Project-Based Development as a Model for Transdisciplinary Research and Education by Shahabedin Sagheb, Katie Walkup, Robert Smith

“…Project-based educational environment that focuses on real-world problems and crosssector collaboration instills students' learning pathways with the proficiency to move from the domain-specific to the domain-general knowledge. …”
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LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells by Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin

“…ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and induced to differentiate into Th17 cells.XIST was over-expressed and silenced by plasmid transfection.Proliferation and apoptosis of Th17 cells with different levels of XIST expression were detected by flow cytometry and CCK-8 assay.Levels of XIST，TLR9 mRNA and protein were detected by quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blot.The effect of XIST on TLR9 expression was predicted by luciferase report analysis and TLR9 mRNA half-life detection.Potential RNA-binding proteins interacting with XIST were searched through Starbase database and detected by RNA immunoprecipitation and Western blot.GraphPad8.0 was utilized for statistical analysis and variables were expressed as average±SD.Student T test or one-way ANOVA was employed.ResultsXIST was distributed predominantly in cytoplasm.It hinted that XIST might be involved in post-transcriptional regulation.A down-regulation of lncRNA XIST expression promoted apoptosis and DNA damage and arrested cell proliferation by regulating TLR9.With an over-expression of lncRNA XIST，TLR9 expression spiked and XIST up-regulated the expression of TLR9 by promoting the stability of TLR9 mRNA.As an RNA-binding protein （RBP），FUS interacted with XIST and FUS antibodies could significantly enrich XIST transcripts.A down-regulation of lncRNA XIST expression had no effect on FUS protein expression.It suggested that XIST might affect FUS function rather than expression.It was further confirmed that a down-regulation of XIST significantly reduced FUS-TLR9 mRNA binding and FUS over-expression rescued a down-regulation and degradation of TLR9 mediated by si-XIST.ConclusionlncRNA XIST and TLR9 play a critical role in Th17 cell proliferation in IgAN through a FUS-mediated signaling pathway.This finding provides new therapeutic ideas for IgAN..…”
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Compassionate end-of-life care: Development, implementation, and evaluation of a comprehensive euthanasia course in veterinary education from 2019–2024 by Virginia K. Corrigan, Kathleen Cooney, Raeann Foster

“…The hybrid format increases flexibility while maintaining high student satisfaction. Longitudinal student surveys (2022–2024) indicated consistently high ratings for instructor effectiveness, course relevance, and overall satisfaction, demonstrating sustained course value with minor fluctuations and highlighting areas for ongoing refinement. …”
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Comparison of Continuous-Time Partial Markov Chain Construction by Heuristic Algorithms for Purpose of Approximate Transient Analysis by Eimutis Valakevičius, Mindaugas Bražėnas, Tomas Ruzgas

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Handgrip Strength Cut-Off Values for the Undernutrition Risk Screening among Elderly Men and Women in Bosnia and Herzegovina by Maja Račić, Jelena Pavlović, Nedeljka Ivković

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Procrastination, well-being, and academic performance among pre-service teachers in blended learning modality by Dann Aibrielle D. Laureles

“…There were a total of 224 students who answered the online survey through Google Forms, but it was found that 32 students did not provide some information that was needed, so the final number of students was 192. …”
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Eponymous Names in Acne by Shekhar K.C.

“… Numerous terminologies have been linked to acne and related lesions which often puzzles students and practitioners. Here we have tried to summarize some of the common acne related terms found in related literatures. …”
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Higher Education governance and policy in Spain by Francisco Rubio, Carlos Llopis-Albert, Shouzhen Zeng, Dayanis García-Hurtado

“…The knowledge society of the 21st century is undergoing important changes in the field of information, communication, and globalization, which has led Higher Education Institutions (HEIs) to play a leading role in its sustainable development, based on three fundamental pillars: social, economic, and environmental, which go beyond its traditional role based on training students to obtain a professional degree. The need to address these significant changes and improve the quality and efficiency of HEIs has led to a reassessment of their governance structures, which require a more agile governance system that includes professionalized management. …”
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PENGEMBANGAN HANDBOOK STRATEGI PEMBELAJARAN INOVATIF UNTUK MENINGKATKAN KOMPETENSI GURU HOMESCHOOLING DI KOTA BANDUNG [THE DEVELOPMENT OF AN INNOVATIVE LEARNING STRATEGY HANDBOOK T... by Edsel Jeremy, Yonathan Winardi

“… Homeschooling is increasingly popular as an alternative educational model, but it faces challenges, including the need for competent teachers who can cater to diverse student needs. This study aimed to develop and evaluate a competency development program for homeschooling teachers in Bandung City, packaged as a handbook titled "Strategi Pembelajaran Inovatif" (Innovative Learning Strategies). …”
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An empirical study on the teaching mode of cultural translation in college English based on the Production Oriented Approach (POA). by Tong He, Chongyue Li

“…The research results indicate that compared to traditional college English teaching, blended teaching model based on POA can enhance the English language and cultural output ability of A-level students. The mode is of sustainable value, which is beneficial to students understanding of Chinese culture, thereby enhancing their cultural confidence. …”
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Biomedical Ethics and its Need by Quratul Ain Omaeer

“…That is the reason why Biomedical ethics should be discussed with the students of health profession right from the beginning of their medical carrier. …”
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Optimizing work movements to reduce injury risk: Application development with Methods-Time Measurement and WebQual analysis by Ari Muzakir, Adhie Tri Wahyudi, Yuli Dwi Astanti, Christofora Desi Kusmindari

“…This study aims to develop a web-based and Android application designed to assist both students and professionals in calculating work times and optimizing movements (such as: material handling) more efficiently. …”
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DEVELOPING PROFESSIONAL INFORMATION AND COMMUNICATION SKILLS THROUGH E-PROJECTS by Yulia V. Krasavina, M. Aiman Al Akkad

“…The article describes the implementation of e-project based approach for teaching English for future teachers (bachelor students) in Kalashnikov Izhevsk Technical University. …”
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Relationship between job characteristics and music performance anxiety in collaborative pianists working in Slovenian music schools by Katarina Babnik, Žan Lep, Žan Lep, Katarina Habe

“…IntroductionMusic performance anxiety (MPA) is a significant challenge for amateur and professional musicians, as well as music students. Systematic literature reviews highlight a lack of research on the role of contextual variables in MPA. …”
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Design of English Mobile Learning Platform Based on GSM-R Wireless Network Communication System by Xiaowei Liu, Hongjin Liu

“…The simulation experiment results show that the application of the designed platform can improve student satisfaction and improve student learning efficiency.…”
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Long-term sickness absences based on mental disorders by socioeconomic group – trends of prevalence in Finland 2010–2023 by Riku Perhoniemi, Jenni Blomgren

“…Employees, but also students and unemployed persons need support to curb the increase in LTSA due to mental disorders.…”
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Sex-related differences in the physical fitness of adolescents aged 16 to 18 years by Ewa Puszczałowska-Lizis, Marcin Kaźmierczak, Jarosław Omorczyk, Sabina Lizis, Rút Lenková, Karolina Pieniądz

“…The aim of this research was to analyse sex-related differences in the physical fitness of young people aged 16 to 18 years.Material and methods: The research comprised 194 students attending randomly selected high schools in the Rzeszów district, including 104 females and 90 males aged 16 to 18 years. …”
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DMYTRО DONTSOV’S TEXTS IN THE ASPECT OF CORPUS LINGUISTICS AND LEXICOGRAPHY by Oksana R. Mykytyuk, Liliia V. Kharchuk

“…The concordance serves as a new material, important for politicians, journalists, teachers, students, for it is an entrance in a system of new words, filling with new ideas, and possibility to perceive the world through the nation-state aspirations of a great thinker. …”
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Implementación de un programa de Gimnasia Acrobática en Educación Secundaria para la mejora del autoconcepto (Implementation of acrobatic gymnastics in Secondary Education for the... by Xoana Reguera López de la Osa, Águeda Gutiérrez-Sánchez

“…The results of the test pre-test and post-test were analyzed using the Student’s t test where significant differences were found. …”
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Influence of Dilation Angle of Soil on Seismic Displacements of Gravity Retaining Walls using Upper Bound Limit Analysis Method by P. Sharifi, O. Farzaneh, F. Askari

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