MCM3 promotes hepatocellular carcinoma progression via Epithelial-mesenchymal Transition through AKT/Twist signaling pathway by Wei-Guo Tang, Jin-Feng Feng, Xian Li, Qi-Man Sun, Jin-Wu Hu, Xiao-Lu Ma, Yan-Yan Nie, Yang Xu, Jian Sun, Qi-Meng Chang

“…Introduction and Objectives: Hepatocellular carcinoma (HCC), a leading cause of cancer fatalities, challenges clinicians with high recurrence and metastasis rates, urging the need for novel prognostic markers and therapeutic avenues. …”
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Multi-Objective Optimization of Off-Grid E-Bikes Charging Stations Powered by PhotoVoltaics by Fabio Corti, Gabriele Maria Lozito, Davide Astolfi, Salvatore Dello Iacono, Antony Vasile, Marco Pasetti, Alberto Reatti, Alessandra Flammini

“…A Genetic Algorithm is employed to determine the most appropriate rated power of the installed PhotoVoltaic (PV) systems and of the energy storage, by incorporating statistical methods to estimate the daily number of e-bikes requiring charging, hence making the optimization process more reflective of actual usage patterns. …”
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Nutritional status, body indices, and somatotype in Aymara and Quechua children from high Andean areas of Peru by Lidia Sofia Caballero Gutiérrez, Rodolfo Adrian Núñez Postigo, Juber Chávez Dominguez, Vilma Lucrecia Tapia Aguirre, José Oscar Alberto Begazo Miranda

“…Infants born at high altitudes, such as in the Puno region, typically exhibit higher birthweights than those born at low altitudes; however, the influence of ethnicity on childhood anthropometric patterns in high-altitude settings remains poorly understood. …”
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Isokinetic Evaluation of Quadriceps and Hamstring Muscle Performance in the Rehabilitation Phase after ACL Reconstruction by Nicolae Stanciu, Razvan Marian Melinte, Mark Slevin, Octav Marius Russu, Cristian Trâmbițaș, Cezara Ilinca Stanciu, Elena Georgiana Bălănescu, Dan Avrămiuc, Gabriel Koszoruș, Klara Brînzaniuc

“…While male and athletic participants exhibited higher absolute and relative strength values (p < 0.05), recovery rates were consistent across subgroups. Adductor and abductor strength also showed post-rehabilitation symmetry and robustness, supporting their relevance in functional assessment.…”
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Mutation Profiling of Premalignant Colorectal Neoplasia by Jakub Karczmarski, Krzysztof Goryca, Jacek Pachlewski, Michalina Dabrowska, Kazimiera Pysniak, Agnieszka Paziewska, Maria Kulecka, Malgorzata Lenarcik, Andrzej Mroz, Michal Mikula, Jerzy Ostrowski

“…HGD adenomas had significantly higher mutation rates than LGD adenomas, while LGD-H adenomas exhibited mutation frequencies similar to those of LGD adenomas. …”
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Intraspecific and Intracolonial Variation in the Profile of Venom Alkaloids and Cuticular Hydrocarbons of the Fire Ant Solenopsis saevissima Smith (Hymenoptera: Formicidae) by Eduardo Gonçalves Paterson Fox, Adriana Pianaro, Daniel Russ Solis, Jacques Hubert Charles Delabie, Bruno Cunha Vairo, Ednildo de Alcântara Machado, Odair Correa Bueno

“…Some fire ant species are top-rated pests spreading throughout the world by trade vessels. …”
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Unravelling molecular transformation of dissolved organic matter in the full quantization treatment of landfill leachate concentrate by ZHONG Quanfa, ZHONG Lin, XU Guohui, JIN Qinghai, YU Jin, XU Fei, HE Di

“…To investigate the removal and transformation patterns of dissolved organic matter(DOM) in the full quantization treatment of landfill leachate concentrate, this study centered on the landfill leachate concentrate derived from a waste transfer station in Shenzhen. …”
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Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review by Nadia Harbeck, Adam Brufsky, Chloe Grace Rose, Beata Korytowsky, Connie Chen, Krista Tantakoun, Endri Jazexhi, Do Hoang Vien Nguyen, Meaghan Bartlett, Imtiaz A. Samjoo, Timothy Pluard

“…Key outcomes for synthesis were effectiveness, treatment patterns, and safety.ResultsThis review included 23 unique studies. …”
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Improvement of Oral Anticoagulant Prescription and Long‐Term Clinical Outcomes of Patients With Atrial Fibrillation After Implementation of a Clinical Decision Support System in Ou... by Po‐Tseng Lee, Mu‐Hsiang Huang, Ting‐Chun Huang, Pi‐Shan Sung, Chi‐Hui Hsu, Ya‐Ling Huang, Sheng‐Hsian Lin, Ping‐Yen Liu

“…Results OAC prescription rates increased from 47.3% to 67.5% after CDSS implementation. …”
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Clinical outcomes of flomoxef versus cefmetazole in hospitalized patients with urinary tract infections: combined retrospective analyses of two real-world databases and in vitro da... by Takahiro Niimura, Mitsuhiro Goda, Satoshi Nakano, Toshiki Kajihara, Koji Yahara, Aki Hirabayashi, Koji Miyata, Marie Ikai, Motoko Shinohara, Yusuke Minato, Masato Suzuki, Keisuke Ishizawa

“…Methods The susceptibility rates of third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae to flomoxef and cefmetazole were compared using comprehensive national antimicrobial resistance surveillance data. …”
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Exploring mobility data for enhancing HIV care engagement in Black/African American and Hispanic/Latinx individuals: a longitudinal observational study protocol by Katherine P Theall, Lisa Hightow-Weidman, Xiaoming Li, Sean Young, Lidia Flores, Seungjun Kim, Maryam Hassani, Cristina De Haro, Mohamed Emish, Zeyad Kelani, Dominic Arjuna Ugarte, Amanda Castel

“…We seek to study the relationship between mobility patterns and HIV care engagement.Ethics and dissemination Ethical approval has been obtained from the Institutional Review Board of the University of California, Irvine (#20205923). …”
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Lignin Unlocks Stealth Carbon Sinks in Cold Seeps via Microbial Enzymatic Gatekeeping by Jialing Li, Jingchun Feng, Pandeng Wang, Mengzhuo Zhu, Yongji Huang, Ying Wu, Junning Fan, Junlin Hu, Xiyang Dong, Yingli Zhou, Xuanyu Tao, Si Zhang

“…Although direct methanogenesis was undetected, methylotrophic potential was evidenced through methane cycle gene expression patterns by lignin decomposers. Phylogenetic surveys further demonstrated the global prevalence of lignin decomposers across 12 major cold seep systems. …”
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The global burden of chronic kidney disease due to diabetes mellitus type 2 attributable to diet high in sugar-sweetened beverages among the elderly: a comprehensive analysis from... by Ben Hu, Ben Hu, Xiaohan Qiu, Zhengbiao Luo, Zhengbiao Luo, Jingxiong Chen, Jun Feng, Jun Feng, Linlin Hou, Linlin Hou

“…However, the global burden of CKD-T2DM attributable to high SSB consumption among elderly populations remains poorly characterized.MethodsUsing data from the Global Burden of Disease Study 2021, we examined age-standardized mortality rates (ASMR) and disability-adjusted life year rates (ASDR) of CKD-T2DM attributable to high SSB consumption among individuals aged 60 years and older across 204 countries and territories from 1990 to 2021. …”
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Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects by Maryam Mohammadi-Bajgiran, Reyhaneh Saffar-Khorasani, Muhammad Islampanah, Reza Nejad Shahrokh Abadi, ‌Bahram Shahri, Sara Saffar Soflaei, Souren Nemati-Khorasani, Habibollah Esmaily, Gordon Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan

“…Cigarette users (92.3% male) had significantly lower BMI and higher employment rates compared to non-smokers, whereas hookah smokers (90.2% female) had higher BMIs and were predominantly retirees. …”
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Analysis of the International, Regional, and National Endocarditis-Related Disease Burdens (1990–2021), and Changes to Projections for the Next 15 Years: A Population-Based Study by Qiyuan Bai, Hao Chen, Hongxu Liu, Xuhua Li, Yang Chen, Dan Guo, Bing Song, Cuntao Yu

“…Clustering analysis assessed the changing patterns of disease burden related to endocarditis in the Global Burden of Disease (GBD) study regions. …”
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Tobacco smoking and smokeless tobacco use among people living with HIV in Zambia: Findings from a 2023 National NCD/HIV Survey. by Cosmas Zyambo, Paul Somwe, Chomba Mandyata, Mwiche Musukuma, Phoebe Bwembya, Henry Phiri, Malizgani P Chavula, Hikabasa Halwindi, Joseph Zulu, Wilbroad Mutale

“…Tobacco smoking, SLT use, behavioral patterns, and clinical characteristics were assessed. …”
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TS-InSAR assessment of groundwater overexploitation-land subsidence linkage: Hengshui case study by Yan An, Qiang Shen, C.K. Shum, Fan Gao, Xu Zhang, Liming Jiang, Hansheng Wang

“…New hydrological insights for the region: Results show subsidence dominates in Hengshui City, with rates up to 141 mm/year (2017–2024), mainly due to falling confined aquifer heads and delayed aquitard drainage. …”
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Effect of nonpharmaceutical interventions on the epidemic trends of scarlet fever in China: a population-based surveillance and modelling study by Xiaojuan Zhang, Yuanhai You, Jie Liu, Lu Sun, Haijian Zhou, Xingxing Zhang, Bike Zhang

“…Dynamic changes in distribution pattern were explored through spatial autocorrelation analysis. …”
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Regional variations in Mediterranean diet adherence: a sociodemographic and lifestyle analysis across Mediterranean and non-Mediterranean regions within the MEDIET4ALL project by Mohamed Ali Boujelbane, Mohamed Ali Boujelbane, Achraf Ammar, Achraf Ammar, Achraf Ammar, Atef Salem, Atef Salem, Mohamed Kerkeni, Mohamed Kerkeni, Khaled Trabelsi, Khaled Trabelsi, Bassem Bouaziz, Bassem Bouaziz, Liwa Masmoudi, Juliane Heydenreich, Christiana Schallhorn, Gabriel Müller, Ayse Merve Uyar, Hadeel Ali Ghazzawi, Adam Tawfiq Amawi, Bekir Erhan Orhan, Giuseppe Grosso, Osama Abdelkarim, Osama Abdelkarim, Tarak Driss, Kais El Abed, Kais El Abed, Piotr Zmijewski, Frédéric Debeaufort, Frédéric Debeaufort, Nasreddine Benbettaieb, Nasreddine Benbettaieb, Clément Poulain, Laura Reyes, Amparo Gamero, Marta Cuenca-Ortolá, Antonio Cilla, Nicola Francesca, Concetta Maria Messina, Enrico Viola, Björn Lorenzen, Stefania Filice, Aadil Bajoub, El-Mehdi Ajal, El-Mehdi Ajal, El Amine Ajal, Majdouline Obtel, Sadjia Lahiani, Taha Khaldi, Nafaa Souissi, Omar Boukhris, Omar Boukhris, Haitham Jahrami, Haitham Jahrami, Waqar Husain, Evelyn Frias-Toral, Evelyn Frias-Toral, Walid Mahdi, Walid Mahdi, Hamdi Chtourou, Wolfgang I. Schöllhorn

“…Sleep quality was poorer in MC (45% below recommended duration vs. 40% in NMC), while NMC reported higher insomnia rates. Mental health symptoms were comparable (33%–35% moderate depression/anxiety in both), reflecting post-pandemic global trends. …”
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Gender-based variations in surgical management of colorectal liver metastases: comprehensive analysis by Pia F. Koch, Kristina Ludwig, Karl H. Hillebrandt, Hannes Freitag, Moritz Blank, Sebastian Knitter, Dominik Paul Modest, Felix Krenzien, Georg Lurje, Wenzel Schöning, Johann Pratschke, Igor M. Sauer, Simon Moosburner, Nathanael Raschzok

“…Postoperative complications and survival rates showed no significant differences by patients’ sex. …”
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