A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by exceedingly high rates of metastatic progression, with the liver representing the most common site of distant spread. …”
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Quality of life and clinical data in hemodialysis patients with different degrees of pruritus by Sebastián Mas Fontao, Paula Manso, Julia Audije-Gil, David Hernán Gascueña, Fabiola Dapena, Nuria Aresté, Emilio Sánchez-Álvarez, Pablo Molina, Raquel Ojeda, Marian Goicoechea, Vicent Esteve Simó, Guillermo Alcalde Bezhold, Mario Prieto-Velasco, María Jesús Lloret, Ana Blanco Santos, Juan Manuel Buades, Carlos Narváez, Rafael Sánchez-Villanueva, Rosa Elena Pérez-Morales, María Dolores Arenas Jiménez, Fundación Renal Española Working Group, Prurito Working Group

“…Each reporting period (morning, midday, evening, and night) revealed distinct patterns in pruritus prevalence and severity (p < 0.05). …”
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Gut Microbiota and Lipid Metabolism in Bullfrog Tadpoles: A Comparative Study Across Nutritional Stages by Zhilong Wang, Pengxiang Liu, Jun Xie, Huirong Yang, Guangjun Wang, Kai Zhang, Rui Shu, Zhifei Li, Jingjing Tian, Hongyan Li, Wenping Xie, Wangbao Gong, Yun Xia

“…These insights provide a theoretical foundation for nutritional interventions aimed at enhancing tadpole growth and survival rates.…”
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Construction of high-density bin genetic map and QTL mapping of fruit aroma in longan (Dimocarpus longan Lour.) by Wenshun Hu, Qing Zhang, Chaojun Deng, Qizhi Xu, Jimou Jiang, Xiuping Chen, Jianguo Li, Jisen Zhang, Shaoquan Zheng

“…These QTLs explained 19.8%–51.0% of the phenotypic variation rates and were distributed across 11 linkage groups, with two QTL-rich regions on LG7 and LG8. …”
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Dynamic immune response to Avian Pathogenic Escherichia coli infection in broiler chickens: Insights into pro-inflammatory and anti-inflammatory cytokine regulation by Xin Ye, Chuan-Yu Hsu, Linan Jia, Xue Zhang, Christopher Magee, Stephanie Whitham, Spencer Leigh, Jeffrey D. Evans, Li Zhang, Kelsy Robinson

“…This study investigates the dynamic immune responses to APEC infection in broiler chickens, with a focus on survival rates, airsac lesion scores, and cytokine gene expression patterns in lung tissue. …”
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Impact of Hepatic Steatosis on the Antiviral Effects of PEG-IFNα-2a in Patients with Chronic Hepatitis B and the Associated Mechanism by Huiqing Liang, Yaoyu Liu, Xiaoqian Jiang, Xiaoting Zheng, Jinmo Tang, Jiaen Yang, Hongli Zhuang, Penghua Lai, Li Peng, Zhenying Guo, Shanshan Cai, Dan Luo, Lingxia Xu, Qianguo Mao, Shaodong Chen

“…After 48 weeks of treatment and 24 weeks of follow-up, the rates of CR, VR, and BR had gradually decreased, whereas the severity of hepatic steatosis had increased. …”
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Resistome and Phylogenomics of <i>Escherichia coli</i> Strains Obtained from Diverse Sources in Jimma, Ethiopia by Mulatu Gashaw, Esayas Kebede Gudina, Guenter Froeschl, Ralph Matar, Solomon Ali, Liegl Gabriele, Amelie Hohensee, Thomas Seeholzer, Arne Kroidl, Andreas Wieser

“…<b>Introduction</b>: In recent years, antimicrobial resistance (AMR) rates have increased significantly in bacterial pathogens, particularly extended beta-lactam resistance. …”
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Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…PDOs reproduced pathological and immunohistochemical patterns of source tumors, with pathogenic variants confirmed in 84% (21/25). …”
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Burden of pulmonary arterial hypertension in Asia from 1990 to 2021: Findings from Global Burden of Disease Study 2021 by Shenshen Huang, Jiayong Qiu, Anyi Wang, Yuejiao Ma, Peiwen Wang, Dong Ding, Luhong Qiu, Shuangping Li, Mengyi Liu, Jiexin Zhang, Yimin Mao, Yi Yan, Xiqi Xu, Zhicheng Jing, Rongman Jia

“…Using the latest data from the Global Burden of Disease 2021, we evaluated and analyzed the distributions and patterns of PAH disease burden among various age groups, sexes, regions, and countries in Asia. …”
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Characteristics and risk factors for outcomes in patients with Mycoplasma pneumoniae mono- and coinfections: A multicenter surveillance study in Wuhan, China, 2023 by Banghua Chen, Jie Pan, Ying Peng, Yuanyuan Zhang, Yunan Wan, Hongjie Wei, Kangguo Li, Wentao Song, Yunkang Zhao, Kang Fang, Huiming Ye, Jiali Cao, Jia Rui, Zeyu Zhao, Tianmu Chen

“…Children aged 1–10 years had the highest incidence, whereas those over 60 years had elevated hospitalization, severe infection, and fatality rates. Coinfection patterns differed by age, with bacterial-viral-Chlamydia pneumoniae (C. pneumoniae) / other pathogens prevalent in infants, bacterial-viral pathogens prevalent in preschoolers, and viral-viral pathogens prevalent in school-aged children. …”
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Bridging micro and macroevolution: insights from chromosomal dynamics in plants by Carmen Benítez-Benítez, Ashwini V. Mohan, Rogelio Sánchez-Villegas, Inés Gómez-Ramos, Ana Valdés-Florido, Kay Lucek, Marek Slovák, Marek Slovák, Filip Kolář, Filip Kolář, Ilia J. Leitch, Modesto Luceño, Isabel Larridon, Angelino Carta, Angelino Carta, Joan Cuscó-Borràs, Enrique Maguilla, Alegría Montero-Ramírez, Patrick G. Meirmans, Alison Dawn Scott, Santiago Martín-Bravo, Marcial Escudero

“…At the macroevolutionary level, we investigated the association between karyotype diversity and diversification rates using evidence from comparative genomics, chromosomal evolution modelling across phylogenies, and the association with several traits across different angiosperm lineages. …”
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Progressive subcortical involvement as spinocerebellar ataxia type 3 advances by Pubing Yuan, Yonghua Huang, Minghui Dai, Xin Jin, Dingxin Zheng, Die Xiao, Lihua Deng, Peiling Ou, Linfeng Shi, Yifan Chen, Jian Wang, Wei Chen, Yuanchao Zhang, Chen Liu

“…Abstract Background and objectives Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disease characterized by heterogeneous motor and nonmotor manifestations. The progressive pattern of subcortical shape abnormalities and their associations with the clinical phenotypes in SCA3 remain unknown. …”
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Global, regional, and national burden and trends of HIV/AIDS among women of childbearing age from 1990 to 2021: results from Global Burden of Disease 2021 by Mingjie Tang, Mingjie Tang, Jun Shao, Yanjie Jiang, Yanjie Jiang, Yinghong Li, Shiwei Li, Yilin Song, Wenxuan Wu, Jiqin Tang, Zhaoming Chen

“…The analysis employed a multidimensional stratification approach, examining temporal patterns, age distributions, geographic variations, and Socio-demographic Index (SDI). …”
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Giant Unicystic Ameloblastoma in a Teenager of Azande Tribe: A Clinical Case Report by Posite Charles M, Faustin TM, Woldemichael MA, Vargas Escalante E, Mohamud Snr MA, Laetitia FM, Moses A, Santos MB, Samuel T, Ali ZI, Olive MM, Maha AB, Baanitse J, Said M, Wabinga H, Rosales YD

“…Incidence varies globally, with lower rates in non-African populations (around 0.5 per million annually) compared to higher prevalence in Nigeria and South Africa, where Black populations show increased susceptibility. …”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…The app received positive ratings, with a System Usability Scale score of 77.4 and a Customer Satisfaction Score of 86.6%. …”
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Work related musculoskeletal stress among residents of internal medicine on cardiological wards in their daily working practice – a kinematic and ergonomic analysis by Fabian Holzgreve, Corinna Rittinghausen, Ingo Hermanns, Britta Weber, Rolf Ellegast, Julia Bille, Doerthe Brueggmann, Stefanie Mache, David A. Groneberg, Daniela Ohlendorf

“…By synchronizing the data obtained from both measurements, postural patterns were chronologically aligned and contextualized with the corresponding task performance. …”
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Influential drivers of the cost-effectiveness of respiratory syncytial virus vaccination in European older adults: a multi-country analysis by Xiao Li, Lander Willem, Caroline Klint Johannesen, Arantxa Urchueguía-Fornes, Toni Lehtonen, Richard Osei-Yeboah, Heini Salo, Alejandro Orrico-Sánchez, Javier Díez-Domingo, Mark Jit, for PROMISE investigators, Joke Bilcke, Harish Nair, Philippe Beutels

“…Both costs and quality-adjusted life-years (QALYs) were discounted at country-specific discount rates and the analysis was conducted from both the healthcare payers’ and societal perspectives. …”
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Ecological Concrete-Based Modular System for Heavy Metal Removal in Riparian Transition Zones: Design, Optimization and Performance Evaluation by Guangbing Liu, Da Ke, Hasnain Moavia, Chen Ling, Yanhong Zhang, Yu Shen

“…The initial rapid surface adsorption phase (0–4 h) achieved removal rates of 0.28–0.42 mg g⁻¹ h⁻¹, followed by pore diffusion (4–24 h) and chemical fixation phases, with removal patterns effectively modeled using a modified pseudo-second-order equation. …”
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Long-term real-world outcomes of first-line immunotherapy in non-small cell lung cancer – a population-based cohort study in Sweden by Gunnar Wagenius, Anders Vikström, Anders Berglund, Stina Salomonsson, Goran Bencina, Xiaohan Hu, Diana Chirovsky, Hans Brunnström

“…Background: In a previous study, we explored real-world programmed death-ligand 1 (PD-L1) testing and treatment patterns for patients with advanced non-small cell lung cancer (NSCLC) in the era of immune-oncology. …”
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Opportunities for immunocorrection aiming for reduction of morbidity in the areas with adverse occupational and environmental conditions by S. V. Petlenko, E. G. Golovacheva, O. I. Afanasieva

“…Origin and severity of immune system disorders depends on the spectrum and duration of exposure to adverse factors and patterns of professional activity at the chemically hazardous facilities. …”
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