Investigation into the effects of temperature levels and relative humidity effects on Nigella (Nigella sativa L.) seed storage by Zeinab Savaedy, Abdolmahdi Bakhshandeh, seyed ata Siadat, Amin Lotfi Jalal Abadi, Seyed Amir Moosavi

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LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells by Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin

“…ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and induced to differentiate into Th17 cells.XIST was over-expressed and silenced by plasmid transfection.Proliferation and apoptosis of Th17 cells with different levels of XIST expression were detected by flow cytometry and CCK-8 assay.Levels of XIST，TLR9 mRNA and protein were detected by quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blot.The effect of XIST on TLR9 expression was predicted by luciferase report analysis and TLR9 mRNA half-life detection.Potential RNA-binding proteins interacting with XIST were searched through Starbase database and detected by RNA immunoprecipitation and Western blot.GraphPad8.0 was utilized for statistical analysis and variables were expressed as average±SD.Student T test or one-way ANOVA was employed.ResultsXIST was distributed predominantly in cytoplasm.It hinted that XIST might be involved in post-transcriptional regulation.A down-regulation of lncRNA XIST expression promoted apoptosis and DNA damage and arrested cell proliferation by regulating TLR9.With an over-expression of lncRNA XIST，TLR9 expression spiked and XIST up-regulated the expression of TLR9 by promoting the stability of TLR9 mRNA.As an RNA-binding protein （RBP），FUS interacted with XIST and FUS antibodies could significantly enrich XIST transcripts.A down-regulation of lncRNA XIST expression had no effect on FUS protein expression.It suggested that XIST might affect FUS function rather than expression.It was further confirmed that a down-regulation of XIST significantly reduced FUS-TLR9 mRNA binding and FUS over-expression rescued a down-regulation and degradation of TLR9 mediated by si-XIST.ConclusionlncRNA XIST and TLR9 play a critical role in Th17 cell proliferation in IgAN through a FUS-mediated signaling pathway.This finding provides new therapeutic ideas for IgAN..…”
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PENGEMBANGAN HANDBOOK STRATEGI PEMBELAJARAN INOVATIF UNTUK MENINGKATKAN KOMPETENSI GURU HOMESCHOOLING DI KOTA BANDUNG [THE DEVELOPMENT OF AN INNOVATIVE LEARNING STRATEGY HANDBOOK T... by Edsel Jeremy, Yonathan Winardi

“… Homeschooling is increasingly popular as an alternative educational model, but it faces challenges, including the need for competent teachers who can cater to diverse student needs. This study aimed to develop and evaluate a competency development program for homeschooling teachers in Bandung City, packaged as a handbook titled "Strategi Pembelajaran Inovatif" (Innovative Learning Strategies). …”
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Design of English Mobile Learning Platform Based on GSM-R Wireless Network Communication System by Xiaowei Liu, Hongjin Liu

“…The simulation experiment results show that the application of the designed platform can improve student satisfaction and improve student learning efficiency.…”
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Influence of Dilation Angle of Soil on Seismic Displacements of Gravity Retaining Walls using Upper Bound Limit Analysis Method by P. Sharifi, O. Farzaneh, F. Askari

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Cycling Operation of a LiFePO₄ Battery and Investigation into the Influence on Equivalent Electrical Circuit Elements by Michal Frivaldsky, Marek Simcak, Darius Andriukaitis, Dangirutis Navikas

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Barriers to urban management in the viability of cities, Case study: Semnan city by abbas Babaei, zeinab korke abadi, saeid kamyabi

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Prospective Applications of Artificial Intelligence In Fetal Medicine: A Scoping Review of Recent Updates by Miskeen E, Alfaifi J, Alhuian DM, Alghamdi M, Alharthi MH, Alshahrani NA, Alosaimi G, Alshomrani RA, Hajlaa AM, Khair NM, Almuawi AM, Al-Jaber KH, Elrasheed FE, Elhassan K, Abbas M

“…Elhadi Miskeen,1 Jaber Alfaifi,2 Dalal Mohammed Alhuian,3 Mushabab Alghamdi,4 Muffarah Hamid Alharthi,5 Nourah Abdullah Alshahrani,3 Ghala Alosaimi,6 Raydaa Abdullah Alshomrani,3 Abdullah Mohammed Hajlaa,3 Nadir Mohammed Khair,7 Abdullah Mohammed Almuawi,3 Khalifa Haytham Al-Jaber,8 Fath Elrahman Elrasheed,9 Kamal Elhassan,5 Mohammed Abbas10 1Department of Obstetrics and Gynecology, College of Medicine, University of Bisha, Bisha, Saudi Arabia; 2Department of Child Health, College of Medicine University of Bisha, Bisha, Saudi Arabia; 3Medical Student, College of Medicine University of Bisha, Bisha, Saudi Arabia; 4Department of Internal Medicine, College of Medicine, University of Bisha, Bisha, Saudi Arabia; 5Department of Family and Community Medicine, College of Medicine, University of Bisha, Bisha, Saudi Arabia; 6Medical student, College of Medicine, Taif University, Taif, Saudi Arabia; 7Department of Child Health, Mother and Children Hospital, Bisha, Saudi Arabia; 8Medical student, Royal College of Surgeons, Dublin, Ireland; 9Department of Obstetrics and Gynecology, Faculty of Medicine Najran University, Najran, Saudi Arabia; 10Department of Pediatrics, College of Medicine, Arab Gulf University, Al Manama, BahrainCorrespondence: Elhadi Miskeen, Head Department of Obstetrics and Gynecology, College of Medicine, University of Bisha, P. …”
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Identification of Second-Generation Afghani Immigrant Women: A Narrative Analysis of the Nonfiction "The Meaninglessness of My Afghan Form Deeply Distressed Me" by Maral Rahimi, Sahar Faeghi

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The Arguments for the Requirement of Contracts Being Settled in Cash in Differential Barter Transactions When the Exchanged Items are Measured or Weighed and are of Different Kinds... by Seyyed Ali sedaghat, Gholamali Masouminia

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Carbohydrate consumption and cirrhosis-related mortality: a prospective cohort study by Nastaran Raissi-Dehkordi, Negar Raissi-Dehkordi, Azita Hekmatdoost, Fereshteh Pashayee-khamene, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Hossein Hatami, Zahra Yari

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The European Union’s Trade Negotiations with the ACP: Entrapped by its own Rhetorical Strategy? by Lotte Drieghe

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Concepts PEDAGOGY and EDUCATION in G. N. Volkov’s “Pedagogy of Love” by O. A. Dimitriyeva

“…It is shown that Volkov has the idea of the eternity of education, which sets the eternity image of teacher and student.…”
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Mitigation of Methotrexate-Induced Intestinal Mucositis in Male Wistar Rats by Gallic Acid: The Role of HGF and C-Met Genes by Reza Norouzirad, Khashayar Zahedi, Mohammad Mehdi Behvandi, Abbas Moridnia, Susan Sabbagh

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Algılanan Örgütsel Desteğin Örgüt Sağlığı Üzerindeki Etkisi: Hastane Çalışanlarına Yönelik Bir Araştırma by Nezihe Tüfekci, Derya Sarıoğlu, İsa Gül

“…Verilerin analizi için SPSS v.22 paket programı kullanılarak; Student-t Testi, One Way Anova, Korelasyon ve Regresyon analizi ile veri çözümlemeleri gerçekleştirilmiştir.Bulgular: Araştırmanın amacı doğrultusunda korelasyon analizi yapılmış ve algılanan örgütsel destek ile örgüt sağlığı arasında pozitif yönde istatistiksel olarak anlamlı düzeyde bir ilişkinin olduğu bulunmuştur. …”
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Identifying and explaining the mechanism of tacit knowledge sharing among University of Tehran employees in the development of successors by Omid Aryani, Hamidreza Yazdani, Majid Ramezan

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Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

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Exploring Applications of Lagrange’s Equations in Technology: A Systematic Literature Review by Fitria Siska Damayanti, RA Sania Noviana, Yora Inda Lestari, Hamdi Akhsan, Ismet Ismet

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Application of QSPM and SWOT Model in Formulating Housing Supply Strategy for the Deprived by Hamid Reza Mohammadi, mohsen pakparvar

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The Jurisprudential Study of the Nature of the Postpaid Landline Phone Subscription Contract by Muhammad Ghanbarzadeh, Ali Akbar Izadifard, Saeed Ebrahimi

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