Efficacy of Pharmacological Treatments in Managing Generalized Anxiety Disorder among Adults in Saudi Arabia: A Cross-sectional Analysis by Abdulsalam Mohammed Aleid, Abdulaziz Matar Alharthi, Rana Abdulmohsen Alotaibi, Ahmed Mohammed Alasmari, Sharifah Ahmed Alzabdawi, Imtinan Jafar Asaeed, Sarah Mousa Alshuqayfi, Shuruq Mohammed Alzahuf, Aliyah Matar Alharthi, Mostafa Habeeb Alhodibi

“…The most commonly used pharmacological strategy was classified as “Others,” with a high satisfaction rate reported by users. Adverse effects were infrequent, affecting only a minority of patients frequently. …”
Get full text

Deep learning approach with ConvNeXt-SE-attn model for in vitro oral squamous cell carcinoma and chemotherapy analysis by Abhay Nath, Om Roy, Priyanka Silveri, Sanskruti Patel

“…Globocan predicts that, OSCC will result in 389,846 new cases and 188,438 deaths globally during 2022 while maintaining an extremely poor 5-year survival rate at about 50%. Our method applies residual connections with Squeeze-and-Excitation blocks along with hybrid attention systems and enhanced activation functions and optimization algorithms to boost gradient movement throughout feature extraction. …”
Get full text

Shoreline time series analysis through the Isoradiometric method: Bridging landscape evolution and coastal management by F. Caldareri, N. Parrino, L. Balsamo, G. Dardanelli, S. Todaro, A. Sulli, A. Maltese

“…Moreover, we calculated the shifts’ gradient to quantify the rate of change in shoreline position. These results demonstrate: i) the necessity of creating shoreline time series as a tool for geological interpretation through the principle of actualism and as a framework for rationalizing contemporary shoreline monitoring approaches; ii) the Isoradiometric Method enables accurate Earth Observation image processing for this purpose.…”
Get full text

Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…Abstract Background Lung adenocarcinoma (LUAD) is one of the most common subtypes of non-small cell lung cancer, and its mortality rate remains high. As a programmed cell death mode closely related to inflammation, pyroptosis has been found to play an important regulatory role in the tumor immune microenvironment and tumor progression in recent years. …”
Get full text

Single-cell RNA sequencing reveals immunological link between house dust mite allergy and childhood asthma by Lingyun Zou, Kang Chen, Xianou Hong, Bo Ye

“…Nevertheless, the diagnostic rate remains below 60% due to the absence of specific symptoms and diagnostic markers, which hinders the implementation of targeted personalized therapies. …”
Get full text

Contribution of icaADBC genes in biofilm production ability of Staphylococcus aureus clinical isolates collected from hospitalized patients at a burn center in North of Iran by Mostafa Alibegli, Aliakbar bay, Amirabbas Fazelnejad, Pouria Nourmohammadi Ghezelghaye, Hossein Jafari Soghondikolaei, Hamid Reza Goli

“…Results Penicillin exhibited the highest resistance rate (94%), while vancomycin was most effective antibiotic with 6% resistance. …”
Get full text

Enterotype-stratified gut microbial signatures in MASLD and cirrhosis based on integrated microbiome data by Heng Yuan, Heng Yuan, Junyu Zhou, Junyu Zhou, Xuangao Wu, Shiwei Wang, Sunmin Park, Sunmin Park

“…Microbial co-occurrence networks and functional predictions via PICRUSt2 revealed distinct patterns across enterotypes.Results and discussionThe Prevotella-dominated(ET-P) group exhibited a 33% higher cirrhosis rate than the Bacteroides-dominated(ET-B) group. …”
Get full text

Profile of the geriatric patient hospitalised at Universitas Hospital, South Africa by Anna M. van Staden, Dirk J.V. Weich

“…Women represented 66% of the patients and the mortality rate was 17% in the total study group. The main admitting clinical problems were hypertension, heart failure, ischemic heart disease and anaemia. …”
Get full text

Heat transfer enhancement using Cu+Al2O3 ferro magnetic nanoparticle confession in an elliptic duct device with energy conservation by Noreen Sher Akbar, M. Fiaz Hussain, Javaria Akram, Fahid Riaz, Muhammad Farooq

“…Various findings suggest that flow rate as well as Brinkmann number enhances entropy for the hybrid nanofluid both independently. …”
Get full text

Metode Deteksi Intrusi Menggunakan Algoritme Extreme Learning Machine dengan Correlation-based Feature Selection by Sulandri Sulandri, Achmad Basuki, Fitra Abdurrachman Bachtiar

“…The results of the research conducted using the ELM method showed an accuracy rate of 81.97% with a computation time of 3.39 seconds. …”
Get full text

Towards more reliable gambling cost estimates, a population-based study with register-linkage by Tiina A. Latvala, Matthew Rockloff, Matthew Browne, Tomi Roukka, Tomi P. Lintonen, Anne H. Salonen

“…Additionally, costs could be presented as Int$ per adult using the PPP exchange rate to facilitate the comparison of gambling costs between countries.…”
Get full text

Non-linear association between neutrophil-to-lymphocyte ratio and 90-day mortality in patients with pneumonia receiving glucocorticoids alone or in combination with other immunosup... by Caizhen Chen, Xiuguo Zhang, Baoli Li, Qian Geng

“…There were 332 individuals (47.7%) aged 18-59 years and 364 (52.3%) aged 60-99 years; 52.6% were male. The 90-day mortality rate across the study population was 26.1%. A non-linear association was noted between NLR and 90-day mortality, with an inflection point at approximately 16.475. …”
Get full text

Quality of life of patients with end-stage renal disease during initial treatment by LV Qing-na, ZHANG Xin-yu, HAN Wei, ZHANG Yan-yun, LI Yan-yan, LIU Qi-gui, REN Xian-long, YIN An-chun, SHI Tie-ying, LI Ping, XING Wei, YANG Yue

“…Objective To explore and compare the effects of hemodialysis（HD） vs.peritoneal dialysis（PD） of the quality of life of patients with end-stage renal disease（ESRD）.Methods Sixty cases of ESRD receiving initial PD（PD group,n = 30） or HD（HD group,n = 30） were surveyed by the questionnaire procedure.Kidney disease quality of life short form(KDQQL SF^TM Version 1.3 was used.The forms were distributed per month for consecutive 8 months.There were 480 questionnaires in total,in which valid questionnaires were 480,with the effective rate being was 100%.Results（1）SPL was continuously increased with time with the correlation being statistically significant（P =0.0000）.HD group got the maximum value for 2 groups at the sixth and seventh month after constant increases,and thereafter the value basically remained unchanged.PD group reached the maximum value at the eighth month after stable increases.（2） Effects of kidney disease（EKD） varied with the time with the correlation being statistically significant（P = 0.018）.PD group got the maximum value for 2groups at the third and fifth month after constant increases and the value was basically the same after that HD group reached the maximum value at the eighth month after stable increases.（3） Sleep patterns increased over time with the correlation being statistically significant（P = 0.029）.HD group got the maximum value for 2 groups at the sixth month after constant increased,and the value was basically the same after that PD group got the maximum value at the third month after stable increases.（4） Physical function（PF） increased over time with the correlation being statistically significant（P =0.0000）.HD group reached the maximum value for 2 groups at the sixth and eighth month after constant increases.PD group got the maximum value at the sixth,seventh and eighth month after significant increases.（5） Vitality（VT） changed over time with the correlation being statistically significant（P = 0.0000）.The VT values in both groups were constantly increased,and got the maximum at the third month and then decreased significantly after that Conclusions In the initial treatment,we can provide the correct guidance and help patients with ESRD to choose the more reasonable and feasible methods of dialysis,according to the patient’s personal situation and family social condition.…”
Get full text

Observational Study on Progressive Muscle Relaxation and Breathing Control for Reducing Dental Anxiety in Children by Sorana Maria Bucur, Ioana Maria Crișan, Dorin Ioan Cocoș, Eugen Silviu Bud, Carmen Galea

“…Dental anxiety was measured with the Romanian-validated IDAF-4C⁺, and physiological stress was measured via blood pressure and heart rate. Pre and post-intervention data were analyzed using paired <i>t</i>-tests, ANOVA, and cluster analysis. …”
Get full text

Neural Networks vs. Regression: A Comparative Analysis in Medical Data Processing by Minodora ANDOR, Gheorghe Ioan MIHALAŞ

“…The regression model followed standard statistical guidelines, while the FFNN required optimization of hyperparameters, including the number of layers, activation functions, learning rate, and  optimization algorithms. We extended the study using simulated data to further compare logistic regression (a data set of 300 patients) with neural networks. …”
Get full text

A biobank for complex post-traumatic stress disorder (C-PTSD) and PTSD: study protocol for a cross-sectional study by Alice Mok, Chrystal Douflias, Lena K. L. Oestreich

“…Additionally, participants will wear an Actigraph smart watch for seven days to collect actigraphy-derived physiological data, including sleep patterns and heart rate variability. All de-identified data will be made openly available on the Open Science Framework upon publication of the main study findings, in accordance with ethical approvals and institutional guidelines for privacy and data security.Conclusion This comprehensive protocol addresses significant gaps in understanding C-PTSD through its multimodal approach. …”
Get full text

A Clinicoepidemiological Cross-sectional Study of Sexually Transmitted Diseases in Men who have Sex with Men Attending Tertiary Care Centre in Kerala, India by Prathyusha Prabhakar, S Darsan

“…STIs were reported more commonly among patients involved in selling sex (Male Sex Workers, MSW) at a rate of 18 (30%). HIV was found in 6 (25%) patients and syphilis in 5 (21%), which are the major contributors, followed by Candidal Balanoposthitis (CBP), genital herpes and Non Gonococcal Urethritis (NGU). …”
Get full text

Long-term clinical sequelae in severe fever with thrombocytopenia syndrome: A longitudinal cohort study. by Ning Cui, Xin Yang, Hong-Han Ge, Xiao-Hong Yin, Yi-Mei Yuan, Chao Zhou, Xi Wang, Hai-Feng Pan, Hao Li, Xiao-Ai Zhang, Li-Qun Fang, Li-Fen Hu, Peng-Tao Bao, Wei Liu

“…<h4>Background</h4>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease characterized by a high case fatality rate. Despite extensive research on acute-phase manifestations, the long-term clinical sequelae in survivors remain poorly characterized.…”
Get full text

Monitoring of urinary microbiota and uropathogens' antibiotic resistance in one urological hospital by Yu. L. Naboka, A. K. Alkina, M. I. Kogan, I. A. Gudima, Kh. S. Ibishev, K. T. Jalagoniya, M. L. Chernitskaya

“…The detection frequencies of E. coli vary around 50.0%, for other causative pathogens a lower detection rate is noted, while non-clostridial anaerobic bacteria are excreted in 96.6% of cases in patients with recurrent uLUTI. …”
Get full text

Adapting Vision Transformer-Based Object Detection Model for Handwritten Text Line Segmentation Task by Osman Furkan KARAKUŞ, Ayla GULCU, Ali Can KARACA

“…Experimental results based on the Intersection over Union (IoU) metric demonstrate that the proposed method outperforms all other methods in terms of the detection rate, recognition accuracy, and Text Line Detection Metric (TLDM). …”
Get full text