Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Results From 184 patients (17 tumor types), 249 samples were collected: 149 (59.8%) from tumor tissue, 61 (24.5%) from peritoneal fluids, 39 (15.7%) from peripheral blood. Success rates for PDO establishment were 39.5%, 34.4%, and 25.6%, respectively. …”
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Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study by Raynaud, Marie, Gagnaire, Pierre-Alexandre, Galtier, Nicolas

“…False positive and false negative hotspots considerably confound fine-scale patterns of inferred recombination under a wide range of conditions, particularly when Ne is small and the mutation/recombination rate ratio is low, to the extent that maps inferred from populations sharing the same recombination landscape appear uncorrelated. …”
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Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation by Marek Jasiński, Maria Zadoń

“…The connection between bioheat transfer and PDT models is taken into account through the respective relationships between perfusion rate, capillary blood velocity, and the maximum oxygen supply rate. …”
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Resolving contiguous vowels across word boundaries in Spanish: L2 learners, levels, and tasks by Erik W. Willis, D. Eric Holt, Carly Carver

“…The intermediate learners increased the frequency of linking contiguous vowels to 49% in the narrative-retell task, whereas the advanced L2 speakers slightly reduced their linking rate to 68%. The Mexican monolingual speaker comparison group produced linked speech in a narrative-retell task at a rate of 93%. …”
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Air Entrainment and Gas Transfer in Wave Breaking Events by S. Di Giorgio, S. Pirozzoli, A. Iafrati

“…We show that the volume of gas transferred across the air‐water interface increases significantly with the amount of air entrained due to wave breaking, peak values in the transfer velocity being concurrent with peaks in energy dissipation rate and air entrainment. The gas transfer velocity is observed to scale approximately as the one‐fourth power of the energy dissipation rate, consistent with previous theoretical predictions. …”
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Size and impact of the Brussels knowledge economy by Tom Van Puyenbroeck, Johan Eyckmans, Peter Teirlinck, André Spithoven, Gilles Van Hamme

“…Over the period 2008-2020, the compound annual growth rate of knowledge-intensive employment was highest in the surrounding Brussels functional metropolitan area. …”
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Evaluating the predictive power of combined gene expression dynamics from single cells on antibiotic survival by Razan N. Alnahhas, Virgile Andreani, Mary J. Dunlop

“…We first identified relationships between growth rate and reporter levels based on auto- and cross-correlation analysis, revealing consistent patterns where changes in growth rate were anticorrelated with fluorescence following a delay. …”
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Timing matters! Academic assessment changes throughout the day by Carmelo M. Vicario, Michael A. Nitsche, Chiara Lucifora, Pietro Perconti, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Francesco Tomaiuolo, Simona Massimino, Alessio Avenanti, Alessio Avenanti, Massimo Mucciardi

“…Our results demonstrate a Gaussian distribution of passing rates throughout the day, with a significant peak at midday. …”
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Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…Annual period prevalence and incidence rates of opioid prescriptions were estimated, and long-term trends were quantified as the percent change from 2012 to 2019. …”
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The system of atmosphere, land, ice and ocean in the region near the 79N Glacier in northeast Greenland: synthesis and key findings from the Greenland Ice Sheet–Ocean Interaction (... by T. Kanzow, T. Kanzow, A. Humbert, A. Humbert, T. Mölg, M. Scheinert, M. Braun, H. Burchard, F. Doglioni, P. Hochreuther, M. Horwath, O. Huhn, M. Kappelsberger, J. Kusche, E. Loebel, K. Lutz, B. Marzeion, B. Marzeion, R. McPherson, M. Mohammadi-Aragh, M. Mohammadi-Aragh, M. Möller, M. Möller, C. Pickler, M. Reinert, M. Rhein, M. Rhein, M. Rückamp, M. Rückamp, J. Schaffer, J. Schaffer, M. Shafeeque, M. Shafeeque, S. Stolzenberger, R. Timmermann, J. Turton, J. Turton, C. Wekerle, O. Zeising

“…Observations and models employed in this study are consistent in terms of melt rates occurring below the floating ice tongue. Our results suggest that the multidecadal warming of Atlantic Intermediate Water flowing into the cavity below the ice tongue – supplied by the recirculating branch of the West Spitsbergen Current in Fram Strait – is the main driver of the recent major increase in basal melt rates. …”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…However, relatively little attention has been given to urbanized areas characterized by high rates of population growth and land development. …”
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A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership by Elizabeth M. Norman, Mildred Ortu Kowalski, Roxanne Sabatini, Carol S. Jones, Wendy Silverstein

“…At the time of this April surge, nurses were exposed to a virus with no standard treatments and high mortality rates. Using a longitudinal qualitative design, the team hoped to answer questions about what compelled these nurses to continue to come to work? …”
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Unveiling the drivers contributing to global wheat yield shocks through quantile regression by Srishti Vishwakarma, Xin Zhang, Vyacheslav Lyubchich

“…Here, we study the spatiotemporal patterns of wheat yield shocks, quantified by the lower quantiles of yield fluctuations, in 86 countries over 30 years. …”
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Fishery, Growth, and Mortality of Threatened Asian Sunfish, Horabagrus brachysoma (Gu¨nther 1864) in Five Rivers of Western Ghats Hotspot, India by Chelapurath Radhakrishnan Renjithkumar, Kuttanelloor Roshni

“…The calculated exploitation rate (E) ranging from 0.49 to 0.72 yr -¹ exceeds the anticipated optimum exploitation levels (0.5). …”
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Heterogeneity Analysis of Resident Demands and Public Service Facilities in Megacities of China from the Perspective of Urban Health Examination by Ning Zhang, Shaohua Wang, Haojian Liang, Zhuonan Huang, Xiao Li, Zhenbo Wang

“…By integrating spatial and temporal social sensing big data, including road networks, population, and points of interest (POI) data, and employing spatial analysis methods including coverage rate calculation, supply–demand matching efficiency, spatial heterogeneity, and sp{atial stability analysis, this study reveals the spatial distribution patterns of various facilities within cities, as well as the heterogeneity, balance, and equity of supply–demand matching efficiency between different cities. …”
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A Novel Carbon Fiber Composite Material for the Simulation of Damage Evolution in Thick Aquifers by Bozhi Zhao, Xing Gao, Weibing Zhu, Jiaxing Ding, Pengjun Gao

“…This study found that as the carbon fiber content increased, the evolution patterns of the electrical resistance change rate and the damage coefficient of the similar material tended to coincide. …”
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Characteristics of left ventricular dysfunction in repaired tetralogy of Fallot: A multi-institutional deep learning analysis of regional strain and dyssynchrony by Brendan T. Crabb, Rahul S. Chandrupatla, Evan M. Masutani, Sophie Y. Wong, Sachin Govil, Silvia Montserrat, Susana Prat-González, Julián Vega-Adauy, Melany Atkins, Daniel Lorenzatti, Chiara Zocchi, Elena Panaioli, Nathalie Boddaert, Laith Alshawabkeh, Lewis Hahn, Sanjeet Hegde, Andrew D. McCulloch, Francesca Raimondi, Albert Hsiao

“…In the multivariate analysis, this contraction pattern was the only LV metric associated with future progression to PVR (heart rate = 2.69, p < 0.005). …”
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A Comparative Analysis of Machine Learning Algorithms for Classification of Diabetes Utilizing Confusion Matrix Analysis by Maad M. Mijwil, Mohammad Aljanabi

“…Mainly, logistic regression and Adaboost had a classification rate above 92%, and the naive bayes algorithm achieved a classification rate above 90%. …”
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Epidemiology of invasive meningococcal disease in Novosibirsk region during 1992–2015 by I. Ya. Izvekova, E. I. Krasnova

“…Aim: To study the epidemiological patterns of invasive meningococcal disease in Novosibirsk region within a time period from 1992 to 2015.Methods: retrospective comparative epidemiological analysis.Results: During the analyzed period the annual incidence rate of invasive meningococcal disease was higher than average annual incidence rate in Russian Federation. …”
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Personal recognition using finger knuckle shape oriented features and texture analysis by K. Usha, M. Ezhilarasan

“…The experimental results confirm that, our proposed method shows a high recognition rate of 98.72% with lower false acceptance rate of 0.06%.…”
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