Characterizing Breast Tumor Heterogeneity Through IVIM-DWI Parameters and Signal Decay Analysis by Si-Wa Chan, Chun-An Lin, Yen-Chieh Ouyang, Guan-Yuan Chen, Chein-I Chang, Chin-Yao Lin, Chih-Chiang Hung, Chih-Yean Lum, Kuo-Chung Wang, Ming-Cheng Liu

“…Evaluation using 3D-ROC analysis also indicated that the DNN was the best detector based on metrics like target detection rate and overall effectiveness. The DNN model further exhibited the capability to identify tumor heterogeneity, differentiating high- and low-cellularity regions. …”
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Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance by Amélie Vergnol, Aly Bourguiba, Stephanie Bauché, Massiré Traoré, Maxime Gelin, Christel Gentil, Sonia Pezet, Lucile Saillard, Pierre Meunier, Mégane Lemaitre, Julianne Perronnet, Frederic Tores, Candice Gautier, Zoheir Guesmia, Eric Allemand, Eric Batsché, France Pietri-Rouxel, Sestina Falcone

“…Voltage-gated Ca²⁺ channels (VGCCs) are regulated by four CaVβ subunits (CaVβ1–CaVβ4), each showing specific expression patterns in excitable cells. …”
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Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation by Tingting Wu, Hu Cheng, Lijie Sima, Zhongyuan Wang, Weiwei Ouyang, Jianta Wang, Yunlei Hou, Dongsheng Zhao, Weike Liao, Chujiao Hu

“…In this study, we employed multistage virtual screening methods to screen multiple compound databases to predict new PD-1/PD-L1 ligands. 35 compounds were proposed by combined analysis of fitness scores, interaction pattern and MM-GBSA binding affinities. Enzymatic assay confirmed that 10 out of 35 ligands were potential PD-L1 inhibitors, with inhibitory rate higher than 50% at the concentration of 30 µM. …”
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A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization by Hua Liu, Zhijie Chen, Qiaowen Lin, Yi Chen, Liwen Hong, Jie Zhong, Zhengwei Cai, Zhengting Wang, Wenguo Cui

“…In vivo, the EMS strategy exhibits 89- and 52-fold higher colonization rate in the cecum and colon of mice, compared to conventional oral probiotics. …”
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Exploring adolescents’ indirect financial and non-financial barriers to dental care non-attendance: the role of payment methods by Alla T. Alsharif, Saba Kassim

“…Regression analysis showed that being male, using publicly funded dental services, and self-rating poor oral health were significantly associated with non-dental attendance (AOR = 2.42; 95% CI: 1.39–4.20; p = 0.002; AOR = 2.00; 95% CI: 1.07–3.75; p = 0.030; AOR = 2.32; 95% CI: 1.05–5.10; p = 0.037, respectively). …”
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Temporal trends of carbon monoxide poisoning mortality at the global, regional and national levels: a cross-sectional study from the Global Burden of Disease study, 1990 and 2017 by Jie Liu, Junxiu Zhao, Jianhai Long, Yawei Sun, Xiaobo Peng

“…The overall ASR decreased by an average of 1.83% (95% CI 2.10% to 1.56%) per year in this period. This decreasing pattern was heterogeneous across ages, regions and countries. …”
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Spatio-Temporal Evolution Characteristics of Tourism Ecological Resilience in China by Li Jiang, Xingpeng Chen, Lili Pu, Huaju Xue

“…This study takes 31 provinces in China as the research area, constructs a comprehensive evaluation index system of TER based on the theory of evolutionary resilience, and uses a comprehensive evaluation index, GIS spatial analysis technology, kernel density estimation, Dagum–Gini coefficient, and other research methods to analyze the spatial and temporal evolution of China’s TER from 2010 to 2022 and the spatial distribution pattern of three dimensions of DPC-ARC-OIC. The results show that (1) In the process of time evolution, the ecological resilience of tourism in China continues to increase, and from 2010 to 2022, China’s TER first increased and then decreased, with an average annual growth rate of 1.47%, among which Yunnan and Jiangxi provinces increased significantly. (2) In the process of spatial evolution, there is an obvious spatial gap in tourism ecological resilience. …”
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A “drop” in the atrioventricular conduction curve and dual-pathway electrophysiology by Youhua Zhang, MD, PhD

“…Background: Atrioventricular (AV) conduction time is rate-dependent. As the atrial coupling interval (A1A2) shortens, AV conduction time (A2H2) prolongs. …”
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Serum matrix metalloproteinase-2,9 activity, galectin-3 and systemic inflammation in patients with postinfarction heart failure with preserved ejection fraction. by O. Kuryata, A. Zabida, O. Sirenko

“…Standard laboratory blood tests for erythrocyte sedimentation rate (ESR), C-RP, haematological parameters, lipid profile, glucose, renal and liver function tests were performed and calculated body mass index (BMI) for all patients. …”
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Data Analysis and Forecasting of COVID-19 Pandemic in Kuwait Based on Daily Observation and Basic Reproduction Number Dynamics by Kayode Oshinubi, Fahima Al-Awadhi, Mustapha Rachdi, Jacques Demongeot

“…When the coronavirus pandemic began early in 2020, experts wondered if there would be waves of cases, a pattern seen in other virus pandemics. The overall pattern so far has been one of increasing cases of COVID-19 followed by a decline, and we observed a second wave of increased cases and yet we are still exploring this pandemic. …”
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OPTIMIZATION OF THE VACUUM-ASSISTED TREATMENT FOR COMPLICATIONS OF DIABETIC FOOT SYNDROME by V.I. Liakhovskyi, O.O. Kyzymenko, O.H. Krasnov, O.I. Krasnov, T.V. Horodova-Andrieieva

“…In the main group, the rate of wound reduction was greatest on the 8th-10th days, and in the comparison group – on the 14th-15th days. …”
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Intrapartum Results on Differing Degrees of Ketonuria in Nulliparous Women with Gestational Diabetes Mellitus during Spontaneous Labor by Shi-Yun Huang, Bo Yu, Xin He, Yi Chen

“…As the degree of ketonuria progressed, we observed a significantly higher number of cases with fetal heart rate pattern III (FHR pattern III), meconium-stained amniotic fluid III (MSAF III), postpartum hemorrhages, prolonged labor, neonatal hypoglycemia, an umbilical cord arterial pH of <7.2, low Apgar scores, increased neonatal intensive care admissions, augmented forceps-assisted deliveries, and conversions to cesarean sections. …”
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Deciphering the complex links between inflammatory bowel diseases and NAFLD through advanced statistical and machine learning analysis by Deepak Kumar, Brijesh Bakariya, Chaman Verma, Zoltán Illés

“…Serum Glutamate Pyruvate Transaminase (GPT), Age at Diagnosis (AAD), Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP) were found the most key important features in liver disease staging increment. …”
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Design of an efficient multi-objective recognition approach for 8-ball billiards vision system by Jiaying Gao, Qiuyang He, Hong Gao, Zhixin Zhan, Zhe Wu

“…In the verification test, the trained CNN model shows a recognition rate of over 98.5%, and outperforms the other three classic methods. …”
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Survey on self-reported psychotropic drug prescribing practices of eating disorder psychiatrists for the treatment of young people with anorexia nervosa by Ian C K Wong, Maedeh Y Beykloo, Dasha Nicholls, Mima Simic, Ruth Brauer, Elizabeth Mills

“…Secondary outcome measures included the process of continuing pharmacotherapy from secondary care to primary care.Results Of the 77 CYP EDS representing every team in England, 44 teams represented by a CAED psychiatrist responded, despite 13 having no psychiatrists in post at the time of the study (response rate 69%). Most (40%) respondents estimated that &lt;10% of patients with AN were prescribed psychotropic medications. …”
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Study on the Evolution Mechanism of the Butterfly-Shaped Plastic Zone in Surrounding Rocks of an Underlying Roadway by Yang Hu, Qingbin Meng, Xu Han, Yongjie Shan, Xueke Wu

“…The results indicate the following: (1) when the horizontal distance between the working face and the roadway exceeds 35 m, no obvious changes are observed in the development pattern of the plastic zone of the surrounding rock of the roadway; (2) when the horizontal distance is less than 35 m, the rate of change in the maximum value of f increases from 0.02 MPa/m to 0.205 MPa/m as the vertical distance decreases, and the β value increases from 0.09°/m to 0.79°/m. …”
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Social control of egg-laying in independently nest-founding bumble bee queens by Blanca R. Peto, Claudinéia P. Costa, Meghan E. Moore, S. Hollis Woodard

“…Bumble bee queens enter their eusocial phase only after successfully rearing their first offspring and thereafter exhibit an increased rate of egg-laying. We tested the idea that during bumble bee nest initiation, queen reproduction is socially context-dependent and under the control of social conditions in the nest. …”
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Mathematical model of the dependence between cerebral ventricular size and capillary pressure in laboratory animals by A. A. Cherevko, G. S. Valova, D. V. Petrovsky, A. E. Akulov

“…To describe the data obtained, the mathematical model was adapted by selecting a scale factor based on the known values of the cerebrospinal fluid formation rate for humans and mice. Results and discussion. …”
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Weak association of Usutu virus and haemosporidian infection in birds collected in Germany by Carolin Hattendorf, Dániel Cadar, Stefan Bosch, Norbert Becker, Lars Lachmann, Jonas Schmidt-Chanasit, Anna Heitmann, Renke Lühken

“…Several studies have reported a high co-infection rate of European birds with both USUV and haemosporidians. …”
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Photon-efficient camera with in-sensor computing by Yanqiu Guan, Haochen Li, Yi Zhang, Yuchen Qiu, Labao Zhang, Xiangyang Ji, Hao Wang, Qi Chen, Liang Ma, Xiaohan Wang, Zhuolin Yang, Xuecou Tu, Qingyuan Zhao, Xiaoqing Jia, Jian Chen, Lin Kang, Peiheng Wu

“…Here, we demonstrate a photon-efficient camera with in-sensor computing based on a superconducting nanowire array detector with four programmable dimensions including photon count rate, response time, pulse amplitude, and spectral responsivity. …”
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