Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review by Nadia Harbeck, Adam Brufsky, Chloe Grace Rose, Beata Korytowsky, Connie Chen, Krista Tantakoun, Endri Jazexhi, Do Hoang Vien Nguyen, Meaghan Bartlett, Imtiaz A. Samjoo, Timothy Pluard

“…Key outcomes for synthesis were effectiveness, treatment patterns, and safety.ResultsThis review included 23 unique studies. …”
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Improvement of Oral Anticoagulant Prescription and Long‐Term Clinical Outcomes of Patients With Atrial Fibrillation After Implementation of a Clinical Decision Support System in Ou... by Po‐Tseng Lee, Mu‐Hsiang Huang, Ting‐Chun Huang, Pi‐Shan Sung, Chi‐Hui Hsu, Ya‐Ling Huang, Sheng‐Hsian Lin, Ping‐Yen Liu

“…Results OAC prescription rates increased from 47.3% to 67.5% after CDSS implementation. …”
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Clinical outcomes of flomoxef versus cefmetazole in hospitalized patients with urinary tract infections: combined retrospective analyses of two real-world databases and in vitro da... by Takahiro Niimura, Mitsuhiro Goda, Satoshi Nakano, Toshiki Kajihara, Koji Yahara, Aki Hirabayashi, Koji Miyata, Marie Ikai, Motoko Shinohara, Yusuke Minato, Masato Suzuki, Keisuke Ishizawa

“…Methods The susceptibility rates of third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae to flomoxef and cefmetazole were compared using comprehensive national antimicrobial resistance surveillance data. …”
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Exploring mobility data for enhancing HIV care engagement in Black/African American and Hispanic/Latinx individuals: a longitudinal observational study protocol by Katherine P Theall, Lisa Hightow-Weidman, Xiaoming Li, Sean Young, Lidia Flores, Seungjun Kim, Maryam Hassani, Cristina De Haro, Mohamed Emish, Zeyad Kelani, Dominic Arjuna Ugarte, Amanda Castel

“…We seek to study the relationship between mobility patterns and HIV care engagement.Ethics and dissemination Ethical approval has been obtained from the Institutional Review Board of the University of California, Irvine (#20205923). …”
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Lignin Unlocks Stealth Carbon Sinks in Cold Seeps via Microbial Enzymatic Gatekeeping by Jialing Li, Jingchun Feng, Pandeng Wang, Mengzhuo Zhu, Yongji Huang, Ying Wu, Junning Fan, Junlin Hu, Xiyang Dong, Yingli Zhou, Xuanyu Tao, Si Zhang

“…Although direct methanogenesis was undetected, methylotrophic potential was evidenced through methane cycle gene expression patterns by lignin decomposers. Phylogenetic surveys further demonstrated the global prevalence of lignin decomposers across 12 major cold seep systems. …”
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Isokinetic Evaluation of Quadriceps and Hamstring Muscle Performance in the Rehabilitation Phase after ACL Reconstruction by Nicolae Stanciu, Razvan Marian Melinte, Mark Slevin, Octav Marius Russu, Cristian Trâmbițaș, Cezara Ilinca Stanciu, Elena Georgiana Bălănescu, Dan Avrămiuc, Gabriel Koszoruș, Klara Brînzaniuc

“…While male and athletic participants exhibited higher absolute and relative strength values (p < 0.05), recovery rates were consistent across subgroups. Adductor and abductor strength also showed post-rehabilitation symmetry and robustness, supporting their relevance in functional assessment.…”
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Antimicrobial susceptibility profiles of thermophilic Campylobacter species from human, pig, and chicken feces in Rwanda by Noel Gahamanyi, Noel Gahamanyi, Arsene Musana Habimana, Jean Paul Harerimana, Josiane Mukayisenga, Salomon Ntwali, Anathali Umuhoza, Emmanuel Nsengiyumva, Emmanuel Irimaso, Jean Bosco Shimirwa, Cheol-Ho Pan, Erick Vitus Komba, Claude Mambo Muvunyi, Nadine Rujeni, Raghavendra G. Amachawadi

“…Further genomic analysis will shed more light on the transmission and drug resistance patterns.…”
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Nutritional status, dietary inflammatory potential, and risk of osteosarcopenia: the Bushehr Elderly Health (BEH) program by Gita Shafiee, Mehrad Nasiri, Zhaleh Shadman, Mehdi Ebrahimi, Narges Zargar Balajam, Ramin Abdi Dezfouli, Iraj Nabipour, Ramin Heshmat

“…Abstract Background Osteosarcopenia is a growingly approved geriatric condition with a significant prevalence that contributes to higher rates of illness and death. Chronic inflammation and inadequate nutrition are key risk factors for numerous age-related diseases. …”
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Seven New Irbesartan Salts: Significantly Improved Dissolution, Excellent Hygrothermal Stability, and Characteristic Supramolecular Synthons by Junxiao Wang, Chuanhua Wu, Menglong Zhang, Lingli Hou, Wei Chen, Dingding Jing, Ying Bao

“…Their vitro dissolution, intrinsic dissolution rates (<i>IDR</i>s), thermal/hygroscopic stability (via thermal analysis, dynamic vapor sorption, and accelerated stability tests), and phase transition process (monitored by in situ Raman spectroscopy) were evaluated. …”
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Ultrasound-activated miR-195-5p/shikonin nanobubbles remodel immunosuppressive microenvironment via immunogenic cell death to potentiate PD-1/PD-L1 blockade in hepatocellular carci... by Yandi Tan, Qiao Xu, Yezi Chen, Yun Liu, Chaoqi Liu, Xinwu Cui, Yun Zhao

“…Despite the transformative clinical impact of programmed cell death ligand 1/programmed death 1 (PD-1/PD-L1) blockade in hepatocellular carcinoma (HCC), therapeutic efficacy remains limited by the tumor immunosuppressive microenvironment (TIME), with objective response rates persistently below 20 %. To address this critical clinical challenge, we engineered ultrasound (US)-responsive lipid nanobubbles (NBs) co-encapsulating microRNA (miR)-195-5p and shikonin (SK) (designated miR-195-5p/SK-NBs), a dual-functional platform designed to synergize PD-L1 suppression with immunogenic cell death (ICD). …”
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Machine Learning-Based Intrusion Detection Systems for the Internet of Drones: A Systematic Literature Review by Mostafa Ogab, Sofiane Zaidi, Abdelhabib Bourouis, Carlos T. Calafate

“…Existing Intrusion Detection Systems (IDS) for IoD face several limitations, including high false positive rates, resource constraints of drones, limited adaptability to evolving attack patterns, and a lack of standardized datasets for benchmarking, despite ongoing research efforts. …”
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Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective by Xinhua Peng, Xinhua Peng, Rongrong Zhu, Ke Zhang, Jianghong Ji, Chuanguo Lv, Feng Feng, Feng Feng

“…AimMalignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. …”
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Profiles and kinetics of PgRNA and clinical characteristics in pregnant, postpartum, and non-pregnant women with chronic HBV infection by Genju Wang, Yandan Wu, Ziyue Zhang, Qiuchen Wu, Juan Tang, Ying Ji, Yan Wang, Guanlun Zhou, Minmin Yu

“…Moreover, the detection rates of pgRNA, DNA, and HBeAg varied significantly across the three stages and different treatment regimens in CHB women. pgRNA was highly correlated with HBeAg, and a moderate correlation was found between pgRNA and HBV DNA levels. …”
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fNIRS evidence of abnormal frontotemporal cortex activation and functional connectivity in depressed patients after stroke: neuromodulatory mechanisms from mild to moderate depress... by Shanshan Zhou, Xiaodie Liu, Mengyuan Chen, Wenyi Chen, Yawen Pan, Yinghao Zhi

“…In contrast, the mild-PSD group displayed no notable connectivity differences between the two groups.ConclusionThis study presents distinct patterns of frontotemporal cortex activation and functional connectivity alterations associated with varying severity levels of PSD. …”
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The Impact of Rural Alimentation on the Motivation and Retention of Indigenous Community Health Workers in India: A Qualitative Study by Ajit Kerketta, Raghavendra A N

“…The interviews were audio recorded, transcribed, and analyzed using thematic analysis to identify common themes and patterns in their experiences related to nutrition and retention. …”
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The Risk of Vestibular Disorders with Semaglutide and Tirzepatide: Findings from a Large Real-World Cohort by Eman A. Toraih, Awwad Alenezy, Mohammad H. Hussein, Shahmeer Hashmat, Saitej Mummadi, Nawaf Farhan Alrawili, Ahmed Abdelmaksoud, Manal S. Fawzy

“…Tirzepatide users demonstrated similar patterns but lower absolute rates (0.10% at 6 months to 0.19% at 3 years vs. controls 0.04% to 0.15%), with hazard ratios from 3.19 (95% CI: 2.11–4.81) to 4.55 (95% CI: 3.43–6.03). …”
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Analyzing the Contents of a Large, Public Online Peer Support Forum for Obsessive-Compulsive Disorder: Thematic Analysis by Nora Yanyi Sun, Christopher Pittenger, Terence Ching

“… Abstract BackgroundObsessive-compulsive disorder (OCD) is a debilitating chronic anxiety disorder with low rates of remission. r/OCD is a peer support forum hosted by the Reddit website with over 180,000 users and 100‐200 new posts daily. …”
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Immunohistochemical analysis of IDH1, ATRX, p53, and Ki-67 in glioblastoma and diffuse infiltrative glioma: Therapeutic and prognostic correlation by Hasbay Bermal, Kayaselçuk Fazilet, Süner Halil İbrahim, Tufan Kadir

“…Kaplan-Meier method and Cox proportional regression model (forward model) were used to estimate the mean and median survival times, failure rates, and hazard ratios. Results. In the study, 115 (56.1%) patients were male and 90 (43.9%) were female. …”
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Dietary strategies for preventing and managing obesity through evidence-based nutritional interventions by Stephen Olaide Aremu, Blessing Akute, Dorcas Oluwakemi Aremu, Caleb Zando, Esther Damilola Aremu, Omagu Julia Nwachukwu, Mary Omolola Omosebi, Victoria Oluwatosin Akute, Stephen Tokunbo Oluwole, Abdillahi Abdi Barkhadle, Matthew Olaleke Aremu

“…This crisis is driven by multifaceted factors, including sedentary lifestyles, urbanization, dietary transitions, and behavioral influences. As obesity rates continue to rise, dietary interventions emerge as crucial and modifiable strategies for prevention and management. …”
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Clinical value and survival analysis of subcutaneous soft tissue metastasis detected by 18F-FDG PET/CT by Yufei Gao, Hui Zhang, Tiancheng Hao, Lizhuo Jia, Jiangmeng Wu, Dongxue Wu, Siqi Wu, Yong Wang

“…Collect patient histological subtypes, metastasis patterns, treatment, and survival rates. Kaplan Meier curves were used to estimate survival time, and Mantel-Cox univariate analysis was used to determine the correlation between extensive metastasis, degree of soft tissue involvement, systemic and local treatment, and survival time.ResultAmong the 57 patients confirmed by pathology, 10 were benign and 47 were malignant. …”
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