MtDNA copy number enrichment is associated with poor prognosis and eosinophilic morphology in clear cell renal cell carcinoma by Sarah Bellal, Sarah Bellal, Cyrielle Rolley, Jeremy Richard, Nolwenn Bounaix, Vincent Le Corre, Marie-Christine Copin, Odile Blanchet, Pierre Bigot, Pierre Bigot, Vincent Procaccio, Vincent Procaccio, Céline Bris, Céline Bris

“…CSS was significantly reduced in the “HIGH” than in the “LOW” group with respective 5-year survival rates: 78.7% (CI 95: 64.8–95.5) and 95.5% (CI 95 87.1–100.0) (Hazard Ratio: 7.4 (CI 95: 1.9–29.9, p = 0.027*) in multivariate analysis, including pathological classification, tumor size, International Society of Urological Pathology grade, lymphovascular invasion, dedifferentiated pattern, necrosis and adjuvant therapy. …”
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Burden of six common sexually transmitted infections groups in North Africa and Middle East Region from 1990 to 2021: A systematic analysis of global burden of diseases by Amirhossein Shahsavand, Leonardo Oliveira Reis, Ali Golestani, Alireza Namazi Shabestari, Ziba Aghsaeifard, Ozra Tabatabaei-Malazy, Iman Menbari Oskouie, Bagher Larijani, Seyed Mohammad Kazem Aghamir

“…Both age-standardized rates (ASRs) and total numbers were evaluated across 21 NAME countries, with breakdowns by sex, age, and sociodemographic index (SDI). …”
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Development of a Quadruplex RT-qPCR Assay for Rapid Detection and Differentiation of PRRSV-2 and Its Predominant Genetic Sublineages in China by Guishan Ye, Siyu Xiong, Zhipeng Su, Guosheng Chen, Siyuan Liu, Zixuan Wang, Huanchun Chen, Anding Zhang

“…Field application using 938 samples from Guangxi A and B farms revealed NADC30-like PRRSV wild-type strains at positivity rates of 13.44% and 3.53%, respectively. Positive samples selected for sequencing were further confirmed using ORF5-based phylogenetic analysis and NSP2 deletion pattern comparison, which aligned with RT-qPCR detection results. …”
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Time Course of Changes in the Level of Procalcitonin in the Development of Nosocomial Pneumonia in Victims with Severe Concomitant Injury in an Intensive Care Unit by A. K. Shabanov, M. Sh. Khubutia, G. V. Bulava, N. V., Beloborodova, A. N. Kuzovlev, O. A. Grebenchikov, D. A. Kosolapov, M. I. Shpitonkov

“…The posttraumatic period in victims with severe concomitant injury is frequently complicated by nosocomial pneumonia, resulting in high mortality rates and longer time and increased cost of treatment in intensive care unit unit patients. …”
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Volumetric evolution of supraglacial lakes in southwestern Greenland using ICESat-2 and Sentinel-2 by T. Feng, T. Feng, X. Ma, X. Ma, X. Liu, X. Liu, X. Liu

“…Additionally, according to the evolution characteristics of SGLs at different elevations, SGLs above 800 m exhibit a similar evolution pattern. A temporal discrepancy in maximum values for both mean area and mean depth implies differential rates of SGL development in the horizontal and vertical dimensions. …”
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Emergency Nursing Didactics – Opinions, Resource, and Skill Exchange (E.N.D.O.R.S.E) – A collaborative academic initiative in the Emergency Department by Mohammad Anzal Rehman, Elrasheed Salih, Honey Mathew, Ramna Abdulrahman, Ahmad Chahla, Rishi Prasad

“…Post-session questionnaires revealed that 92.3% of participants found the sessions provided them with new information, with approximately 88% of them ‘Very confident' (5/5) in using the skills taught thereafter. 77% of participants rated the quality of the sessions as ‘Excellent' (5/5), and 88% indicated they would like for the topics to be repeated in future sessions. …”
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Duration of the hypotensive effect of modified transscleral cyclophotocoagulation in patients with diabetic neovascular glaucoma by O. V. Guzun, O. S. Zadorozhnyy, I. O. Nasinnyk, Wael Chargui, A. R. Korol

“…Nine patients (20%) had a history or retinal laser photocoagulation and no pattern vision. All patients received TSCPC with a diode laser (810 nm, 1.5 J/ pulse) or neodymium:yttrium-aluminum-garnet (Nd:YAG) laser (1064 nm, 1.0 J/ pulse). …”
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Does Seasonality Affect Peptic Ulcer Perforation? A Single-Center Retrospective Study by Iva Krajnović, Zenon Pogorelić, Iva Perić, Marija Ćavar, Matija Borić

“…Previous studies have suggested a seasonal pattern in the occurrence of symptomatic perforated peptic ulcers. …”
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Postoperative liver dysfunction in gastric cancer patients following early enhanced nutritional protocols: a retrospective observational study by Kazuo Kobayashi, Satoshi Ida, Masanari Tsuji, Arisa Nawa, Takeshi Aoyama, Takashi Yokokawa, Yoshikazu Tateai, Shuichi Watabe, Hisanori Shimizu, Souya Nunobe, Masakazu Yamaguchi

“…AST and ALT levels showed a biphasic pattern, with two distinct peaks observed on POD 1 and POD 7. …”
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Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling by Ling Li, Yun Zhao, Rong Liu, Chen Yao, Zhijun Zhang, Yingying Hu, Ruifang Wu, Ruifang An, Hui Du, Xinfeng Qu, Lihui Wei, Bei Lin, Mingzhu Li, Chao Zhao, Jingran Li, Zhixin Lin, Jihong Deng, Songling Zhang

“…Different HPV subtypes have different detection rates for CIN2+, and combining HPV16/18/33 significantly improved the sensitivity for detecting CIN2+.…”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. by Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, John Rek, Maato Zedi, Catherine Maiteki-Sebuguzi, Jimmy Opigo, Sarah G Staedke, Ambrose Oruni, Martin J Donnelly, Bryan Greenhouse, Jessica Briggs, Paul J Krezanoski, Teun Bousema, Philip J Rosenthal, Peter Olwoch, Prasanna Jagannathan, Isabel Rodriguez-Barraquer, Grant Dorsey

“…In Busia, An. gambiae s.s. remained the primary vector throughout the observation period. Sporozoite rates were approximately 50% higher among An. funestus compared to the other common malaria vectors. …”
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Treatment of total hip arthroplasty between two surgical access routes associated chronic pain, function and biomechanical parameters in older after osteoporotic femur fracture: co... by Marco Antônio Leite Pereira Pinto, Giovanna Truyts Biscardi Pinto, Mariana Afonso Ribeiro Sarquis Ude, Claudia Aparecida de Morais, Ana Paula Ribeiro

“…Conclusion Total hip arthroplasty via the posterolateral approach proved to be more successful when associated with reducing chronic pain, improving functional parameters and hip joint mobility, as well as facilitating a more efficient gait pattern with lower rates of plantar overload and enhanced body balance in older adults undergoing total hip arthroplasty after osteoporotic femur fracture. …”
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Dynamic Effects of Sodium Selenite on the Rhizospheric Microenvironment, Growth, and Antioxidative Responses of Wheat (<i>Triticum aestivum</i> L.) by Fang Qin, Han Zhang, Feiyan Zhang, Xiangrui Zhu, Hongji Li, Yuefeng Xu

“…Soil selenium (Se) speciation characteristics and their influence on the Se enrichment pattern and physiological characteristics of wheat are poorly understood. …”
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Renal prognostic value of serum monoclonal immunoglobulin in cryoglobulinemic glomerulonephritis by Lei Ma, Yuanyuan Xia, Yun Fan, Dan Zhou, Xinchen Yao, Yongzhong Zhong, Fan Yang, Feng Xu, Shaoshan Liang, Yujie Wang, Xiaodong Zhu, Dacheng Chen, Rong Tan, Zhengyun Zhu, Dandan Liang, Caihong Zeng

“…The MIg group had significantly lower eGFR levels, higher cryoglobulin levels, and higher rates of abnormal serum-free light chain ratios than the MIg/HBV/HCV negative group. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Classification of finger movements through optimal EEG channel and feature selection by Murside Degirmenci, Yilmaz Kemal Yuce, Matjaž Perc, Matjaž Perc, Matjaž Perc, Matjaž Perc, Matjaž Perc, Yalcin Isler

“…This study design may result in an increasing number of false positives and a significant decrease in the prediction rates and classification performance. Moreover, recent studies have focused on improving prediction performance using complex feature extraction and machine learning algorithms while ignoring comprehensive EEG channels and feature investigation in the prediction of finger movements from EEGs. …”
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Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A randomized c... by Ana M. Celorrio San Miguel, Luis M. Cacharro, Gema Santamaría, Manuel Garrosa, Manuel Garrosa, Marta Celorrio San Miguel, Enrique Roche, Enrique Roche, Enrique Roche, Enrique Roche, Evelina Garrosa, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Diego Fernández-Lázaro

“…Both MEL and CG exhibited a significant reduction (p &lt; 0.05) in the Borg Rating of Perceived Exertion (RPE) when comparing the beginning (T1) and end (T2) of the study Additionally, statistically significant differences (p = 0.018) were observed overtime between T1 and T2 in the MEL and CG in RPE, with a moderate effect size (η2p = 0.347). …”
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Differences in the inflammatory response and outcome among hospitalized patients during different waves of the COVID-19 pandemic by Violeta Briciu, Violeta Briciu, Daniel-Corneliu Leucuta, Monica Muntean, Monica Muntean, Amanda Radulescu, Amanda Radulescu, Cristina Cismaru, Cristina Cismaru, Adriana Topan, Adriana Topan, Lucia Herbel, Melinda Horvat, Melinda Horvat, Mirela Flonta, Mihai Calin, Roxana Dobrota, Mihaela Lupse, Mihaela Lupse

“…Leukocytes and neutrophils increased in their median values from the Wuhan to Delta wave and decreased in the Omicron wave, while an inverse pattern can be observed for lymphocytes, monocytes, and basophils. …”
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Characterisation of Flavonoid Aglycones by Negative Ion Chip-Based Nanospray Tandem Mass Spectrometry by Paul J. Gates, Norberto P. Lopes

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