High-fat diet mouse model receiving L-glucose supplementations propagates liver injury by Johnny Amer, Athar Amleh, Ahmad Salhab, Yuval Kolodny, Shira Yochelis, Baker Saffouri, Yossi Paltiel, Rifaat Safadi

“…D- and L-Glu supplementations showed significant decrease of Glycogenesis (low GYS2/PYGL ratio) and unchanged p-AKT pattern compared to their RD counterparts.ConclusionOur data indicate an increase in rate of de-novo lipogenesis (DNL) in RD-fed mice (High carbohydrate diet) and liver fibrosis following additional sugar supplementations. …”
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Association of cancer and outcomes of patients hospitalized for COVID-19 between 2020 and 2023 [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Robert F Terry, Rugiatu Z Kamara, Robert J Samuels, Donald S Grant, Sulaiman Lakoh, Mustapha Kabba, Innocent Nuwagira, Yusuf Sheku Tejan, Sia Morenike Tengbe, Ibrahim Franklyn Kamara, Shermarke Hassan, Abdulai Tejan Jalloh, Divya Nair, Laura Merson

“…Conclusions This study's findings underscore the heightened vulnerability of hospitalized COVID-19 patients with cancer, revealing a higher mortality rate, longer hospital stays, and an unstructured pattern of care that reflects the complexity of managing severely ill patients during a public health crisis like the COVID-19 pandemic.…”
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Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis by Yue Shen, Lu Lin, Weijun Yu, Zhurong Cui, Tingting Lin, Shucheng Hu, Yuanjie Shi, Yuting Gu, Min Jin, Eryi Lu

“…Introduction and aims: Carnitine palmitoyltransferase I (CPT1), the rate-limiting enzyme of fatty acid oxidation, plays a crucial role in inflammation. …”
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Seroprevalence and risk factors of bluetongue virus infection in sheep and goats in West Gondar zone, Northwest Ethiopia by Adem Beyan, Wassie Molla, Adugna Berju Molla, Mastewal Birhan, Saddam Mohammed Ibrahim, Bereket Dessalegn, Ambaye Kenubih, Abebe Tesfaye Gessese, Mebrie Zemene Kinde, Gashaw Getaneh Dagnaw, Melkie Dagnaw Fenta, Hana Tesfaye, Takele Tesgera, Liyuwork Tesfaw, Habtamu Abesha, Zewdu Seyoum Tarekegn, Haileyesus Dejene, Molalegne Bitew

“…A mixed-effects logistic regression was employed to evaluate the relationship between Bluetongue virus seropositivity and potential risk factors.ResultsThe overall seroprevalence rate at the individual animal level was 84.5% (95% CI: 81.09–87.82). …”
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Prevalence of Genetic Mutations in Patients with Metastatic Prostate Cancer in a Cohort of Mexican Patients by Orión Erenhú Rodríguez González, Edgar Iván Bravo Castro, Jesus Eduardo Osorio, Habiram Pacheco Guerrero, Brenda Suaste Carmona, Luis David Arreola Peralta, Noe Esaul Martinez Juárez, Juan Samuel Izquierdo Luna, José de Jesús Oswaldo Islas García, Omar Dimas Victorio Vargas, Rafael Alberto Valdez Flores, Jesús Javier Torres Gómez, José Gadú Campos Salcedo

“…<b>Conclusions:</b> Our study unveiled a mutation rate of 21.73%, marked by a significant prevalence of ATM, FANCA, FANCM, and Variants of Uncertain Significance (VUS). …”
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The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing by Na Zhao, Guojian Wang, Shuang Long, Xiaofan Lv, Xinze Ran, Junping Wang, Yongping Su, Tao Wang

“…In both Spink7 knockdown and knockout models, quantitative comparisons were made between the healing rate of wounds and histopathological morphometric analysis. …”
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Habit-learning and decision-making circuits are susceptible to glycemic variability in type 2 diabetes: a longitudinal study by Carolina Moreno, Carolina Moreno, Carolina Moreno, Otília C. d’Almeida, Otília C. d’Almeida, Joana Crisóstomo, Nádia Canário, Leonor Gomes, Leonor Gomes, Leonor Gomes, Miguel Castelo-Branco, Miguel Castelo-Branco

“…Linear regression analysis showed that, for each increase of 1 mmol/L in MAGE value, the SPC of the temporal lobe decreases on average by 1.2% (higher atrophy rate).ConclusionThe relationship between longitudinal GM atrophy and GV has a regionally specific pattern, suggesting localized brain susceptibility to intra-daily glucose fluctuations. …”
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Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy by Wei Wu, Qihan Fu, Lulu Liu, Yi Zheng, Hangyu Zhang, Peng Zhao, Weijia Fang, Xuanwen Bao, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Zhou Tong, Fanglong Liu

“…A receiver operating characteristic curve was used to evaluate the accuracy rate of neural network, reaching 100%.Conclusion Our analysis unraveled the difference in the molecular nature and genomic variance in MSI and MSS colon cancer. …”
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Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging by Qian-Qian Zeng, Shi-Zhe An, Chao-Nan Chen, Zhen Wang, Jia-Cheng Liu, Ming-Xi Wan, Yu-Jin Zong, Xiao-Hua Jian, Jie Yu, Ping Liang

“…Following bolus injection of microbubbles at clinical concentration, SR-US was performed using a high frame rate (350–500 Hz) modified ultrasound scanner and a convex array transducer with a central frequency of 3.1 MHz. …”
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Variant pubertal development in Prader-Willi syndrome: early and slow progression of pubarche with normal age at gonadarche by Aneta Kodytková, Petra Dušátková, Shenali Anne Amaratunga, Stanislava Koloušková, Barbora Obermannová, Renata Pomahačová, Štěpánka Průhová, Marta Šnajderová, Zdeněk Šumník, Jiřina Zapletalová, Valerij Semjonov, Jan Lebl

“…The age at gonadarche was adequate – 10.0 years in girls (8.8–11.2), and 11.0 in boys (9.8–12.1). Progression rate of breast development from B2 to B4 was 3.9 (0.2–7.5) years in girls and of testicular volume from 4 ml to 15ml was 3.8 (0.0–8.1) years in boys. …”
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Viral characterization of the reassortants between canine influenza H3N2 and human pandemic (2009) H1N1 and avian H9N2 viruses in canine ex vivo tracheal explants by Tonia T. Kam, Christine H. T. Bui, Hin-Wo Yeung, Peter C. H. Wong, Alex W. H. Chin, John M. Nicholls, Malik Peiris, Kenrie P. Y. Hui, Leo L. M. Poon, Michael C. W. Chan

“…Results Co-passaging H3N2-CIV with human/avian influenza A viruses in canine tracheal explants resulted in a high rate of reassortment. Plaque-purified reassortants were all viable and able to propagate in mammalian alveolar epithelial cells. …”
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Exhaled breath particles as a diagnostic tool for bronchiolitis obliterans syndrome in lung transplant recipients: a longitudinal study by Runchuan Gu, Runchuan Gu, Runchuan Gu, Embla Bodén, Embla Bodén, Embla Bodén, Embla Bodén, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Franziska Olm, Franziska Olm, Franziska Olm, Franziska Olm

“…Exhaled breath particles (EBP) measured as particle flow rate (PFR) from the airways have been explored as a potential method to diagnose lung injury in preclinical and clinical settings of acute respiratory distress syndrome (ARDS) and primary graft dysfunction (PGD). …”
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Preexisting Heart Disease Spectrum and In‐Hospital Outcomes for Patients With Acute Ischemic Stroke by Hong‐Qiu Gu, Kai‐Xuan Yang, Xing‐Quan Zhao, Yi‐Long Wang, Li‐Ping Liu, Zi‐Xiao Li, Yong Jiang, Hao Li, Wen Zhang, Ze‐Ning Jin, Jing Han, Yong‐Jun Wang

“…Preexisting heart disease spectrum was defined based on the combination pattern of coronary heart disease, atrial fibrillation, and heart failure. …”
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Overweight and Helicobacter pylori infection: a correlation in metabolic dysfunction-associated fatty liver disease by Xu Chen, Jiayue Fu, Jiayue Fu, Kejia Jin, Kejia Jin, Zixuan Yang, Zixuan Yang, Yidan Qian, Yidan Qian, Kehan Mei, Yihan Wang, Jialei Min, Yilin Du, Zaisheng Zhu, Zaisheng Zhu, Shengcun Li, Shengcun Li

“…Therefore, eradication of H. pylori infection may have positive implications for reducing the incidence rate of overweight MAFLD.…”
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…The APOE ɛ4 genotype was enriched in the Amnestic Predominant group, who were also rated as least impaired. Cortical thickness analysis validated these clinical phenotypes with dissociations in atrophy patterns observed between the Dysexecutive and Amnestic Predominant groups. …”
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Examining the Spatial Disequilibrium and Driving Factors of Population Aging and Elderly Service Resource Allocation in Rural Areas: A Case Study of Wenzhou City by Xiang Xiaoye, Lin Liyue, Xu Shiyu, Huang Tao

“…The results can be summarized as follows: 1) As Wenzhou enters a deeply aging society, the spatial distribution of the elderly population, elderly population density, population aging coefficient, elderly population support ratio, and comprehensive aging index are basically the same, showing a gradually increasing spatial pattern from the municipal district to the peripheral streets of the municipal district to the remote towns; 2) Elderly care service resources in Wenzhou present an asymmetrical and unbalanced north-south spatial distribution pattern with the municipal districts as " diversified supply in municipal streets, basic guarantee in developed coastal towns, and shortage of supply in inland mountainous towns "; 3) The streets of the municipal district have rich elderly care service resources, including Grade 3 general hospitals and comprehensive nursing homes, to provide diversified elderly care services for the elderly in the municipal district; there are many old-age care facilities such as hospitals, clinics, and nursing homes in Ruian, Yueqing City, and central towns such as Hongqiao and Aojiang, which provide basic old-age security for the elderly in and around the area. …”
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Spatial and Temporal Variation of GPP and Its Response to Urban Environmental Changes in Beijing by Le Chen, Simin Yu, Shi Shen, You Wan, Changqing Song

“…The results showed that the spatial distribution pattern of GPP in Beijing was higher in the northwest and lower in the southeast, and it showed an overall upward trend from 2000 to 2020, with an average annual growth rate of 14.39 g C·m⁻²·a⁻¹. …”
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Simulation and zoning evaluation of in-situ stress field within ultra-deep tight sandstone reservoirs in thrust-nappe structures of Bozi-Dabei area, Tarim Basin by Zimeng XING, Ruixue LI, Hucheng DENG, Hang SU, Jiawei ZHANG, Jianhua HE, Hui ZHANG, Xiaofei HU, Shunting MA

“…A detailed three-dimensional heterogeneous in-situ stress field model was constructed for well B1, a key development area in the Bozi-Dabei area, to clarify the stress distribution characteristics and conduct zoning evaluations. The average error rate between the numerical simulation results and single-well in-situ stress interpretations was less than 10%. …”
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IMPACT OF THE INFLAMMATORY AND ISCHEMIC HEART DISEASE MARKERS INTO THE OVERALL CARDIOVASCULAR MORTALITY IN SENILE CITIZENS OF A LARGE CITY (THE DATA FROM SAHR TRIAL) by S. A. Shalnova, S. E. Evstifeeva, A. D. Deev, V. A. Metelskaya, A. V. Kapustina, G. A. Muromtseva, Yu. A. Balanova, E. M. Tuaeva, A. E. Imajeva, N. V. Kiseleva, M. A. Shkolnikova

“…For the assessment of current subclinical inflammation we used high-sensititvity C-reactive protein (hsCRP), interleucine 6 (IL-6), fibrinogen (FG), leucocytes, erythrocyte sedimentation rate (ESR). For CHD screening, we used standard ROse questionnaire and ECG pattern by Minnesota coding. …”
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A clinico-epidemiological study, assessing possible predictors of mortality and health-related quality of life for people living with visceral leishmaniasis – human immune virus (V... by Niyamat Ali Siddiqui, Dhruv Kumar Pandey, Ashish Kumar Singh, Sanjay Kumar Sinha, Mohd. Zahid Ansari, Rishikesh Kumar, Biplab Pal, Vidya Nand Rabi Das, Rajatashuvra Adhikary, Saurabh Jain, Krishna Pandey

“…These patients have a poor VL therapeutic success rate, more drug-related toxicity, and relapses resulting in high mortality. …”
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