MtDNA copy number enrichment is associated with poor prognosis and eosinophilic morphology in clear cell renal cell carcinoma by Sarah Bellal, Sarah Bellal, Cyrielle Rolley, Jeremy Richard, Nolwenn Bounaix, Vincent Le Corre, Marie-Christine Copin, Odile Blanchet, Pierre Bigot, Pierre Bigot, Vincent Procaccio, Vincent Procaccio, Céline Bris, Céline Bris

“…CSS was significantly reduced in the “HIGH” than in the “LOW” group with respective 5-year survival rates: 78.7% (CI 95: 64.8–95.5) and 95.5% (CI 95 87.1–100.0) (Hazard Ratio: 7.4 (CI 95: 1.9–29.9, p = 0.027*) in multivariate analysis, including pathological classification, tumor size, International Society of Urological Pathology grade, lymphovascular invasion, dedifferentiated pattern, necrosis and adjuvant therapy. …”
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Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, indi... by Emmanuel Bottieau, Achilleas Tsoumanis, Yven Van Herrewege, Diana Arango, Christophe Burm, Badara Cisse, Souleymane Mboup, Clémentine Roucher, Isabel Brosius, Moustapha Mbow, Babacar Thiendella Faye, Annelies De Hondt, Bart Smekens, Linda Paredis, Idzi Potters, Katja Polman

“…The trial’s primary endpoints are the efficacy (cure rate (CR), assessed by microscopy) and safety (frequency and pattern of drug-related adverse events) of one AM course versus PZQ at 4 weeks after treatment. …”
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Comparing survival outcomes of anti-fibrotic therapy for idiopathic pulmonary fibrosis with and without emphysema: a multi-center real-world study from Taiwan by Yu-Hung Fang, Yi-An Hsieh, Yen-Fu Chen, Yu-Chi Chiu, Yu-Ching Lin, Kuo-Tung Huang, Yung-Chia Huang, Yu-Feng Wei, Chien-Wen Huang, Pin-Kuei Fu, Taiwan Multi-Centre Interstitial Lung Disease Research Consortium

“…During a median follow-up of 3.7 years, the overall survival rates were comparable (IPF only: 45.6%; IPF with emphysema: 48.4%). …”
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Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. by Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, John Rek, Maato Zedi, Catherine Maiteki-Sebuguzi, Jimmy Opigo, Sarah G Staedke, Ambrose Oruni, Martin J Donnelly, Bryan Greenhouse, Jessica Briggs, Paul J Krezanoski, Teun Bousema, Philip J Rosenthal, Peter Olwoch, Prasanna Jagannathan, Isabel Rodriguez-Barraquer, Grant Dorsey

“…In Busia, An. gambiae s.s. remained the primary vector throughout the observation period. Sporozoite rates were approximately 50% higher among An. funestus compared to the other common malaria vectors. …”
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Treatment of total hip arthroplasty between two surgical access routes associated chronic pain, function and biomechanical parameters in older after osteoporotic femur fracture: co... by Marco Antônio Leite Pereira Pinto, Giovanna Truyts Biscardi Pinto, Mariana Afonso Ribeiro Sarquis Ude, Claudia Aparecida de Morais, Ana Paula Ribeiro

“…Conclusion Total hip arthroplasty via the posterolateral approach proved to be more successful when associated with reducing chronic pain, improving functional parameters and hip joint mobility, as well as facilitating a more efficient gait pattern with lower rates of plantar overload and enhanced body balance in older adults undergoing total hip arthroplasty after osteoporotic femur fracture. …”
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Spatiotemporal Change in Climate Variables and Resources of Wind， Solar Radiation and Precipitation in Qinghai Province from 1961 to 2021 by Meixia DUAN, Miaoni GAO, Han JIANG, Runhong XU, buda SU, Tong JIANG

“…In order to evaluate the potential of wind， solar radiation and precipitation in guaranteeing the development of clean energy comprehensively， this study analyzed the temporal and spatial changes in climate variables and resources of wind speed， solar radiation and precipitation in Qinghai Province throughout the year and four seasons from 1961 to 2021 based on the observation data of daily 10-meter-height wind speed， sunshine duration and precipitation at 51 meteorological stations.The results are as follows： （1） The annual average wind speed， solar radiation and precipitation in Qinghai Province are 2.67 m·s-1， 6084.2 MJ·m-2， and 299.7 mm， respectively.Wind speed tends to be higher in the western regions and lower in the east， which exceeds 3 m/s and reaches the standard for wind energy resource development in western Qinghai.The annual solar radiation in the entire Province exceeds 5040 MJ·m-2， and reaches the "very rich" level according to China Solar energy GB Standards.The solar radiation of Qaidam Basin is at its highest abundance level， which is ideal for solar energy resource development.Precipitation generally decreases from southeast to northwest.The resources of wind， solar radiation， and precipitation in Qinghai Province exhibits seasonal complementarity， characterized by a pattern of “strong winds， good sunlight， and less water in spring， whereas weak winds， good sunlight， and abundant water in summer”.（2） Under climate change， the annual average wind speed and total solar radiation in Qinghai Province show a significant decrease at rates of 0.16 m·s-1·10a-1and 29.04 MJ·m-2·（10a）-1， respectively.The western and central parts of Haixi are most affected by these changes， but the wind speed and solar radiation still remain within the acceptable range for wind energy and photovoltaic resource development.Meanwhile， precipitation increases significantly at a rate of 8.85 mm·（10a）-1， with the largest increase observed in western Yushu， eastern Haixi and northern Guoluo.The most significant decrease in wind speed is observed in spring， while summer solar radiation decreases at the fastest rate but with a substantial increase in precipitation.The changes in solar radiation and precipitation could be ascribed to the increased cloud cover in this region.（3） The changes in the areas where wind speed and solar radiation meet suitable development standards in Qinghai Province are not significant with reduced variabilities， which could ensure the stable development of clean energy.Wind energy resources in western Qinghai （such as Tanggula Mountains）， solar energy resources in the Qaidam Basin， and water energy resources in the three major river basins of the Yangtze River， Yellow River， and Lancang River have great potential for development.Overall， the results provide a theoretical foundation for the development of a balanced clean energy system encompassing wind， solar and hydropower.This contributes to achieving national "dual carbon" goals and enhancing the high-quality development of Qinghai Province.…”
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The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-eco... by Mengsha Chen, Mengya Yang, Rui Yan, Zhengwei Liu, Can Chen, Rongrong Qu, Wenkai Zhou, Jiaxing Qi, Kexin Cao, Jiani Miao, Xiaoyue Wu, Jiaxin Chen, Qianqian Feng, HuiHui Zhang, Anqi Dai, Yi Yang, Jingtong Zhou, Qin Chen, Jimin Sun, Shigui Yang

“…Results Between 2018 and 2020, influenza incidence in Zhejiang Province followed typical seasonal patterns. However, during the COVID-19 pandemic, these patterns became irregular, culminating in a high-intensity influenza season in 2022–2023. …”
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Phylogeochemistry: exploring evolutionary constraints on belemnite rostrum element composition by A. Pohle, K. Stevens, R. Hoffmann, A. Immenhauser, A. Immenhauser

“…We used comparative Bayesian phylogenetic tools to reconstruct ancestral states and phenotypic evolutionary rates of these geochemical data based on trees inferred from morphological data. …”
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Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE) by Daixuan Wu, Yuecheng Shen, Zhongzheng Zhu, Tijian Li, Jiawei Luo, Zhengyang Wang, Jiaming Liang, Zhiling Zhang, Yunhua Yao, Dalong Qi, Lianzhong Deng, Zhenrong Sun, Meng Liu, Zhi-Chao Luo, Shian Zhang

“…However, limitations such as slow pattern projection rates and time-consuming reconstruction algorithms hinder its throughput for real-time imaging. …”
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A Detailed Analysis of the Milky Way Warp Based on Classical Cepheids by Xiaoyue Zhou, Xiaodian Chen, Licai Deng, Shu Wang, Jiyu Wang, Jianxing Zhang

“…We analyze the impact of the adopted solar vertical velocity on the inferred warp precession rate and confirm the reliability of the measured precession rate. …”
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Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling by Ling Li, Yun Zhao, Rong Liu, Chen Yao, Zhijun Zhang, Yingying Hu, Ruifang Wu, Ruifang An, Hui Du, Xinfeng Qu, Lihui Wei, Bei Lin, Mingzhu Li, Chao Zhao, Jingran Li, Zhixin Lin, Jihong Deng, Songling Zhang

“…Different HPV subtypes have different detection rates for CIN2+, and combining HPV16/18/33 significantly improved the sensitivity for detecting CIN2+.…”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Emergency EEG: study of survival EEG de urgência: taxa de sobrevivência by Moacir Alves Borges, Harethusa Junia Botós, Ricardo Funes Bastos, Moacir Fernandes Godoy, Nely Silvia Aragão de Marchi

“…In the three months following EEG, a survival rate of 75% was found in patients with normal, discreet slow activity or intermittent rhythmic delta activity EEGs, of 50% for those with continuous delta activity and generalized epileptiform discharges, and of 25% for those with burst-suppression, diffuse depression, and in alpha/theta-pattern coma. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic... by Xu Wang, Chuizhao Xue, Xueying Deng, Qilu Chen, Chunyang Li, Baixue Liu, Ying Wang, Yan Kui, Qingqiu Zuo, Jianhai Yin, Shuai Han, Yujuan Shen, Jianping Cao

“…This dietary diversification correlated with seasonal resource scarcity, driving foxes to exploit alternative prey. The infection rates of Echinococcus in V. ferrilata displayed the U-shaped seasonal patterns. …”
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Fertility intentions among Chinese adults: a cross-sectional study using a national survey by Mingyan Hao, Chenxiao Zhang, Haofeng Fu, Jingting Zhang, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Chen Chen, Yajing Zhou, Jianzhong Zheng, Wei Liu, Lizheng Wang

“…Through the adoption of these approaches, stakeholders can strive to counteract the patterns of low fertility intentions and create an environment that supports family growth.…”
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Mapping Antimicrobial Resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights by Nawal AL Shizawi, Zaaima AL Jabri, Fatima Khan, Hiba Sami, Turkiya AL Siyabi, Zakariya AL Muharrmi, Srinivasa Rao Sirasanagandla, Meher Rizvi

“…In comparison, susceptibility rates of <i>K. pneumoniae</i> were far lower: nitrofurantoin (38%), fosfomycin (89%), aminoglycosides (82%), piperacillin-tazobactam (72%), and carbapenems (83%). …”
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Groundwater ammonia-oxidizing bacteria distribution and the correlations between the distribution and environmental factors around livestock lagoons by REN Juan, ZHANG Lei, ZENG Lingzao, WU Laosheng, SHI Jiachun

“…Principal component analysis (PCA) result showed that the concentrations of NH₄⁺-N and NO₃^--N are the two principal components of environmental factors with contribution rates are respectively 45.7% and 25.1%. AOB abundance also had a similar distribution pattern with NH₄⁺-N. …”
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Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China by Ming-Fang Ji, Yong-Qiao He, Min-Zhong Tang, Wen-Qiong Xue, Xia Yu, Hua Diao, Da-Wei Yang, Zhi-Ming Mai, Io Hong Cheong, Zhi-Yang Zhao, Biao-Hua Wu, Fu-Gui Li, Ji-Yun Zhan, Chang-Ling Huang, Hao-Lin Ma, Jun Li, Yan-Cheng Li, Tong-Min Wang, Ying Liao, Xue-Yin Chen, Zhi-Heng Liang, Shi-Feng Lian, Yun Du, Xue-Jun Liang, Zisis Kozlakidis, Jun Ma, Wei-Hua Jia

“…The associations showed an increased dose-response pattern, and keep persistent even up to ten years prior to diagnosis. …”
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Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury by Hong Duo, Yanwei Yang, Jun Luo, Yumeng Cao, Qian Liu, Jiarui Zhang, Siqi Du, Jian You, Guqing Zhang, Qifa Ye, Huaqin Pan

“…Abstract Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. …”
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