Heterologous expression of the ThIPK2 gene enhances drought resistance of common wheat by Shu-juan ZHANG, Yu-lian LI, Guo-qi SONG, Jie GAO, Rong-zhi ZHANG, Wei LI, Ming-li CHEN, Gen-ying LI

“…Compared to the wild type (WT) plants, the transgenic plants showed higher seed germination rates, better developed root systems, a higher relative water content (RWC) and total soluble sugar content, and less cell membrane damage under drought stress conditions. …”
Get full text

Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer by Sharda P. Singh, Chathurika S. Dhanasekara, Michael W. Melkus, Chhanda Bose, Sonia Y. Khan, Flavia Sardela de Miranda, Maria F. Mahecha, Prrishti J. Gukhool, Sahil S. Tonk, Se-Ran Jun, Sahra Uygun, Rakhshanda Layeequr Rahman

“…Demographic factors such as age, race/ethnicity, menopausal status, and body mass index have been correlated with variations in incidence, mortality, and survival rates. Over the past decade, comprehensive genomic profiling has been widely used to identify molecular biomarkers and signatures to develop novel therapeutic strategies for patients. …”
Get full text

Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Nomogram-based risk stratification effectively predicted biologic treatment responses across multiple therapeutic classes using four independent treatment datasets (GSE16879, GSE92415, GSE73661, GSE206285): low-risk patients demonstrated superior response rates to golimumab (63.3%), infliximab (54.8%), and vedolizumab (29% vs. 15% in high-risk group). …”
Get full text

Development of lactation and breast/chestfeeding adverse event terminology (LaBAET) through a Delphi consensus approach by Katarzyna M. Maksym, Kinga Kalita-Kurzyńska, Diane Spatz, Melinda Boss, Maria Carmen Collado, Anna Gonciarz-Dytman, Bei Han, Asma Khalil, Joanna Kozakiewicz, Ernest Kuchar, Karolina Morze, Rebecca Powell, Natalie Shenker, Sławomir Wątroba, Anna L. David, Aleksandra Wesołowska

“…The lack of information on the safety of medications during lactation may lead to cessation of lactation in favor of treatments, therefore contribute to suboptimal breastfeeding rates. Inadequate terminology to define and grade adverse events for lactation and breast/chestfeeding limits the understanding of potential therapeutic harms. …”
Get full text

Child-therapist acoustic synchrony and response trajectories in autism intervention: an AI-based automated analysis using dynamic systems theory and affective computing by Giulio Bertamini, Silvia Perzolli, Arianna Bentenuto, Cesare Furlanello, Mohamed Chetouani, David Cohen, Paola Venuti

“…However, quantitatively studying fine-grained aspects such as the child-clinician synchrony patterns poses challenges, limiting translational research. …”
Get full text

Research on the Protection Status and Development Strategies for New Varieties of Lychee and Longan in China by Yingjie WEN, Zhixian TANG, Fachao SHI, Hailun LIU, Yonghua JIANG, Qian YAN

“…Of these, 21 litchi and 5 longan varieties were granted protection, yielding authorization rates of 33.3% and 19.2%. The average duration for examination and authorization was 30.5 months. …”
Get full text

Precision public health alliances as a model and method for community engagement by Margaret L. McGladrey, Mary Elizabeth Lacy, Kristen McQuerry, Rachel Hogg-Graham, Svetla Slavova, Emily R. Clear, Kory Heier, Caitline Phan, Megan Hall, Ryan Parker, Mindy Keeton, Jennifer Sword, Thomas Ard, Charbel Salem

“…In Fall 2024, UKKD and UKCPH developed a statistical analysis plan to examine the interplay of social, geographic, and clinical factors associated with CRC screening rates, which is a UKKD quality improvement priority. …”
Get full text

A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by exceedingly high rates of metastatic progression, with the liver representing the most common site of distant spread. …”
Get full text

Dynamic immune response to Avian Pathogenic Escherichia coli infection in broiler chickens: Insights into pro-inflammatory and anti-inflammatory cytokine regulation by Xin Ye, Chuan-Yu Hsu, Linan Jia, Xue Zhang, Christopher Magee, Stephanie Whitham, Spencer Leigh, Jeffrey D. Evans, Li Zhang, Kelsy Robinson

“…This study investigates the dynamic immune responses to APEC infection in broiler chickens, with a focus on survival rates, airsac lesion scores, and cytokine gene expression patterns in lung tissue. …”
Get full text

Impact of Hepatic Steatosis on the Antiviral Effects of PEG-IFNα-2a in Patients with Chronic Hepatitis B and the Associated Mechanism by Huiqing Liang, Yaoyu Liu, Xiaoqian Jiang, Xiaoting Zheng, Jinmo Tang, Jiaen Yang, Hongli Zhuang, Penghua Lai, Li Peng, Zhenying Guo, Shanshan Cai, Dan Luo, Lingxia Xu, Qianguo Mao, Shaodong Chen

“…After 48 weeks of treatment and 24 weeks of follow-up, the rates of CR, VR, and BR had gradually decreased, whereas the severity of hepatic steatosis had increased. …”
Get full text

Resistome and Phylogenomics of <i>Escherichia coli</i> Strains Obtained from Diverse Sources in Jimma, Ethiopia by Mulatu Gashaw, Esayas Kebede Gudina, Guenter Froeschl, Ralph Matar, Solomon Ali, Liegl Gabriele, Amelie Hohensee, Thomas Seeholzer, Arne Kroidl, Andreas Wieser

“…<b>Introduction</b>: In recent years, antimicrobial resistance (AMR) rates have increased significantly in bacterial pathogens, particularly extended beta-lactam resistance. …”
Get full text

Global, regional, and national burden and trends of HIV/AIDS among women of childbearing age from 1990 to 2021: results from Global Burden of Disease 2021 by Mingjie Tang, Mingjie Tang, Jun Shao, Yanjie Jiang, Yanjie Jiang, Yinghong Li, Shiwei Li, Yilin Song, Wenxuan Wu, Jiqin Tang, Zhaoming Chen

“…In 2021, the global age-standardized rates for incidence (ASIR), prevalence (ASPR), mortality (ASMR), and DALYs (ASDALYR) were 34.73 (95% uncertainty interval [UI]: 30.03 to 40.54) per 100,000, 830.87 (95% UI: 784.57 to 884.29) per 100,000, 13.39 (95% UI: 10.34 to 17.56) per 100,000, and 829.75 (95% UI: 658.24 to 1,063.9) per 100,000, respectively. …”
Get full text

Giant Unicystic Ameloblastoma in a Teenager of Azande Tribe: A Clinical Case Report by Posite Charles M, Faustin TM, Woldemichael MA, Vargas Escalante E, Mohamud Snr MA, Laetitia FM, Moses A, Santos MB, Samuel T, Ali ZI, Olive MM, Maha AB, Baanitse J, Said M, Wabinga H, Rosales YD

“…Incidence varies globally, with lower rates in non-African populations (around 0.5 per million annually) compared to higher prevalence in Nigeria and South Africa, where Black populations show increased susceptibility. …”
Get full text

Work related musculoskeletal stress among residents of internal medicine on cardiological wards in their daily working practice – a kinematic and ergonomic analysis by Fabian Holzgreve, Corinna Rittinghausen, Ingo Hermanns, Britta Weber, Rolf Ellegast, Julia Bille, Doerthe Brueggmann, Stefanie Mache, David A. Groneberg, Daniela Ohlendorf

“…The office type work situations showed high sedentary rates with increased ergonomic risk for postures of the cervical and thoracolumbar spine (moderate to unfavorable postures for back curvature in almost all percentiles and office activities, reclination of the neck during (-8°- -16° in P05 and P25) for ‘use of computer’. …”
Get full text

Opportunities for immunocorrection aiming for reduction of morbidity in the areas with adverse occupational and environmental conditions by S. V. Petlenko, E. G. Golovacheva, O. I. Afanasieva

“…The one-year follow-up showed high effectiveness of these drugs, as shown by decreased incidence of acute infectious and lower exacerbation rates of chronic respiratory and gastrointestinal diseases. …”
Get full text

Organisation of physical education in universities for students with disabilities: Modular approach by L. V. Zakharova, O. N. Moskovchenko, U. Solimene, N. V. Tretyakova, N. V. Bannikova, N. V. Lyulina, O. A. Kattsin

“…The evaluation of the validity of differences in the average values of the studied indicators was performed according to Student’s t-test at a significance level of 5%. The growth rates of indicators were calculated according to Brody’s formula.Results and scientific novelty. …”
Get full text

Fungi present distinguishable isotopic signals in their lipids when grown on glycolytic versus tricarboxylic acid cycle intermediates by S. Jabinski, S. Jabinski, V. Kučera, V. Kučera, M. Kopáček, M. Kopáček, J. Jansa, T. B. Meador, T. B. Meador, T. B. Meador

“…<p>Microbial activity in soils controls both the size and turnover rates of large carbon (<span class="inline-formula">C</span>) inventories stored in the subsurface, having important consequences for partitioning of <span class="inline-formula">C</span> between terrestrial and atmospheric reservoirs as well as recycling of mineral nutrients such as nitrogen or phosphorus (often bound to the <span class="inline-formula">C</span>) that support plant growth. …”
Get full text

Development of approaches to the evaluation of pharmacotherapy effectiveness for chronic hepatitis C by I. A. Narkevich, E. A. Tsitlionok

“…Objective: to analyse the consumption pattern of antiviral therapy (AVT) for chronic hepatitis C on the example of an infectious hospital.Material and methods. …”
Get full text

Influence of SCD and FABP3 genetic markers on carcass traits and meat quality in Aberdeen Angus bulls by Sena Ardicli, Nursen Senturk, Tugce Necla Selvi, Sena Yonga, Rumeysa Celik, Beyza Karalar, Aleyna Ozdeniz, Madina Aliyeva, Havvanur Aydin, Ozgur Toprak Ay, Ozge Ardicli, Muhammed Emin Sari, Berkay Bozkurt, Oliva Giannelli Viscardi, Huseyn Babayev, Hakan Ustuner

“…The results suggest a notable impact of the FABP3 rs210042291 gene on growth rates. These findings highlight the complexity of genetic influences on meat quality traits.…”
Get full text

Supershear source model of the 2025 M7.8 Myanmar earthquake and paleoseismology of the Sagaing Fault: regions of significant overlap with past earthquakes by Diego Melgar, Ray Weldon, Yu Wang, Mary Grace Bato, Lin Thu Aung, Xuhua Shi, Weerachat Wiwegwing, Saw Ngwe Khaing, Soe Min, Myo Thant, Cole Speed, Robert Zinke, Eric Fielding, Aron Meltzner, Timothy Dawson

“…Given the exceptional exposure to earthquakes and high strain rates, our findings underscore the need for urgent attention to earthquake preparedness and infrastructure resilience in central Myanmar. …”
Get full text