Pitfalls in the diagnosis of apparent homozygous mutations: two cases of IL10RA deficiency inflammatory bowel disease and a literature review by Xiu Shi, Ziqing Ye, Lai Qian, Wenhui Hu, Ye Yang, Chunmeng He, Zhiheng Huang, Bingbing Wu, Ying Huang

“…Abstract Background In East Asia, IL10RA is the predominant pathogenic gene in patients with very early-onset inflammatory bowel disease (VEO-IBD), frequently characterised by refractory diarrhoea and severe perianal disease, resulting in elevated death rates. IL10RA-deficient IBD, an autosomal recessive genetic disorder, has been documented to be inherited through the conventional compound heterozygous or homozygous mutation patterns from both parents. …”
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Multimorbidity frailty index and clinical outcomes among 42,989 older heart failure patients directly discharged from emergency departments: A nationwide retrospective cohort study by Wan-Ju Liao, Hsi-Yu Lai, Liang-Yi Lin, Cheng-Hsueh Wu, Fei-Yuan Hsiao, Liang-Kung Chen

“…Readmission rates showed similar patterns. The severely frail group had higher risks of mortality (aHR 1.44, 95 % CI 1.33–1.55), all-cause readmissions (sHR 1.69, 95 % CI 1.62–1.76), and HF-related readmissions (sHR 1.59, 95 % CI 1.48–1.71). …”
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Farm households’ livelihood adaptive capacity under multiple pressures of small watershed management by Yaru Sun, Yilin Gan, Jing Luo, Tingting Han, Hafo Wang, Ruirui Yang, Lingling Tian

“…However, the FHLAC remains predominantly low to moderate in the small watershed. The contribution rates of livelihood pressure, livelihood capital, and willingness to adapt to FHLAC are 22.24 %, 28.69 %, and 49.07 %, respectively. …”
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RNAi-mediated suppression of toll-like receptor NlToll1 enhances Nilaparvata lugens susceptibility to entomopathogenic fungal infection by Zhu-Long Shao, Chen-Ping Lan, Xiao-Ping Yu, Zheng-Liang Wang

“…Toll-like receptors (TLRs) are a family of crucial pattern recognition proteins that are responsible for the immunologic recognition of invading pathogen in insects. …”
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Geospatial analysis of cholera outbreak in Lusaka, Zambia, between 2023 and 2024 by William Ngosa, Tadatsugu Imamura, Nyuma Mbewe, Joseph Seriki, Oscar Nzila, Fred Mfune, Godfrey Zulu, Chomba Mulando, Tizha Chiluba, Luo Miyanda, Agness Phiri, Lucy Sichone, Galion Mwape, Kapambwe Mulenga, Charles Chileshe, Nawa Mabuku, Dabwiso Banda, Fangyu Yan, Taro Kamigaki, Roma Chilengi, Nyambe Sinyange

“…Results Over the study period, 4,591 suspected cholera cases with geocoordinate data were identified, with incidence rates varying across the constituencies. Median cholera incidence (IQR) was 0.55 (0.27–1.44) in Lusaka, with higher incidence rates observed in unplanned residential areas. …”
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Molecular and genomic investigation of an urban outbreak of dengue virus serotype 2 in Angola, 2017-2019. by Zoraima Neto, Pedro A Martinez, Sarah C Hill, Domingos Jandondo, Julien Thézé, Marinela Mirandela, Renato Santana Aguiar, Joilson Xavier, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Filipa Vaz, Gisel Reyes Castro, Joana Paula Paixão, Nicholas J Loman, Philippe Lemey, Oliver G Pybus, Jocelyne Vasconcelos, Nuno Rodrigues Faria, Joana de Morais

“…<h4>Background</h4>The transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remain poorly understood. …”
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Dynamic parking space allocation at urban scale: Problem formulation and resolution by Hanae Errousso, Jihane El Ouadi, El Arbi Abdellaoui Alaoui, Siham Benhadou

“…To do this, we consider both solicitation rates in these areas and coverage ratios of received parking demands. …”
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The characteristics of new-onset myasthenia gravis after COVID-19 outbreak: a cross-sectional study by Yanzhen Huang, Yu Wu, Shaodan Zhou, Xianting Que, Ailing Jiang, Danli Shi, Ting Lu, Yanlan Chen, Ziqun Lin, Chao Liu, Yishuang Wen, Shuyi Zhang, Wen Huang

“…After COVID-19 outbreak, there was an increase in new-onset MG patients, with more cases occurring within the first three months. The rates of pulmonary inflammation (40.28%), COVID-19 vaccination (88.14%), and treatment with tacrolimus (15.98%) and MG duration (15 weeks, IQR: 5.75, 32) were higher, while rates of thymectomy (13.92%), baseline MG-ADL (3, IQR: 3, 6), and QMGS (7, IQR: 5,8) were lower compared to new-onset MG patients before COVID-19 outbreak. …”
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Extreme Oncoplastic Surgery for Multifocal/Multicentric and Locally Advanced Breast Cancer by Chaitanyanand B. Koppiker, Aijaz Ul Noor, Santosh Dixit, Laleh Busheri, Gautam Sharan, Upendra Dhar, Hari Kiran Allampati, Smeeta Nare

“…EO followed by RT results in acceptable local-regional control, low rate of complications, and high patient satisfaction. …”
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Predictive value of D-Dimer and thromboplastin time as coagulation indicators for COVID-19 patients by Marwan Alshipli, Thamer A Altaim, Ammar A Oglat, Samira Ahmed Alsenany, Osama Khodrog, Hanan Hasan, Sally Mohammed Farghaly Abdelaliem, A Matrieh, Bassam Z Shakhreet, Riziq Allah Gaowgzeh

“…Within the two groups of patients, the rate of coagulation disorders was as follows: mild = 8.8 % within coagulation disorders, 4.8% within the two Groups; severe = 91.2 % within coagulation disorders, 77.8 % within the two Groups. …”
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Fosfomycin susceptibility in multidrug resistant uropathogens: A retrospective study in the era of antimicrobial resistance by Jasleen Kaur, Priya Bhat, Upasana Bhumbla

“…Background: Urinary tract Infection is one of the most prevalent clinical entities affecting people worldwide. The accelerating rate of antimicrobial resistance due to the unimpeded and rampant use of antimicrobials with over the counter availability of drugs has limited the therapeutic options for the treatment of UTI. …”
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Salmonella spp. Inactivation During Hot Air Drying of Apples: Influence of Temperature, Bed Depth, and Air Velocity by Xiyang Liu, Elizabeth M. Grasso-Kelley, Alvin Lee, Lilybell Warda, Nathan M. Anderson

“…Increased air velocity shortened the constant-rate drying period, promoted a faster temperature increase in the apple cubes, and resulted in higher lethality within a shorter drying period. …”
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The Effects of a Small Dose of Tannin Supplementation on In Vitro Fermentation Characteristics of Different Forages by Sytske de Jong, Fabiellen C. Pereira, Alejandro R. Castillo, Wilbert F. Pellikaan, Pablo Gregorini

“…The addition of tannins reduced the fractional rate of gas production for alfalfa (<i>p</i> ≤ 0.04) but increased it for ryegrass and plantain. …”
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Efficiency of foliar application with organic fertilizer agrochelate on seed plots of summer sowing watermelon by O. V. Yakimova, V. E. Lazko, E. N. Blagorodova

“…Organic fertilizer AGROCHELATE was used to treat the leaf surface of plants with a consumption rate of 100 ml/ha. A single spraying was used during the flowering phase of the plants. …”
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Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study by Tung-Hua Chen, Yung-Chieh Lin, Yuh-Jyh Lin, Chyi-Her Lin

“…Mean TCB levels increased at a rate of 0.01–0.21 mg/dL/h initially, followed by a decrease after 96–108 h of age. …”
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Subnational malaria burden in Sindh, Pakistan: over a decade of evidence for tailored strategies by Nelofer Baig, Zakir Ali, Muhammad Ahmed, Wafa Zehra Jamal, Saqib Ur Rehman, Zafar Ahmed, Riaz Hussain Rahoojo, Javed Ali Jagirani, Bilal Ahmed Usmani, Zafar Fatmi

“…Marked heterogeneity observed in malaria burden across districts. Malaria positivity rate was 12.3%. Six districts (Khairpur, Sanghar, Naushero Feroze, Badin, Mirpurkhas, and Larkana) carried over 53% burden of malaria in Sindh. …”
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Tetrahymena ATG8 homologs, TtATG8A and TtATG8B, are responsible for mitochondrial degradation induced by starvation by Shinya Matsuda, Chieko Saito, Mami Nomura, Hitomi Kawahara, Noboru Mizushima, Kentaro Nakano

“…The ciliate Tetrahymena exhibits active swimming behavior in water, preying on microorganisms and growing exponentially at a rate of 0.5–0.75 h⁻¹ under optimal conditions. In this organism, numerous mitochondria localize to the cell cortex along the ciliary rows, likely ensuring an efficient ATP supply necessary for vigorous cell movement. …”
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Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multic... by Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Cheol-Hyun Kim, Dong-Jun Choi

“…Efficacy will be assessed using the recurrence rate of ischemic stroke, which will be assessed on days 30, 90, 180, 270, 360, 450, 540, 630, 720, and 750 after starting the medication. …”
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An Epidemiological Review of the Impact of COVID-19 on Achilles Tendon Rupture Injuries, Experience from a Large London District General Hospital by Lena Al-Hilfi, Irrum Afzal, Sarkhell Radha, Mohamed Abdalla, Mohammed Al-Maiyah

“…As lockdown measures began to ease, hospitals experienced a high admission rate of patients presenting with Achilles Tendon Rupture [ATR]. …”
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Prognostic significance of acute exacerbations and usual interstitial pneumonia in fibrotic interstitial lung disease by Yun Zhang, Zekai Cen, Qunli Ding, Yanan Ying, Chengna Lv, Tingting Wu

“…The Kaplan‒Meier survival analysis showed that the IPF group (HR 1.97, 95% CI 1.05–3.70, P = 0.011) had a worse survival rate than the FILD group, and landmark analyses showed that the survival of FILD patients with the UIP pattern (HR 3.07 95% CI 1.37–6.86 P = 0.006) was significantly shorter than that of FILD patients with the NSIP pattern 48 months after ILD diagnosis. …”
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