Treatment Pattern and Outcome of Locally Advanced Rectal Cancer in Resource-Constrained Countries: Experience at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia by Elias Amare Hailu, Edom Seife Woldetsadik, Biruk Legesse Tadesse, Abdi Dandena Dibaba, Girum Tessema Zingeta, Hidagewoin Frew Kelemu, Yonas Alemayehu Zewde, Ruth Shimeles Aytehgeza, Kebede H. Begna

“…Among 81 treatment-naïve patients, 79 were triaged for surgery, but only 47 (59.5%) underwent surgery, achieving an 89.9% R0 resection rate. Of 36 up-front planned surgeries, 35 proceeded as planned, whereas only 12 of 43 (28%) planned after neoadjuvant treatment underwent surgery. …”
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Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes? by Sarbani Ghosh Laskar, Anuj Kumar, Ashwini Adhau, Shwetabh Sinha, Samarpita Mohanty, Munita Bal, Neha Mittal, Swapnil Rane, Asawari Patil, Ashwini Budrukkar, Monali Swain, Pallavi Rane, Gouri Pantvaidya, Sudhir Nair, Deepa Nair, Anuja Deshmukh, Shivakumar Thiagarajan, Richa Vaish, Vidisha Tuljapurkar, Chandrashekhar Dravid, Poonam Joshi, Rathan Shetty, Arjun Singh, Pankaj Chaturvedi

“…All patients underwent surgery followed by adjuvant RT, with or without concurrent chemotherapy. Recurrence patterns were categorised as in‐field, marginal or out‐of‐field. …”
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Opioid-use disorder and reported pain after spine surgery: Risk-group patterns in cognitive-appraisal processes in a longitudinal cohort study by Carolyn E Schwartz, ScD, Katrina Borowiec, MA, Bruce D Rapkin, PhD, Joel A Finkelstein, MD, MSc, FRCS(C), Tai Sutherland, BA, Olivia B Caan, BA, MS, Richard L Skolasky, ScD

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Changes in prevalence and patterns of consanguinity in Bradford, UK  – evidence from two cohort studies [version 2; peer review: 1 approved, 2 approved with reservations] by Brian Kelly, John Wright, Neil Small

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Reappraisal of the clinical and anatomic characteristics of idiopathic outflow tract ventricular arrhythmias with an R wave pattern break in precordial lead: A multi-center study by Muhammad Rafdi Amadis, Satoshi Higa, Chin-Yu Lin, Yuen Hoong Phang, Chia-Hsin Chiang, Jose Antonio Lopez Bautista, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Ting-Yung Chang, Ling Kuo, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Ming-Jen Kuo, Thien-Chuong Nguyen-Khac, Guan-Yi Li, Yu-Shan Huang, Shih-Ann Chen

“…Background: Idiopathic outflow tract ventricular arrhythmia (OT-VA) with a pattern break (PB) in the precordial leads is challenging to treat and is associated with low success rates. …”
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Distribution and Antimicrobial Resistance Patterns of Aerobic Bacterial Isolates from Clinically Ill Pet Guinea Pigs (<i>Cavia porcellus</i>) in Hong Kong by Desiree Hung, Ibrahim Elsohaby, Fraser Hill, Andrew Ferguson, Colin T. McDermott

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Prevalence and antimicrobial susceptibility patterns of Salmonella from apparently healthy slaughtered cattle and abattoir workers at Gondar Elfora abattoir, Central Gondar Zone, E... by Firdyawukal Abuhay Tafere, Melkie Dagnaw Fenta, Mastewal Birhan Atanaw, Elias Melkamu Tsehay, Yelak Hulugeza Mengstu, Atsede Solomon Mebiratu

“…Salmonella isolates were resistant to antimicrobials with specific resistance rates 58.82% for cefoxitin (95%Rn: 42.28 – 75.37), 41.2% (95%Rn: 24.63 – 57.72) for ampicillin and 35.3% (95%Rn: 19.23 – 51.36) for tetracycline. …”
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Socio-economic position and type 2 diabetes risk factors: patterns in UK children of South Asian, black African-Caribbean and white European origin. by Claudia Thomas, Claire M Nightingale, Claire M Nightingale, Angela S Donin, Alicja R Rudnicka, Christopher G Owen, Naveed Sattar, Derek G Cook, Peter H Whincup

“…<h4>Methods and findings</h4>Cross-sectional school-based study of 4,804 UK children aged 9-10 years, including anthropometry and fasting blood analytes (response rates 70%, 68% and 58% for schools, individuals and blood measurements). …”
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War’s youngest victims: a descriptive cross-sectional study on injury distributions, severity patterns, and outcomes among paediatric trauma patients in Kharkiv, Ukraine by Filippa Sennersten, Safora Frogh, Gustav Falk, Mariia Matvieienko, Olha Karafulidi, Olha Konstantynovska, Yohan Robinson, Andreas Wladis, Denise Bäckström

“…Conclusions This study offers new insights into paediatric trauma from modern warfare in a high-income setting, highlighting the occurrence of blast and shelling injuries, injury patterns overall similar to previous conflicts, and high disability rates at discharge. …”
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Random forest-driven mortality prediction in critical IBD care: a dual-database model integrating comorbidity patterns and real-time physiometrics by Zhenze Zhang, Zhenze Zhang, Caiqing Zhao, Caiqing Zhao, Yijun Zhou, Ling Yao, Peng Liu, Ziling Fang, Nian Fang, Nian Fang

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Emerging and legacy organophosphate flame retardants in the tropical estuarine food web: Do they exhibit similar bioaccumulation patterns, trophic partitioning and dietary exposure... by Qianyi Huang, Rui Hou, Yuchen Wang, Lang Lin, Hengxiang Li, Shan Liu, Xiangrong Xu, Kefu Yu, Xiaoping Huang

“…The investigation of metabolites and the biotransformation rate (KM) confirmed the role of biotransformation in offsetting trophic transfer for both legacy and emerging OPFRs. …”
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Real-world treatment patterns and survival outcomes in patients with locally advanced squamous cell carcinoma of the head and neck in Germany using claims data by Kathrin Hering, Thomas Kuhnt, Nils Kossack, Lena M. Richter, Michael Schultze, Ulrike Osowski, Luisa Henkel, Ann-Christin Gaupel, Marie-Noelle Solbes, Bernard Zolyniak, Nancy Schoenherr

“…Index treatment was similar for male and female patients. The rate of surgical resection and definitive non-surgical treatment was similar in patients with oral cavity cancer [50.6% (128/253) and 49.4% (125/253), respectively]; all other tumor sites were treated more frequently (&gt;60%) with definitive non-surgical treatment. …”
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Gas composition and pressure in the hypopharynx during high-flow oxygen therapy through a nasal cannula in healthy volunteers with different breathing patterns by Andrey I. Yaroshetskiy, Anna P. Krasnoshchekova, Fedor D. Tkachenko, Alina V. Rubashchenko, Daniil D. Zubarev, Vasiliy D. Konanykhin, Maxim I. Savelenok, Maxim M. Nosenko, Zamira M. Merzhoeva, Sergey N. Avdeev

“…Abstract Background High-flow nasal cannula is widespread in patients with hypoxemic and hypercapnic respiratory failure, but physiological data concerning influence of the combination of breathing pattern, preset flow rate (PFR), and inspiratory oxygen fraction (FDO2) on end-expiratory pressure (EEP), capnogram, oxygram, and exhaled tidal volume (VTe) remains insufficient. …”
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Bacterial Superinfections After SARS-CoV-2 Pneumonia: Antimicrobial Resistance Patterns, Impact on Inflammatory Profiles, Severity Scores, and Clinical Outcomes by Petrinela Daliu, Iulia Bogdan, Ovidiu Rosca, Alexandra Laura Aelenei, Ioan Sîrbu, Mihai Calin Bica, Monica Licker, Elena Hogea, Delia Muntean

“…Inflammatory markers (C-reactive protein, procalcitonin, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index) and the severity indices Acute Physiology and Chronic Health Evaluation (APACHE) II, Confusion, Urea, Respiratory rate, Blood pressure (CURB), and National Early Warning Score (NEWS) were measured at admission. …”
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MRSA Profiles Reveal Age- and Gender-Specificity in a Tertiary Care Hospital: High Burden in ICU Elderly and Emerging Community Patterns in Youth by Kamaleldin B. Said, Khalid Alshammari, Ruba M. Elsaid Ahmed, Fawwaz Alshammari, Ahmed H. Jadani, Ihab Rakha, Salem A. Almijrad, Anwar E. Almallahi, Bader Alkharisi, Naif M. Altamimi, Tarig Mahmoud, Nada A. Abozaid, Amal D. Alshammari

“…Respiratory specimens constituted 37% and had the highest MRSA rate (42%), followed by blood (24.5%) and wounds (10.3%). …”
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Systematic Review and Meta-Analysis on Prevalence and Antimicrobial Resistance Patterns of Important Foodborne Pathogens Isolated from Retail Chicken Meat and Associated Environmen... by Haris Ayoub, Murthy Suman Kumar, Zunjar Baburao Dubal, Kiran Narayan Bhilegaonkar, Hung Nguyen-Viet, Delia Grace, Sakshi Thapliyal, Ekkoruparambil Sethurajan Sanjumon, Elisetty Naga Pavana Sneha, Dharavath Premkumar, Vinodh Kumar Obli Rajendran, Ram Pratim Deka

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Respiratory Mycopathogens: A study of mycological, risk factors, clinical profiles and antifungal resistance pattern in a tertiary health care centre in the foothills of Himalaya by Dr Amber Prasad, Dr Priyal Anand, Dr Mukesh Bairwa, Dr Uttam Kumar Nath, Dr Smita Sinha, Dr PV Sowjanya, Dr Yogendra Pratap Mathuria

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Saudi urologists’ treatment pattern for high-risk Bacillus Calmette–Guérin naïve and Bacillus Calmette–Guérin unresponsive nonmuscle invasive bladder cancer by Mohammad Alghafees, Mohamad Abou Chakra, Abdullah Alkhayal, Mohamad Moussa, Mohammad Alkhamees, Bader Alsaikhan, Ahmed Alasker, Abdulrahman Alsayyari, Abdullah Alsaghyir, Ali Alkahtani, Michael A. O'Donnell

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Beneficial effect of Gyejibokryeong-hwan on climacteric syndrome with blood stasis pattern: A randomized, double-blinded, placebo-controlled clinical pilot trial by Kyungsun Han, Jeong-Eun Yoo, Jung-Eun Kim, Ojin Kwon, Ae-Ran Kim, Hyo-Ju Park, So-Young Jung, Mikyung Kim, Changsop Yang, Jung-Hyo Cho, Jun-Hwan Lee

“…For the primary outcome, the Menopause Rating Scale (MRS) was evaluated. For the secondary outcomes, quality of life, degrees of abdominal resistance and tenderness, blood-stasis pattern questionnaire and degree of upward movement of Qi were evaluated. …”
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Opioid prescription patterns and pain severity among patients with opioid use disorder and other substance use disorders: a mixed methods study by Erin F. Madden, Gintare Daulys, Benjamin Tingey, Felicia Frabis, Pooja Lagisetty, Philip J. Kroth, Fares Qeadan

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