In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance by Junwei Zhang, Pengtao He

“…The aim of this study was to investigate the expression patterns of these genes in gastric cancer, their potential role in radiotherapy resistance, and their diagnostic value. …”
Get full text

Decoding stimulus-specific regulation of promoter activity of p53 target genes by Flavia Vigliotti, Nicolai Engelmann, Mark Sinzger-D’Angelo, Heinz Koeppl, Heinz Koeppl, Alexander Loewer, Alexander Loewer

“…Here, we characterized how stimulus-dependent p53 dynamics are converted into specific gene regulation patterns by inducing diverse forms of DNA damage ranging from ionizing and UV radiation to clinically relevant chemotherapeutics. …”
Get full text

An approach to arousal disorder classification using deformable convolution and adaptive multiscale features in EEG signals by Andia Foroughi, Fardad Farokhi, Fereidoun Nowshiravan Rahatabad, Alireza Kashaninia

“…Our method achieved an accuracy rate exceeding 96 %, outperforming other multi-scale channel attention modules. …”
Get full text

Integrating Occupant Behavior into Window Design: A Dynamic Simulation Study for Enhancing Natural Ventilation in Residential Buildings by Mojgan Pourtangestani, Nima Izadyar, Elmira Jamei, Zora Vrcelj

“…Survey data from 150 Melbourne residents were converted into two window-operation schedules: Same Behavior (SB), representing average patterns, and Probable Behavior (PB), capturing stochastic responses to comfort, privacy, and climate. …”
Get full text

NDL-Net: A Hybrid Deep Learning Framework for Diagnosing Neonatal Respiratory Distress Syndrome From Chest X-Rays by Malik Muhammad Arslan, Xiaodong Yang, Nan Zhao, Lei Guan, Tao Cui, Daniyal Haider

“…The model's low false negative and false positive rates underscore its superior diagnostic capabilities. …”
Get full text

Is mechanism of injury associated with outcome in spinal trauma? An observational cohort study from Tanzania. by Chibuikem Anthony Ikwuegbuenyi, Julie Woodfield, François Waterkeyn, Scott L Zuckerman, Beverly Cheserem, Andreas Leidinger, Albert Lazaro, Hamisi K Shabani, Roger Härtl, Halinder S Mangat

“…This study compared the demographics, injury patterns, and outcomes of TSI caused by road traffic accidents (RTAs) to non-traffic related TSI.…”
Get full text

Direct and Indirect Protection with Pediatric Quadrivalent Live-Attenuated Influenza Vaccination in Europe Estimated by a Dynamic Transmission Model by Laetitia Gerlier, Judith Hackett, Richard Lawson, Sofia Dos Santos Mendes, Catherine Weil-Olivier, Markus Schwehm, Martin Eichner

“… # Conclusions The model highlights direct and indirect protection benefits when vaccinating healthy children with QLAIV in Europe, across a range of demographic structures, contact patterns and vaccination coverage rates.…”
Get full text

Century-Long Cycles of Evolution of the Country’s Active Population by A. I. Latysheva

“…The collected factual material allows us to draw a conclusion about the general patterns of creative activity of the population both at the beginning of the last century and in our years. …”
Get full text

A Retrospective Analysis of CLL Patients in a Romanian Hematology Center by Ana-Maria IORDAN, Minodora Cezarina ONISAI, Anca RAITARU, Claudia DESPAN, Ionel GELATU, Silvia CIORTAN, Daniela GEORGESCU

“…Time to first treatment (TTFT), treatment patterns, and response rates were evaluated. Statistical tests included MannWhitney U and Fisher’s exact test, with p < 0.05 considered significant. …”
Get full text

Impact of COVID-19 on mucormycosis presentation and laboratory values: A comparative analysis. by Sepideh Hejazi, Ali Gholampour Kargar, Sahar Ravanshad, Arash Ziaee, Maryam Emadzadeh, Mona Kabiri, Reza Khoshbakht, Mohammad Hossein Ahmadi, Masoumeh Hosseinpoor, Hamed Khosravi, Imtiaz Ahmed, Mehdi Bakhshaee

“…The research highlights varied symptom patterns across patient subgroups and underscores the complexity of interactions between COVID-19, cancer, and diabetes in mucormycosis cases. …”
Get full text

Magnetohydrodynamic control of Falkner–Skan nanofluid transport around a wedge-shaped geometry for advanced thermal solutions: Applications in medical skin patches by Abdul Kareem Abdul Jawwad, Ali B.M. Ali, A. Divya, Narinderjit Singh Sawaran Singh, Muhammad Jawad, Hakim AL Garalleh, Ibrahim Mahariq

“…Binary processes have direct impact on heat generation and dissipation, fluid flow patterns and thermal properties. For example, depending on the specific active dynamics of such reactions heat and mass transfer rates may be either speeded-up or impeded. …”
Get full text

A Platform for Early Class Dropout Prediction of University Students by Guilherme Antonio Borges, Carolina Filipa Dos Santos Pedro, Julio Cesar Santos Dos Anjos, Andre Rodrigues, Fernando Boavida, Jorge Sa Silva

“…The analysis revealed that student performance, re-enrollment behavior, and attendance patterns are strongly correlated with the risk of early dropout. …”
Get full text

Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma by Fenglin Zhang, Kexin Liu, Mengfan Ao, Jiangang Zhao, Xinghe Liao, Ping Li, Hao Chen

“…The elevated-risk cohort, as identified by the risk assessment metric, correlates with poorer survival rates. Additionally, we uncover an association between the risk indicator and the tumor milieu, encompassing immune cell infiltration patterns and drug sensitivity profiles. …”
Get full text

Estimating the burden of underdiagnosis within England: A modelling study of linked primary care data. by Olga Anosova, Anna Head, Brendan Collins, Alexandros Alexiou, Kostas Darras, Matt Sutton, Richard Cookson, Laura Anselmi, Martin O'Flaherty, Ben Barr, Chris Kypridemos

“…<h4>Introduction</h4>Undiagnosed chronic disease has serious health consequences, and variation in rates of underdiagnosis between populations can contribute to health inequalities. …”
Get full text

Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics by Zhouquan Li, Guanghua Huang, Jingyi Zhang, Mingyou Li, Zhizhi Liu, Sihua Peng, Rui Wang, Dong Liu

“…White spot syndrome virus (WSSV) has emerged as a significant threat to global shrimp aquaculture, causing economic losses because of its rapid spread and high mortality rates. This study aims to elucidate the genetic and evolutionary dynamics of WSSV through a comprehensive genome analysis. …”
Get full text

Burden and inequality of autism spectrum disorders in global, East asian, and Southeast Asian regions, 1990–2021: result from the global burden of disease study 2021 by Wen Liu, Xinhao Gong, Jinping Ou, Shoulin Chen

“…Abstract Introduction Autism Spectrum Disorders (ASD) represent a range of neurodevelopmental conditions characterized by abnormal behavioral patterns. ASD is frequently comorbid with other neurodevelopmental disorders. …”
Get full text

Intramedullary nailing with and without cerclage in subtrochanteric fractures: an updated systematic review and meta-analysis by Ahmed Oun, Omar Abdelaziz, Islam Saeed Elhois, Mohamed Al-Badaineh, Karim Zinhom, George Jabrieh, Hamza S. Al-Himyari, Abdullah A. Nada

“…No significant differences were observed in non-union, infection, or mortality rates. Quality assessment using the Newcastle–Ottawa Scale indicated high quality studies. …”
Get full text

Applying a logistic regression-clustering joint model to analyze the causes of prolonged pre-analytic turnaround time for urine culture testing in hospital wards by Shuangshuang Lv, Huan Ye, Yuan Li, Jian Zhang

“…Contamination rate decreased by 59.8% (5.67% → 2.28%, P &lt; 0.01). …”
Get full text

INFLUENCE OF THE EVAPORITE FORMATION STRUCTURE ON SALT TECTONICS AND HYDROCARBON TRAPS (BY THE RESULTS OF NUMERICAL SIMULATION OF HALOKINESIS IN THE PRE-CASPIAN) by B. V. Lunev, V. V. Lapkovsky, M. P. Antipov, Y. A. Volozh, I. S. Postnikova

“…Since halokinesis is the main factor controlling the migration and accumulation of hydrocarbons in the Preaspian region, background and aim of prospecting and exploration require identifying the specifics of the formation of various types of salt structures and the relationship between their location patterns and halokinesis process.Numerical simulation shows that, depending on the instable layer thickness and its relationship with the total thickness of the overlying layers, the instability development occurs at different rates, forming different types of structures. …”
Get full text

The tsunami of antibiotic resistance as a global health crisis in otorhinolaryngology patients; a cross-sectional study by Peter Milad, Ossama Ibrahim Mansour, Mohammed Shehata Taha, Tarek Ashmawy, Heba Mahmoud Abdelmageed, Samia Abdou Girgis, Azza Omran, Anas Askoura, Omar Yassin, Amr Hamed, Mena Maher Nassif

“…Objective Due to the desperate need for sustainable access to effective antibiotic the patterns of antimicrobial resistance among ORL patients in Egypt were studied and the implications for clinical management and public health were assessed. …”
Get full text