Molecular and genomic investigation of an urban outbreak of dengue virus serotype 2 in Angola, 2017-2019. by Zoraima Neto, Pedro A Martinez, Sarah C Hill, Domingos Jandondo, Julien Thézé, Marinela Mirandela, Renato Santana Aguiar, Joilson Xavier, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Filipa Vaz, Gisel Reyes Castro, Joana Paula Paixão, Nicholas J Loman, Philippe Lemey, Oliver G Pybus, Jocelyne Vasconcelos, Nuno Rodrigues Faria, Joana de Morais

“…<h4>Background</h4>The transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remain poorly understood. …”
Get full text

Dynamic parking space allocation at urban scale: Problem formulation and resolution by Hanae Errousso, Jihane El Ouadi, El Arbi Abdellaoui Alaoui, Siham Benhadou

“…To do this, we consider both solicitation rates in these areas and coverage ratios of received parking demands. …”
Get full text

The characteristics of new-onset myasthenia gravis after COVID-19 outbreak: a cross-sectional study by Yanzhen Huang, Yu Wu, Shaodan Zhou, Xianting Que, Ailing Jiang, Danli Shi, Ting Lu, Yanlan Chen, Ziqun Lin, Chao Liu, Yishuang Wen, Shuyi Zhang, Wen Huang

“…After COVID-19 outbreak, there was an increase in new-onset MG patients, with more cases occurring within the first three months. The rates of pulmonary inflammation (40.28%), COVID-19 vaccination (88.14%), and treatment with tacrolimus (15.98%) and MG duration (15 weeks, IQR: 5.75, 32) were higher, while rates of thymectomy (13.92%), baseline MG-ADL (3, IQR: 3, 6), and QMGS (7, IQR: 5,8) were lower compared to new-onset MG patients before COVID-19 outbreak. …”
Get full text

Whole Blood Stimulation Assay as a Treatment Outcome Monitoring Tool for VL Patients in Ethiopia: A Pilot Evaluation by Yetemwork Aleka, Ana Victoria Ibarra-Meneses, Meseret Workineh, Fitsumbrhan Tajebe, Amare Kiflie, Mekibib Kassa Tessema, Roma Melkamu, Azeb Tadesse, Javier Moreno, Johan van Griensven, Eugenia Carrillo, Wim Adriaensen

“…Current treatments produce variable rates of treatment failure and toxicity without sterile cure, rendering treatment efficacy monitoring essential. …”
Get full text

Geospatial Analytics of Urban Bus Network Evolution Based on Multi-Source Spatiotemporal Data Fusion: A Case Study of Beijing, China by Xiao Li, Shaohua Wang, Liang Zhou, Yeran Sun, Jiayi Zheng, Chang Liu, Junyuan Zhou, Cheng Su, Dachuan Xu

“…By analyzing spatial coverage rates of transit stations using road network and administrative division data, the study reveals the convenience of bus networks in different regions. …”
Get full text

Optimizing dance motion reconstruction using a two-dimensional matrix approach with hybrid genetic and fuzzy logic differential evolution by Lin Wang, Yutong Liu, Yucong Geng, Mohammad Khishe

“…We develop the Two-Dimensional Matrix-Calculation (TDMC) model, combined with the Hybrid Genetic Algorithm with Fuzzy Logic Differential Evolution (HGA-FLDE), which aims to optimize the reconstruction of complex dance movements by leveraging Riemannian geometry and adaptive optimization for biomechanical nonlinear motion patterns and missing joint data. Furthermore, accuracy is achieved through other approaches, such as the Long Short-Term Memory (LSTM), Support Vector Regression (SVR), Kinect Sensors (KS), and Evolved Deep Gated Recurrent Unit (EDGRU) models, which were all thoroughly tested against one another. …”
Get full text

The association between four dietary indices and mortality risk in cardiovascular disease patients by Mengshan Pan, Tongle Yin, Ying Yang, Feiyun Zhu, Jiamin Xu, Rucheng Chen, Weijun Zheng

“…Abstract Background The Planetary Healthy Diet Index-United States, the Healthy Diet Index, the Mediterranean Diet, and the Dietary Inflammation Index were linked to mortality rates in cardiovascular patients. This study investigated the relationship between these dietary patterns and all-cause mortality risk in U.S. cardiovascular patients from 2005 to 2006 to 2017–2018. …”
Get full text

Statistics and behavior of clinically significant extra-pulmonary vein atrial fibrillation sources: machine-learning-enhanced electrographic flow mapping in persistent atrial fibri... by Peter Ruppersberg, Steven Castellano, Philip Haeusser, Kostiantyn Ahapov, Melissa H. Kong, Stefan G. Spitzer, Stefan G. Spitzer, Georg Nölker, Andreas Rillig, Tamas Szili-Torok

“…Our machine learning approach established an activity threshold, above which divergent wavefront patterns—termed “significant sources”—predicted AF recurrence. …”
Get full text

Can Fire Season Type Serve as a Critical Factor in Fire Regime Classification System in China? by Huijuan Li, Sumei Zhang, Xugang Lian, Yuan Zhang, Fengfeng Zhao

“…Fire regime (FR) is a key element in the study of ecosystem dynamics, supporting natural resource management planning by identifying gaps in fire patterns in time and space and planning to assess ecological conditions. …”
Get full text

Integrative single‐cell transcriptomic analysis deciphers heterogeneous characteristics of gastrointestinal tract cancer by Chuwen Sun, Tong Li, Xin Jin, Zhihui Xiu, Hang Su, Huanming Yang, Ming Liu, Kui Wu

“…Abstract Background Gastrointestinal tract cancer (GIC), including oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC), is characterised with high global incidence and mortality rates, with similar tumourigenic processes. However, the common and heterogeneous molecular features among GIC at single‐cell level remain poorly characterised. …”
Get full text

Pitfalls in the diagnosis of apparent homozygous mutations: two cases of IL10RA deficiency inflammatory bowel disease and a literature review by Xiu Shi, Ziqing Ye, Lai Qian, Wenhui Hu, Ye Yang, Chunmeng He, Zhiheng Huang, Bingbing Wu, Ying Huang

“…Abstract Background In East Asia, IL10RA is the predominant pathogenic gene in patients with very early-onset inflammatory bowel disease (VEO-IBD), frequently characterised by refractory diarrhoea and severe perianal disease, resulting in elevated death rates. IL10RA-deficient IBD, an autosomal recessive genetic disorder, has been documented to be inherited through the conventional compound heterozygous or homozygous mutation patterns from both parents. …”
Get full text

Characterizing Breast Tumor Heterogeneity Through IVIM-DWI Parameters and Signal Decay Analysis by Si-Wa Chan, Chun-An Lin, Yen-Chieh Ouyang, Guan-Yuan Chen, Chein-I Chang, Chin-Yao Lin, Chih-Chiang Hung, Chih-Yean Lum, Kuo-Chung Wang, Ming-Cheng Liu

“…Evaluation using 3D-ROC analysis also indicated that the DNN was the best detector based on metrics like target detection rate and overall effectiveness. The DNN model further exhibited the capability to identify tumor heterogeneity, differentiating high- and low-cellularity regions. …”
Get full text

EFFECT OF NEURODEGENERATIVE CHANGES IN THE BRAIN ON THE FORMATION OF THE DISEASE CLINICAL PICTURE IN PATIENTS WITH MULTIPLE SCLEROSIS by L. N. Prakhova, Ye. P. Magonov, A. G. Ilves, A. A. Bogdan, G. V. Kataeva, Ye. S. Malakhova, Zh. I. Savintseva, I. D. Stolyarov, T. N. Trofimova

“…Neurodegenerative changes of brain structures evolve with different rates, have different intensity and determine the set of symptoms of neurological impairment and severity of disability, which indicates the presence of certain patterns of the process of atrophy in the brain, forming the clinical picture of the disease.…”
Get full text

Verification of a Probabilistic Model and Optimization in Long-Range Networks by José Luis Romero Vázquez, Abel García-Barrientos, José Alberto Del-Puerto-Flores, Francisco R. Castillo Soria, Roilhi F. Ibarra-Hernández, Ulises Pineda Rico, Ernesto Zambrano-Serrano

“…The proposed model integrates multiple critical factors, including packet arrival rates, transmission power levels, and the distance between transmitting nodes and the gateway. …”
Get full text

Comparative analysis of soil thermal conductivity in the permafrost regions of the Qinghai–Tibetan Plateau and the Arctic by Wenhao Liu, Ren Li, Tonghua Wu, Guojie Hu, Xiaodong Wu, Shenning Wang, Junjie Ma, Jianzong Shi, Shengfeng Tang, Xiaofan Zhu, Yongping Qiao

“…The mean STC values in the QTP permafrost region during the thawing period are significantly higher than those during the freezing period. (2) STC of the QTP exhibits a fluctuating pattern at different depths, in contrast, the average STC value in the Arctic increases steadily with depth, with an increase rate of approximately 0.005 Wm−1 K−1/cm. (3) The analysis of influencing factors revealed that although moisture content, bulk density, and porosity are the primary drivers of regional variations in STC between the QTP and the Arctic permafrost, moisture elements in the QTP region have a greater influence on STC and the effect is stronger with increasing depth and during the freeze–thaw cycles. …”
Get full text

Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region by Yun Luo, Elaine Cheong, Qiao Bian, Deirdre A. Collins, Julian Ye, Jeong Hwan Shin, Wing Cheong Yam, Tohru Takata, Xiaojun Song, Xianjun Wang, Mini Kamboj, Thomas Gottlieb, Jianmin Jiang, Thomas V. Riley, Yi-Wei Tang, Dazhi Jin

“…Healthcare-associated (HA) CDI was mainly from older patients with more frequent antimicrobial use and higher A-B+ positive rates. Higher resistance to gatifloxacin, tetracycline, and erythromycin were observed in HA-CDI patients (χ2 = 4.76-7.89, p = 0.005-0.029). …”
Get full text

Antimicrobial susceptibility profiles of thermophilic Campylobacter species from human, pig, and chicken feces in Rwanda by Noel Gahamanyi, Noel Gahamanyi, Arsene Musana Habimana, Jean Paul Harerimana, Josiane Mukayisenga, Salomon Ntwali, Anathali Umuhoza, Emmanuel Nsengiyumva, Emmanuel Irimaso, Jean Bosco Shimirwa, Cheol-Ho Pan, Erick Vitus Komba, Claude Mambo Muvunyi, Nadine Rujeni, Raghavendra G. Amachawadi

“…Multi-drug resistance (MDR) was observed among the isolates, with the highest rates observed in chicken isolates (88.0%). Proportions of MDR among pig (40.9%) and human (40.7%) isolates were more or less similar. …”
Get full text

Cancelable Multi-Branch Deep Learning Framework for Privacy-Preserving ECG Biometric Authentication by Mohamed Hammad, Ali Abdullah S. AlQahtani, Mohammed ELAffendi, Abdelhamied A. Ateya, Nebojsa Bacanin

“…We evaluate the framework on two publicly available ECG datasets (PTB and ECG-ID) achieving high authentication performance with accuracies of 96.25% and 96.43%, respectively, and Equal Error Rates (EER) of 3.55% and 3.6%. The system meets critical privacy-preserving criteria, including irreversibility, unlinkability, diversity, and revocability. …”
Get full text

Evolutionary trajectory estimation via replication simulation of coronavirus spike gene based on random mutation and similarity-based selection by Min Chan Kim, Hye Ji Jung, Seong Sik Jang, Van Thi Lo, Hye Kwon Kim

“…Simulations tracking the evolution of SARS-CoV-2 Wuhan-Hu-1 toward the Omicron variant (BA.1) displayed plateau-like similarity trajectories, where increased substitution rates resulted in a more rapid attainment of the plateau stage. …”
Get full text

Insights from the Biorepository and Integrative Genomics pediatric resource by Silvia Buonaiuto, Franco Marsico, Akram Mohammed, Lokesh K. Chinthala, Ernestine K. Amos-Abanyie, Regeneron Genetics Center, Pjotr Prins, Khyobeni Mozhui, Robert J. Rooney, Robert W. Williams, Robert L. Davis, Terri H. Finkel, Chester W. Brown, Vincenza Colonna

“…We observe ancestry-specific rates of novel genetic variants, which are enriched for functional or clinical relevance. …”
Get full text