors of surgical site infections following limb amputation at Bugando medical centre and Sekou toure referral regional hospital, Mwanza... by Haitham Hamudu, Helmut Nyawale, Vitus Silago, Mariam M. Mirambo, Phillipo L. Chalya, Stephen E. Mshana

“…Abstract Background Surgical site infections (SSIs) after limb amputations have been associated with increased patient morbidity, mortality and costs. This study aimed to determine the incidence, bacteriological profile and predictors of SSIs following limb amputation at Bugando Medical Centre (BMC) and Sekou Toure Regional Referral Hospital (SRRH). …”
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The impact of primary mental healthcare on core symptoms of depression among underrepresented adolescents: a network analysis perspective by Qianyu Zhang, Li Ran, Wei Li, Xuerong Liu, Jie Gong, Xianyong An, Zhengzhi Feng, Zhiyi Chen, Jingxuan Zhang

“…Despite the World Health Organization’s promotion of primary mental healthcare as a critical solution, its real-world effectiveness in low- and middle-income countries remains debated due to high costs and insufficient follow-up. This study aimed to explore the impact of primary mental healthcare on the core symptoms of adolescent depression using network analysis, while examining the influence of demographic factors such as gender, age, and family support, to identify more precise and targeted healthcare strategies, improving its effectiveness. …”
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Forecasting the development of poultry farming based on time series by Anatolii Kulyk, Katerina Fokina-Mezentseva, Alla Saiun, Daryna Saiun

“…In addition, the ability to pre-estimate future changes allows enterprises to adapt to market fluctuations, reduce losses, minimise excess costs and make informed management decisions.…”
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Molecular simulation study on effect of mine water hardness on foam stability by Qinggang LU, Kai WANG, Honghu HUANG, Yi LIANG, Jiangshi ZHANG, Yanan WANG, Yulu JIA, Yunfei LIANG

“…Mine water contains a large amount of hard water ions, and as the main water used in foam dust suppressants, its water hardness is crucial to the dust removal efficiency and economic costs of foam dust suppressants. In order to study the variation law and microscopic mechanism of foam stability influenced by mine water hardness, molecular simulation was employed to investigate the effects of mine waters containing different concentrations of Ca2+, Mg2+, and Na+ on the stability of foam liquid films. …”
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Transformer Oil Acid Value Prediction Method Based on Infrared Spectroscopy and Deep Neural Network by Linjie Fang, Chuanshuai Zong, Zhenguo Pang, Ye Tian, Xuezeng Huang, Yining Zhang, Xiaolong Wang, Shiji Zhang

“…Conversely, delayed detection accelerates aging and can cause costly repairs or unplanned outages. To address this need, this paper proposes a new method for predicting the acid value content of the transformer oil based on the infrared spectra in the transformer oil and a deep neural network (DNN). …”
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A density functional theory investigation of the substituent effect on acyclovir and guanine derivatives for applications on energetic materials by Luciana Amorim da Silva, Gabriel Monteiro-de-Castro, Erick Braga Ferrão Galante, Itamar Borges Jr, Aline Cardoso Anastácio

“…The main challenge in designing new energetic materials is to find a good balance between four seemingly incompatible requirements, namely, high-energy content, low sensitivity, low production costs and less-polluting content. Fused nitrogen heterocycles of imidazole and pyrimidine, such as acyclovir and guanine, may offer interesting features due to the combination of a coplanar framework and a large conjugate system, which contribute to a reduced sensitivity, and a number of energetic bonds that can be increased by the introduction of explosophore substituents. …”
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Thoracic dysfunction in whiplash associated disorders: A systematic review. by Nicola R Heneghan, Richard Smith, Isaak Tyros, Deborah Falla, Alison Rushton

“…Approximately 50% WAD patients develop chronic pain and disability resulting in high levels of societal and healthcare costs. It is time to look beyond the cervical spine to fully understand anatomical dysfunction in WAD and provide new directions for clinical practice and research.…”
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Análisis técnico económico preliminar para generar electricidad con energía renovable // Preliminary technical economic analysis to generate electricity with renewable energy by M. Menéndez González

“…</p><p><br />Key words: Renewable energy, hybrid systems, autonomous systems, renewable resources, energy costs,<br />environmental contamination.</p>…”
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Association of activity-based food environment index with obesity-related cancer mortality in the US by Qinyun Lin, Xiang Chen, Xukun Xiang, Weixuan Lyu, Congcong Miao, Gaofei Zhang, Ran Xu

“…Abstract Background Obesity and obesity-related cancers contribute to rising healthcare costs and declining life expectancy in the US and improving diet quality plays a crucial role in reversing such trends. …”
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Exploring artificial intelligence in orthopaedics: A collaborative survey from the ISAKOS Young Professional Task Force by Filippo Familiari, Adnan Saithna, Juan Pablo Martinez‐Cano, Jorge Chahla, Juan Miguel Del Castillo, Nicholas N. DePhillipo, Gilbert Moatshe, Edoardo Monaco, Jaime Palos Lucio, Pieter D'Hooghe, Robert F. LaPrade, the ISAKOS Young Professionals Task Force

“…Conclusions This survey demonstrates that there is currently limited use of AI in orthopaedic practice, mainly due to a lack of knowledge about the subject, a lack of proven evidence of its real utility and high costs. These findings are in accordance with other surveys in the literature. …”
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Reading the Sufi Discourse in the Patterns and Design of Heriz Carpets: A Study from the Late 13th to the Late 14th Century by Azam Rasooli, Kazem Chalipa, ali asghar shirazi, Seyed Jalal Eedin Bassam

“…Furthermore, as an applied art, carpet weaving—especially using all-silk materials—is labor-intensive and costly, making the reasons behind the choice of such imagery and the Sufis' affinity for these carpets especially significant. …”
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Reported reasons for breakdown of marriage and cohabitation in Britain: Findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). by Kirsten Gravningen, Kirstin R Mitchell, Kaye Wellings, Anne M Johnson, Rebecca Geary, Kyle G Jones, Soazig Clifton, Bob Erens, Michelle Lu, Chenchit Chayachinda, Nigel Field, Pam Sonnenberg, Catherine H Mercer

“…<h4>Objectives</h4>Breakdown of marriage and cohabitation is common in Western countries and is costly for individuals and society. Most research on reasons for breakdown has focused on marriages ending in divorce and/or have used data unrepresentative of the population. …”
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